Role of some epigenetic factors in DNA damage response pathway

Mrinalini Tiwari; Suhel Parvez; Paban K Agrawala; Mrinalini Tiwari; Suhel Parvez; Paban K Agrawala

doi:10.3934/genet.2017.1.69

AIMS Genetics

2017, Volume 4, Issue 1: 69-83. doi: 10.3934/genet.2017.1.69

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Review

Role of some epigenetic factors in DNA damage response pathway

1.
Department of Radiation Genetics and Epigenetics, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Road, Timarpur, Delhi 110054 India
2.
Department of Toxicology, Jamia Hamdard University, Hamdard Nagar, Delhi 110062 India

Received: 16 December 2016 Accepted: 17 March 2017 Published: 24 March 2017

The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review.
- DNA damage response,
- epigenetics,
- histone acetylation,
- radiomitigation
Citation: Mrinalini Tiwari, Suhel Parvez, Paban K Agrawala. Role of some epigenetic factors in DNA damage response pathway[J]. AIMS Genetics, 2017, 4(1): 69-83. doi: 10.3934/genet.2017.1.69

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Abstract

The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review.

References

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