Research article Topical Sections

Assessment of efficacy of secondary prophylactic complex of bronchial obstruction syndrome in young children with respiratory disorders in neonatal period: analysis of symptoms and serological markers

  • Received: 28 November 2021 Revised: 31 March 2022 Accepted: 11 April 2022 Published: 14 April 2022
  • Diseases of respiratory tract in young children are often accompanied by the development of bronchial obstruction syndrome. Recurrent episodes of bronchial obstruction are a common problem in young children with respiratory disorders in neonatal period. The aim of our work was to test secondary prophylactic measures concerning development and progression of recurrent bronchial obstructive syndrome in young children, who had suffered respiratory disorders in neonatal period. Prophylactic complex included basic therapy (inhalation of glucocorticosteroids—fluticasone propionate or budesonide), administration of immunomodulating drug Ribomunyl and conducting of prophylactic vaccination in specialized inpatient department after prior preparation whith antihistamines.

    Objectives

    The feature of disease course was assessed based on the need of using drugs with symptomatic action, frequency of exacerbations, their mean duration and severity in 60 children, who had breathing disorders in neonatal period. Children were randomly divided into two groups. The study of efficacy of secondary prophylactic measures was conducted in 30 children (basic group) and in other 30 patients secondary prophylactic complex was not used (control group).

    Methods

    Algorithm of secondary prophylactic complex included basic therapy involving inhalation glucocorticosteroids, administration of immunomodulatory drug Ribomunyl as recommended and conduction of planned prophylactic inoculations with the use of antihistamines.

    Conclusions

    In children, who were administered secondary prophylactic complex was a positive dynamics in clinical picture and laboratory data.

    Results

    Administration of secondary prophylactic complex enabled, to a certain extent, to prevent progression of bronchial obstructive syndrome and achieve a reliable increase in γ-INF, IgA, IgM, IgG levels and decrease in IL-4 (р < 0.01).

    Citation: Matsyura Oksana, Besh Lesya, Zubchenko Svitlana, Gutor Taras, Lukyanenko Natalia, Slivinska-Kurchak Khrystyna, Borysiuk Olena. Assessment of efficacy of secondary prophylactic complex of bronchial obstruction syndrome in young children with respiratory disorders in neonatal period: analysis of symptoms and serological markers[J]. AIMS Allergy and Immunology, 2022, 6(2): 25-41. doi: 10.3934/Allergy.2022005

    Related Papers:

  • Diseases of respiratory tract in young children are often accompanied by the development of bronchial obstruction syndrome. Recurrent episodes of bronchial obstruction are a common problem in young children with respiratory disorders in neonatal period. The aim of our work was to test secondary prophylactic measures concerning development and progression of recurrent bronchial obstructive syndrome in young children, who had suffered respiratory disorders in neonatal period. Prophylactic complex included basic therapy (inhalation of glucocorticosteroids—fluticasone propionate or budesonide), administration of immunomodulating drug Ribomunyl and conducting of prophylactic vaccination in specialized inpatient department after prior preparation whith antihistamines.

    Objectives

    The feature of disease course was assessed based on the need of using drugs with symptomatic action, frequency of exacerbations, their mean duration and severity in 60 children, who had breathing disorders in neonatal period. Children were randomly divided into two groups. The study of efficacy of secondary prophylactic measures was conducted in 30 children (basic group) and in other 30 patients secondary prophylactic complex was not used (control group).

    Methods

    Algorithm of secondary prophylactic complex included basic therapy involving inhalation glucocorticosteroids, administration of immunomodulatory drug Ribomunyl as recommended and conduction of planned prophylactic inoculations with the use of antihistamines.

    Conclusions

    In children, who were administered secondary prophylactic complex was a positive dynamics in clinical picture and laboratory data.

    Results

    Administration of secondary prophylactic complex enabled, to a certain extent, to prevent progression of bronchial obstructive syndrome and achieve a reliable increase in γ-INF, IgA, IgM, IgG levels and decrease in IL-4 (р < 0.01).


    Abbreviations

    OB

    obstructive bronchitis

    BA

    bronchial asthma

    Ig

    immunoglobulin

    Th-1

    T-helpers I

    Th-2

    T-helpers IІ

    IFN-γ

    γ-interferon

    IL

    interleukin

    SPC

    secondary prophylactic complex

    TMB

    tetramethylbenzidine

    BOS

    bronchial obstruction syndrome

    CS

    corticosteroids

    ARVI

    acute respiratory viral infections

    加载中

    Acknowledgments



    We are grateful to the children and their parents for participating in the study.

    Conflict of interest



    All authors declare no conflicts of interest in this paper.

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