AIMS Medical Science, 2015, 2(4): 396-409. doi: 10.3934/medsci.2015.4.396

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Multi-layer Attribute Selection and Classification Algorithm for the Diagnosis of Cardiac Autonomic Neuropathy Based on HRV Attributes

1. Centre for Research in Complex Systems and School of Community Health, Charles Sturt University, Albury, NSW, Australia;
2. School of Information Technology, Deakin University, 221 Burwood Hwy, Melbourne, Victoria 3125, Australia;
3. School of Design Communication and IT, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia;
4. Department of Computer Science and Software Engineering, University of Melbourne, Parkville, Victoria 3010, Australia;
5. School of Engineering & ICT, University of Tasmania, Private Bag 65, Hobart 7001, Australia;
6. Rural Medical School, University of Melbourne, Wangaratta, Victoria, Australia

Cardiac autonomic neuropathy (CAN) poses an important clinical problem, which often remains undetected due difficulty of conducting the current tests and their lack of sensitivity. CAN has been associated with growth in the risk of unexpected death in cardiac patients with diabetes mellitus. Heart rate variability (HRV) attributes have been actively investigated, since they are important for diagnostics in diabetes, Parkinson's disease, cardiac and renal disease. Due to the adverse effects of CAN it is important to obtain a robust and highly accurate diagnostic tool for identification of early CAN, when treatment has the best outcome. Use of HRV attributes to enhance the effectiveness of diagnosis of CAN progression may provide such a tool. In the present paper we propose a new machine learning algorithm, the Multi-Layer Attribute Selection and Classification (MLASC), for the diagnosis of CAN progression based on HRV attributes. It incorporates our new automated attribute selection procedure, Double Wrapper Subset Evaluator with Particle Swarm Optimization (DWSE-PSO). We present the results of experiments, which compare MLASC with other simpler versions and counterpart methods. The experiments used our large and well-known diabetes complications database. The results of experiments demonstrate that MLASC has significantly outperformed other simpler techniques.
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