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Toll-like receptors and immune cell crosstalk in the intestinal epithelium

Pharmacology & Therapeutics, Human Biology Building, School of Medicine, National University of Ireland, Galway, H91 TK33, Republic of Ireland

The intestinal epithelium consists of a barrier one cell thick found along the length of the gastrointestinal tract composed of many cell subtypes such as absorptive enterocytes and secretory Paneth cells, Goblet cells and enteroendocrine cells. Primarily known as a cell layer used to absorb nutrients from the products of digestion and as a protective barrier from infection, this has changed in recent years with numerous discoveries indicating its importance in priming and tolerising immune cells. Toll-like receptors are a family of pathogen recognition receptors that are widely expressed in human cells including the intestinal epithelium and are known primarily as initiators of inflammatory responses. However, recent evidence suggest that they may have a variety of roles and are involved in cross-talk with a variety of cell types. This review discusses TLR signalling pathways in the context of the intestinal epithelial microenvironment, namely innate and adaptive immune cells as well as microorganisms that resident in the lumen of the gut. TLR signalling is not only involved in defence against such microorganisms but also in communicating with the underlying immune cells. This review describes the many mechanisms by which such communication is executed. It also highlights potential sources of variation in such signalling in the general population in particular the effects of genetic variation, diversity of the microbiota, concomitant disease, diet and age.
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1. McKernan DP and Egan LJ (2015) The intestinal epithelial cell cycle: uncovering its 'cryptic' nature. Curr Opin Gastroenterol 31: 124–129.    

2. Gunther C, Neumann H, Neurath MF, et al. (2013) Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium. Gut 62: 1062–1071.    

3. Kurashima Y and Kiyono H (2017) Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing. Annu Rev Immunol 35: 119–147.    

4. Donaldson GP, Lee SM and Mazmanian SK (2016) Gut biogeography of the bacterial microbiota. Nat Rev Microbiol 14: 20–32.    

5. Belkaid Y and Harrison OJ (2017) Homeostatic Immunity and the microbiota. Immunity 46: 562–576.    

6. Farache J, Zigmond E, Shakhar G, et al. (2013) Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense. Immunol Cell Biol 91: 232–239.    

7. Van Kaer L and Olivares-Villagomez D (2018) Development, homeostasis, and functions of intestinal intraepithelial lymphocytes. J Immunol 200: 2235–2244.    

8. Melody YZ, Cisalpino D, Varadarajan S, et al. (2016) Gut microbiota-induced immunoglobulin g controls systemic infection by symbiotic bacteria and pathogens. Immunity 44: 647–658.    

9. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118: 229–241.    

10. Oppong GO, Rapsinski GJ, Newman TN, et al. (2013) Epithelial cells augment barrier function via activation of the Toll-like receptor 2/phosphatidylinositol 3-kinase pathway upon recognition of Salmonella enterica serovar Typhimurium curli fibrils in the gut. Infect Immun 81: 478–486.    

11. Deshmukh HS, Liu Y, Menkiti OR, et al. (2014) The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nat Med 20: 524–530.    

12. Habtezion A, Nguyen LP, Hadeiba H, et al. (2016) Leukocyte trafficking to the small intestine and colon. Gastroenterology 150: 340–354.    

13. Abreu MT (2010) Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol 10: 131–144.    

14. Allaire JM, Crowley SM, Law HT, et al. (2018)The intestinal epithelium: Central coordinator of mucosal immunity. Trends Immunol.

15. Pott J and Hornef M (2012) Innate immune signalling at the intestinal epithelium in homeostasis and disease. EMBO Rep 13: 684–698.    

16. Hennessy C and McKernan DP (2016) Epigenetics and innate immunity: the 'unTolld' story. Immunol Cell Biol 94: 631–639.    

17. Yu S and Gao N (2015) Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance. Cell Mol Life Sci 72: 3343–3353.    

18. Martini E, Krug SM, Siegmund B, et al. (2017) Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol 4: 33–46.    

19. Netea MG, Wijmenga C and O'Neill LA (2012) Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol 13: 535–542.    

20. Sommer F, Nookaew I, Sommer N, et al. (2015) Site-specific programming of the host epithelial transcriptome by the gut microbiota. Genome Biol 16: 62.    

21. Cario E (2018) Barrier-protective function of intestinal epithelial Toll-like receptor 2. Mucosal Immunol 1: S62–S66.

22. Cario E, Gerken G and Podolsky DK (2007) Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132: 1359–1374.    

23. Cario E, Gerken G and Podolsky DK (2004) Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127: 224–238.    

24. Li Y (2017) Retinoic acid facilitates Toll-Like Receptor 4 expression to improve intestinal barrier function through retinoic acid receptor beta. Cell Physiol Biochem 42: 1390–1406.    

25. Ey B, Eyking A, Gerken G, et al. (2009) TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury. J Biol Chem 284: 22332–22343.    

26. Brun P, Maria CG and Marsela Q, et al. (2013) Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system. Gastroenterology 145: 1323–1333.    

27. Nighot M, Al-Sadi R, Guo S, et al. (2017) Lipopolysaccharide-induced increase in intestinal epithelial tight permeability is mediated by Toll-Like receptor 4/myeloid differentiation primary response 88 (MyD88) activation of myosin light chain kinase expression. Am J Pathol 187: 2698–2710.    

28. Podolsky DK, Gerken G, Eyking A, et al. (2009) Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 137: 209–220.    

29. Lin N, Xu LF and Sun M (2013) The protective effect of trefoil factor 3 on the intestinal tight junction barrier is mediated by toll-like receptor 2 via a PI3K/Akt dependent mechanism. Biochem Biophys Res Commun 440: 143–149.    

30. Birchenough GMH, Nystrom EEL, Johansson MEV, et al. (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352: 1535–1542.    

31. Johansson MEV, Phillipson M, Petersson J, et al. (2008) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA 105: 15064–15069.    

32. Vaishnava S, Behrendt CL, Ismail AS, et al. (2008) Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA 105: 20858–20863.    

33. Vora P, Youdim A, Thomas LS, et al. (2004) Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol 173: 5398–5405.    

34. Rumio C, Sommariva M, Sfondrini L, et al. (2012) Induction of Paneth cell degranulation by orally administered Toll-like receptor ligands. J Cell Physiol 227: 1107–1113.    

35. Kinnebrew M, Buffie C, Diehl G, et al. (2012) Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36: 276–287.    

36. Ta A, Thakur BK, Dutta P, et al. (2017) Double-stranded RNA induces cathelicidin expression in the intestinal epithelial cells through phosphatidylinositol 3-kinase-protein kinase C ζ -Sp1 pathway and ameliorates shigellosis in mice. Cellular Signalling 35: 140–153.    

37. Marin M, Holani R, Shah CB, et al. (2017) Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium. Mol Immunol 91: 249–258.    

38. Bhinder G, Stahl M, Sham HP, et al. (2014) Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses. Infect Immun 82: 3753–3763.    

39. Friedrich C, Mamareli P, Thiemann S, et al. (2017) MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium. PLoS Pathog 13: e1006357.    

40. Macpherson AJ and Uhr T (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303: 1662–1665.    

41. Akira N, Alexis V, Mikako M, et al. (2018) IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria. J Exp Med 215: 2019–2034.    

42. Bruno MEC, Frantz AL, Rogier EW, et al. (2011) Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-kappaB pathways in intestinal epithelial cells. Mucosal Immunol 4: 468–478.    

43. Schneeman TA, Bruno MEC, Schjerven H, et al. (2005) Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol 175: 376–384.    

44. Bogunovic M, Shaival HD, Tilstra JS, et al. (2007) Enteroendocrine cells express functional Toll-like receptors. Am J Physiol Gastrointest Liver Physiol 292: G1770–G1783.    

45. Palazzo M, Balsari A, Rossini A, et al. (2007) Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion. J Immunol 178: 4296–4303.    

46. Selleri S, Palazzo M, Deola S, et al. (2008) Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS. Int Immunol 20: 961–970.    

47. Larraufie P, Doré J, Lapaque N, et al. (2017) TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways. Cell Microbiol 19.

48. Lotz M (2006) Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J Exp Med 203: 973–984.    

49. Wittkopf N, Neurath MF and Becker C (2014) Immune-epithelial crosstalk at the intestinal surface. J Gastroenterol 49: 375–387.    

50. Tomishige K, Yamazaki O, Chen Y, et al. (2005) Acute induction of human IL-8 production by intestinal epithelium triggers neutrophil infiltration without mucosal injury. Gut 54: 1565–1572.    

51. Schuerer-Maly CC (1994) Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide. Immunology 81: 85–91.

52. Fukata M, Michelsen KS, Eri R, et al. (2005) Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol 288: G1055–G1065.    

53. Lebeis SL, Bommarius B, Parkos CA, et al. (2007) TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol 179: 566–577.    

54. Sitaraman SV, Merlin D, Wang L, et al. (2001) Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6. J Clin Invest 107: 861–869.    

55. Sierro F, Dubois B, Coste A, et al. (2001) Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci USA 98: 13722–13727.    

56. Maaser C, Schoeppner S, Kucharzik T, et al. (2001) Colonic epithelial cells induce endothelial cell expression of ICAM-1 and VCAM-1 by a NF-kappaB-dependent mechanism. Clin Exp Immunol 124: 208–213.    

57. Huang GT, Eckmann L, Savidge TC, et al. (1996) Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion. J Clin Invest 98: 572–583.    

58. Neal MD, Leaphart C, Levy R, et al. (2006) Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 176: 3070–3079.    

59. Kivit SD, Hoffen EV, Korthagen N, et al. (2011) Apical TLR ligation of intestinal epithelial cells drives a Th1-polarized regulatory or inflammatory type effector response in vitro. Immunobiology 216: 518–527.    

60. Hyun J, Romero L, Riveron R, et al. (2015) Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. J Innate Immun 7: 87–101.    

61. Costanza A, Barbara V, Patrizia P, et al. (2017) Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14(+)CD16(+) Monocytes and gammadelta T Lymphocytes. Front Immunol 8: 1813.    

62. Al-Ghadban S, Kaissi S, Homaidan FR, et al. (2016) Cross-talk between intestinal epithelial cells and immune cells in inflammatory bowel disease. Sci Rep 6: 29783.    

63. Jin B, Sun T, Yu XH, et al. (2012) The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol 2012: 836485.

64. Chieppa M, Rescigno M, Huang AYC, et al. (2006) Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 203: 2841–2852.    

65. Farache J, Julia I, Koren I, et al. (2013) Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation. Immunity 38: 581–595.    

66. Zeuthen LH, Fink LN, and Frokiaer H (2008) Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-beta. Immunology 123: 197–208.

67. Iliev ID, Spadoni I, Mileti E, et al. (2009) Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 58: 1481–1489.    

68. Rimoldi M, Chieppa M, Salucci V, et al. (2005) Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 6: 507–514.    

69. Shan M, Gentile M, Yeiser JR, et al. (2013) Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342: 447–453.    

70. Villablanca EJ, Wang S, Calisto JD, et al. (2011) MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells. Gastroenterology 141: 176–185.    

71. Wang S, Villablanca E, De Calisto J, et al. (2011) MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol 187: 141–150.    

72. de Kivit S (2017) Galectin-9 produced by intestinal epithelial cells enhances aldehyde dehydrogenase activity in dendritic cells in a PI3K- and p38-dependent manner. J Innate Immun 9: 609–620.    

73. Dillon SM, Rogers LM, Howe R, et al. (2010) Human intestinal lamina propria CD1c+ dendritic cells display an activated phenotype at steady state and produce IL-23 in response to TLR7/8 stimulation. J Immunol 184: 6612–6621.    

74. Monteleone I, Platt A, Jaensson E, et al. (2008) IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function. Eur J Immunol 38: 1533–1547.    

75. Kaneko M, Mizunuma T, Takimoto H, et al. (2004) Development of TCR alpha beta CD8 alpha alpha intestinal intraepithelial lymphocytes is promoted by interleukin-15-producing epithelial cells constitutively stimulated by gram-negative bacteria via TLR4. Biol Pharm Bull 27: 883–889.    

76. Yu Q, Tang C, Xun S, et al. (2006) MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8 alpha alpha TCR alpha beta and TCR gamma delta intestinal intraepithelial lymphocytes. J Immunol 176: 6180–6185.    

77. Edelblum KL, Shen L, Weber CR, et al. (2012) Dynamic migration of gammadelta intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci USA 109: 7097–7102.    

78. Edelblum KL, Singh G, Odenwald MA, et al. (2015) Gammadelta intraepithelial lymphocyte migration limits transepithelial pathogen invasion and systemic disease in mice. Gastroenterology 148: 1417–1426.    

79. Ismail AS, Singh G, Odenwald MA, et al. (2011) Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci USA 108: 8743–8748.    

80. Konijnenburg DPHV, Reis BS, Pedicord VA, et al. (2017) Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection. Cell 171: 783–794 e13.    

81. Yin PJ, Kun W, Zhu JZ, et al. (2017) TLR2/TLR4 activation induces Tregs and suppresses intestinal inflammation caused by Fusobacterium nucleatum in vivo. PLoS One 12: e0186179.    

82. Atarashi K, Tanoue T, Shima T, et al. (2011) Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331: 337–341.    

83. Rivas MN, Koh YT, Chen A, et al. (2012) MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice. J Clin Invest 122: 1933–1947.    

84. Ivanov II, Atarashi K, Manel N, et al. (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139: 485–498.    

85. Walker CR, Isabelle H, Dalton JE, et al. (2013) Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge. PLoS One 8: e84553.    

86. Xu W, He B, Chiu A, et al. (2007) Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nat Immunol 8: 294–303.    

87. He B, Xu W, Santini PA, et al. (2007) Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 26: 812–826.    

88. Shang L, Fukata M, Thirunarayanan N, et al. (2008) Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology 135: 529–538.    

89. Oh JZ, Ravindran R, Chassaing B, et al. (2014) TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity 41: 478–492.    

90. Kamdar K, Johnson AMF, Chac D, et al. (2018) Innate recognition of the microbiota by tlr1 promotes epithelial homeostasis and prevents chronic inflammation. J Immunol 201: 230–242.    

91. Chassaing B, Ley RE and Gewirtz AT (2014) Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology 147: 1363–77 e17.    

92. Lee J, Mo JH, Katakura K, et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol 8: 1327–1336.    

93. Sodhi CP, Neal MD, Siggers R, et al. (2012) Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology 143: 708–718 e5.    

94. Frantz AL, Rogier EW, Weber CR, et al. (2012) Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol 5: 501–512.    

95. Mowat AM and Agace WW (2014) Regional specialization within the intestinal immune system. Nat Rev Immunol 14: 667–685.    

96. Agace WW and McCoy KD (2017) Regionalized development and maintenance of the intestinal adaptive immune landscape. Immunity 46: 532–548.    

97. Price AE (2018) A map of Toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns. Immunity 49: 560–575 e6.    

98. Abreu MT, Vora P, Faure E, et al. (2001) Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol 167: 1609–1616.    

99. Sabharwal H, Cichon C, Tobias AÖ, et al. (2016) Interleukin-8, CXCL1, and MicroRNA miR-146a responses to probiotic escherichia coli Nissle 1917 and Enteropathogenic E. coli in Human Intestinal Epithelial T84 and Monocytic THP-1 Cells after Apical or Basolateral Infection. Infect Immun 84: 2482–2492.

100. Cario E and Podolsky DK (2000) Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68: 7010–7017.    

101. Abreu MT, Arnold ET, Thomas LS, et al. (2002) TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem 277: 20431–20437.    

102. Mueller T, Terada T, Rosenberg IM, et al. (2006) Th2 cytokines down-regulate TLR expression and function in human intestinal epithelial cells. J Immunol 176: 5805–5814.    

103. Suzuki M, Hisamatsu T and Podolsky DK (2003) Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex. Infect Immun 71: 3503–3511.    

104. Mukherji A, Kobiita A, Ye T, et al. (2013) Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell 153: 812–27.    

105. Yang X, Gao XC, Liu J, et al. (2017) Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18. World J Gastroenterol 23: 4744–4751.    

106. Iraporda C, Errea A, Romanin DE, et al. (2015) Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells. Immunobiology 220: 1161–9.    

107. Chang PV, Hao L, Offermanns S, et al. (2014) The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci USA 111: 2247–52.    

108. Lebouder E, Rey-Nores JE, Raby AC, et al. (2006) Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J Immunol 176: 3742–52.    

109. Venkatesh M, Mukherjee S, Wang HW, et al. (2014) Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity 41: 296–310.    

110. Bansal T, Alaniz RC, Wood TK, et al. (2010) The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Proc Natl Acad Sci USA 107: 228–33.    

© 2019 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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