In a mouse study we found increased myelination of pathways surrounding the anterior cingulate cortex (ACC) following stimulation near the theta rhythm (4–8 Hz), and evidence that this change in connectivity reduced behavioral anxiety. We cannot use the optogenetic methods with humans that were used in our mouse studies. This paper examines whether it is possible to enhance intrinsic theta amplitudes in humans using less invasive methods. The first experiment compares electrical, auditory and biofeedback as methods for increasing intrinsic theta rhythm amplitudes in the Anterior Cingulate Cortex (ACC). These methods are used alone or in conjunction with a task designed to activate the same area. The results favor using electrical stimulation in conjunction with a task targeting this region. Stimulating the ACC increases intrinsic theta more in this area than in a control area distant from the site of stimulation, suggesting some degree of localization of the stimulation. In Experiment 2, we employed electrical stimulation with the electrodes common to each person, or with electrodes selected from an individual head model. We targeted the ACC or Motor Cortex (PMC). At baseline, intrinsic theta is higher in the ACC than the PMC. In both areas, theta can be increased in amplitude by electrical stimulation plus task. In the PMC, theta levels during stimulation plus task are not significantly higher than during task alone. There is no significant difference between generic and individual electrodes. We discuss steps needed to determine whether we can use the electrical stimulation + task to improve the connectivity of white matter in different brain areas.
Citation: Pascale Voelker, Ashley N Parker, Phan Luu, Colin Davey, Mary K Rothbart, Michael I Posner. Increasing the amplitude of intrinsic theta in the human brain[J]. AIMS Neuroscience, 2020, 7(4): 418-437. doi: 10.3934/Neuroscience.2020026
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Abstract
In a mouse study we found increased myelination of pathways surrounding the anterior cingulate cortex (ACC) following stimulation near the theta rhythm (4–8 Hz), and evidence that this change in connectivity reduced behavioral anxiety. We cannot use the optogenetic methods with humans that were used in our mouse studies. This paper examines whether it is possible to enhance intrinsic theta amplitudes in humans using less invasive methods. The first experiment compares electrical, auditory and biofeedback as methods for increasing intrinsic theta rhythm amplitudes in the Anterior Cingulate Cortex (ACC). These methods are used alone or in conjunction with a task designed to activate the same area. The results favor using electrical stimulation in conjunction with a task targeting this region. Stimulating the ACC increases intrinsic theta more in this area than in a control area distant from the site of stimulation, suggesting some degree of localization of the stimulation. In Experiment 2, we employed electrical stimulation with the electrodes common to each person, or with electrodes selected from an individual head model. We targeted the ACC or Motor Cortex (PMC). At baseline, intrinsic theta is higher in the ACC than the PMC. In both areas, theta can be increased in amplitude by electrical stimulation plus task. In the PMC, theta levels during stimulation plus task are not significantly higher than during task alone. There is no significant difference between generic and individual electrodes. We discuss steps needed to determine whether we can use the electrical stimulation + task to improve the connectivity of white matter in different brain areas.
1.
Introduction
It is very tough to visualize humans living in a recent time without heat transference. Maximum heat transmission processes in heat systems are achieved by employing the thermal transmission of fluids. The utilization of conventional thermal transfer fluids like ethylene glycol, water, engine oil and methanol is finite because of their short heat conductions [1]. For the advancement of the energy effectiveness of systems in different fields of science and engineering, the conventional thermal transference of fluids was substituted by nanofluids (NFs) [2]. NFs are an emulsion of little complex non-metallic or metallic elements, named nanoparticles in the base as mentioned for earlier liquids [3]. Through the more significant heat conduction of nanoparticles, the use of NFs boosts the thermal transmission. The NFs, in terms of their thermal performance, construction, solidity, and properties, were studied by Aydin and Guru [4]. Although NFs are formed through scattering one kind of nanoparticles in the base liquid, the thermal characteristics of NFs might be enhanced by using hybrid nanofluids (HNFs). HNFs combine two or more two different nanoparticles in the base liquid. Suitable nanoparticle kinds with precise weight percent are utilized to attain the required thermal exchange percentage. The HNFs institute enormous utilization in various features of the human life cycle, for instance, in defense, microfluidics and transportation [5,6], in this mode, the idea of HNFs has been the topic of several numerical and experimental investigations. An excellent analysis of HNFs, their techniques of preparation and the features affecting their performance and areas of employment were examined in [7]. The water-based HNF of silicon dioxide and graphite was groomed by Dalkılıç et al. [8], and its thickness in dissimilar NP volume fractions and temperatures was calculated. The thickness increases by the volume fraction rise and temperature decline were established; the maximum thickness increase was also attained. Numerous researches work on the movement of HNFs have been investigated in the relevant literature; see [9,10]. A Casson fluid is an essential form of non-Newtonian fluid that acts identical to a flexible solid in which no movement happens with minor yield stress [11]. It is appropriate for cooling and heating operations because of its powerful influence on the energy communication rate, which qualifies it for application in numerous fields like diet processing, drilling, metallurgy, and biotechnology developments. A Casson fluid is helpful during the construction of printing ink [12]. Casson fluid is also proficiently efficient at describing many polymers' movement features extensively [13].
Moreover, experiments based on blood have established that blood can perform as a Casson fluid [14,15]. Human blood, tomato sauce, custard, toothpaste, foams, starch suspensions, yogurt, nail polish and molten cosmetics are well-known examples of this fluid. Recently, Mustafa et al. [16] testified, when the speed is reducing and temperature is growing, raising the Casson parameter increases shear stress as well as thermal transfer. Mukhopadhyay et al. [17] exploited the shooting technique to study the flow of a Casson liquid as well as energy communication. Khalid et al. [18] studied the magneto-natural convection flow of a Casson fluid on a plate in a porous medium. Animasaun et al. [19] verified that the development in the Casson constraint source estimations enhances curve growth and reduces temperature curves. The influence of chemical reactions with a Casson liquid and a sphere was reviewed in [20]. Makinde et al. [21] discussed a meaningful connection between the influence of the Lorentz force and the movement of Casson fluid. The influence and skill of HNFs as the heat transfer fluid with a moving surface were numerically examined in [22]. A numerical investigation was done to study the HNFs boundary layer flow by Khashi'ie et al. [23]. They proved that the surface of a flat plate reduces the difference of the boundary layer and improves the heat transmission phenomena. The numerical solution and stability investigation for HNFs flow on a porous stretching/shrinking cylinder was discussed in [24] by utilizing the bvp4c problem solver in the Matlab package. They proved that a rise in the melting factor decreases the quantity of heat transmission and boosts the difference in the boundary layer. Ahmad et al. [25] investigated the analytical solution of a Casson NF flowing on an infinite vertical plate by utilizing the Caputo fractional derivatives definition.
The construction of different physical phenomena consequences complicated partial differential equations. The solution to such problems is relatively substantial in evaluating diverse types of physical phenomena. Fractional calculus excellently defines different approaches for investigating this type of problem. The terms, with the local and non-local kernels, are proficiently conserved by fractional technique. In the branch of fractional calculus, Caputo-Fabrizio (CF) and Atangana-Baleanu (AB) approaches are well-known techniques which have been extensively applied by investigators for several years in the past [26,27]. A well-known Indian mathematician, Tialk Raj Prabhakar, anticipated an innovative fractional operator along with three parameters. The Prabhakar fractional operator is a Mittag-Leffer function with three dissimilar fractional derivative operators. This operator has Mittag-Leffer tails using classical kernels positively [28]. Ali et al. [29] applied a Laplace transform and fractional approach to discuss a viscous fractional fluid model. Raza et al. [30,31] applied Prabhakar and Caputo fractional approach and a Laplace transform to study different fluid models and tools to improve the thermal transfer methods. Samia et al. [32] discussed a rate-type fractional model with a semi-analytical approach. Different numerical familiar techniques were applied for a fractional Oldroyd-B fluid mathematical model in [33]. Wang et al. [34] applied a Prabhakar approach to examine the blood-based HNF models with diverse nanoparticles by considering the Newtonian heating effect. Jie et al. [35] discussed the Brinkman NF fractional model and sinusoidal oscillations and submitted significant results. Suganya et al. [36] discussed an innovative numerical technique for 2-D stimulation energy along with an unsteady and revolving HNF flow for stretching and moving surfaces by exploiting the explicit finite-difference method. Their results revealed that the stimulation energy controls the thermal transmission amount. Abu Bakar et al. [37]studied the flow of HNFs over a porous medium along with the slip and radiation effects on a shrinking sheet by employing the shooting method. They perceived the rise of thermal transfer in the HNF relative to the usual NF. Shoeibi et al. [38] studied the glass chilling of a double-slope lunar still by utilizing an HNF (TiO2-Al2O3) at a 0.4% concentration numerically. Kanti et al. [39] applied the two-step technique to formulate the nanofluids. Their results exposed that the thermal conductivity of the NFs increased with increasing concentration and temperature. Nadeem et al. [40] discussed the heat transmission and MHD (magnetohydrodynamics) second-grade stagnation point flow of HNF with a convectively heated porous sheet to enhance the quantity of heat transfer by exploiting the numerical bvp4c method.
After reviewing the above literature, we have examined the Casson NF with sinusoidal heat transference and slip boundaries in this article. Different nanoparticles, i.e., copper (Cu), titanium dioxide (TiO2) and aluminum oxide (Al2O3) have been utilized for the suspension of NFs with water as the base fluid. The comparative analysis of the attained results of governed equations with innovative fractional derivatives, i.e., AB and CF-time fractional derivatives are examined. The semi-analytical solution of thermal and momentum fields is attained with the assistance of the Laplace transform and some numerical methods. To analyze the effects of different parameters on the governing equations, graphical and numerical comparisons are discussed with different values of parameters. Furthermore, the numerical comparison of the Nusselt number and skin friction is inspected at different times and numerical schemes.
2.
Problem description
In this manuscript, we have supposed a free mixed-convection viscous Casson NF flowing on an oscillating poured inclined plate due to the influence of applied inclined magnetic field with a strength of Bo. The flowing Casson fluid is mixed with different (Al2O3,Cu,TiO2) nanoparticles. Thermophysical properties and their values of base fluid and nanoparticles are described in Tables 1 and 2. Primarily at t=0, the temperature and inclined poured plate are both in a stable position. With the time at t>0+, the inclined plate begins to vibrate with a velocity UoCos(ωt), where ω shows the frequency of oscillations of the inclined plate. Due to the plate oscillations and rise in the thermal profile, the fluid also begins to flow on the oscillating plate with the same velocity as the plate oscillations, as displayed in Figure 1.
Table 1.
Model for thermophysical properties of NF quantities.
By neglecting the pressure gradient and utilizing the Boussinesq's [41,42] and Rosseland estimations, the governed equations for this fractional model can be originated as follows [43,44]:
In Eq (8) the initial conditions of the flowing mathematical model are described with the zero velocity and temperature at time t=0. And in Eq (9) the boundary conditions at ξ=0 are described with slipping boundary effect and sinusoidal thermal conditions, where
Definition 1. The mathematical form of the AB-fractional derivative for the function u(y,t) is
ABDβtu(y,t)=11−β∫t0Eβ[β(t−z)β1−β]u'(y,t)dt;0<β<1,
(11)
where ABDβt is the AB-fractional operator with fractional order parameterβ[46] and Eβ(z) is a Mittag-Leffer function with the mathematical form of
Eβ(z)=∑∞r=0zβΓ(rβ+1);z∈C.
The Laplace transform of the AB-fractional derivative (Eq(5)) can be well-defined as [47]
L{ABDβtw(ξ,t)}=qβL[w(ξ,t)]−qβ−1w(ξ,0)(1−β)qβ+β,
(12)
where q is the transformed constraint via the Laplace scheme.
Definition 2. The CF-time-fractional derivative for the function u(y,t) can be notarized as
CFDαtu(y,t)=11−α∫t0exp(α(1−τ)1−α)u'(y,t)dτ;0<α<1,
(13)
where CFDαt is the CF-fractional operator with non-integer order α, and its Laplace transformation is [48,49]
L{CFDαtw(ξ,t)}=sL[w(ξ,t)]−w(ξ,0)(1−α)s+α.
(14)
4.
AB-fractional model
The dimensionless version of the AB-fractional model may be attained by substituting the partial derivative with the AB-time fractional operator ABDβt of Eqs (6) and (7).
Exploiting the above transformed conditions, the simulation of the energy profile is summarized as
ˉT(ξ,q)=1−e−qq2e−ξ√(Π5PrΠ6qβ(1−β)qβ+β).
(18)
In Tables 3–5, we show the inverse results for Eq (18) that were obtained numerically by using inverse procedures such as the Stehfest and Tzou's approaches.
Table 3.
Numerical analysis results for the Nusselt number Nu for the AB- and CF-fractional models.
By substituting the partial derivative with respect to time with the CF-fractional operator CFDαt, the model equations for the CF-fractional derivative will be obtained as
Because the thermal profile in Eq (23) is agnostic of the momentum profile, applying the Laplace transform to the heat equation (Eq (23)) yields
Π5Pr(sL[T(ξ,t)]−T(ξ,0)(1−α)s+α)=Π6∂2ˉT(ξ,s)∂ξ2,
(24)
with the following conditions:
ˉT(ξ,s)=1−e−ss2andˉT(ξ,s)→0asξ→∞.
Employing the above conditions, the thermal profile will be
ˉϑ(y,s)=1−e−ss2e−ξ√(Π5PrΠ6a1ss+a2).
(25)
Again the Laplace inverse of the above equation can be observed numerically in Table 4.
5.2. Momentum field by CF
Now, for the velocity solution, apply the Laplace transform to the CF-fractional version given by Eq (22), as well as the temperature solution found in Eq (25)
We will utilize Stehfest and Tzou's numerical methods to compute the inverse Laplace transform of the temperature and velocity profiles using the AB and CF-fractional derivatives of Eqs (18), (21), (25) and (28), correspondingly [50,51,52]:
The fundamental goal of this investigation was to demonstrate the importance of fractional derivatives for the Casson-type NF by means of AB and CF derivatives. For the energy and momentum equations, an NF mixed with various nanoparticles, such as Al2O3,Cu,TiO2 was assumed and water was applied as the base fluid. The solution of the non-dimensional governing equations, i.e., the energy and momentum fields were found by applying the Laplace approach to the AB and CF-fractional models. The impacts of various constraints on non-dimensional governing equations are visually shown in Figures 2–13. The results of the numerical analysis of the Nusselt number and the skin friction are shown in Tables 3–5.
Figure 2.
Temperature profile against ξ due to α,β when Pr=6.2, φ=0.02, and t=1.0.
The effects of the fractional parameters (α,β) on temperature are shown in Figure 2(a) and 2(b). It is perceived that the temperature behavior decreases with growing estimations of fractional parameters for both fractional approaches. The AB-fractional operators have a more substantial impact than the CF-fractional operators on the energy profile. Such an impact happens because of the kernel of both diverse fractional operators. Figure 2(b) also shows the comparison of two different nanoparticles indicating that titanium dioxide (TiO2)-based NFs have a relatively more progressive value than copper (Cu)-based NFs, due to the physical characteristics of the considered nanoparticles. Figure 3(a) and 3(b) were made to intercept the response of the temperature profile when the volume fraction of the TiO2 and Cu nanoparticles are equally varied. The response of the temperature field declined for improvement of the volume fraction (φ) for both fractional models. Figure 3(b) shows that the profile of the temperature of the TiO2-based NF was better than that of the Cu-based NF. These suspension consequences are due to a growth in the thickness of the subsequent impact of the nanoparticles. Further, this effect is primarily attributed to the thermal features of the included nanoparticles, which refine the thermal presentation of the host fluid. Figure 4(a) and 4(b) were designed for the temperature profile to display the impacts of the Pr; the thermal boundary layer is shown as the same for both cases of fractional techniques. The temperature profile can be perceived as reciprocal performance for heat transmission over the whole domain. Figure 4(b) shows that the temperature for the normal working-based fluid. Here, the rising impacts of Pr decelerates the temperature profile.
The effects of the fractional parameters (α,β) on velocity are exposed in Figure 5(a) and 5(b). It is noted that the velocity behavior also lessened with growing estimations of the fractional parameters for both cases of fractional approaches. The AB-fractional operators had a more significant impact than CF fractional operators owing to the different kernels of the diverse fractional derivatives on the velocity profile. Figure 5(b) also illustrates the comparison of two different nanoparticles, and we concluded that titanium dioxide (TiO2)-based NFs has a relatively progressive value than copper (Cu)-based nanofluid, due to the physical characteristics of the considered nanoparticles, like the thermal profile.
Figure 6(a) and 6(b) were sketched for the profile of the velocity to see the impact of Pr and it is noted that the velocity profile also had reciprocal performance for heat transmission over the whole domain due to the fact that Pr states the ratio of momentum diffusivity to thermal diffusivity. In heat transference models, Pr controls the relative viscosity of the momentum and thermal boundary layers. Figure 6(b) describes the velocity for the normal working-based fluid. The results reveal that, with the rising value of Pr, the velocity profile declines. The effects of the volume fraction (φ) on the velocity are shown in Figure 7(a) and 7(b) for both fractional models. It was detected that the velocity decelerates by increasing the estimations of φ because of the thermal conductivity of NFs for the φ parameters. Moreover, Figure 7(b) depicts that TiO2-based NFs have a superior velocity value compared to Cu-based NFs. Figure 8(a) is portrayed to examine the behavior of β on a velocity, along with the slip and no-slip conditions. It is observed that the velocity declines due to more significant estimations of β. Moreover, it is distinguished that the velocity graph with slip conditions was higher than the graph without slip conditions near the oscillating plate. The effect of the Casson parameter λ1 on the velocity is shown in Figure 8(b). It can be seen that the velocity behavior represents the dual behavior for the Casson parameter λ1for both cases of fractional approaches. Initially, the momentum profile decreases due to increase in λ1, but and then decelerate its impact and the fluid flows more significantly. The AB-fractional operators have a more significant impact than the CF-fractional operators owing to the different kernels of the diverse fractional derivatives on the velocity.
Figure 9(a) and 9(b) represent the velocity diagrams that can be used to understand the influence of Gr and K, respectively. A rise in the velocity appeared because an enhancement in the estimations of Gr and the decreasing behavior can be seen for the porosity constraint K. Physically, the upsurge in the Gr results from significant induced fluid flows because of an increase in buoyancy influences. Consequently, these forces may influence an increase in the velocity. Moreover, for the porosity constraint, physically, when in the porous medium, the holes are significantly sufficient, so the resistance of the permeability medium can be ignored. Therefore, the velocity rises as the existence of the porous surface increases the resistance to the fluid.
Figure 10(a) illustrates the impact of the magnetic field M on the velocity. It is defined that magnetic field existence creates a Lorentz force in an electrically conducting fluid, which acts inversely to the fluid movement path if the value of M is imposed in the perpendicular direction, decelerating the velocity of the fluid. Furthermore, Figure 10(b) shows a comparison of different nanoparticles, and it is concluded that titanium dioxide (TiO2)-based NFs have a more significant impact on the momentum field as compared to the copper (Cu) and aluminum oxide (Al2O3) nanoparticles. Figure 11(a) and 11(b) signify the effects of ordinary and fractional derivatives on velocity and temperature. It is perceived that the velocity and temperature for the ordinary model were more extensive than those for the AB- and CF-fractional models. Figure 12(a) and 12(b) were drawn to compare two different numerical methods, i.e., the Stehfest and Tzou methods, for thermal and momentum profiles. The outcomes from both curves show a slight overlap, which signifies this work's validity. Figure 13(a) and 13(b) were plotted to check the validity of our attained results in comparison with the results of Ahmad et al. [25] for velocity and temperature fields, respectively. It can be realized from these figures that our obtained results match those acquired by Ahmad et al. [25] by the overlapping of both curves.
Table 3 shows the numerical analysis of the Nusselt number Nu with the impact of diverse parameters for the AB and CF models. It is perceived that the value of Nu for the CF model is larger than that for the AB model. Physically, it is due to the kernels of different fractional operators. Table 4 signifies the results of the numerical investigation of the skin friction Cf with the disparity in the fractional parameters at various times for the AB- and CF-fractional derivatives; it was concluded that the value of Cf for the CF model was larger than that for the AB model. Table 5 represents the results of the numerical study of velocity and temperature via diverse numerical inverse systems for the validation and accuracy of our obtained results as well as applied techniques. Furthermore, the results of the numerical comparison of our attained temperature and velocity profiles are examined in Table 6.
Table 6.
Numerical comparison results for the temperature and velocity with Ahmad et al. [25].
The Casson nanoparticles flow via AB and CF time-fractional derivatives has been studied. An NF mixed with various nanoparticles was assumed with water as the base fluid for the energy and momentum equations. The inversion algorithms as well as the Laplace transform were employed to obtain the solutions of velocity and temperature. A comparison was carried out for the ordinary, AB- and CF models. Some consequences from the literature can also be recovered from our obtained outcomes. Some concluding remarks are as follows:
● Temperature and momentum fields illustrate decaying behavior for fractional parameters in the case of the AB and CF models.
● The response of temperature and velocity fields declined to improve the volume fraction (φ) for both fractional models.
● The computations show that temperature, as well as the velocity field rate declined by growing Pr for both fractional techniques.
● The velocity behavior also lessened with λ1 for both cases of fractional approaches.
● An increasing behavior for the velocity appeared due to an enhancement in the estimations of Gr and decreasing behavior was seen for K.
● The behavior of velocity declined with the growing estimations of M.
● The velocity and temperature for the ordinary model were more extensive than those for the AB- and CF- fractional models.
● The comparison of the two different numerical methods, i.e., the Stehfest and Tzou methods for thermal and momentum profiles, showed that the outcomes from both curves have a slight overlap.
● Our obtained temperature and velocity profile results match those acquired by Ahmad et al. [25].
● Velocity field increases are more significant than increase in the values of Gr.
● The solution attained via the CF approach showed more decaying behavior then the AB model.
Acknowledgments
This research received funding support from the NSRF via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation (grant number B05F640092).
Conflict of interest
The authors declare no conflict of interest.
Acknowledgments
We would like to thank Don Tucker and Amanda Gunn for their assistance and support in this project.
Funding
This research was supported by ONR grant N00014-19-1-2015 and N00014-15-1-2148 to the University of Oregon.
Conflict of interest
The apparatus and laboratory used in these studies were contributed by EGI (now Phillips-EGI). One of the authors was a former employee of EGI. Members of the EGI staff including Don Tucker and Amanda Gunn advised and helped in the studies. It is understood by all parties that the design and analysis of these studies were under the direction of Dr.Voelker and Posner and that the results would be freely available to all.
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Pascale Voelker, Ashley N Parker, Phan Luu, Colin Davey, Mary K Rothbart, Michael I Posner. Increasing the amplitude of intrinsic theta in the human brain[J]. AIMS Neuroscience, 2020, 7(4): 418-437. doi: 10.3934/Neuroscience.2020026
Pascale Voelker, Ashley N Parker, Phan Luu, Colin Davey, Mary K Rothbart, Michael I Posner. Increasing the amplitude of intrinsic theta in the human brain[J]. AIMS Neuroscience, 2020, 7(4): 418-437. doi: 10.3934/Neuroscience.2020026
Figure 1. The 256 electrode sites are shown from the Phillips Neuro Geodesic Sensor Net. Electrodes used for stimulation or recording for the ACC (top) and PMC (left) are shown in shaded areas. We used 20 electrodes for each area during stimulation but show only the 10 electrodes used for recording and which lie over the region of interest
Figure 2. shows theta amplitude above baseline in each condition of Experiment 1. Significant theta above baseline following corrections for multiple tests is shown by asterisk
Figure 3. Cortical radial current density (i.e., density of current in direction aligned with direction of pyramidal neurons) model using generic stimulation montages. Left: Cortical current density associated with stimulation montage (anode: red electrodes and cathode: blue electrodes) optimized for ACC target (region highlighted with yellow oval). Right: Cortical current density associated with stimulation montage optimized for PMC target (region highlighted with yellow oval)
Figure 4. Compares intrinsic theta amplitude above the preceding baseline found in each brain area for the generic electrode configuration. The figure includes stimulation alone, task alone and stimulation plus task which are discussed in detail below. An asterisk indicates the value is significant p ≤ 0.01
Figure 5. Mean theta amplitude for generic (light) and individual (dark) electrodes in PMC and ACC