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Review

Insights on neuroendocrine regulation of immune mediators in female reproductive aging and cancer

  • Neuroendocrine-immune homeostasis in health and disease is a tightly regulated bidirectional network that influences predisposition, onset and progression of age-associated disorders. The complexity of interactions among the nervous, endocrine and immune systems necessitates a complete review of all the likely mechanisms by which each individual system can alter neuroendocrine-immune homeostasis and influence the outcome in age and disease. Dysfunctions in this network with age or external/internal stimuli are implicated in the development of several disorders including autoimmunity and cancer. The existence of sympathetic noradrenergic innervations on lymphoid organs in synaptic association with immune cells that express receptors for endocrine mediators such as hormones, neural mediators such as neurotransmitters and immune effector molecules such as cytokines explains the complicated nature of the regulatory pathways that must always maintain homeostatic equilibrium within and among the nervous, endocrine and immune systems. The incidence, development and progression of cancer, affects each of the three systems by disrupting regulatory pathways and tipping the scales away from homeostasis to favour pathways that enable it to evade, override and thrive by using the network to its advantage. In this review, we have explained how the neuroendocrine-immune network is altered in female reproductive aging and cancer, and how these modulations contribute to incidence and progression of cancer and hence prove to be valuable targets from a therapeutic standpoint. Reproductive aging, stress-associated central pathways, sympathetic immunomodulation in the periphery, inflammatory and immunomodulatory changes in central, peripheral and tumor-microenvironment, and neuro-neoplastic associations are all likely candidates that influence the onset, incidence and progression of cancer.

    Citation: Hannah P. Priyanka, Rahul S. Nair, Sanjana Kumaraguru, Kirtikesav Saravanaraj, Vasantharekha Ramasamy. Insights on neuroendocrine regulation of immune mediators in female reproductive aging and cancer[J]. AIMS Molecular Science, 2021, 8(2): 127-148. doi: 10.3934/molsci.2021010

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  • Neuroendocrine-immune homeostasis in health and disease is a tightly regulated bidirectional network that influences predisposition, onset and progression of age-associated disorders. The complexity of interactions among the nervous, endocrine and immune systems necessitates a complete review of all the likely mechanisms by which each individual system can alter neuroendocrine-immune homeostasis and influence the outcome in age and disease. Dysfunctions in this network with age or external/internal stimuli are implicated in the development of several disorders including autoimmunity and cancer. The existence of sympathetic noradrenergic innervations on lymphoid organs in synaptic association with immune cells that express receptors for endocrine mediators such as hormones, neural mediators such as neurotransmitters and immune effector molecules such as cytokines explains the complicated nature of the regulatory pathways that must always maintain homeostatic equilibrium within and among the nervous, endocrine and immune systems. The incidence, development and progression of cancer, affects each of the three systems by disrupting regulatory pathways and tipping the scales away from homeostasis to favour pathways that enable it to evade, override and thrive by using the network to its advantage. In this review, we have explained how the neuroendocrine-immune network is altered in female reproductive aging and cancer, and how these modulations contribute to incidence and progression of cancer and hence prove to be valuable targets from a therapeutic standpoint. Reproductive aging, stress-associated central pathways, sympathetic immunomodulation in the periphery, inflammatory and immunomodulatory changes in central, peripheral and tumor-microenvironment, and neuro-neoplastic associations are all likely candidates that influence the onset, incidence and progression of cancer.



    The classical hyperbolic-parabolic system of the compressible Navier-Stokes (CNS) equations has been subject to a hyperbolization via a relaxation ansatz. The latter — known for classical heat conduction ever since Maxwell [1] in the 19th century or Cattaneo [2] in the 20th century introduced in order to avoid the phenomenon of infinite speed of propagation inherent in classical modeling of heat conduction — turns the system into a hyperbolic one. In view of the nonlinear character of CNS equations, the question of a possible blow-up of the solution is raised, since, roughly speaking, nonlinear hyperbolic systems tend to generate blow-ups in comparison to the corresponding parabolic ones. Here, corresponding means that the hyperbolized systems are characterized by a relaxation parameter τ>0, and formally turn into the original parabolic one for τ=0. See the linear example: the standard heat equation

    θt+divq=0,q+θ=0,

    with temperature θ and heat flux q, leading to

    θtΔθ=0,

    turns with the relaxed/hyperbolized model

    θt+divq=0,τqt+q+θ=0,

    into

    τθtt+θtΔθ=0.

    Naturally, the singular limit as τ0 is of interest, in particular for the nonlinear CNS equations to be discussed.

    We will consider the following fully or partly hyperbolized models for compressible Navier-Stokes systems with heat conduction.

    Model 1: ([3])

    First, relaxing only in the heat conduction as above, we have in Rn×[0,)(n=1,2,3)

    {tρ+div(ρu)=0,t(ρu)+div(ρuu)+p=divS,t(ρ(e+12u2))+div(ρu(e+12u2)+up)+divq=div(uS), (1.1)

    where ρ, u=(u1,u2,,un), p, S, e, and q represent fluid density, velocity, pressure, stress tensor, specific internal energy per unit mass, and heat flux, respectively. The equations (1.1)1, (1.1)2, and (1.1)3 are the consequence of conservation of mass, momentum, and energy, respectively. To complete the system (1.1), we need to impose constitutive assumptions on p, S, e, and q. First, we assume the fluid to be a Newtonian fluid, that is,

    S=μ(u+uT2ndivuIn)+λdivuIn, (1.2)

    where μ and λ are positive constants. The heat flux q is assumed to satisfy

    τtq+q+κθ=0, (1.3)

    which represents Cattaneo's law (Maxwell's law, …), and where θ denotes the absolute temperature. The pressure p=p(ρ,θ) and e=e(ρ,θ) satisfy

    ρ2eρ(ρ,θ)=p(ρ,θ)θpθ(ρ,θ). (1.4)

    In particular, the case of a polytropic gas p=Rρθ, e=cvθ is included here.

    For the limit case τ=0, the system (1.1)–(1.3) is exactly the system of classical compressible Navier-Stokes equations, in which the relation between the heat flux and the temperature is governed by Fourier's law,

    q=κθ. (1.5)

    The well-posed theory has been widely studied for the system (1.1), (1.2) combined with Fourier's law (1.5), see [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18]. In particular, the local existence and uniqueness of smooth solutions was established by Serrin [17] and Nash [16] for initial data far away from a vacuum. Later, Matsumura and Nishida [14] got global smooth solutions for small initial data without a vacuum. For large data, Xin [18], and Cho and Jin [4], showed that smooth solutions must blow up in finite time if the initial data has a vacuum state.

    Although Fourier's law plays an important role in experimental and applied physics, it has the drawback of an inherent infinite propagation speed of signals. Cattaneo's (Maxwell's) law has been widely used in thermoelasticity which results in the second sound phenomenon, see [19,20,21] and the references cited therein. Note that it is not obvious that the results which hold for Fourier's law also hold for Cattaneo's law. Indeed, and for example, Fernández Sare and Racke [22] showed that, for certain Timoshenko-type thermoelastic system, Fourier's law preserves the property of exponential stability while Cattaneo's law destroys such a property.

    Model 2: ([23])

    Instead of relaxing in the heat equation as in Model 1, we take Fourier's law for the heat flux, but now Maxwell's relaxation for the stress tensor S, which replaces (1.2) by the differential equation

    τtS+S=μ(u+uT2ndivuIn)+λdivuIn. (1.6)

    Here we will discuss a splitting of the tensor S, which was discussed by Yong [24] in the isentropic case leading to the following system with a revised Maxwell law, now for the non-isentropic case, that we are going to further investigate further.

    {tρ+div(ρu)=0,t(ρu)+div(ρuu)+p=div(S1)+S2,t(ρ(e+12u2))+div(ρu(e+12u2)+up)κθ=div(u(S1+S2In)),τ1tS1+S1=μ(u+uT2ndivuIn),τ2tS2+S2=λdivu, (1.7)

    where S1 is an n×n square matrix, symmetric and traceless if it was initially, and S2 is a scalar variable.

    Pelton, Chakraborty, Malachosky, Guyot-Sionnest, and Sader [25] showed that such a "time lag", represented by τ1,τ2>0, cannot be neglected, even for simple fluids, in the experiments of high-frequency vibration of nano-scale mechanical devices immersed in water-glycerol mixtures. A similar revised Maxwell model was considered by Chakraborty and Sader [26] for a compressible viscoelastic fluid (isentropic case), where τ1 counts for the shear relaxation time, and τ2 counts for the compressional relaxation time. The importance of this model for describing high-frequency limits is underlined together with the presentation of numerical experiments. The authors conclude that it provides a general formalism to characterize the fluid-structure interaction of nanoscale mechanical devices vibrating in simple liquids.

    Model 3: ([27])

    Considering the two relaxations from Model 1 (resp., Model 2) in one space dimension simultaneously, and, additionally, reflecting Galilean invariance in the constitutive equations for these, we look at

    {ρt+(ρu)x=0,ρut+ρuux+px=Sx,ρet+ρuex+pux+qx=Sux, (1.8)

    with

    τ1(qt+uqx)+q+κθx=0, (1.9)

    proposed by Christov and Jordan [28], and

    τ2(St+uSx)+S=μux. (1.10)

    Addtionally we specify the constitutive assumptions to

    e=Cvθ+τ1κθρq2+τ22μρS2, (1.11)
    p=Rρθτ12κθq2τ22μS2, (1.12)

    with positive constants Cv,R denoting the heat capacity at constant volume and the gas constant, respectively, such that they satisfy the thermodynamic equation (1.4). The dependence of the internal energy on q2 is indicated by Coleman, Fabrizio, and Owen [29], where they rigorously prove that for heat equations with Cattaneo-type law, the formulation (1.20) is consistent with the second law of thermodynamics, see also [30,31,32].

    Model 4: ([33])

    For the results in dimensions n=2,3 having two relaxations, we consider the specialized model

    {tρ+div(ρu)=0,ρtu+ρuu+p=μdiv(u+uT2ndivuIn)+S2,ρte+ρue+pdivu+divq=μ(u+(u)T2ndivuIn):u+S2divu,τ1(tq+uq)+q+κθ=0,τ3(tS2+uS2)+S2=λdivu, (1.13)

    where we have taken τ2=0 in (1.7). That is, we do not have a relaxation in S1. This case seems to be mathematically not yet accessible, even locally. For the blow-up result in Section 4, we restrict the considerations to the limiting case μ=0. This restriction is not only motivated because it is mathematically accessible with respect to local existence and blow-up, but also with a physical background. In fact, there are recent studies determining the volume viscosity of a variety of gases which were found to be much larger (factor 104) than the corresponding shear viscosities, see [34]. For the blow-up result, we specify the constitutive equations,

    e=Cvθ+τ1κρθq2+τ32λρS22, (1.14)
    p=Rρθτ12κθq2τ32λS22. (1.15)

    Model 5: ([35])

    For the second blow-up result in one space dimension, we modify Model 3, which was the basis for the first blow-up result, as follows.

    {ρt+(ρu)x=0,ρut+ρuux+px=Sx,Et+(uE+pu+qSu)x=0, (1.16)

    where E represents the total energy,

    τ1(θ)(ρqt+ρuqx)+q+κ(θ)θx=0, (1.17)

    and

    τ2(ρSt+ρuSx)+S=μux. (1.18)

    The constitutive equation (1.18) was proposed by Freistühler [36,37] for the isentropic case, see also Ruggeri [38] and Müller [39] for a similar model in the non-isentropic case.

    Furthermore, we assume that the energy is given by

    E=12ρu2+τ22μρS2+ρe(θ,q), (1.19)

    and the specific internal energy e and the pressure p are given by

    e(θ)=Cvθ+a(θ)q2,p(ρ,θ)=Rρθ, (1.20)

    where

    a(θ)=Z(θ)θ12Z(θ)withZ(θ)=τ1(θ)κ(θ).

    The paper is organized as follows. In Section 2, we will recall results on the local well-posedness, small data global well-posedness, and the singular limit in finite time intervals. In Sections 3, 4, and 5, we will present blow-up results for one- and multi-dimensional models. Using ideas and techniques of Sideris from the 1980s [40,41], the blow-up for some of the models above will be demonstrated by studying appropriate functionals that satisfy differential inequalities implying a blow-up of smooth solutions in finite time.

    We introduce some notation. Wm,p=Wm,p(Rn),0m,1p, denotes the usual Sobolev space with norm Wm,p. Hm and Lp stand for Wm,2(Rn) and W0,p(Rn), respectively.

    Here, results on local well-posedness, on global well-posedness for small data, and on the singular limit τ0 are presented for the Models 1–5. In addition to the governing differential equations, we always need initial conditions.

    Starting with Model 1 with differential equations (1.1)–(1.3), we have the initial conditions

    (ρ(x,0),u(x,0),θ(x,0),q(x,0))=(ρ0,u0,θ0,q0). (2.1)

    ● Assumption A.1. The initial data satisfy

    {(ρ0,u0,θ0,q0)(x):xRn}[ρ,ρ]×[C1,C1]n×[θ,θ]×[C1,C1]n=:G0,

    where C1>0 as well as 0<ρ<1<ρ< and 0<θ<1<θ< are constants.

    ● Assumption A.2. Let G:=R+×Rn×R+×Rn denote the physical state space. For each given G1 satisfying G0⊂⊂G1⊂⊂G, and for all (ρ,u,θ,q)G1, the pressure p and the internal energy e satisfy

    p(ρ,θ),pθ(ρ,θ),pρ(ρ,θ),eθ(ρ,θ)>C(G1)>0, (2.2)

    where C(G1) is a positive constant depending on G1.

    Under these assumptions we have

    Theorem 2.1 ([3]). Let n1 and ss0+1, with s0[n2]+1, be integers. Suppose that the assumptions A.1 and A.2 hold and that the initial data (ρ01,u0,θ01,q0) are in Hs. Then, for each convex open subset G1 satisfying G0⊂⊂G1⊂⊂G, there exists T>0 such that the system (1.1), (1.3), (2.1) has a unique classical solution (ρτ,uτ,θτ,qτ) satisfying

    (ρτ1,θτ1,qτ)C([0,T],Hs)C1([0,T],Hs1),uτC([0,T],Hs)C1([0,T],Hs2) (2.3)

    and

    (ρτ,uτ,θτ,qτ)(x,t)G1,(x,t)Rn×[0,T].

    We write the system (1.1) as a symmetric hyperbolic-parabolic system for for ω:=(ρ,u,θ,q),

    A0(ω)tω+Σnj=1Aj(ω)xjωΣnj=1Bjk(ω)2xjxkω+L(ω)ω=g(ω,Dxω), (2.4)

    where

    A0(ω)=(c2ρ0000ρIn0000ρeθθ0000τκθ),Σnj=1Ajξj=(c2ρuξc2ξ00c2ξTρ(uξ)InpθξT00pθξρeθθuξξθ00ξTθ0),Σnj=1Bjkξjξk=(00000μIn+(μ+μ)ξTξ0000000000),L(ω)=(0000000000000001κθIn),g(ω,Dxω)=(00μ2θ|u+(u)T|2+μθ|divu|20),c2=pρ,ξ=(ξ1,,ξn)Sn1.

    The local existence theorem now follows from [42] (or see [43]). As the global existence result for small data, we have:

    Theorem 2.2 ([3]). Let n2 and ss0+1, with s0[n2]+1, be integers. Suppose that 0<τ<2κpθ(1,1)2 and (ρ01,u0,θ01,q0)Hs. Then there exists a positive constant δ such that if (ρ01,u0,θ01,q0)sδ, then there exists a global unique solution (ρτ,uτ,θτ,qτ) of (1.1), (1.3), (2.1) satisfying

    (ρτ1,θτ1,qτ)C([0,),Hs)C1([0,),Hs1),uτC([0,),Hs)C1([0,,Hs2). (2.5)

    For the proof, one linearizes the above system around the steady state ˉω=(ˉρ,ˉu,ˉθ,ˉq):=(1,0,1,0), and one has

    A0(ˉω)tω+ΣAj(ˉω)xjωΣBjk(ˉω)2xjxkω+L(ˉω)ω=0, (2.6)

    where

    A0(ˉω)=(ˉc20000In0000ˉeθ0000τκ),ΣAj(ˉω)ξj=(0ˉc2ξ00ˉc2ξT0ˉpθξT00ˉpθξ0ξ00ξT0),ΣBjk(ˉω)ξjξk=(00000μIn+(μ+μ)ξTξ0000000000),L(ˉω)=(0000000000000001κIn),ˉc=c(1,1),ˉpθ=pθ(1,1),ˉeθ=eθ(1,1),ξ=(ξ1,ξ2,,ξn)Sn1.

    We choose Kj such that

    ΣKjξj=α(0ˉc2ξ00ξT000000κτξ00ξTeθ0),

    where α>0 will be chosen later. In order to satisfy the Kawashima conditions from [42], for proving the global existence for small data, one has to check that

    12Σ{KjAkξjξk+(KjAkξjξk)T}+ΣBjkξjξk+L=(αˉc4012αˉpθˉc200μIn+((μ+μ)αˉc2)ξTξ0αˉpθ2ˉeθξTξ12αˉpθˉc20ακτ00αˉpθ2ˉeθξTξ01κInα1ˉeθξTξ)

    is a positive definite matrix for any ξSn1, which holds true for sufficiently small α.

    To show the convergence of the relaxed system (τ>0) to the classical CNS equations (τ=0), we assume the natural compatibility condition q0=κθ0. Let G1 be given satisfying G0⊂⊂G1⊂⊂G. Define Tτ=sup{T>0;(ρτ1,vτ,θτ1,qτ)C([0,T],Hs),(ρτ,vτ,θτ,qτ)(x,t)G1,(x,t)Rn×[0,T]}.

    Theorem 2.3 ([3]). Let (ρ,u,θ) be a smooth solution to the classical compressible Navier-Stokes equations with (ρ(x,0),u(x,0),θ(x,0))=(ρ0,u0,θ0) satisfying

    ρC([0,T],Hs+3)C1([0,T],Hs+2),(u,θ)C([0,T],Hs+3)C1([0,T],Hs+1)

    with T>0 finite. Then there are positive constants τ0 and C such that for ττ0,

    (ρτ,uτ,θτ)(t,)(ρ,u,θ)(t,)sCτ (2.7)

    and

    (qτ+κθ)(t,)sCτ12 (2.8)

    for t[0,min{T,Tτ}), where C does not depend on τ. In particular, Tτ is independent of τ.

    For the proof, we introduce the variable q:=κθ and define

    ρd:=ρτρτ,ud=uτuτ,θd=θτθτ,qd=qτqτ. (2.9)

    Lengthy energy estimates give, for small τ and for t<min{T,Tτ},

    (ρd,ud,θd)(t,)sC,τqd(t,)sC, (2.10)

    where C>0 denotes constants not depending on τ or t.

    Looking at Model 2 with differential equations (1.7), we have the initial conditions

    (ρ(x,0),u(x,0),θ(x,0),S1(x,0),S2(x,0))=(ρ0,u0,θ0,S10,S20)). (2.11)

    Assumptions analogous to Assumptions A.1 and A.2 in (2.2) are assumed to hold. Then we have the following local existence theorem.

    Theorem 2.4 ([23]). Let ss0+1 with s0[n2]+1 be integers. Suppose that the initial data (ρ01,u0,θ01,S10,S20) are in Hs. Then, for each convex open subset G1 satisfying G0⊂⊂G1⊂⊂G, there exists Tex>0 such that the system (1.7), (2.11) has a unique classical solution (ρ,u,θ,S1,S2) satisfying

    {(ρ1,u,S1,S2)C([0,Tex],Hs)C1([0,Tex],Hs1),θ1C([0,Tex],Hs)C1([0,Tex],Hs2) (2.12)

    and

    (ρ,u,θ,S1,S2)(x,t)G1,(x,t)Rn×[0,Tex].

    For the proof, a similar strategy as in the proof of Theorem 2.1 in Model 1 is applicable, i.e., transforming, after linearizing around a constant state, the system to a symmetric hyperbolic-parabolic one. In the two-dimensional case n=2, one can easily check that the system can be written in a symmetric form immediately, while in the 3-d case one needs further transformations to get a system in a symmetric form, see [23].

    Using the explicit symmetrizer, one can check Kawashima's conditions, yielding the following global existence theorem for small data.

    Theorem 2.5 ([23]). Let ss0+1 with s0[n2]+1 be integers. Suppose that the initial data satisfy (ρ01,u0,θ01,S10,S20)Hs. Then there exists a positive constant δ such that if (ρ01,u0,θ01,S10,S20)sδ, there exists a global unique solution (ρ,u,θ,S1,S2) to the system (1.7), (2.11) satisfying

    {(ρ1,u,S1,S2)C([0,),Hs)C1([0,),Hs1),(θ1)C([0,),Hs)C1([0,,Hs2). (2.13)

    We remark that Kawashima's results also imply decay properties of the solutions, that is,

    (ρ1,u,θ1,S1,S2)s(s0+1)0,ast.

    Moreover, for n=3, if we further assume ss0+2 and (ρ1,u,θ1,S1,S2)Lpδ where p[1,32], then the solutions have the following decay:

    (ρ1,u,θ1,S1,S2)s1C(1+t)32(1p12)(ρ01,u0,θ01,S10,S20)s1,p,

    where the constant C is neither depending on t nor on the data.

    The compatibility of the revised Maxwell law with the Newtonian law in terms of the limit τ1=τ2=:τ0 is described in the next theorem, where the following natural compatibility conditions on the initial data are assumed:

    S10=μ(u0+(u0)T2ndivu0In),S20=λdivu0. (2.14)

    Denote by (ρτ,uτ,θτ,Sτ1,Sτ2) the solutions given by Theorem 2.4 with G1 satisfying G0⊂⊂G1⊂⊂G. Denoting

    Tτ=sup{T>0,(ρτ1,uτ,θτ1,Sτ1,Sτ2)C([0,T],Hs),(ρτ,uτ,θτ,Sτ1,Sτ2)G1},

    we have:

    Theorem 2.6 ([23]). Let (ρ,u,θ) be a smooth solution to the classical compressible Navier-Stokes equations with (ρ(x,0),u(x,0),θ(x,0))=(ρ0,u0,θ0) satisfying

    ρC([0,T],Hs+3)C1([0,T],Hs+2),(u,θ)C([0,T],Hs+3)C1([0,T],Hs+1)

    with T>0 (finite). Then there are positive constants τ0 and C such that for ττ0,

    (ρτ,uτ,θτ)(t,)(ρ,u,θ)(t,)sCτ (2.15)

    and

    Sτ1(t,)μ(u+(u)T2ndivuIn)(t,)s+Sτ2(t,)λdivu(t,)sCτ12 (2.16)

    for t[0,min{T,Tτ}), where C does not depend on τ.

    Introducing the variables S01:=μ(u+uT2ndivuIn),S02:=λdivu and defining

    ρd:=ρτρτ,ud:=uτuτ,θd:=θτθτ,Sd1:=Sτ1S01τ,Sd2:=Sτ2S02τ, (2.17)

    the aim is to show that, for small τ and for t<min{T,Tτ},

    (ρd,ud,θd)(t,)sC,τ(Sd1,Sd2)(t,)sC, (2.18)

    where C>0 denotes constants not depending on τ or t. This is achieved using the energy method combined with sophisticated estimates of the nonlinear terms.

    For Model 3 in one space dimension with differential equations (1.8)–(1.10), where we consider two relaxations with nonlinearities in the relaxed equations reflecting the Galilean invariance, we have the initial conditions

    (ρ(x,0),u(x,0),θ(x,0),q(x,0),S(x,0))=(ρ0,u0,θ0,q0,S0). (2.19)

    We recall that the internal energy e and the pressure p are assumed to have the form (1.11) (resp., (1.12)) and satisfy the thermodynamic equation ρ2eρ=pθpθ. Using this we may rewrite the differential equations as follows:

    {ρt+(ρu)x=0,ρut+ρuux+pρρx+pθθx+pqqx+(pS1)Sx=0,ρeθθt+(ρueθ2qθ)θx+θpθux+qx=2q2κθ+S2μ,τ1(qt+uqx)+q+κθx=0,τ2(St+uSx)+S=μux. (2.20)

    The system (2.20) is not symmetric. But one can show that there exists a δ such that if |(ρ1,θ1,q,S)|<δ, then the system (2.20) is strictly hyperbolic, since for the first-order system for V:=(ρ,u,θ,q,S), given by

    Vt+A(V)xV+B(V)V=F(V), (2.21)

    where

    A(V)=(uρ000pρρupθρpqρpS1ρ0θpθρeθu2qρθeθ1000κτ1u00μτ200u),B(V)=(0000000000000000001τ1000001τ2) (2.22)

    and F(V):=(0,0,2q2κθ+S2μ,0,0), the eigenvalues of the matrix A(V) are then real and distinct. The following local existence theorem then follows, see [47], and it also implies that (2.20) is symmetrizable.

    Theorem 2.7 ([27]). Let s2. Then there is δ>0 such that for (ρ01,u0,θ01,q0,S0)Ws,2(R) with (ρ01,u0,θ01,q0,S0)s,2<δ, there exists a unique local solution (ρ,u,θ,q,S) to the system (1.8)(1.10), (2.19) in some time interval [0,T] with

    (ρ1,u,θ1,q,S)C0([0,T],Hs(R))C1([0,T],Hs1(R)). (2.23)

    The global well-posedness for small data is given by:

    Theorem 2.8 ([27]). There exists ε>0 such that if

    (ρ01,u0,θ01,q0,S02H2<ε2, (2.24)

    there exists a global solution (ρ,u,θ,q,S)(x,t)C1([0,+)×R) to the system (1.8)(1.10), (2.19) satisfying

    34supx,t(ρ(x,t),θ(x,t))54

    and

    supt[0,)(ρ1,u,θ1,q,S)2H2C(ρ01,u0,θ01,q0,S02H2Cε2, (2.25)

    where C is a constant which is independent of ε. Moreover, the solution converges uniformly in xR to the constant state (1,0,1,0,0) as t. Namely,

    (ρ1,u,θ1,q,S)L+(ρx,ux,θx,qx,Sx)L20ast.

    For the proof, a series of a priori estimates for the local solution is derived, using the energy functional

    E(t):=sup0st(ρ1,u,θ1,q,S)(s,)2H2+sup0st(ρt,ut,θt,qt,St)2H1+t0(ρx,ρt,ux,ut,θx,θt,qx,qt,q,Sx,St,S)(s,)2H1ds (2.26)

    and the equality

    [cvρ(θlnθ1)+R(ρlnρρ+1)+(112θ)τ1κθq2+12ρu2+τ22μS2]t+ [ρucv(θlnθ1)+u(112θ)τ1κθq2+τ22μuS2+RρulnρRρu qθ+12ρu3+pu+qSu]x+q2κθ2+S2θμ=0, (2.27)

    finally allowing to continue a local solution.

    For a description of the singular limit, we assume τ1=τ2=:τ and the compatibility condition

    S0=μ(u0)x,q0=κ(θ0)x.

    Let (ρτ,uτ,θτ,qτ,Sτ) be solutions given by Theorem 2.7. Define

    Tτ=sup{T>0;(ρτ1,uτ,θτ1,qτ,Sτ)C([0,T],H2),ρτ>0,θτ>0,(x,t)Rn×[0,T]}.

    Theorem 2.9 ([27]). Let (ρ,u,θ) be the smooth solution to the classical compressible Navier-Stokes equations with (ρ(x,0),u(x,0),θ(x,0))=(ρ0,u0,θ0) satisfying

    inf(x,t)R×[0,T](ρ(x,t),θ(x,t))>0

    and

    (ρ1)C([0,T],H5)C1([0,T],H4),(u,θ1)C([0,T],H5)C1([0,T],H3),

    with finite T>0. Then, there exist constants τ0 and C such that for ττ0,

    (ρτ,uτ,θτ)(t,)(ρ,u,θ)(t,)H2Cτ, (2.28)

    and

    (qτ+κθx,Sτμux)H2Cτ12, (2.29)

    for all t(0,min(T,Tτ)), and the constant C is independent of τ.

    The proof again looks at the differential equations for the differences ρd=ρτρτ, ud=uτuτ, θd=θτθτ, qd=qτqτ, Sd=SτSτ, where q=κθx and S=μux. For small τ and t<min{T,Tτ}, one proves

    (ρd,ud,θd)(t,)H2C,τ(qd,Sd)(t,)H2C, (2.30)

    with C>0 not depending on τ. Here, on a technical level, the H5-regularity is needed.

    For Model 4 in higher dimensions with differential equations (1.13) and initial conditions

    (ρ(x,0),u(x,0),θ(x,0),q(x,0),S2(x,0))=(ρ0,u0,θ0,q0,S20), (2.31)

    we distinguish the cases μ>0 and μ=0.

    For μ>0_, the local existence theorem reads:

    Theorem 2.10 ([33]). Suppose that the initial data (ρ01,u0,θ01,q0,S20)H3. Then there exists T=T((ρ0,,S20)H3)>0, such that the system (1.13), (2.31) has an unique classical solution (ρ,u,θ,q,S2) satisfying

    (ρ1,θ1,q,S2)C([0,T],H3)C1([0,T],H2)uC([0,T],H3)C1([0,T],H1).

    The proof rewrites the system as a symmetric hyperbolic-parabolic one and uses the results of Kawashima, see [42] or [44].

    For the global existence for small data let

    En(t):=sup0τt(ρ1,u,θ1,q,S2)(τ,)2H3+t0((ρ,θ)2H2+(q,S2)2H3+u2H3)dt. (2.32)

    Then we have:

    Theorem 2.11 ([33]). Let τ1>0,τ2=0,τ3>0, and μ>0. Suppose for the initial data

    (ρ01,u0,θ01,q0,S20)H3.

    Then, there exists a small constant δ>0 such that if En(0)<δ, then the system (1.13), (2.31) has a unique solution (ρ,u,θ,q,S2) globally in time such that (ρ1,u,θ1,q,S2)C(0,+;H3), (ρ,θ)L2(0,+;H2), uL2(0,+;H3), (q,S2)L2(0,+;H3).

    For any t>0, we have

    (ρ1,u,θ1,q,S2)2H3+t0((ρ,θ)2H2+u2H3+(q,S2)2H3)dtCEn(0), (2.33)

    where C is a constant being independent of t and of the initial data. Moreover, the solution decays in the sense

    (ρ,u,θ,q,S2)L20 as t. (2.34)

    The long proof consists of energy estimates using the entropy relation

    t(ρη)+div(ρuη)+div(qθ)=q2κθ2+S22θλ+S212μθ (2.35)

    for the entropy η defined by

    η:=CvlnθRlnρ+τ12κθ2ρq2, (2.36)

    and the dissipative relation

    t[Cvρ(θlnθ1)+R(ρlnρρ+1)+(112θ)τ1κθq2+12ρu2+τ32λS22]+ div[Cvρu(θlnθ1)+u(112θ)τ1κθq2+τ32λuS22+RρulnρRρu qθ+12ρu|u|2+pu+qμu(u+uT2ndivuIn)S2u]+ q2κθ2+S22θλ+μ2θ|u+uT2ndivuIn|2=0. (2.37)

    Assuming again for simplicity τ1=τ3=:τ and letting (ρτ,uτ,θτ,qτ,Sτ2) denote the local solution defined on [0,Tτ), we have:

    Theorem 2.12 ([33]). Let (ρ,u,θ) be the smooth solution to the classical compressible Navier-Stokes equations with (ρ(x,0),u(x,0),θ(x,0))=(ρ0,u0,θ0) satisfying

    inf(x,t)R3×[0,T](ρ(x,t),θ(x,t))>0

    and

    (ρ1)C([0,T],H6)C1([0,T],H5),(u,θ1)C([0,T],H6)C1([0,T],H4),

    with finite T>0. Moreover, assume that the initial data satisfy

    (ρτ0ρ0,uτ0u0,θτ0θ0,τ(qτ0+κθ0),τ(Sτ20λdivu0))H3τ.

    Then, there exist constants τ0 and C>0 such that for ττ0,

    (ρτ,uτ,θτ)(,t)(ρ,u,θ)(,t)H3Cτ, (2.38)

    and

    (qτ+κθ,Sτ2λu)H3Cτ12, (2.39)

    for all t(0,min(T,Tτ)), and the constant C is independent of τ.

    The proof can be done in the spirit of corresponding considerations in [23], overcoming a higher complexity given here by energy estimates similar to those used in the proof of Theorem 2.11.

    Peng and Zhao [45] studied the 1D version and obtained in particular a global existence result which is uniform with respect to τ as well as a global convergence result in a weak topology.

    For the case μ=0_, we have a local existence theorem. In Section 4, a blow-up result will be presented. The differential equations (1.13) reduce to a purely hyperbolic one with zero-order damping terms,

    {tρ+div(ρu)=0,ρtu+ρuu+p=S2,ρte+ρue+pdivu+divq=S2divu,τ1(tq+uq)+q+κθ=0,τ3(tS2+uS2)+S2=λdivu. (2.40)

    The existence of solutions to (2.40) with initial conditions (2.31), even locally, is not immediately clear, since it is neither symmetric nor strictly hyperbolic. By carefully calculating the eigenvalues and eigenvectors of the corresponding matrix in the associated first-order system, one realizes that it is a constantly hyperbolic system, and thus has a local solution.

    Assume that there exists δ>0, sufficiently small, such that

    minxRn(ρ0(x),θ0(x))>0,maxxRn(|ρ01|,|θ01|,|q0(x)|,|S20(x)|)δ2. (2.41)

    Then we have:

    Theorem 2.13. ([33]) Let s>n2+1 and (ρ0,u0,θ0,q0,S20):RnR2n+3 be given with

    ρ01,u0,θ01,q0,S0Hs.

    Then, there exists a unique local solution (ρ,u,θ,q,S2) to system (2.40), (2.31) in some time interval [0,T0) with

    (ρ1,u,θ1,q,S2)C0([0,T0),Hs)C1([0,T0),Hs1)

    and

    min(x,t)Rn×[0,T0)(ρ(x,t),θ(x,t))>0,
    max(x,t)Rn×[0,T0)(|ρ(x,t)1|,|θ(x,t)1|,|q(x,t)|,|S2(x,t)|)δ.

    For the proof, one rewrites the system as a first-order system for V:=(ρ,u,θ,q,S2)T,

    tV+3j=1Aj(V)xjV+B(V)V=F(V), (2.42)

    where

    3j=1Ajξj=(uξρξT000pρρξ(uξ)InpθρξpqρξTpS21ρξ0θpθρeθξT(u2qρθeθ)ξξT000κτ1ξ(uξ)In00λτ3ξT00uξ),B(V)=diag{0,0,0,1τ1,1τ3},F(V)=(0,0,2κθq2+1λS22,0,0)T.

    Since the (2n+3)×(2n+3)-matrix nj=1Ajξj is not symmetric, the system (2.42) is neither symmetric-hyperbolic nor strictly hyperbolic, and a symmetrizer is not obvious. So, the local existence does not follow immediately by the classical theory of symmetric-hyperbolic or strictly hyperbolic systems. Carefully analyzing the dimensions of the eigenspaces of the eigenvalues of the matrix, here using the smallness assumption (2.41), it can be shown that the system is constantly hyperbolic. Referring to [46, Thm. 2.3 and Thm. 10.2], we conclude the local well-posedness.

    The last Model 5, a modification of Model 3, considers, in one dimension, the differential equations (1.16)–(1.18) together with the constitutive equations (1.19), (1.20), and the initial conditions

    (ρ(x,0),u(x,0),θ(x,0),q(x,0),S(x,0))=(ρ0,u0,θ0,q0,S0). (2.43)

    It is assumed that, for θ>0,

    a(θ)>0,a(θ)0,12(Z(θ)θ)0 (2.44)

    holds. The assumption a(θ)0 implies eθCv>0, which make the system (1.16)–(1.18) uniformly hyperbolic without a smallness condition. The third inequality in (2.44) will give the L2 estimates of q, which will be used in the blow-up result in Section 5. Note that by choosing Z(θ)=τ1(θ)κ(θ)=kθα with k as any constant and 1α<2, the assumption (2.44) holds.

    Now, we transform the equations (1.16)–(1.18) into a first-order symmetric hyperbolic system. First, we rewrite the equation (1.16)3 for θ as

    ρeθθt+(ρueθ2a(θ)Z(θ)q)θx+Rρθux+qx=2a(θ)τ1(θ)q2+1μS2. (2.45)

    Then, we have

    A0(U)Ut+A1(U)Ux+B(U)U=F(U), (2.46)

    where U=(ρ,u,θ,q,S) and

    A0(U)=diag{Rθρ,ρ,ρeθθ,τ1(θ)ρκ(θ),τ2ρμ},A1(U)=(RθρuRθ000RθρuRρ010Rρ(ρueθθ2a(θ)θZ(θ)q)1θ0001θτ1(θ)κ(θ)ρu00100τ2μρu),B(U)=diag{0,0,0,1κθ,1μ},F(U)=diag{0,0,2a(θ)τ1(θ)θq2S2μθ,0,0}.

    Therefore, the local existence follows immediately, see [42,43,47]:

    Theorem 2.14 ([35]). Let s2. Suppose that

    (ρ01,u0,θ01,q0,S0)Hs(R)

    with minx(ρ0(x),θ0(x))>0, then there exists a unique local solution (ρ,u,θ,q,S) to the system (1.16)(1.18), (2.43) in some time interval [0,T] with

    (ρ1,u,θ1,q,S)C0([0,T],Hs(R))C1([0,T],Hs1(R)), (2.47)
    minx(ρ(t,x),θ(t,x))>0,t>0. (2.48)

    In this section, we present a blow-up result for large data in the one-dimensional case of Model 3. We recall the differential equations (1.8)–(1.10) and the constitutive equations (1.11), (1.12),

    {ρt+(ρu)x=0,ρut+ρuux+px=Sx,ρet+ρuex+pux+qx=Sux, (3.1)

    with

    τ1(qt+uqx)+q+κθx=0, (3.2)

    and

    τ2(St+uSx)+S=μux, (3.3)
    e=Cvθ+τ1κθρq2+τ22μρS2, (3.4)
    p=Rρθτ12κθq2τ22μS2. (3.5)

    The initial conditions are given by

    (ρ(x,0),u(x,0),θ(x,0),S(x,0),q(x,0))=(ρ0,u0,θ0,S0,q0). (3.6)

    The local well-posedness and the global existence for small data were given in Theorem 2.7 and Theorem 2.8, respectively. When τ1=τ2=0, the system is reduced to the classical compressible Navier-Stokes equations for which smooth solutions exist globally for arbitrary initial data away from a vacuum, see [48]. On the other hand, when the relaxation parameters go to zero, smooth solutions of the system converge to that of the classical system, see Theorem 1.17. This indicates that the relaxed system exhibits a similar qualitative behavior as the classical system. However, and surprisingly, we show that there are in general no C1-solutions to the system (3.1)–(3.3) for some large initial data. That is, we have another nonlinear system where the relaxation process turns a (globally) well-posed system into a not (globally) well-posed one, only visible in the nonlinear system, since the linearized systems behave similarly, see [49]. This sheds light on the difficulties in proving some global existence results in fluid dynamics, and in finding the "correct" model.

    We choose δ>0 small enough such that pρ,pθ,eθ are positive and bounded away from zero and |pS|,|pq| are sufficiently small as functions of (ρ,θ,q,S) on

    Ω:=(1δ,1+δ)×(1δ,1+δ)×(δ,δ)×(δ,δ). (3.7)

    The method to prove the blow-up result is mainly motivated by Sideris' paper [41] where he showed that any C1 solutions of compressible Euler equations must blow up in finite time. As was shown in [19], the system (3.1)–(3.3) is a strictly hyperbolic system which implies the property of finite propagation speed, which in turn allows one to define some averaged quantities as in [41] and finally show a blow-up of solutions in finite time by establishing a Riccati-type inequality.

    The finite propagation speed is expressed in:

    Lemma 3.1. ([49]) Let (ρ,u,θ,q,S) be a local solution to (3.1)(3.3), (3.6) on [0,T0). Let M>0. Assume that the initial data (ρ01,u0,θ01,q0,S0) are compactly supported in (M,M) and (ρ0,θ0,q0,S0)Ω. Then, there exists a constant σ such that

    (ρ(,t),u(,t),θ(,t),q(,t),S(,t)=(1,0,1,0,0):=(ˉρ,ˉu,ˉθ,ˉq,ˉS)

    on D(t)={xR||x|M+σt},0t<T0.

    The averaged quantities used are

    F(t):=Rxρ(x,t)u(x,t)dx, (3.8)
    G(t):=R(E(x,t)ˉE)dx, (3.9)

    where

    E(x,t):=ρ(e+12u2)

    is the total energy and

    ˉE:=ˉρ(ˉe+12ˉu2)=Cv.

    Now the blow-up result is given by:

    Theorem 3.2. ([49]) Assuming

    G(0)>0, (3.10)

    there exists u0 satisfying

    F(0)>max{32σmaxρ03γ,4maxρ03γ}M2,1<γ:=1+RCv<3 (3.11)

    such that the length T0 of the maximal interval of existence of a smooth solution (ρ,u,θ,q,S) to (3.1)(3.3), 3.6 is finite, provided the compact support of the initial data is sufficiently large.

    The assumption 1<γ<3 holds for the elementary kinetic theory of gases, cf. [41]. Note that it is assumed that the local solution satisfies (ρ,θ,q,S)(t)Ω. This a priori assumption does not affect u, which blows up, but is a restriction; the solutions might reach the boundary. In Section 5, we will consider Model 5, a modification of Model 3, and show a blow-up result excluding this possibility.

    Sketch of the proof of Theorem 3.2: Using the constitutive equations and the constancy of G, we get

    F(t)3γ2Rρu2dxRτ1(2γ1)2κθq2dxR(τ2(2γ1)2μ+12)S2dx(M+σt). (3.12)

    On the other hand

    F2(t)=(Rxρ(x,t)u(x,t)dx)2Btx2ρdxBtρu2dx(M+˜σt)2BtρdxBtρu2dx=(M+˜σt)2Btρ0dxBtρu2dx2maxρ0(M+˜σt)3Rρu2dx,

    where Bt={xR||x|M+˜σt} = ((M+˜σt),M+˜σt) and ˜σσ can be chosen arbitrary. For simplicity, we still denote ˜σ by σ in the following calculations. Therefore, we have

    F(t)3γ4maxρ0(M+σt)3F2Rτ1(2γ1)2κθq2dxRτ2(2γ1)+μ2μS2dx (M+σt). (3.13)

    Let

    c2:=σM,c3:=3γ4maxρ0M3.

    Assume, for the moment a priori,

    F(t)c1>0 (3.14)

    and

    M+σt=M(1+c2t)c32(1+c2t)3F2, (3.15)

    where c1 is to be determined later. Then

    F(t)F2c32(1+c2t)3τ1(2γ1)c21κˉθRq2dxτ2(2γ1)+μc212μRS2dx. (3.16)

    Using the identity (2.27) and defining

    H0:=R(Cvρ0(θ0lnθ01)+R(ρ0lnρ0ρ0+1)+(112θ0)τ1κθq20+τ22μS20)dx,

    we obtain

    τ1(2γ1)c21κˉθt0Rq2dxdt+τ2(2γ1)+μc212μt0RS2dxdtc4+c5u02L2, (3.17)

    where

    c4:=1c21[ˉθ(4τ1(2γ1)+τ2(2γ1)+μ)H0]

    and

    c5:=1c21[ˉθ(4τ1(2γ1)+τ2(2γ1)+μ)maxρ02].

    Integrating the inequality (3.16), we get

    1F01Fc34c2(1+c2t)2+c34c2c4c5u02L2. (3.18)

    Now we assume additionally and a priori

    F0>8c2c3 (3.19)

    and

    c4+c5u02L2c38c2. (3.20)

    Then, we get

    1F01F01Fc34c2(1+c2t)2+c38c2, (3.21)

    which means that T0 cannot be arbitrarily large without contradicting (3.19). It remains to show that the a priori assumptions (3.14), (3.15), (3.19), and (3.20) can be justified.

    (3.14) is easy to show with c1:=2c2c3. For (3.15) to hold, we only need to show the following inequality:

    M(1+c2t)c34(1+c2t)3F2. (3.22)

    For t=0, it is sufficient to guarantee

    σ23γ16maxρ0, (3.23)

    which is satisfied naturally since σ can be chosen arbitrarily large. Thus, the proof will be finished if we can show the existence of u0 such that (3.19) and (3.20) hold, and the assumption (3.10) is satisfied. As in [19], we choose u0H2(R)C1(R) as follows:

    u0(x):={0,x(,M],L2cos(π(x+M))L2,x(M,M+1],L,x(M+1,1],Lcos(π2(x1)),x(1,1],L,x(1,M1],L2cos(π(xM+1))+L2,x(M1,M],0,x(M,), (3.24)

    where L is a positive constant to be determined later. We assume M4. Assumption (3.10) can easily be satisfied since it is equivalent to requiring

    R(ρ0e0ˉρˉe+12u20)dx>0,

    which is satisfied by choosing ρ0θ0>ˉρˉθ=1. Since

    F0=Rxρ0(x)u0(x)dxL2minρ0M2,

    we can choose L large enough, independent of M, such that

    L2minρ0>max{32σmaxρ03γ,4maxρ03γ}

    implying (3.19). On the other hand, since u02L22L2M, we can choose M sufficiently large such that

    ˉθ(8γτ1+2γτ2+μ)(H0+maxρ0ML2)2σmaxρ0(3γ)M2

    holds, implying (3.20), and the proof is finished.

    A blow-up result is presented for Model 4 in the case μ=0, in dimensions n=2,3. We recall the differential equations (2.40) and the initial conditions (2.31):

    {tρ+div(ρu)=0,ρtu+ρuu+p=S2,ρte+ρue+pdivu+divq=S2divu,τ1(tq+uq)+q+κθ=0,τ3(tS2+uS2)+S2=λdivu, (4.1)
    (ρ(x,0),u(x,0),θ(x,0),q(x,0),S2(x,0))=(ρ0,u0,θ0,q0,S20). (4.2)

    Additionally, we assume the specified constitutive equations (1.14), (1.15),

    e=Cvθ+τ1κρθq2+τ32λρS22, (4.3)
    p=Rρθτ12κθq2τ32λS22. (4.4)

    A local solution was given in Theorem 2.13. For the blow-up result, we need to assume there exists δ>0, sufficiently small, such that

    maxxRn(|ρ01|,|θ01|,|q0(x)|,|S20(x)|)δ2 (4.5)

    and that this implies on the interval of local existence

    maxxRn(|ρ01|,|θ01|,|q0(x)|,|S20(x)|)δ. (4.6)

    We remark that this assumption does not affect u which is shown to blow-up in finite time. The finite propagation speed of the hyperbolic system is expressed in:

    Lemma 4.1. ([33]) Let (ρ,u,θ,q,S2) be the local solution to (4.1), (4.2) on [0,T0). We further assume that the initial data (ρ01,u0,θ01,q0,S20) are compactly supported in a ball B0(M) with radius M>0. Then, there exists a constant σ such that

    (ρ(,t),u(,t),θ(,t),q(,t),S2(,t))=(1,0,1,0,0)=:(ˉρ,ˉu,ˉθ,ˉq,ˉS2) (4.7)

    on D(t):={xRn||x|M+σt},0t<T0.

    The following averaged quantities are used, cf. Section 3:

    F(t):=Rnxρ(x,t)u(x,t)dx, (4.8)
    G(t):=Rn(E(x,t)ˉE)dx, (4.9)

    where E(x,t):=ρ(e+12u2) is the total energy and ˉE:=ˉρ(ˉe+12ˉu2)=Cv. Then we have:

    Theorem 4.2. Let (ρ,u,θ,q,S2) be the local solution to (4.1), (4.2) on [0,T0). Assume that the initial data (ρ01,u0,θ01,q0,S20) are compactly supported in a ball B0(M) with radius M>0. Moreover, we assume that

    G(0)>0, (4.10)
    1<γ:=1+RCv<53. (4.11)

    Then, there exists u0 satisfying

    F(0)>max{128σmaxρ03(53γ),8πmaxρ03(53γ)}M4, (4.12)

    such that the length T0 of the maximal interval of existence of a smooth solution (ρ,u,θ,q,S2) is finite, provided the compact support of the initial data is sufficiently large.

    This blow-up result relies on assumption (4.6) assuring the remaining of the solutions in the hyperbolic region, cf. the remarks in Section 3. A modification of the system, as done for Model 3 in Model 5, might remove this assumption, see Sections 3 and 5. The proof is similar to that of Theorem 3.2 in Section 3 and is presented for the case n=3. The case n=2 is proved by easy modifications.

    Sketch of the proof of Theorem 4.2: Using the constancy of G and the constitutive equations (4.3), (4.4), we conclude

    F(t)53γ2R3ρu2dx3R3τ1γκθq2dx3R3(τ3γλ+12)S22dx2π(M+σt)3. (4.13)

    Similar to the one-dimensional case discussed in Section 3, we obtain

    F(t)3(53γ)8πmaxρ0(M+σt)5F23R3(τ1γκθq2+2τ3γ+λ2λS22)dx2π(M+σt)3. (4.14)

    Let c2:=σM,c3:=3(53γ)8πmaxρ0M5. We assume a priori for the moment

    F(t)c1>0 (4.15)

    and

    2π(M+σt)3=2πM3(1+c2t)3c32(1+c2t)5F2, (4.16)

    where c1 is to be determined later. Then

    F(t)F2(t)c32(1+c2t)56τ1γc21κˉθR3q2dx6τ3γ+3λc212λR3S22dx. (4.17)

    Using the the dissipative entropy equation (2.37), with μ=0, and

    W0:=R3(Cvρ0(θ0lnθ01)+R(ρ0lnρ0ρ0+1) +(112θ0)τ1κθq20+τ22λS220)dx,

    we obtain

    6τ1γc21κˉθt0R3q2dxdt+6τ3γ+3λc212λt0R3S22dxdtc4+c5u02L2, (4.18)

    where

    c4=3c21[ˉθ(8τ1γ+2τ3γ+λ)W0],c5=3c21[ˉθ(8τ1γ+2τ3γ+λ)maxρ02].

    Integrating (4.17), we have

    1F01F(t)c38c2(1+c2t)4+c38c2c4c5u02L2. (4.19)

    Now, we additionally assume a priori

    F0>16c2c3, (4.20)
    c4+c5u02L2c316c2. (4.21)

    Then we get

    1F01F01F(t)c38c2(1+c2t)4+c316c2 (4.22)

    which implies that the maximal time of existence T cannot be arbitrarily large without contradicting (4.20). It remains to show that the a priori assumptions (4.15), (4.16), (4.20), and (4.21) can be justified.

    (4.15) is easy to show with c1:=4c2c3. For (4.16) to hold, it suffices to show

    2πM3(1+c2t)3c34(1+c2t)5F(t)2. (4.23)

    For t=0, it is sufficient to guarantee

    σ23(53γ)64maxρ0, (4.24)

    which is satisfied naturally since σ can be chosen arbitrarily large. Thus, the proof will be finished if we can show the existence of u0 such that (4.20) and (4.21) hold and the assumption (4.10) is satisfied. Let

    ˜v(r)={Lcos(π2(r1)),r[0,1],L,r(1,M1],L2cos(π(rM+1))+L2,r(M1,M],0,r(M,+), (4.25)

    where L is a positive constant to be determined later. ˜v is not in H3(R+), but we can think of ˜v being smoothed around the singular points r=1,M1,M and put to zero around r=0, yielding a function v, with vL22˜vL2. We choose

    u0(x):=v(|x|)x|x|.

    Assumption (4.10) can easily be satisfied since it is equivalent to requiring

    R3(ρ0e0ˉρˉe+12u20)dx>0,

    which is satisfied by choosing ρ0θ0>ˉρˉθ=1. Let M5. Since

    F0=R3xρ0(x)u0(x)dxπminρ032LM4,

    we can choose L sufficiently large, independent of M, such that

    πminρ032Lmax{64πmaxρ03(53γ),128σπmaxρ03(53γ)},

    implying (4.20). On the other hand, since u02L24L24π3M3, we can choose M sufficiently large such that

    ˉθ(8τ1γ+2τ2γ+μ)(W0+2πmaxρ0L23M3)16πσmaxρ09(53γ)M4

    holds, implying (4.21), and the proof is finished.

    Here we present a second blow-up result in one dimension, for Model 5 being a modification of Model 3, avoiding the possibility of reaching the hyperbolic boundary, cf. Section 3. We recall the differential equations and the initial conditions,

    {ρt+(ρu)x=0,ρut+ρuux+px=Sx,Et+(uE+pu+qSu)x=0, (5.1)

    where E represents the total energy,

    τ1(θ)(ρqt+ρuqx)+q+κ(θ)θx=0, (5.2)

    and

    τ2(ρSt+ρuSx)+S=μux, (5.3)
    (ρ(x,0),u(x,0),θ(x,0),q(x,0),S(x,0))=(ρ0,u0,θ0,q0,S0), (5.4)

    as well as the constitutive equations

    E=12ρu2+τ22μρS2+ρe(θ,q), (5.5)

    and the specific internal energy e and the pressure p are given by

    e(θ)=Cvθ+a(θ)q2,p(ρ,θ)=Rρθ, (5.6)

    where

    a(θ)=Z(θ)θ12Z(θ)withZ(θ)=τ1(θ)κ(θ).

    The local existence is given in Theorem 2.14. Neglecting ρ in the constitutive relations (1.3)–(1.5) and assuming τ1,κ to be constants, in Section 3 a blow-up result was established under the assumption that (ρ1,θ1,q,S)Ω with Ω=((δ,δ))4 being a "small" domain requiring δ to be sufficiently small to assure that the arising system is — though non-symmetric — strictly hyperbolic, which, in turn, assures the local solvability. This smallness of |(ρ1,θ1,q,S)| — notice: not including u — has been established globally only for small data. Therefore, the solutions in Section 3 might "blow up" in the sense that one may reach the boundary of Ω. In the present paper, the system is a symmetric hyperbolic one, not requiring any smallness condition of this kind.

    The most interesting aspect, as in Section 3, might be that the blow-up result contrasts the situation without relaxation. i.e., for the classical compressible Navier-Stokes system corresponding to τ1=τ2=0, where large global solutions exist, see Kazhikhov [48]. This really nonlinear effect — loosing the global existence for large data —, not anticipated from the linearized version, shows the possible impact a relaxation might have. For several linear systems of various type an effect is visible in loosing exponential stability in bounded domains or becoming of regularity loss type in the Cauchy problem, see the discussion in our paper [49].

    The method we use to prove the blow-up result is mainly motivated by Sideris' paper [41] where he showed that any C1-solutions of compressible Euler equations must blow up in finite time. A blow-up result for a similar system has also been proved recently by Freistühler [50] applying the general result for hyperbolic systems with sources in one space dimension by Bärlin [51]. A solution remains bounded, but the solution does not remain in C1, provided the data are small enough. In contrast to [50,51], our blow-up requires large initial velocities; moreover, here the largeness is described explicitly. For initial data being small in higher-order Sobolev spaces (H2), there exist global solutions. The method used here, and before in Sections 3 and 4, also extends to higher dimensions, as seen in Section 4.

    Since the system is symmetric hyperbolic, the local solution possesses the finite propagation speed property:

    Lemma 5.1. Let (ρ,u,θ,q,S) be the local solution according to Theorem 2.14 on [0,T0). Let M>0. We assume that the initial data (ρ01,u0,θ01,q0,S0) are compactly supported in (M,M). Then, there exists a constant σ such that

    (ρ(,t),u(,t),θ(,t),q(,t),S(,t)=(1,0,1,0,0):=(ˉρ,ˉu,ˉθ,ˉq,ˉS)

    on D(t)={xR||x|M+σt},0t<T0.

    We define again some averaged quantities,

    F(t):=ρuxdxτ2ρSdx, (5.7)
    G(t):=R(E(x,t)ˉE)dx, (5.8)

    where

    E=12ρu2+τ22μρS2+ρe(θ,q)

    is the total energy and

    ˉE:=ˉρ(ˉe+12ˉu2)=Cv.

    The functional F with the second term involving S is different from those used in [41] and [49] (resp., Section 3). This second term is new and technically motivated. The blow-up result is now given by:

    Theorem 5.2. We assume

    G(0)>0. (5.9)

    Then, there exists (ρ0,u0,θ0,q0,S0) satisfying

    F(0)>32σmaxρ03γM2 (5.10)

    and

    4((3γ)μτ2M2+γ1)(H0+maxρ02u02L2)128σ2maxρ0M3γ, (5.11)

    where

    H0:=Cvρ0(θ0lnθ01)+R(ρ0lnρ0ρ0+1)+ρ0(a(θ0)+12(Z(θ0)θ0))q20+τ22μS20dx, (5.12)

    such that the length T0 of the maximal interval of existence of a smooth solution (ρ,u,θ,q,S) to system (1.16)(1.18), (2.43) is finite, provided the compact support of the initial data is sufficiently large and γ:=1+RCv is sufficiently close to 1.

    Sketch of the proof: It is in the line of the proofs of the blow-up theorems in Sections 3 and 4, but with a slightly higher complexity due to the necessarily modified quantity F, but also with an improved strategy.

    The entropy η, defined by

    η:=CvlnθRlnρ(Z(θ)2θ)q2, (5.13)

    satisfies

    (ρη)t+(ρuη+qθ)x=q2κ(θ)θ2+S2μθ. (5.14)

    Using this and the constancy of G, we can derive

    F(t)3γ2ρu2dx(γ1)(H0+maxρ02u02L2).

    On the other hand, F satisfies

    ρu2dxF(t)24maxρ0(M+σt)32μτ2(H0+maxρ02u02L2)(M+σt)2.

    The last two estimates imply

    F(t)3γ8maxρ0(M+σt)3F2(t)((3γ)μτ2(M+σt)2+γ1)(H0+maxρ02u02L2)c3(1+c2t)3F(t)2K(t) (5.15)

    where c2:=σM,c3:=3γ8maxρ0M3. With this Riccati-type inequality, we can show the blow-up result. Indeed, assuming a priori that

    2K(t)c3(1+c2t)3F2(t), (5.16)

    we have

    F(t)c32(1+c2t)3F2(t),

    which gives

    1F(0)1F(0)1F(t)c34c2c34c2(1+c2t)2. (5.17)

    Hence, the maximal existence time T0 cannot be infinite provided

    F(0)>4c2c3=32σmaxρ0M23γ, (5.18)

    which is equivalent to assumption (5.10). Using (5.18), we get

    1F(t)1F(0)c34c2+c34c2(1+c2t)2c34c2(1+c2t)2, (5.19)

    which implies

    F(t)4c2(1+c2t)2c3. (5.20)

    To show that the a priori estimate (5.16) holds, we use the bootstrap method expressed in the following simple lemma.

    Lemma 5.3. Let fC0([0,),[0,)) and 0<a<b such that the following holds for any 0α<β<:

    f(0)<aand(t[α,β]:f(t)bt[α,β]:f(t)a.).

    Then we have

    t0:f(t)a.

    We will apply this lemma in the time domain of existence to f,a,b with

    f(t):=K(t)(1+c2t)3F2(t)c3,a:=14,b:=12.

    That is, we need to show that

    4K(t)c3(1+c2t)3F2(t). (5.21)

    Next, to get (5.21), using (5.20), one only needs to show

    4K(t)(1+c2t)3c316c22c23(1+c2t)4 (5.22)

    for which it is sufficient to show

    4((3γ)μτ2M2+γ1)(H0+maxρ02u02L2)16c22c3, (5.23)

    since K is a decreasing function. The last inequality is equivalent to assumption (5.11). This proves (5.16).

    Finally, we need to find some u0 such that the assumptions (5.10) and (5.11) hold. We choose, similarly to Sections 3 and 4, u0H2(R)C1(R) as follows:

    u0(x):={0,x(,M],L2cos(π(x+M))L2,x(M,M+1],L,x(M+1,1],Lcos(π2(x1)),x(1,1],L,x(1,M1],L2cos(π(xM+1))+L2,x(M1,M],0,x(M,), (5.24)

    where L is a positive constant to be determined later. We assume M4. Assumption (5.9) can easily be satisfied since it is equivalent to requiring

    R(ρ0e0ˉρˉe+12u20)dx>0,

    which is satisfied by choosing ρ0θ0>ˉρˉθ=1. Since

    R(xρ0(x)u0(x))dxL2minρ0M2

    and

    |τ2ρ0S0dx|MMρ0dx+τ2ρ0S20dxmaxρ0(1+μH20)M2,

    we choose L large enough, and independent of M, such that

    L4minρ0>max{maxρ0(1+μH20),32σmaxρ03γ}.

    Therefore, (5.10) holds. Now, after having chosen σ large enough, fix L. Then we choose M sufficiently large and γ1 sufficiently small such that (5.11) holds. This finishes the proof.

    The author declares he has not used Artificial Intelligence (AI) tools in the creation of this article.

    The author acknowledges with great gratitude the inspiring mathematical environment and hospitality experienced during various stays with Professor Thomas C. Sideris at the University of California at Santa Barbara.

    The successful co-operation with Professor Yuxi Hu leading to the results presented in this survey is also gratefully acknowledged.

    The author declares no conflict of interest in this paper.


    Acknowledgments



    Supported by the Department of Science and Technology, Government of India, New Delhi under the Inspire Faculty Award Scheme of AORC (IFA15/LSBM-154).

    Conflict of interest



    The authors declare no conflict of interest.

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