Role of PTH in the Renal Handling of Phosphate

Rebecca D. Murray, Eleanor D. Lederer, Syed J. Khundmiri

1 Department of Physiology & Biophysics, University of Louisville, Louisville, KY, USA;
2 Department of Medicine, University of Louisville, Louisville, KY, USA;
3 Robley Rex VAMC, Louisville, KY, USA;
4 Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

Received date: , Accepted date: , Published date:

Special Issues: Developmental and Physiological roles of PTH ligands and receptors: New Insights

References

1. Gates F, Grant J (1927) Experimental Observations on Irradiated, Normal, and Partially Parathyroidectomized Rabbits. J Exp Med 45:125-137.

2. Beck L, Karaplis A, Amizuka N, et al. (1998) Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A 95:5372-5377.    

3. Hedbäck G, Odén A (1998) Increased risk of death from primary hyperparathyroidism－an update. Eur J Clin Invest 28:271-276.    

4. Raue F (1998) Increased incidence of cardiovascular diseases in primary hyperparathyroidism－a cause for more aggressive treatment? Eur J Clin Invest 28:277-278.    

5. Conzo G, Perna A, Candela G, et al. (2012) Long-term outcomes following “presumed” total parathyroidectomy for secondary hyperparathyroidism of chronic kidney disease. G Chir 33:379-382.

6. Bansal V (1990) Serum Inorganic Phosphorus. In: Walker HK, Hall WD, Hurst JW (eds) Clin. Methods Hist. Phys Lab Exam 895-899.

7. Menon M, Ix J (2013) Dietary phosphorus, serum phosphorus, and cardiovascular disease. Ann N Y Acad Sci 1301:21-26.    

8. Baker S, Worthley L (2002) The essentials of calcium, magnesium and phosphate metabolism: part I. Physiology. Crit Care Resusc 4:301-306.

9. Penido M, Alon U (2012) Phosphate homeostasis and its role in bone health. Pediatr Nephrol 27:2039-2048.    

10. Mason J (2011) Vitamins, trace minerals, and other micronutrients. In: Goldman L, Ausiello D, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; chap 225.

11. Takeda E, Taketani Y, Sawada N, et al. (2004) The regulation and function of phosphate in the human body. Biofactors 21:345-355.    

12. Loghman-Adham M (1997) Adaptation to changes in dietary phosphorus intake in health and in renal failure. J Lab Clin Med 129:176-188.    

13. Katai K, Miyamoto K, Kishida S, et al. (1999) Regulation of intestinal Na⁺-dependent phosphate co-transporters by a low-phosphate diet and 1,25-dihydroxyvitamin D3. Biochem J 343 Pt 3:705-712.

14. Hildmann B, Storelli C, Danisi G, et al. (1982) Regulation of Na⁺-Pi cotransport by 1,25-dihydroxyvitamin D3 in rabbit duodenal brush-border membrane. Am J Physiol 242:G533-G539.

15. Danisi G, Caverzasio J, Trechsel U, et al. (1990) Phosphate transport adaptation in rat jejunum and plasma level of 1,25-dihydroxyvitamin D3. Scand J Gastroenterol 25:210-215.

16. Kido S, Kaneko I, Tatsumi S, et al. (2013) Vitamin D and type II sodium-dependent phosphate cotransporters. Contrib Nephrol 180:86-97.    

17. Kaneko I, Segawa H, Furutani J, et al. (2011) Hypophosphatemia in vitamin D receptor null mice: Effect of rescue diet on the developmental changes in renal Na⁺-dependent phosphate cotransporters. Pflugers Arch Eur J Physiol 461:77-90.    

18. Ikeda K, Takeshita S (2014) Factors and mechanisms involved in the coupling from bone resorption to formation: how osteoclasts talk to osteoblasts. J bone Metab 21:163-167.    

19. Agus Z, Puscttrr J, Senesky D, et al. (1971) Mode of Action of Parathyroid Hormone and cyclic adenosine 3',5'-monophosphate on Renal Tubular Phosphate Reabsorption in the Dog. J Clin Invest 50:617-626.    

20. Collins J, Bai L, Ghishan F (2004) The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflugers Arch 447:647-652.    

21. Nishimura M, Naito S (2008) Tissue-specific mRNA Expression Profiles of Human Solute Carrier Transporter Superfamilies. Drug Metab Pharmacokinet 23:22-44.    

22. Villa-Bellosta R, Ravera S, Sorribas V, et al. (2009) The Na⁺-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am J Physiol Renal Physiol 296:F691-699.    

23. Bacconi A, Virkki L V, Biber J, et al. (2005) Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter. Proc Natl Acad Sci U S A 102:12606-12611.    

24. Renkema K, Alexander R, Bindels R, et al. (2008) Calcium and phosphate homeostasis: concerted interplay of new regulators. Ann Med 40:82-91.    

25. Tenenhouse H (2007) Phosphate transport: molecular basis, regulation and pathophysiology. J Steroid Biochem Mol Biol 103:572-577.    

26. Forster IC, Hernando N, Biber J, et al. (2006) Proximal tubular handling of phosphate: A molecular perspective. Kidney Int 70:1548-1559.    

27. Custer M, Lötscher M, Biber J, et al. (1994) Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am J Physiol 266:F767-F774.

28. Picard N, Capuano P, Stange G, et al. (2010) Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters. Pflugers Arch Eur J Physiol 460:677-687.    

29. Segawa H, Kaneko I, Takahashi A, et al. (2002) Growth-related renal type II Na/Pi cotransporter. J Biol Chem 277:19665-19672.    

30. Chau H, El-Maadawy S, McKee M, et al. (2003) Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene Npt2. J Bone Miner Res 18:644-657.    

31. Levi M, Lötscher M, Sorribas V, et al. (1994) Cellular mechanisms of acute and chronic adaptation of rat renal P(i) transporter to alterations in dietary P(i). Am J Physiol 267:F900-908.

32. Pfister M, Hilfiker H, Forgo J, et al. (1998) Cellular mechanisms involved in the acute adaptation of OK cell Na/Pi-cotransport to high- or low-Pi medium. Pflugers Arch 435:713-719.    

33. Tenenhouse H (2005) Regulation of phosphorus homeostasis by the type iia na/phosphate cotransporter. Annu Rev Nutr 25:197-214.    

34. Murer H, Hernando N, Forster I, et al. (2000) Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol Rev 80:1373-1409.

35. Khan S, Canales B (2011) Ultrastructural investigation of crystal deposits in Npt2a knockout mice: are they similar to human Randall's plaques? J Urol 186:1107-1113.    

36. Iwaki T, Sandoval-Cooper M, Tenenhouse H, et al. (2008) A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. J Am Soc Nephrol 19:1753-1762.    

37. Myakala K, Motta S, Murer H, et al. (2014) Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice. Am J Physiol - Ren Physiol 306:F833-F843.    

38. Segawa H, Onitsuka A, Kuwahata M, et al (2009) Type IIc sodium-dependent phosphate transporter regulates calcium metabolism. J Am Soc Nephrol 20:104-113.    

39. Haussler M, Whitfield G, Kaneko I, et al. (2012) The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev Endocr Metab Disord 13:57-69.    

40. Stechman M, Loh N, Thakker R (2009) Genetic causes of hypercalciuric nephrolithiasis. Pediatr Nephrol 24:2321-32.    

41. Prié D, Beck L, Friedlander G, et al. (2004) Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization. Curr Opin Nephrol Hypertens 13:675-681.    

42. Magen D, Berger L, Coady M, et al. (2010) A Loss-of-Function Mutation in NaPi-IIa and Renal Fanconi's Syndrome. N Engl J Med 362:1102-1109.    

43. Rajagopal A, Débora B, James T, et al. (2014) Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis. J Clin Endocrinol Metab jc20141517.

44. Kenny J, Lees M, Drury S, et al. (2011) Sotos syndrome, infantile hypercalcemia, and nephrocalcinosis: a contiguous gene syndrome. Pediatr Nephrol 26:1331-1334.    

45. Schlingmann K, Ruminska J, Kaufmann M, et al. (2015) Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia. J Am Soc Nephrol 1-11.

46. Kestenbaum B, Glazer N, Köttgen A, et al. (2010) Common genetic variants associate with serum phosphorus concentration. J Am Soc Nephrol 21:1223-1232.    

47. Silver J, Naveh-Many T (2009) Phosphate and the parathyroid. Kidney Int 75:898-905.    

48. Bergwitz C, Jüppner H (2010) Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med 61:91-104.    

49. Caniggia A, Lore F, di Cairano G, et al. (1987) Main endocrine modulators of vitamin D hydroxylases in human pathophysiology. J Steroid Biochem 27:815-824.    

50. Wang W, Li C, Kwon T, et al. (2004) Reduced expression of renal Na⁺ transporters in rats with PTH-induced hypercalcemia. Am J Physiol Ren Physiol 286:534-545.    

51. Haramati A, Knox F (1983) Tubular capacity of phosphate transport in phosphate-deprived rats: effects of nicotinamide and PTH. Am J Physiol 244:F178-F184.

52. Guo J, Song L, Liu M, et al. (2013) Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice. Endocrinology 154:1680-1689.    

53. Yamamoto H, Tani Y, Kobayashi K, et al. (2005) Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene. Biochim Biophys Acta 1732:43-52.    

54. Silver J, Russell J, Sherwood L (1985) Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci U S A 82:4270-4273.    

55. Silver J, Yalcindag C, Sela-Brown A, et al. (1999) Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate. Kidney Int 73:S2-7.

56. Barthel T, Mathern D, Whitfield G, et al. (2007) 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol 103:381-388.    

57. Friedlaender M, Wald H, Dranitzki-Elhalel M, et al. (2001) Vitamin D reduces renal NaPi-2 in PTH-infused rats: complexity of vitamin D action on renal Pi handling. Am J Physiol Ren Physiol 281:428-433.

58. Weinman E, Steplock D, Wang Y, et al. (1995) Characterization of a Protein Cofactor that Mediates Protein Kinase A Regulation of the Renal Brush Border Membrane Na⁺-H⁺ Exchanger. J Clin Invest 95:2143-2149.    

59. Weinman E, Lederer E (2012) NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones. Am J Physiol Renal Physiol 303:F321-327.    

60. Weinman E, Biswas R, Peng G, et al. (2007) Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. J Clin Invest 117:3412-3420.    

61. Mahon M, Segre G (2004) Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. J Biol Chem 279:23550-23558.    

62. Khundmiri S, Rane M, Lederer E (2003) Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein. J Biol Chem 278:10134-10141.    

63. Lederer E, Khundmiri S, Weinman E (2003) Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol 14:1711-1719.    

64. Hernando N, Deliot N, Gisler S, et al. (2002) PDZ-domain interactions and apical expression of type IIa Na/Pi cotransporters. Proc Natl Acad Sci U S A 99:11957-11962.    

65. Mahon M, Cole J, Lederer E, et al. (2003) Na⁺/H⁺ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Mol Endocrinol 17:2355-2364.    

66. Weinman E, Steplock D, Shenolikar S, et al. (2011) Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. Am J Physiol Renal Physiol 300:F231-F235.    

67. Kempson S, Lötscher M, Kaissling B, et al. (1995) Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules. Am J Physiol 268:F784-791.

68. Pfister M, Ruf I, Stange G, et al. (1998) Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter. Proc Natl Acad Sci U S A 95:1909-1914.    

69. Pfister M, Lederer E, Forgo J, et al. (1997) Parathyroid Hormone-dependent Degradation of Type II Na⁺/Pi Cotransporters. J Biol Chem 272:20125-20130.    

70. Abou-Samra A, Jüppner H, Force T, et al. (1992) Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracel. Proc Natl Acad Sci U S A 89:2732-2736.    

71. Watson P, Fraher L, Hendy G, et al. (2000) Nuclear localization of the type 1 PTH/PTHrP receptor in rat tissues. J Bone Miner Res 15:1033-1044.    

72. Friedman P, Gesek F, Morley P, et al. (1999) Cell-specific signaling and structure-activity relations of parathyroid hormone analogs in mouse kidney cells. Endocrinology 140:301-309.

73. Amizuka N, Lee H, Kwan M, et al. (1997) Cell-Specific Expression of the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene in Kidney from Kidney-Specific and Ubiquitous Promoters. Endocrinology 138:469-481.

74. Taylor C, Tovey S (2012) From parathyroid hormone to cytosolic Ca²⁺ signals. Biochem Soc Trans 40:147-52.    

75. Muff R, Fischer J, Biber J, et al. (1992) Parathyroid Hormone Receptors in Control of Proximal Tubule Function. Annu Rev Physiol 54:67-79.    

76. Suarez F, Silve C (1992) Effect of Parathyroid Hormone on Arachidonic Acid Metabolism in Mouse Osteoblasts: Permissive Action of Dexamethasone. Endocrinology 130:592-598.

77. Cole J (1999) Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells. Endocrinology 140:5771-5779.    

78. Khundmiri S, Ameen M, Delamere N, et al. (2008) PTH-mediated regulation of Na⁽⁺⁾-K⁽⁺⁾-ATPase requires Src kinase-dependent ERK phosphorylation. Am J Physiol - Ren Physiol 295:F426-F437.    

79. Bacic D, Schulz N, Biber J, et al. (2003) Involvement of the MAPK-kinase pathway in the PTH-mediated regulation of the proximal tubule type IIa Na⁺/Pi cotransporter in mouse kidney. Pflugers Arch 446:52-60.

80. Yang S, Xiao L, Li J, et al. (2013) Role of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiology. Am J Physiol Ren Physiol 304:F831-839.    

81. Li Y, Konings I, Zhao J, et al. (2008) Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2. Am J Physiol Ren Physiol 295:F525-533.    

82. Ostrom R, Bogard A, Gros R, et al. (2012) Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps. Naunyn Schmiedebergs Arch Pharmacol 385:5-12.    

83. Bek M, Zheng S, Xu J, et al. (2001) Differential expression of adenylyl cyclases in the rat nephron. Kidney Int 60:890-899.    

84. Murtazina R, Kovbasnjuk O, Zachos NC, et al. (2007) Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na⁽⁺⁾/H⁽⁺⁾ exchanger regulatory factor 1 (NHERF1) null mice. J Biol Chem 282:25141-25151.    

85. Courbebaisse M, Leroy C, Bakouh N, et al. (2012) A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism. PLoS One 7:e34764.    

86. Ferrandon S, Feinstein T, Castro M, et al. (2009) Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol 5:734-742.    

87. Ahlström M, Lamberg‐Allardt C (1997) Rapid Protein Kinase A—Mediated Activation of Cyclic AMP-Phosphodiesterase by Parathyroid Hormone in UMR-106 Osteoblast-like Cells. J Bone Miner Res 12:172-178.    

88. Whitfield J, Isaacs R, Chakravarthy B, et al. (2001) Stimulation of protein kinase C activity in cells expressing human parathyroid hormone receptors by C- and N-terminally truncated fragments of parathyroid hormone 1-34. J Bone Miner Res 16:441-447.    

89. Mahon M, Donowitz M, Yun C, et al. (2002) Na⁺/H⁺ exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 417:858-861.    

90. Jouishomme H, Whitfield J, Gagnon L, et al. (1994) Further definition of the protein kinase C activation domain of the parathyroid hormone. J Bone Miner Res 9:943-949.

91. Whitfield J, Isaacs R, Chakravarthy B, et al. (2001) Protein Kinase C Activity in Cells Expressing Human Parathyroid Hormone Receptors by C‐and N‐Terminally Truncated Fragments of Parathyroid Hormone 1. J Bone Miner Res 16:441-447.    

92. Wang B, Yang Y, Abou-Samra A, et al. (2009) NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding. Mol Pharmacol 75:1189-1197.    

93. Alonso V, Magyar C, Wang B, et al. (2011) Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting. J bone Miner Res 26:2923-2934.    

94. Chauvin S, Bencsik M, Bambino T, et al. (2002) Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin. Mol Endocrinol 16:2720-2732.    

95. Wang B, Bisello A, Yang Y, et al. (2007) NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J Biol Chem 282:36214-36222.    

96. Khundmiri S, Weinman E, Steplock D, et al. (2005) Parathyroid hormone regulation of NA⁺,K⁺-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells. J Am Soc Nephrol 16:2598-2607.    

97. Salyer S, Lesousky N, Weinman E, et al. (2011) Dopamine regulation of Na⁺-K⁺-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells. Am J Physiol Cell Physiol 300:C425-C434.    

98. Tawfeek H, Abou-Samra A (2004) Important role for the V-type H⁺-ATPase and the Golgi apparatus in the recycling of PTH/PTHrP receptor. Am J Physiol Endocrinol Metab 286:704-710.

99. Pickard B, Hodsman A, Fraher L, et al. (2007) Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: regulation of PTH1R nuclear-cytoplasmic shuttling by importin-alpha/beta and chromosomal region maintenance 1/exportin 1. Endocrinology 148:2282-2289.    

100. Silverstein D, Spitzer A, Barac-Nieto M (2005) Parathormone sensitivity and responses to protein kinases in subclones of opossum kidney cells. Pediatr Nephrol 20:721-724.    

101. Nagai S, Okazaki M, Segawa H, et al. (2011) Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs. J Biol Chem 286:1618-1626.    

102. Cole J, Eber S, Poelling R, et al. (1987) A dual mechanism for regulation of kidney phosphate transport by parathyroid hormone. Am J Physiol 253:E221-227.

103. Cole J, Forte L, Eber S, et al. (1988) Regulation of sodium-dependent phosphate transport by parathyroid hormone in opossum kidney cells: Adenosine 3',5'-monophosphate-dependent and -independent mechanisms. Endocrinology 122:2981-2989.    

104. Fenton R, Murray F, Dominguez J, et al. (2014) Renal phosphate wasting in the absence of adenylyl cyclase 6. J Am Soc Nephrol 1-13.

105. Weinstein L, Yu S, Warner D, et al. (2001) Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. Endocr Rev 22:675-705.

106. Mantovani G (2011) Clinical review: Pseudohypoparathyroidism: diagnosis and treatment. J Clin Endocrinol Metab 96:3020-3030.    

107. Carpenter T, McPhee M, Bort R, et al. (1992) Dissociation of phosphaturia and 25(OH)D-1a-hydroxylase trophism using a novel analogue of parathyroid hormone. Am J Physiol 25:483-487.

108. Cunningham R, Biswas R, Brazie M, et al. (2009) Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. Am J Physiol Renal Physiol 296:F355-361.

109. Ranch D, Zhang M, Portale A, et al. (2011) Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice. J Bone Miner Res 26:1883-1890.    

110. Kilav R, Silver J, Biber J, et al. (1995) Coordinate regulation of rat renal parathyroid hormone receptor mRNA and Na-Pi cotransporter mRNA and protein. Am J Physiol 268:F1017-1022.

111. Moe S, Radcliffe J, White K, et al. (2011) The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. J Bone Miner Res 26:2672-2681.    

112. Hilfiker H, Hartmann C, Stange G, et al. (1998) Characterization of the 5 J-flanking region of OK cell type II Na-Pi cotransporter gene. 12:197-204.

113. Murray R, Holthouser K, Clark B, et al. (2013) Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability. Am J Physiol Renal Physiol 304:F1076-1085.    

114. Moz Y, Silver J, Naveh-Many T. (1999) Protein-RNA Interactions Determine the Stability of the Renal NaPi-2 Cotransporter mRNA and Its Translation in Hypophosphatemic Rats. J Biol Chem 274:25266-25272.    

115. Moz Y, Silver J, Naveh-Many T. (2003) Characterization of cis-acting element in renal NaPi-2 cotransporter mRNA that determines mRNA stability. Am J Physiol Renal Physiol 284:F663-670.    

116. Noronha-Blob L, Sacktor B. (1986) Inhibition by glucocorticoids of phosphate transport in primary cultured renal cells. J Biol Chem 261:2164-2169.

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