Relationship between lipid metabolism state, lipid peroxidation and antioxidant defense system in girls with constitutional obesity

Marina A. Darenskaya; Liubov I. Kolesnikova; Liubov V. Rychkova; Olga V. Kravtsova; Natalya V. Semenova; Sergei I. Kolesnikov; Marina A. Darenskaya; Liubov I. Kolesnikova; Liubov V. Rychkova; Olga V. Kravtsova; Natalya V. Semenova; Sergei I. Kolesnikov

doi:10.3934/molsci.2021009

AIMS Molecular Science

2021, Volume 8, Issue 2: 117-126. doi: 10.3934/molsci.2021009

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Research article

Relationship between lipid metabolism state, lipid peroxidation and antioxidant defense system in girls with constitutional obesity

Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia

Received: 26 February 2021 Accepted: 15 April 2021 Published: 26 April 2021

The study of the molecular mechanisms involved in adolescent obesity formation is important due to the severe and prolonged complications in adulthood. Here, we analyzed the lipid metabolism and peroxidation systems and the relationships between them in girls with constitutional obesity. Thirty-nine adolescent girls 14–16 age with constitutional obesity and twenty-six girls with a normal body mass index (control group) of the same age were examined. Spectrophotometric and fluorometric research methods were used. Constitutional obesity in adolescent girls is accompanied by the development of dyslipidemia (increased concentrations of total cholesterol, triacylglycerols, and very-low-density lipoproteins), as well as by reduced antioxidant defense components (total antioxidant activity, retinol, and the oxidized form of glutathione). In addition, adolescent girls with constitutional obesity had an increased number of correlations in the lipid peroxidation–antioxidant defense system and intersystem correlations, which indicates the insufficient activity of the antioxidant defense system. These results increase our understanding of the pathogenic mechanisms involved in adolescent.
- obesity,
- adolescence,
- lipids,
- antioxidants,
- lipid peroxidation
Citation: Marina A. Darenskaya, Liubov I. Kolesnikova, Liubov V. Rychkova, Olga V. Kravtsova, Natalya V. Semenova, Sergei I. Kolesnikov. Relationship between lipid metabolism state, lipid peroxidation and antioxidant defense system in girls with constitutional obesity[J]. AIMS Molecular Science, 2021, 8(2): 117-126. doi: 10.3934/molsci.2021009

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Abstract

The study of the molecular mechanisms involved in adolescent obesity formation is important due to the severe and prolonged complications in adulthood. Here, we analyzed the lipid metabolism and peroxidation systems and the relationships between them in girls with constitutional obesity. Thirty-nine adolescent girls 14–16 age with constitutional obesity and twenty-six girls with a normal body mass index (control group) of the same age were examined. Spectrophotometric and fluorometric research methods were used. Constitutional obesity in adolescent girls is accompanied by the development of dyslipidemia (increased concentrations of total cholesterol, triacylglycerols, and very-low-density lipoproteins), as well as by reduced antioxidant defense components (total antioxidant activity, retinol, and the oxidized form of glutathione). In addition, adolescent girls with constitutional obesity had an increased number of correlations in the lipid peroxidation–antioxidant defense system and intersystem correlations, which indicates the insufficient activity of the antioxidant defense system. These results increase our understanding of the pathogenic mechanisms involved in adolescent.

Abbreviations

AOD

antioxidant defense

BMI

body mass index

conjugated

DBP

diastolic blood pressure

GSH

reduced glutathione

GSSG

oxidized glutathione

HDL

high-density lipoproteins

LDL

low-density lipoproteins

LPO

lipid peroxidation

oxidative stress

PUFA

polyunsaturated fatty acids

SBP

systolic blood pressure

standard deviation

SDS BMI

standard deviation score of body mass index

SOD

superoxide dismutase

TAA

total antioxidant activity

TBAR

thiobarbituric acid

VLDL

low-density lipoproteins

WHO

World Health Organization

Conflict of interest

All authors declare that there is no conflict of interest in this paper.

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