Numerical characterization of hemodynamics conditions near aortic valve after implantation of left ventricular assist device
-
1.
Department of Mathematics, University of Houston 4800 Calhoun Rd, Houston (TX) 77204
-
2.
Department of Mathematics, University of Houston, 4800 Calhoun Rd, Houston, TX 77204
-
3.
Department of Cardiology, Texas Heart Institute at St. Lukes Episcopal Hospital, and Mickael E Debakey VA Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030
-
Received:
01 June 2010
Accepted:
29 June 2018
Published:
01 June 2011
-
-
MSC :
Primary: 65M60, 74F10, 76D05.
-
-
Left Ventricular Assist Devices (LVADs) are implantable mechanical pumps that temporarily aid the function of the
left ventricle. The use of LVADs has been associated with thrombus formation next to the aortic valve and close to the anastomosis region,
especially in patients in which the native cardiac function is
negligible and the aortic valve remains closed.
Stagnation points and recirculation zones have been implicated as the main fluid dynamics factors contributing to thrombus formation.
The purpose of the present study was to develop and use computer simulations based on a
fluid-structure interaction (FSI) solver to study flow conditions corresponding to different strategies in
LVAD ascending aortic anastomosis providing a scenario with the lowest likelihood of thrombus formation.
A novel FSI algorithm was developed to deal
with the presence of multiple structures corresponding to different elastic properties of
the native aorta and of the LVAD cannula.
A sensitivity analysis of different variables was performed to assess their impact of flow conditions
potentially leading to thrombus formation.
It was found that the location of the anastomosis closest to the aortic valve
(within 4 cm away from the valve)
and at the angle of 30$^\circ$ minimizes the likelihood of thrombus formation.
Furthermore, it was shown
that the rigidity of the dacron anastomosis cannula plays almost no role in generating pathological
conditions downstream from the anastomosis.
Additionally, the flow analysis presented in this manuscript
indicates that compliance of the cardiovascular tissue acts as a natural inhibitor of pathological flow conditions conducive to thrombus formation
and should not be neglected in computer simulations.
Citation: Annalisa Quaini, Sunčica Čanić, David Paniagua. Numerical characterization of hemodynamics conditions near aortic valve after implantation of left ventricular assist device[J]. Mathematical Biosciences and Engineering, 2011, 8(3): 785-806. doi: 10.3934/mbe.2011.8.785
-
Abstract
Left Ventricular Assist Devices (LVADs) are implantable mechanical pumps that temporarily aid the function of the
left ventricle. The use of LVADs has been associated with thrombus formation next to the aortic valve and close to the anastomosis region,
especially in patients in which the native cardiac function is
negligible and the aortic valve remains closed.
Stagnation points and recirculation zones have been implicated as the main fluid dynamics factors contributing to thrombus formation.
The purpose of the present study was to develop and use computer simulations based on a
fluid-structure interaction (FSI) solver to study flow conditions corresponding to different strategies in
LVAD ascending aortic anastomosis providing a scenario with the lowest likelihood of thrombus formation.
A novel FSI algorithm was developed to deal
with the presence of multiple structures corresponding to different elastic properties of
the native aorta and of the LVAD cannula.
A sensitivity analysis of different variables was performed to assess their impact of flow conditions
potentially leading to thrombus formation.
It was found that the location of the anastomosis closest to the aortic valve
(within 4 cm away from the valve)
and at the angle of 30$^\circ$ minimizes the likelihood of thrombus formation.
Furthermore, it was shown
that the rigidity of the dacron anastomosis cannula plays almost no role in generating pathological
conditions downstream from the anastomosis.
Additionally, the flow analysis presented in this manuscript
indicates that compliance of the cardiovascular tissue acts as a natural inhibitor of pathological flow conditions conducive to thrombus formation
and should not be neglected in computer simulations.
-
-
-
-