Chemical structure, properties and potential applications of surfactin, as well as advanced strategies for improving its microbial production

Cheng Zhen; Xian-Feng Ge; Yi-Ting Lu; Wen-Zheng Liu; Cheng Zhen; Xian-Feng Ge; Yi-Ting Lu; Wen-Zheng Liu

doi:10.3934/microbiol.2023012

AIMS Microbiology

2023, Volume 9, Issue 2: 195-217. doi: 10.3934/microbiol.2023012

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Review Special Issues

Chemical structure, properties and potential applications of surfactin, as well as advanced strategies for improving its microbial production

School of Food and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China
^#Authors contributed equally to this work

Received: 01 December 2022 Revised: 08 February 2023 Accepted: 08 March 2023 Published: 14 March 2023

Surfactin, a cyclic lipopeptide produced by microbes belonging to the genus Bacillus, is one of the most effective biosurfactants available in many industrial fields. However, its low production and high cost have intensively constrained its commercial applications. In this review, we first summarize the molecular structure, biological properties, beneficial roles and potential applications of surfactin in the fields of medical care and food safety, highlighting the great medical and commercial values of making its industrial production into reality. Further, genetic regulation for surfactin biosynthesis and advanced strategies for enhancing its microbial production, including optimizing fermentation conditions, rational genetic engineering and synthetic biology combined with metabolic engineering approaches, are elucidated. Finally, prospects for improving surfactin biosynthesis are discussed, and the establishment of suitable chassis hosts for exogenous production of surfactin might serve as an important strategy in future research.
- surfactin,
- biological property,
- biosynthesis,
- genetic engineering,
- synthetic biology
Citation: Cheng Zhen, Xian-Feng Ge, Yi-Ting Lu, Wen-Zheng Liu. Chemical structure, properties and potential applications of surfactin, as well as advanced strategies for improving its microbial production[J]. AIMS Microbiology, 2023, 9(2): 195-217. doi: 10.3934/microbiol.2023012

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Abstract

Surfactin, a cyclic lipopeptide produced by microbes belonging to the genus Bacillus, is one of the most effective biosurfactants available in many industrial fields. However, its low production and high cost have intensively constrained its commercial applications. In this review, we first summarize the molecular structure, biological properties, beneficial roles and potential applications of surfactin in the fields of medical care and food safety, highlighting the great medical and commercial values of making its industrial production into reality. Further, genetic regulation for surfactin biosynthesis and advanced strategies for enhancing its microbial production, including optimizing fermentation conditions, rational genetic engineering and synthetic biology combined with metabolic engineering approaches, are elucidated. Finally, prospects for improving surfactin biosynthesis are discussed, and the establishment of suitable chassis hosts for exogenous production of surfactin might serve as an important strategy in future research.

Acknowledgments

This work was supported by the National Natural Science Foundation of China (grant number 32202121).

Conflict of interest

The authors declare no competing interests.

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