Review Topical Sections

Role of RP105 and A20 in negative regulation of toll-like receptor activity in fibrosis: potential targets for therapeutic intervention

  • Received: 15 January 2021 Accepted: 12 April 2021 Published: 14 April 2021
  • Toll-like receptors (TLRs) are essential defensive mediators implicated in immune diseases. Tight regulation of TLR function is indispensable to avoid the damaging effects of chronic signaling. Several endogenous molecules have emerged as negative regulators of TLR signaling. In this review, we highlighted the structure, regulation, and function of RP105 and A20 in negatively modulating TLR-dependent inflammatory diseases, and in fibrosis and potential therapeutic approaches.

    Citation: Swarna Bale, John Varga, Swati Bhattacharyya. Role of RP105 and A20 in negative regulation of toll-like receptor activity in fibrosis: potential targets for therapeutic intervention[J]. AIMS Allergy and Immunology, 2021, 5(2): 102-126. doi: 10.3934/Allergy.2021009

    Related Papers:

  • Toll-like receptors (TLRs) are essential defensive mediators implicated in immune diseases. Tight regulation of TLR function is indispensable to avoid the damaging effects of chronic signaling. Several endogenous molecules have emerged as negative regulators of TLR signaling. In this review, we highlighted the structure, regulation, and function of RP105 and A20 in negatively modulating TLR-dependent inflammatory diseases, and in fibrosis and potential therapeutic approaches.



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    Acknowledgments



    We are grateful for helpful discussions with Drs Benjamin Korman, Warren Tourtellotte, Bettina Shock, Christian Stehlik, Feng Fan, Kim Midwood, Averil Ma, Christopher Karp and members of the Varga Lab. Supported by grants from the National Institutes of Health (AR42309) and the Scleroderma Foundation.

    Conflict of interest



    All authors declare no conflicts of interest in this paper.

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