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Classification of Spike Wave Propagations in a Cultured Neuronal Network: Investigating a Brain Communication Mechanism

1 Dept. of Radiology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;
2 Biomedical Research Institute, AIST, Ikeda, Osaka 563-8577, Japan;
3 Graduate School of Applied Informatics, University of Hyogo, Kobe 650-0044, Japan;
4 Dept. of Integrative Physiology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;
5 NBL Technovator Co., Ltd., 631 Shindachimakino, Sennan 590-0522, Japan

Topical Section: Communication and Language: Theoretical Advances in Explaining Brain Mechanisms

In brain information science, it is still unclear how multiple data can be stored and transmitted in ambiguously behaving neuronal networks. In the present study, we analyze the spatiotemporal propagation of spike trains in neuronal networks. Recently, spike propagation was observed functioning as a cluster of excitation waves (spike wave propagation) in cultured neuronal networks. We now assume that spike wave propagations are just events of communications in the brain. However, in reality, various spike wave propagations are generated in neuronal networks. Thus, there should be some mechanism to classify these spike wave propagations so that multiple communications in brain can be distinguished. To prove this assumption, we attempt to classify various spike wave propagations generated from different stimulated neurons using our original spatiotemporal pattern matching method for spike temporal patterns at each neuron in spike wave propagation in the cultured neuronal network. Based on the experimental results, it became clear that spike wave propagations have various temporal patterns from stimulated neurons. Therefore these stimulated neurons could be classified at several neurons away from the stimulated neurons. These are the classifiable neurons. Moreover, distribution of classifiable neurons in a network is also different when stimulated neurons generating spike wave propagations are different. These results suggest that distinct communications occur via multiple communication links and that classifiable neurons serve this function.
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Keywords cultured neuronal network; spike wave propagation; spatiotemporal form; classifying; multiple communications

Citation: Yoshi Nishitani, Chie Hosokawa, Yuko Mizuno-Matsumoto, Tomomitsu Miyoshi, Shinichi Tamura. Classification of Spike Wave Propagations in a Cultured Neuronal Network: Investigating a Brain Communication Mechanism. AIMS Neuroscience, 2017, 4(1): 1-13. doi: 10.3934/Neuroscience.2017.1.1


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