Research article

MiR-608 rs4919510 C>G polymorphism increased the risk of bladder cancer in an Iranian population

  • Received: 21 September 2016 Accepted: 08 November 2016 Published: 10 November 2016
  • MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. The single nucleotide polymorphisms (SNPs) in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on bladder cancer risk. This case-control study conducted on 233 bladder cancer patients and 252 healthy subjects. Genotyping of miR-608 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our findings showed that CG as well as CG+GG genotypes significantly increased the risk of bladder cancer (OR = 1.94, 95% CI = 1.28–2.94, p = 0.002, and OR = 1.90, 95% CI = 1.26–2.86, p = 0.002, respectively) compared to CC genotype. The G allele significantly increased the risk of bladder cancer compared to C allele (OR = 1.69, 95% CI = 1.17–2.45, p = 0.005). Our findings proposed that miR-608 polymorphism might be associated with increased risk of bladder cancer in a sample of Iranian population. Further large-scale studies with different ethnicities are needed to verify our findings

    Citation: Mohammad Hashemi, Fatemeh Bizhani, Hiva Danesh, Behzad Narouie, Mehdi Sotoudeh, Mohammad Hadi Radfar, Mehdi Honarkar Ramezani, Gholamreza Bahari, Mohsen Taheri, Saeid Ghavami. MiR-608 rs4919510 C>G polymorphism increased the risk of bladder cancer in an Iranian population[J]. AIMS Genetics, 2016, 3(4): 212-218. doi: 10.3934/genet.2016.4.212

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  • MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. The single nucleotide polymorphisms (SNPs) in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on bladder cancer risk. This case-control study conducted on 233 bladder cancer patients and 252 healthy subjects. Genotyping of miR-608 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our findings showed that CG as well as CG+GG genotypes significantly increased the risk of bladder cancer (OR = 1.94, 95% CI = 1.28–2.94, p = 0.002, and OR = 1.90, 95% CI = 1.26–2.86, p = 0.002, respectively) compared to CC genotype. The G allele significantly increased the risk of bladder cancer compared to C allele (OR = 1.69, 95% CI = 1.17–2.45, p = 0.005). Our findings proposed that miR-608 polymorphism might be associated with increased risk of bladder cancer in a sample of Iranian population. Further large-scale studies with different ethnicities are needed to verify our findings


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    [1] Torre LA, Bray F, Siegel RL, et al. (2015) Global cancer statistics, 2012. CA Cancer J Clin 65: 87-108. doi: 10.3322/caac.21262
    [2] Antoni S, Ferlay J, Soerjomataram I, et al. (2016) Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends. Eur Urol.
    [3] Cancer Genome Atlas Research N (2014) Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507: 315-322. doi: 10.1038/nature12965
    [4] Shiels MS, Gibson T, Sampson J, et al. (2014) Cigarette smoking prior to first cancer and risk of second smoking-associated cancers among survivors of bladder, kidney, head and neck, and stage I lung cancers. J Clin Oncol 32: 3989-3995. doi: 10.1200/JCO.2014.56.8220
    [5] Vermeulen SH, Hanum N, Grotenhuis AJ, et al. (2015) Recurrent urinary tract infection and risk of bladder cancer in the Nijmegen bladder cancer study. Br J Cancer 112: 594-600. doi: 10.1038/bjc.2014.601
    [6] Burger M, Catto JW, Dalbagni G, et al. (2013) Epidemiology and risk factors of urothelial bladder cancer. Eur Urol 63: 234-241. doi: 10.1016/j.eururo.2012.07.033
    [7] Giedl J, Rogler A, Wild A, et al. (2016) TERT Core Promotor Mutations in Early-Onset Bladder Cancer. J Cancer 7: 915-920. doi: 10.7150/jca.15006
    [8] Sankhwar M, Sankhwar SN, Bansal SK, et al. (2016) Polymorphisms in the XPC gene affect urinary bladder cancer risk: a case-control study, meta-analyses and trial sequential analyses. Sci Rep 6: 27018. doi: 10.1038/srep27018
    [9] Hua Q, Lv X, Gu X, et al. (2016) Genetic variants in lncRNA H19 are associated with the risk of bladder cancer in a Chinese population. Mutagenesis: gew018
    [10] Aben KK, Witjes JA, Schoenberg MP, et al. (2002) Familial aggregation of urothelial cell carcinoma. Int J Cancer 98: 274-278. doi: 10.1002/ijc.10191
    [11] He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5: 522-531. doi: 10.1038/nrg1379
    [12] Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297. doi: 10.1016/S0092-8674(04)00045-5
    [13] Lee Y, Kim M, Han J, et al. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23: 4051-4060. doi: 10.1038/sj.emboj.7600385
    [14] Ryan BM, Robles AI, Harris CC (2010) Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer 10: 389-402. doi: 10.1038/nrc2867
    [15] Landi D, Gemignani F, Barale R, et al. (2008) A catalog of polymorphisms falling in microRNA-binding regions of cancer genes. DNA Cell Biol 27: 35-43. doi: 10.1089/dna.2007.0650
    [16] Wei WJ, Wang YL, Li DS, et al. (2015) Association study of single nucleotide polymorphisms in mature microRNAs and the risk of thyroid tumor in a Chinese population. Endocrine 49: 436-444. doi: 10.1007/s12020-014-0467-8
    [17] Jiao L, Zhang J, Dong Y, et al. (2014) Association between miR-125a rs12976445 and survival in breast cancer patients. Am J Transl Res 6: 869-875.
    [18] Kupcinskas J, Bruzaite I, Juzenas S, et al. (2014) Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer. Sci Rep 4: 5993.
    [19] Lin M, Gu J, Eng C, et al. (2012) Genetic polymorphisms in MicroRNA-related genes as predictors of clinical outcomes in colorectal adenocarcinoma patients. Clin Cancer Res 18: 3982-3991. doi: 10.1158/1078-0432.CCR-11-2951
    [20] Ryan BM, McClary AC, Valeri N, et al. (2012) rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer. PLoS One 7: e36306. doi: 10.1371/journal.pone.0036306
    [21] Wang R, Zhang J, Ma Y, et al. (2014) Association study of miR149 rs2292832 and miR608 rs4919510 and the risk of hepatocellular carcinoma in a largescale population. Mol Med Rep 10: 2736-2744.
    [22] Zhang P, Wang J, Lu T, et al. (2015) miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. Tumour Biol 36: 8789-8795. doi: 10.1007/s13277-015-3422-2
    [23] Morales S, Gulppi F, Gonzalez-Hormazabal P, et al. (2016) Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population. BMC Genet 17: 109.
    [24] Ma XP, Yu G, Chen X, et al. (2016) MiR-608 rs4919510 is associated with prognosis of hepatocellular carcinoma. Tumour Biol 2016: 1-12.
    [25] Sclafani F, Chau I, Cunningham D, et al. (2016) Sequence Variation in Mature MicroRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients. Carcinogenesis: bgw073.
    [26] Jiang J, Jia ZF, Cao DH, et al. (2016) Association of the miR-146a rs2910164 polymorphism with gastric cancer susceptibility and prognosis. Future Oncol 0.
    [27] Yang PW, Huang YC, Hsieh CY, et al. (2014) Association of miRNA-related Genetic Polymorphisms and Prognosis in Patients with Esophageal Squamous Cell Carcinoma. Ann Surg Oncol 21: 601-609. doi: 10.1245/s10434-014-3709-3
    [28] Hashemi M, Sanaei S, Rezaei M, et al. (2016) miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation. Exp Oncol 38: 57-59.
    [29] Qiu F, Yang L, Zhang L, et al. (2015) Polymorphism in mature microRNA-608 sequence is associated with an increased risk of nasopharyngeal carcinoma. Gene 565: 180-186. doi: 10.1016/j.gene.2015.04.008
    [30] Huang AJ, Yu KD, Li J, et al. (2012) Polymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes. PLoS One 7: e35252. doi: 10.1371/journal.pone.0035252
    [31] Dai ZM, Kang HF, Zhang WG, et al. (2016) The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. Medicine (Baltimore) 95: e2826. doi: 10.1097/MD.0000000000002826
    [32] Yin Z, Cui Z, Guan P, et al. (2015) Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population. PLoS One 10: e0128572. doi: 10.1371/journal.pone.0128572
    [33] Yin Z, Cui Z, Ren Y, et al. (2016) Association between polymorphisms in pre-miRNA genes and risk of lung cancer in a Chinese non-smoking female population. Lung Cancer 94: 15-21. doi: 10.1016/j.lungcan.2016.01.013
    [34] Kupcinskas J, Wex T, Link A, et al. (2014) Gene polymorphisms of micrornas in Helicobacter pylori-induced high risk atrophic gastritis and gastric cancer. PLoS One 9: e87467. doi: 10.1371/journal.pone.0087467
    [35] Wang K, Liang Q, Wei L, et al. (2016) MicroRNA-608 acts as a prognostic marker and inhibits the cell proliferation in hepatocellular carcinoma by macrophage migration inhibitory factor. Tumour Biol 37: 3823-3830. doi: 10.1007/s13277-015-4213-5
    [36] Xing J, Wan S, Zhou F, et al. (2012) Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer. Cancer Epidemiol Biomarkers Prev 21: 217-227. doi: 10.1158/1055-9965.EPI-11-0624
    [37] Pardini B, Rosa F, Naccarati A, et al. (2015) Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients. Carcinogenesis 36: 82-86. doi: 10.1093/carcin/bgu224
    [38] Liu H, Zhou Y, Liu Q, et al. (2016) Association of miR-608 rs4919510 polymorphism and cancer risk: a meta-analysis based on 13,664 subjects. Oncotarget.
    [39] Rah H, Kim HS, Cha SH, et al. (2015) Association of breast cancer-related microRNA polymorphisms with idiopathic primary ovarian insufficiency. Menopause 22: 437-443. doi: 10.1097/GME.0000000000000325
    [40] Li D, Zhu G, Di H, et al. (2016) Associations between genetic variants located in mature microRNAs and risk of lung cancer. Oncotarget.
    [41] Zhang Y, Schiff D, Park D, et al. (2014) MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET. PLoS One 9: e91546. doi: 10.1371/journal.pone.0091546
    [42] Hezaveh K, Kloetgen A, Bernhart SH, et al. (2016) Alterations of miRNAs and miRNA-regulated mRNA expression in GC B cell lymphomas determined by integrative sequencing analysis. Haematologica.
    [43] Marzec-Kotarska B, Cybulski M, Kotarski JC, et al. (2016) Molecular bases of aberrant miR-182 expression in ovarian cancer. Genes Chromosomes Cancer 55: 877-889. doi: 10.1002/gcc.22387
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  • © 2016 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
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