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Is COVID 19, a beginning of new entity called chronic viral systemic inflammatory syndrome?

  • Received: 08 March 2021 Accepted: 19 April 2021 Published: 20 April 2021
  • Since the emergence of SARS-COV-2, many updates and assumptions are being discussed based on the emerging understanding of the pathophysiology and outcomes of the infection. The host immune response is the critical factor in disease severity and the unique immune response of each individual has resulted in a broad spectrum of disease severity and clinical presentations. In this article, combining the emerging knowledge on the immunopathogenesis of COVID-19 infection with insights into the underlying mechanisms of certain autoimmune and chronic Immune-mediated inflammatory diseases we propound our hypothesis that SARS-CoV-2 infection produces chronic viral inflammatory syndrome.

    Citation: DharmaSaranya Gurusamy, Vasuki Selvamurugesan, Swaminathan Kalyanasundaram, Shantaraman Kalyanaraman. Is COVID 19, a beginning of new entity called chronic viral systemic inflammatory syndrome?[J]. AIMS Allergy and Immunology, 2021, 5(2): 127-134. doi: 10.3934/Allergy.2021010

    Related Papers:

  • Since the emergence of SARS-COV-2, many updates and assumptions are being discussed based on the emerging understanding of the pathophysiology and outcomes of the infection. The host immune response is the critical factor in disease severity and the unique immune response of each individual has resulted in a broad spectrum of disease severity and clinical presentations. In this article, combining the emerging knowledge on the immunopathogenesis of COVID-19 infection with insights into the underlying mechanisms of certain autoimmune and chronic Immune-mediated inflammatory diseases we propound our hypothesis that SARS-CoV-2 infection produces chronic viral inflammatory syndrome.


    Abbreviations

    DAB1

    disabled homolog 1

    SURF1

    surfeit locus protein 1

    AIFM

    apoptosis-inducing factor mitochondrial

    TIM-3

    T cell immunoglobulin and mucin domain 3

    CTLA4

    cytotoxic T lymphocyte associated protein 4

    PD1

    programmed cell death protein 1

    TIGIT

    T cell immunoglobulin and ITIM domain receptor

    MAVS

    mitochondrial antiviral signaling proteins

    VDAC

    voltage dependent anion channel

    ACE II

    angiotensin converting enzyme II

    AT1R

    angiotensin I receptor

    NLRP3

    nuclear NOD, LRR, pyrin domain containing protein 3

    IL

    interleukin

    GMCSF

    granulocyte monocyte colony stimulating factor

    TNF

    tumor necrosis factor

    PDGF

    platelet derived growth factor

    FGF

    fibroblast growth factor

    IFN-γ

    Interferon gamma

    TNF-α

    tumor necrosis factor alpha

    NF-κB

    nuclear factor κB

    加载中


    Conflict of interest



    All authors declare no conflicts of interest in this paper.

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