
Curcumin (CUR) a natural polyphenolic compound, has attracted significant attention due to its broad-spectrum anti-inflammatory, antioxidant, antimicrobial, and antitumor activities. However, its poor water solubility, low bioavailability, and limited stability have hindered clinical applications. Novel approaches utilizing nanocarrier-based delivery systems (e.g., liposomes, micelles) and structural modification strategies offer promising solutions to enhance the therapeutic efficacy of curcumin. This review and analysis attempted to summarize the therapeutical applications and working mechanisms of CUR in oral infectious diseases, inflammation, traumatic disease and immune disorder. Publications included in this review included references were confined to curcumin, nano-curcumin (nCUR), and the names of different oral diseases; the different methodologies included clinical trials, in vivo animal studies and in vitro studies. Web of Science and Pubmed/MEDLINE databases were explored. The antioxidant, anti-inflammatory, immune regulation and anticancer properties of CUR and nCUR are reported, and their positive applications in oral diseases is discussed. With more favorable structure and improved solubility and bioavailability, nCUR is more beneficial, stable and efficient than CUR. Local application seems to be more effective on oral diseases, which allows for higher concentrations and better bioavailability, and can directly targets specific areas of the mouth, providing more precise treatment. Both CUR and nCUR are likely to be developed into a next-generation drug, but there is no consensus on their concentration, irradiation times and light intensity. Additional trials are required to obtain clinical standards, and establish specific dose ranges and clinical procedures.
Citation: Juan Zhang, Yuhan Peng, Siting Hu, Jianmeng Xu, Chengcheng Yu, Lei Hua, Shihui Zhou, Qi Liu. Therapeutic application of curcumin and its nanoformulation in dentistry: Opportunities and challenges[J]. AIMS Molecular Science, 2025, 12(2): 148-172. doi: 10.3934/molsci.2025010
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Curcumin (CUR) a natural polyphenolic compound, has attracted significant attention due to its broad-spectrum anti-inflammatory, antioxidant, antimicrobial, and antitumor activities. However, its poor water solubility, low bioavailability, and limited stability have hindered clinical applications. Novel approaches utilizing nanocarrier-based delivery systems (e.g., liposomes, micelles) and structural modification strategies offer promising solutions to enhance the therapeutic efficacy of curcumin. This review and analysis attempted to summarize the therapeutical applications and working mechanisms of CUR in oral infectious diseases, inflammation, traumatic disease and immune disorder. Publications included in this review included references were confined to curcumin, nano-curcumin (nCUR), and the names of different oral diseases; the different methodologies included clinical trials, in vivo animal studies and in vitro studies. Web of Science and Pubmed/MEDLINE databases were explored. The antioxidant, anti-inflammatory, immune regulation and anticancer properties of CUR and nCUR are reported, and their positive applications in oral diseases is discussed. With more favorable structure and improved solubility and bioavailability, nCUR is more beneficial, stable and efficient than CUR. Local application seems to be more effective on oral diseases, which allows for higher concentrations and better bioavailability, and can directly targets specific areas of the mouth, providing more precise treatment. Both CUR and nCUR are likely to be developed into a next-generation drug, but there is no consensus on their concentration, irradiation times and light intensity. Additional trials are required to obtain clinical standards, and establish specific dose ranges and clinical procedures.
Inequalities are essential and instrumental in dealing with several complex mathematical quantities that appeared in diverse domains of physical sciences. They have been investigated from multiple aspects, including expanding the applicable domain and eliminating the limitations of already proved results and utilizing various approaches from functional analysis, generalized calculus, and convex analysis. Originally, they were pivotal to acquiring bounds for different mappings, integrals, the uniqueness and stability of solutions, error analysis of quadrature algorithms, information theory, etc. Based on these factors, this theory has grown exponentially through convex analysis. Additionally, the impact of concavity is exemplary in inequalities due to plenty of factors, particularly the fact that several inequalities can be derived from the premise of convexity. This suggests that one of the main motives for studying classical inequalities is to characterize convexity and its generalizations. One of the notable classes of convexity depending upon quadratic support is known to us as strong convexity, which generalizes the classical concepts and is highly applied to conclude the novel refinements of already proven results. This class has inspired the development of several new mapping classes in the literature. For comprehensive details on generalizations of strongly convex, consult [1,2,3,4,5,6]. In 2007, Abramovich et al. [7] demonstrated another concept of a super-quadratic mapping incorporated with translations of itself and a support line. It is defined as:
A mapping Ψ:[0,∞)→R is considered to be a super-quadratic for μ≥0 if there exist a constant C(μ)∈R, such that
Ψ(μ1)≥Ψ(μ)+C(μ)(μ1−μ)+Ψ(|μ−μ1|),μ1≥0. |
It can also be interpreted as:
Definition 1.1 ([7]). A mapping Ψ:[0,∞)→R is called super-quadratic if, and only if,
Ψ((1−φ)μ+φy)≤(1−φ)Ψ(μ)+φΨ(y)−φΨ((1−φ)|μ−y|)−(1−φ)Ψ(φ|μ−y|), | (1.1) |
holds ∀μ,y≥0 and 0≤φ≤1.
Here, we provide some instrumental results to discuss super-quadratic mappings.
Lemma 1.1 ([7]). If Ψ:[0,∞)→R is a super-quadratic mapping, then
(1) Ψ(0)≤0,
(2) C(μ)=Ψ′(μ), when Ψ(μ) is differentiable with Ψ(0)=Ψ′(0)=0, for all μ≥0,
(3) for all μ≥0, if Ψ(μ)≥0, then Ψ is convex and Ψ(0)=Ψ′(0)=0.
Kian and his coauthors [8,9] came up with the idea of operator super-quadratic mappings and Jensen's kinds of inequalities that are related to them. Oguntuase and Persson [10] discussed Hardy-like inequalities utilizing the notion of super-quadratic mappings. Study these additional papers for more comprehensive research on super-quadraticity, [11,12,13,14,15].
Varosanec [16] proposed the unified class of convexity through control mapping and provided new insight to conduct research in the following field. Throughout the investigation, let ℏ∘:(0,1)→R be a mapping such that ℏ∘≥0.
Definition 1.2 ([16]). A mapping Ψ:[s3,s4]→R is considered to be a ℏ∘-convex, if
Ψ((1−φ)μ+φy)≤ℏ∘(φ)Ψ(μ)+ℏ∘(1−φ)Ψ(y). |
Inspired by the idea presented in [16], Alomari and Chesneau [17] developed a general class of super-quadratic mappings and investigated some of their essential properties, defined as:
Definition 1.3 ([17]). Any mapping Ψ:[s3,s4]→R is regraded as ℏ∘-super-quadratic, If
Ψ((1−φ)μ+φy)≤ℏ∘(φ)[Ψ(y)−Ψ((1−φ)|y−μ|)]+ℏ∘(1−φ)[Ψ(μ)−Ψ(φ|μ−y|)]. |
Lemma 1.2 ([17]). Suppose Ψ:[s3,s4]→R is a ℏ∘-super-quadratic mapping, then
(1) Ψ(0)≤0,
(2) for all μ≥0, if Ψ(μ)≥0, then Ψ is ℏ∘-convex such that Ψ(0)=Ψ′(0)=0.
The Jensen's inequality for this class of mappings is given as
Theorem 1.1 ([17]). Suppose Ψ:[s3,s4]→R is a ℏ∘-super-quadratic mapping, then
Ψ(1Cϑϑ∑ν=1φνμν)≤ϑ∑ν=1ℏ∘(φνCϑ)Ψ(μν)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ(|μν−1Cϑϑ∑ν=1φνμν|). |
Also, they proved the Jensen-Mercer inequality for ℏ∘-super-quadratic mappings.
Theorem 1.2 ([17]). Let Ψ:[s3,s4]→R be a ℏ∘-super-quadratic mapping, then
Ψ(s3+s4−1Cϑϑ∑ν=1φνμν)≤Ψ(s3)+Ψ(s4)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ(μν)−ϑ∑ν=1ℏ∘(φνCϑ)[Ψ(μν−s3)+Ψ(s4−μν)]−ϑ∑ν=1ℏ∘(φνCϑ)Ψ(|μν−1Cϑϑ∑ν=1φνμν|). |
Set-valued analysis and its subdomains are cornerstones in mathematical sciences to generalize the previously obtained results. In this regard, Moore [18] applied the set-valued mappings to establish bounded solutions of differential equations. Recently, researchers have focused on decision-making, multi-objective optimization, numerical analysis, mathematical modeling, and advanced nonlinear analysis through interval-valued mapping. Probabilistic and interval-valued techniques are utilized to extract the results from data having randomness. However, these approaches are not applicable to quantities that possess vagueness. To deal with such problems, Zadeh [19] proposed the idea of a fuzzy set based on generalized indicator mapping and also presented the idea of a fuzzy convex set. This theory emerged as a potential theory in the last few decades. The contribution of these concepts in optimization, decision-making, inequalities, differential equations, mathematical modeling, approximation methodologies, dynamic systems, and computer science is unprecedented. Note that this theory is not statistical in nature but sets new trends in possibility theory. Dubois and Prade [20] researched preliminary terminologies related to area and tangent problems and offered new insights to carry new developments. Nanda and Kar [21] explored diverse groups of fuzzy convex mappings and reported their essential characterization.
As we move ahead, let us go over certain previously laid-out concepts and implications of fuzzy interval analysis. Assume that Kc symbolizes the space of all closed and bounded intervals in R, while K+c represents the space of positive intervals. The interval 1χ is defined as:
[1χ]=[1χ−,−1χ]={μ:1χ−≤μ≤−1χ,μ∈R}. |
Given χ,ϕ∈Kc and δ1∈R, Minkowski's operations are given as:
δ1.χ:={[δ1χ∗,δ1χ∗]ifδ1≥0,[δ1χ∗,δ1χ∗]ifδ1<0. |
Then the Minkowski addition χ+ϕ and χ×ϕ for χ,ϕ∈Kc are defined by
[ϕ∗,ϕ∗]+[χ∗,χ∗]:=[ϕ∗+χ∗,ϕ∗+χ∗], |
and
[ϕ∗,ϕ∗]×[χ∗,χ∗]:=[min{ϕ∗χ∗,ϕ∗χ∗,ϕ∗χ∗,ϕ∗χ∗},max{ϕ∗χ∗,ϕ∗χ∗,ϕ∗χ∗,ϕ∗χ∗}]. |
Definition 1.4 ([22]). For any compact intervals A=[s3∗,s∗3], B=[s4∗,s∗4] and C=[c∗,c∗], the generalized Hukuhara difference (gH-difference) is explored as:
[s3∗,s∗3]⊖g[s4∗,s∗4]=[c∗,c∗]⇔{(i){s3∗=s4∗+c∗s∗3=s∗4+c∗,(ii){s4∗=s3∗−c∗s∗4=s∗3−c∗. |
Also, the gH-difference can be illustrated as:
[s3∗,s∗3]⊖g[s4∗,s∗4]=[min{s3∗−s4∗,s∗3−s∗4},max{s3∗−s4∗,s∗3−s∗4}]. |
Also for A∈Kc, the length of interval is computed by l(A)=s∗3−s3∗. Then, for all A,B∈Kc, we have
A⊖gB={[s3∗−s4∗,s∗3−s∗4],l(A)≥l(B),[s∗3−s∗4,s3∗−s4∗],l(A)≤l(B). |
Definition 1.5 ([23]). The "≤ρ" relation over Kc is provided as:
[ϕ∗,ϕ∗]≤ρ[χ∗,χ∗], |
if and only if,
ϕ∗≤χ∗,ϕ∗≤χ∗, |
for all [ϕ∗,ϕ∗],[χ∗,χ∗]∈Kc is a pseudo-order or left-right (LR) ordering relation.
Theorem 1.3 ([23,24]). Every fuzzy set and δ1∈(0,1], the representations of δ1-level set of 1π are examined in the following order: 1πδ1={μ∈R:1π(μ)≥δ1} and supp(1π)=cl{μ∈R:1π(μ)>0}. The fuzzy sets in R are represented by Θδ1 and 1π∈Θδ1. A 1π is considered to be a fuzzy number (interval) if it is normal, fuzzy convex, semi-continuous, and has compact support. The space of all real fuzzy numbers are specified by Υδ1.
Let 1π∈Υδ1 be a fuzzy interval if, and only if, δ1-levels [1π]δ1is a compact convex set of R. Now, we deliver the representation of fuzzy number:
[1π]δ1=[1π∗(δ1),1π∗(δ1)], |
where
1π∗(δ1):=inf{μ∈R:1π(μ)≥δ1},1π∗(δ1):=sup{μ∈R:1π(μ)≥δ1}. |
Thus, a fuzzy-interval can be investigated and characterized by a parameterized triplet. For more details, see [26].
{1π∗(δ1),1π∗(δ1);δ1∈[0,1]}. |
These two endpoint mappings 1π∗(δ1) and 1π∗(δ1) play a vital role in exploring the fuzzy numbers.
Proposition 1.1 ([25]). If V,χ∈Υδ1, then the relation "⪯" explored on Υδ1 by
V⪯χ if, and only if, [V]δ1≤ρ[χ]δ1, for all δ1∈[0,1], this relation is known as a partial order relation.
For V,χ∈Υδ1 and c∈R, the scalar product c⋅χ, sum with constant, the sum V⊕χ, and product V⊙χ are defined by:
[c⋅V]δ1=c⋅[V]δ1,[c⊕V]δ1=c+[V]δ1.[V⊕χ]δ1=[V]δ1+[χ]δ1,[V⊙χ]δ1=[V]δ1×[χ]δ1. |
The level wise difference of the fuzzy number is stated as follows:
Definition 1.6 ([27]). Let V, χ be the two fuzzy numbers. Then the level-wise difference is defined as
[V⊖χ]δ1=[V∗(δ1)−χ∗(δ1),V∗(δ1)−χ∗(δ1)]. |
To overcome the limitations of Hukuhara difference, the following difference is defined as follows.
Definition 1.7 ([22]). Let V, χ be the two fuzzy numbers. Then the generalized Hukuhara difference (gH-difference) of V⊖gχ is a fuzzy number ξ such that
V⊖gχ=ξ⇔{(i)V=χ⊕ξ(ii)χ=V⊕(−1)ξ. |
Also the gH-difference based on δ1 can be illustrated as:
[V⊖gχ]δ1=[min{V∗(δ1)−χ∗(δ1),V∗(δ1)−χ∗(δ1)},max{V∗(δ1)−χ∗(δ1),V∗(δ1)−χ∗(δ1)}]. |
Also for V∈Υδ1, the length of the fuzzy interval is given by l(V(δ1))=V∗(δ1)−V∗(δ1). Then, for all V,χ∈Υδ1, we have
V⊖gχ={[V∗(δ1)−χ∗(δ1),V∗(δ1)−χ∗(δ1)],l(V(δ))≥l(χ(δ)),[V∗(δ1)−χ∗(δ1),V∗(δ1)−χ∗(δ1)],l(V(δ))≤l(χ(δ)). | (1.2) |
Note that a function Ψ:[s3,s4]⊆R→Υδ1 is said to be l-increasing, if length function len([Ψ(μ)]δ1)=Ψ∗(μ,δ1)−Ψ∗(μ,δ1) is increasing with respect μ for all δ1∈[0,1]. Mathematically, for any μ1,μ2∈[s3,s4] and μ1≤μ2. Then len([Ψ(μ2)]δ1)≥len([Ψ(μ1)]δ1),∀δ1∈[0,1]. For more details, see [28].
Proposition 1.2 ([28]). Let Ψ:T=(s3,s4)⊆R→Υδ1 be a Fuzzy number valued (F.N.V) mapping. If Ψ(μ+h)⊖gΨ(μ) exists for some h such that μ+h∈T, then one of the following conditions hold:
Case (i){len([Ψ(μ+h)]δ1)≥len([Ψ(μ)]δ1),∀δ1∈[0,1]Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1),is a monotonic increasing with respect toδ1Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1),is a monotonic decreasing with respect toδ1. |
Case (ii){len([Ψ(μ+h)]δ1)≤len([Ψ(μ)]δ1),∀δ1∈[0,1]Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1),is a monotonic decreasing with respect toδ1Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1),is a monotonic increasing with respect toδ1. |
Remark 1.1. From Proposition 2.4, the Ψ(μ+h)⊖gΨ(μ) can be written by the definition of the fuzzy interval as:
Case (i){len([Ψ(μ)]δ1),is a monotonic increasing with respect to μ,∀δ1∈[0,1]Ψ(μ+h)⊖gΨ(μ)=[Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1),Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1)]. |
Case (ii){len([Ψ(μ)]δ1),is a monotonic decreasing with respect to μ,∀δ1∈[0,1]Ψ(μ+h)⊖gΨ(μ)=[Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1),Ψ∗(μ+h,δ1)−Ψ∗(μ,δ1)]. |
Definition 1.8 ([25]). If Ψ:[s3,s4]⊂R→Υδ1 is an F.N.V mapping. For each δ1∈[0,1], whose δ1-cuts highlight the bundle of I.V.F, such that Ψδ1:[s3,s4]⊂R→Kc is described as Ψδ1(μ)=[Ψ∗(μ,δ1),Ψ∗(μ,δ1)], μ∈[s3,s4]. Every δ1∈[0,1], the left and right real valued mappings Ψ∗(μ,δ1),Ψ∗(μ,δ1):[s3,s4]→R are sometimes referred to as Ψ end points.
Definition 1.9 ([29]). Let Ψ:[s3,s4]⊂R→Υδ1 be an F.N.V mapping. Then, fuzzy integral of Ψ over [s3,s4] is projected as (FR)∫s4s3Ψ(μ)dμ,
[(FR)∫s4s3Ψ(μ)dμ]δ1=(FR)∫s4s3Ψδ1(μ)dμ={∫s4s3Ψ(μ,δ1)dμ:Ψ(μ,δ1)∈R([s3,s4],δ1)}, |
for all δ1∈[0,1], where R([s3,s4],δ1) describes the space of integrable mappings.
Theorem 1.4 ([26]). If Ψ:[s3,s4]⊂R→Υδ1 is an F.N.V mapping. For each δ1∈[0,1], whose δ1-cuts highlight the bundle of I.V.F, such that Ψδ1:[s3,s4]⊂R→Kc is described as Ψδ1(μ)=[Ψ∗(μ,δ1),Ψ∗(μ,δ1)], μ∈[s3,s4]. Then, Ψ is fuzzy Riemann integrable (FR-integrable) over [s3,s4], ⇔ Ψ∗(μ,δ1),Ψ∗(μ,δ1)∈R([s3,s4],δ1), then
[(FR)∫s4s3Ψ(μ)dμ]δ1=[(R)∫s4s3Ψ∗(μ,δ1),(R)∫s4s3Ψ∗(μ,δ1)]=(FR)∫s4s3Ψδ1(μ)dμ, |
for all δ1∈[0,1], where FR represents interval Riemann integration of Ψδ1(μ). For all δ1∈[0,1], FR([s3,s4],δ1) specifies the class of all FR-integrable F.N.V mappings over [s3,s4].
Definition 1.10 ([21]). A mapping Ψ:[s3,s4]→Υδ1 is termed as an F.N.V LR-convex mapping on [s3,s4] if
Ψ((1−φ)μ+φY)⪯(1−φ)Ψ(μ)˜+φΨ(Y), | (1.3) |
for all μ,Y∈[s3,s4],ϱ∘∈[0,1], where Ψ(μ)≽˜0 for all μ∈[s3,s4].
Definition 1.11 ([26]). Let τ>0 and Ł(s3,s4,Υδ1) be the space of all Lebesgue measurable F.N.V mapping on [s3,s4]. Then, the fuzzy left and right RL-fractional integral operator of Ψ∈Ł(s3,s4,Υδ1) are defined as:
Jτa+Ψ(s3)=1Γ(τ)∫s4s3(μ−s3)τ−1Ψ(μ)dμ,μ≥a |
and
Jτs4−Ψ(s4)=1Γ(τ)∫s4s3(s4−μ)τ−1Ψ(μ)dμ,μ≤s4. |
Furthermore, the left and right RL-fractional operator based on left and right endpoint mappings can be defined, that is,
[Jτa+Ψ(s3)]δ1=1Γ(τ)∫s4s3(μ−s3)τ−1Ψδ1(ϱ∘)dϱ∘=1Γ(τ)∫s4s3(μ−s3)τ−1Ψδ1[Ψ∗(ϱ∘,δ1),Ψ∗(ϱ∘,δ1)]dϱ∘, |
where
Jτa+Ψ∗(a,δ1)=1Γ(τ)∫s4s3(μ−s3)τ−1Ψ∗(ϱ∘,δ1)dϱ∘, |
and
Jτa+Ψ∗(a,δ1)=1Γ(τ)∫s4s3(μ−s3)τ−1Ψ∗(ϱ∘,δ1)dϱ∘. |
By similar argument, we can define the right operator.
The authors [30] employed interval-valued unified approximate convexity to examine new refinements of inequalities. Nwaeze et al.[31] proposed the class of interval-valued ϑ-polynomial convex mappings and reported several interesting inequalities. Abdeljawad et al. [32] utilized the p mean to develop the idea of interval-valued p convexity and presented some corresponding general inequalities of Hermite-Hadamard type. Shi and his colleagues [33] studied the totally ordered unified convexity in the perspective of integral inequalities. Through interval-valued log-convexity and cr-harmonic convexity, Liu et al. [34,35] found the trapezium and Jensen's-like inequalities.
Budak et al. [36] implemented the interval-valued RL-fractional operators and convexity to derive the trapezoidal inequalities. Vivas-Cortez [37] introduced the totally ordered τ-convex mappings and analyzed several Jensen's, Schur's, and fractional Hadamard's and kinds of inequalities. Cheng et al. [38] looked at new kinds of Hadamard-like inequalities using fuzzy-valued mapping and fractional quantum calculus. Bin-Mohsin et al. [39] bridged the harmonic coordinated convexity and fractional operators relying on Raina's special mapping to establish new 2-dimensional inequalities. For comprehensive details, consult [40,41,42,43,44].
Recently, Fahad [45] proposed some novel bounds of classical inequalities pertaining to center-radius ordered geometric-arithmetic convexity and some interesting applications to information theory. Authors [46] explored the unified class of stochastic convex processes relying on quasi-weighted mean and cr ordering relation to conclude new forms of inequalities. For the first time, Khan and Butt established the new counterparts of classical inequalities depending upon partially and totally ordered super-quadraticity, respectively, in [47,48].
Costa et al. [49] implemented the fuzzy-valued mappings to acquire some boundaries in a one-point quadrature scheme. Zhang and his coauthors [50] focused on set-valued Jensen-like inequalities along with some interesting applications. Khan et al. [51] examined fractional analogues of fuzzy interval-valued integral inequalities. In [52], authors discussed fuzzy valued Hadamard-like inequalities associated with log convexity. Abbaszadeh and Eshaghi employed the fuzzy valued r convex mappings to establish the trapezium type inequalities. Bin-Mohsin [53] introduced the idea of fuzzy bi-convex mappings and derived the various inequalities. For comprehensive details, see [54,55,56,57,58].
The above literature is evidence that theories of inequalities are interlinked with convexity. Several classes of convexity have been introduced to reduce the limitations of classical convexity or to acquire better estimations of existing results. Researchers have applied several techniques to produce better estimations of mathematical quantities. The principle motivation is to explore super-quadratic mappings in fuzzy environments through a unified approach. First, we will propose a new class of fuzzy number-valued super-quadratic mappings based on left and right ordering relations. Further, we will give a detailed description of newly developed concepts along with their potential cases. Most importantly, we will derive classical inequalities like the trapezoidal inequality, the weighted form for symmetric mappings, and Jensen's and its related inequalities. Later on, some fractional inequalities will be presented and graphed. To increase the reliability and accuracy, some visuals and related numerical data will be provided. Finally, we will present applications based on our primary findings. This is the first study regarding super-quadraticity via fuzzy calculus.
This part contains the results related to newly proposed notion of fuzzy super-quadratic mappings.
First, we investigate the fuzzy-valued ℏ∘-super-quadratic mapping.
Definition 2.1. Suppose ℏ∘≥0. Let Ψ:[s3,s4]⊆[0,∞)→Υδ1 be an F.N.V mapping such that Ψδ1(γ)=[Ψ∗(δ1,γ),Ψ∗(δ1,γ)], and len([Ψ(γ)]δ1)=Ψ∗(γ,δ1)−Ψ∗(γ,δ1) is increasing with respect γ for all δ1∈[0,1]. Then Ψ is considered to be an F.N.V ℏ∘-super-quadratic mapping if
Ψ((1−φ)γ+φy)⪯ℏ∘(φ)[Ψ(y)⊖gΨ((1−φ)|γ−y|)]⊕ℏ∘(1−φ)[Ψ(γ)⊖gΨ(φ|γ−y|)], |
holds ∀γ,y∈[s3,s4] such that γ<y and |y−γ|<γ where φ∈[0,1].
Now, we enlist some potential deductions of Definitions 2.1.
● Inserting ℏ∘(φ)=φ, we recapture the class of F.N.V super-quadratic mappings.
● Inserting ℏ∘(φ)=φs, we recapture the class of F.N.V-s-super-quadratic mappings:
Ψ((1−φ)γ+φy)⪯φs[Ψ(y)⊖gΨ((1−φ)|γ−y|)]⊕(1−φ)s[Ψ(γ)⊖gΨ(φ|γ−y|)]. |
● Inserting ℏ∘(φ)=φ−s, we recapture the class of F.N.V-s Godunova super-quadratic mappings:
Ψ((1−φ)γ+φy)⪯φ−s[Ψ(y)⊖gΨ((1−φ)|γ−y|)]⊕(1−φ)−s[Ψ(γ)⊖gΨ(φ|γ−y|)]. |
● Inserting ℏ∘(φ)=φ(1−φ), we recapture the class of F.N.V-tgs super-quadratic mappings:
Ψ((1−φ)γ+φy)⪯φ(1−φ)[Ψ(y)⊖gΨ((1−φ)|γ−y|)]⊕φ(1−φ)[Ψ(γ)⊖gΨ(φ|γ−y|)]. |
● Inserting ℏ∘(φ)=1, we recapture the class of F.N.V-P super-quadratic mappings:
Ψ((1−φ)γ+φy)⪯[Ψ(y)⊖gΨ((1−φ)|γ−y|)]⊕[Ψ(γ)⊖gΨ(φ|γ−y|)]. |
● Inserting ℏ∘(φ)=exp(φ)−1, we recapture the class of F.N.V-exponential super-quadratic mappings:
Ψ((1−φ)γ+φy)⪯[exp(φ)−1][Ψ(y)⊖gΨ((1−φ)|γ−y|)]⊕[exp(1−φ)−1][Ψ(γ)⊖gΨ(φ|γ−y|)]. |
● Selecting Ψ∗(γ,δ1)=Ψ∗(γ,δ1) and δ1=1, we acquire the notion of ℏ∘-super-quadratic mapping defined in [17].
The spaces of ℏ∘-super-quadratic mappings and (F.N.V)–ℏ∘ l-increasing super-quadratic mappings defined over [s3,s4] are represented by SSQF([s3,s4],ℏ∘) and SSQFNF([s3,s4],ℏ∘) respectively.
Proposition 2.1. Let Ψ,g:[s3,s4]→Υδ1 be two F.N.V mappings. If Ψ,g∈SSQFNF([s3,s4],ℏ∘), then
● Ψ+g∈SSQFNF([s3,s4],ℏ∘).
● cΨ∈SSQFNF([s3,s4],ℏ∘), c≥0.
Proof. The proof is obvious.
Proposition 2.2. If Ψ∈SSQFNF([s3,s4],ℏ∘1) and ℏ∘1(φ)≤ℏ2∘(φ), then Ψ∈SSQFNF([s3,s4],ℏ∘2).
Now we prove the criteria to investigate the class of F.N.V–ℏ∘ super-quadratic mappings.
Proposition 2.3. If Ψ∈SSQFNF([s3,s4],ℏ∘1) and ℏ∘1(φ)≤ℏ2∘(φ), then Ψ∈SSQFNF([s3,s4],ℏ∘2).
Now we prove the criteria to investigate class of F.N.V–ℏ∘ super-quadratic mappings.
Proposition 2.4. Let Ψ:[s3,s4]⊆[0,∞)→Υδ1 be an F.N.V mapping. For any γ,y∈[s3,s4] such that γ<y and satisfying the condition that |y−γ|<γ. Then, Ψ∈SSQFNF([s3,s4],ℏ∘) if, and only if, Ψ∗(γ,δ1),Ψ∗(γ,δ1)∈SSQF([s3,s4],ℏ∘) and len([Ψ(γ)]δ1)=Ψ∗(γ,δ1)−Ψ∗(γ,δ1) is increasing with respect γ for all δ1∈[0,1].
Proof. Let Ψ∗,Ψ∗∈SSQF([s3,s4],ℏ∘) and ∀γ,y∈[s3,s4] such that γ<y and satisfying the condition |y−γ|<γ. Then:
Ψ∗((1−φ)y+φγ,δ1)≤ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)], | (2.1) |
and
Ψ∗((1−φ)y+φγ,δ1)≤ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)]. | (2.2) |
Combining (2.1) and (2.2) by definition of pseudo ordering relation, we have
[Ψ∗((1−φ)y+φγ,δ1),Ψ∗((1−φ)y+φγ,δ1)]⪯[ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)],ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)]]. |
Then by Case (ⅰ) of Remark (1.1), we have
Ψ((1−φ)y+φγ)⪯ℏ∘(1−φ)[Ψ(y)⊖gΨ(φ|y−γ|)]⊕ℏ∘(φ)[Ψ(γ)⊖gΨ((1−φ)|y−γ|)]. |
This completes the proof of first part. For the converse part, consider Ψ∈SSQFNF([s3,s4],ℏ∘), then
Ψ((1−φ)y+φγ)⪯ℏ∘(1−φ)[Ψ(y)⊖gΨ(φ|y−γ|)]⊕ℏ∘(φ)[Ψ(γ)⊖gΨ((1−φ)|y−γ|)]. |
The above inequality can be written as
[Ψ∗((1−φ)y+φγ,δ1),Ψ∗((1−φ)y+φγ,δ1)]⪯[min{ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)],ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)]},max{ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)],ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)]}]. |
From Definition 2.1, it is clear that len([Ψ(γ)]δ1) is increasing. Using Case (ⅰ) of Remark 1.1, we have
[Ψ∗((1−φ)y+φγ,δ1),Ψ∗((1−φ)y+φγ,δ1)]⪯[ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)],ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)]]. | (2.3) |
From (2.3), we can write as
Ψ∗((1−φ)y+φγ,δ1)≤ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)], | (2.4) |
and
Ψ∗((1−φ)y+φγ,δ1)≤ℏ∘(1−φ)[Ψ∗(y,δ1)−Ψ∗(φ|y−γ|,δ1)]+ℏ∘(φ)[Ψ∗(γ,δ1)−Ψ∗((1−φ)|y−γ|,δ1)]. | (2.5) |
It is evident from (2.4) and (2.5) that both Ψ∗,Ψ∗∈SSQF([s3,s4],ℏ∘). Hence, the result is proved.
It is noteworthy to mention that Proposition 2.4 provides the necessary and sufficient condition for F.N.V–ℏ∘ super-quadratic mapping. It is noteworthy to mention that Proposition 2.4 provides the necessary and sufficient condition for the F.N.V–ℏ∘ super-quadratic mapping.
Example 2.1. Let us consider F.N.V. Ψ:[s3,s4]=[0,2]→R∘, which is defined as follows
Ψμ(μ1)={μ13μ3,μ1∈[0,3μ3]6μ3−μ13μ3,μ1∈(3μ3,6μ3]. |
Then, for δ1∈[0,1], we have
Ψδ1=[3δ1μ3,(6−3δ1)μ3]. |
Notice that both endpoint mappings Ψ(μ,δ1)=3δ1μ3 and Ψ(μ,δ1)=(6−3δ1)μ3 are ℏ∘-super-quadratic mappings, respectively. So, Ψ∈SSQFNF([s3,s4],ℏ∘). Also len([Ψ(μ)]δ1)=(6−6δ1)μ3 is increasing with respect to μ for all δ1∈[0,1].
Now, we prove an alternative definition of this class of convexity for ϑ different points of [s3,s4] known as Jensen's inequality. This inequality is useful for the development of further integral inequalities.
Theorem 2.1. Let ℏ∘:(0,1]:→[0,∞) be a nonnegative super-multiplicative mapping. If Ψ∈SSQFNF([s3,s4],ℏ∘), then
Ψ(1Cϑϑ∑ν=0φν(μν))⪯ϑ∑ν=1ℏ∘(φνCϑ)Ψ(μν)⊖gϑ∑ν=1ℏ∘(φνCϑ)Ψ(|μν−1Cϑϑ∑ν=0φν(μν)|), | (2.6) |
for μν∈[s3,s4],φν∈[0,1] such that Cϑ=∑ϑν=1φν.
Proof. If Ψ∈SSQFNF([s3,s4],ℏ∘), then it can be written as:
[Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1),Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1)]⪯[ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φν(μν)|,δ1),ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φν(μν)|,δ1)]. |
By pseudo order relation, one can resolve the above inequality as:
Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1)≤ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φν(μν)|,δ1), | (2.7) |
and
Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1)≤ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φν(μν)|,δ1). | (2.8) |
We employ induction technique to prove both inequalities (2.7) and (2.8). Fixing ϑ=2 and φ1C2=α and φ2C2=1−α in (2.7), we acquire the definition of ℏ∘-super-quadratic mapping. To proceed further, we assume that (2.7) holds true for ϑ=ν−1, then
Ψ∗(ϑ−1∑ν=1φνCϑ−1(μν),δ1)≤ϑ−1∑ν=1ℏ∘(φνCϑ−1)Ψ∗(μν,δ1)−ϑ−1∑ν=1ℏ∘(φνCϑ−1)Ψ∗(|μν−ϑ−1∑ν=1φνCϑ−1(μν)|,δ1). | (2.9) |
Next, we prove the validity of (2.6).
Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1)=Ψ∗(φnxϑCϑ+Cϑ−1Cϑϑ−1∑ν=1φνCϑ−1(μν),δ1)≤ℏ∘(φϑCϑ)Ψ∗(μϑ,δ1)+ℏ∘(Cϑ−1Cϑ)Ψ∗(ϑ−1∑ν=1(φνμνCϑ−1),δ1)−ℏ∘(φϑCϑ)Ψ∗(Cϑ−1Cϑ|μϑ−ϑ−1∑ν=1(φνμνCϑ−1)|,δ1)−ℏ∘(Cϑ−1Cϑ)Ψ∗(φϑCϑ|μϑ−ϑ−1∑ν=1(φνμνCϑ−1)|,δ1). | (2.10) |
Using (2.9) in (2.10) and the super-multiplicative property of ℏ∘, we recapture
Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1)≤ℏ∘(φϑCϑ)Ψ∗(μϑ,δ1)+ℏ∘(Cϑ−1Cϑ)[ϑ−1∑ν=1ℏ∘(φνCϑ−1)Ψ∗(μν,δ1)−ϑ−1∑ν=1ℏ∘(φνCϑ−1)Ψ∗(|μν−ϑ−1∑ν=1φνCϑ−1(μν)|,δ1)]−ℏ∘(φϑCϑ)Ψ∗(Cϑ−1Cϑ|μϑ−ϑ−1∑ν=1(φνμνCϑ−1)|,δ1)−ℏ∘(Cϑ−1Cϑ)Ψ∗(φϑCϑ|μϑ−ϑ−1∑ν=1(φνμνCϑ−1)|,δ1). |
Thus, we have
Ψ∗(1Cϑϑ∑ν=0φνμν,δ1)≤ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φνμν|,δ1), | (2.11) |
By similar proceedings, we have
Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1)≤ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φνμν|,δ1). | (2.12) |
Comparing inequalities (2.11) and (2.12) through Pseudo ordering relation, we have
[Ψ∗(1Cϑϑ∑ν=0φνμν,δ1),Ψ∗(1Cϑϑ∑ν=0φν(μν),δ1)]⪯[ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φνμν|,δ1),ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=0φνμν|,δ1)]. |
Finally, it can be transformed as
Ψ(1Cϑϑ∑ν=0φν(μν))⪯ϑ∑ν=1ℏ∘(φνCϑ)Ψ(μν)⊖gϑ∑ν=1ℏ∘(φνCϑ)Ψ(|μν−1Cϑϑ∑ν=0φν(μν)|). |
Hence, the result is accomplished.
We deliver some corollaries of Theorem 2.1.
● Setting ∑ϑν=1φν=Cϑ=1 in Theorem 2.1, we attain the generalized Jensen's inequality:
Ψ(ϑ∑ν=0φν(μν))⪯ϑ∑ν=1ℏ∘(φν)Ψ(μν)⊖gϑ∑ν=1ℏ∘(φν)Ψ(|μν−ϑ∑ν=0φν(μν)|). |
● To attain Jensen's inequality for the fuzzy interval-valued super-quadratic mapping, we set ℏ∘(φ)=φ in Theorem 2.1.
Ψ(1Cϑϑ∑ν=0φν(μν))⪯ϑ∑ν=1φνCϑΨ(μν)⊖gϑ∑ν=1φνCϑΨ(|μν−1Cϑϑ∑ν=0φν(μν)|). |
● To attain Jensen's inequality for the fuzzy interval-valued s-super-quadratic mapping, we set ℏ∘(φ)=φs in Theorem 2.1.
Ψ(1Cϑϑ∑ν=0φν(μν))⪯ϑ∑ν=1(φνCϑ)sf(μν)⊖gϑ∑ν=1(φνCϑ)sf(|μν−1Cϑϑ∑ν=0φν(μν)|). |
● To attain Jensen's inequality for the fuzzy interval-valued s Godunova-Levin super-quadratic mapping, we set ℏ∘(φ)=φ−s in Theorem 2.1.
Ψ(1Cϑϑ∑ν=0φν(μν))⪯ϑ∑ν=1(φνCϑ)−sΨ(μν)⊖gϑ∑ν=1(φνCϑ)−sΨ(|μν−1Cϑϑ∑ν=0φν(μν)|). |
● To attain Jensen's inequality for the fuzzy interval-valued P-super-quadratic mapping, we set ℏ∘(φ)=1 in Theorem 2.1.
Ψ(1Cϑϑ∑ν=0φν(μν))⪯ϑ∑ν=1(φνCϑ)−sΨ(μν)⊖gϑ∑ν=1(φνCϑ)−sΨ(|μν−1Cϑϑ∑ν=0φν(μν)|). |
● To attain Jensen's inequality for the fuzzy interval-valued exponential super-quadratic mapping, we set ℏ∘(φ)=exp(φ)−1 in Theorem 2.1.
Ψ(1Cϑϑ∑ν=0φν(μν))⪯ϑ∑ν=1[exp(φνCϑ)−1]Ψ(μν)⊖gϑ∑ν=1[exp(φνCϑ)−1]Ψ(|μν−1Cϑϑ∑ν=0φν(μν)|). |
● By taking Ψ∗(μ,δ1)=Ψ∗(μ,δ1) and δ1 in Theorem 2.1, we get Theorem 1.1.
Next, the result is the Schur inequality for the fuzzy interval-valued super-quadratic mappings.
Theorem 2.2. If Ψ∈SSQFNF([s3,s4],ℏ∘) and μ,y,μ3∈[s3,s4] with μ<y<μ3 such that y−μ,μ3−y and μ3−μ∈[0,1], then
ℏ∘(μ3−μ)Ψ(y)⪯ℏ∘(μ3−y)[Ψ(μ)⊖gΨ(y−μ)]⊕ℏ∘(y−μ)[Ψ(μ3)⊖gΨ(μ3−y)]. |
Proof. Assume that μ,y,μ3∈I with μ<y<μ3 such that y−μ,μ3−y and μ3−μ∈[0,1]. Since Ψ∈SSQFNF([s3,s4],ℏ∘), and ℏ∘ is a super-multiplicative mapping, then
Ψ∗(y,δ1)=Ψ∗(μ3−yμ3−μμ+y−μμ3−μy,δ1)≤ℏ∘(μ3−yμ3−μ)[Ψ∗(μ,δ1)−Ψ∗(y−μμ3−μ|μ3−μ|,δ1)]+ℏ∘(y−μμ3−μ)[Ψ∗(μ3,δ1)−Ψ∗(μ3−yμ3−μ|μ3−μ|,δ1)]. |
Multiplying both sides of the aforementioned inequality by ℏ∘(μ3−μ) and utilizing the supermultiplicative property, we recapture
ℏ∘(μ3−μ)Ψ∗(y,δ1)≤ℏ∘(μ3−y)[Ψ∗(μ,δ1)−Ψ∗(y−μ,δ1)]+ℏ∘(y−μ)[Ψ∗(μ3,δ1)−Ψ∗(μ3−y,δ1)]. | (2.13) |
Likewise, we can prove that
ℏ∘(μ3−μ)Ψ∗(y,δ1)≤ℏ∘(μ3−y)[Ψ∗(μ,δ1)−Ψ∗(y−μ,δ1)]+ℏ∘(y−μ)[Ψ∗(μ3,δ1)−Ψ∗(μ3−y,δ1)]. | (2.14) |
From (2.13) and (2.14), we get the desired containment.
Remark 2.1. For different substitution of ℏ∘(φ)=φ,φs,φ−s,φ(1−φ), we get a blend of new counterparts for different classes of super-quadraticity. By taking Ψ∗(μ,δ1)=Ψ∗(μ,δ1) and δ1=1 in Theorem 2.2, we get the reverse Jensen's inequality, and that is proved in [17].
Through Theorem 2.2, we construct reverse Jensen's inequality leveraging the fuzzy number valued super-quadraticity.
Theorem 2.3. For φν≥0 and (v,V)⊆I. Let ℏ∘:(0,1]→[0,∞) be nonnegative super-multiplicative mapping and Ψ∈SSQFNF([s3,s4],ℏ∘). Then,
ϑ∑ν=1ℏ∘(φνCϑ)Ψ(μν)⪯ϑ∑ν=1ℏ∘(φνCϑ)[ℏ∘(V−μνV−v)Ψ(v)+ℏ∘(μν−vV−v)Ψ(V)]⊖gℏ∘(φνCϑ)[ℏ∘(V−μνV−v)Ψ(μν−v)+ℏ∘(μν−vV−v)Ψ(V−μν)]. |
Proof. Substitute μν=v,y=μν and μ3=V in Theorem 2.2 and multiply both sides by ℏ∘(φνCϑ). Finally, we apply the sum up to ϑ to acquire the desired estimate.
Now, we prove the Jensen-Mercer inequality pertaining to the fuzzy interval-valued super-quaraticity.
Theorem 2.4. Let Ψ∈SSQFNF([s3,s4],ℏ∘) and μν∈(s3,s4) and φν≥0, then
Ψ(s3+s4−1Cϑϑ∑ν=1φνμν)⪯Ψ(s3)⊕Ψ(s4)⊖gϑ∑ν=1ℏ∘(φνCϑ)Ψ(μν)⊖gϑ∑ν=1ℏ∘(φνCϑ)[Ψ(μν−s3)⊕Ψ(s4−μν)]⊖gϑ∑ν=1ℏ∘(φνCϑ)Ψ(|μν−1Cϑϑ∑ν=1φνμν|). |
Proof. Let Ψ∗,Ψ∗∈SSQF([s3,s4],ℏ∘), then from Theorem 1.2, we get the following inequalities.
Ψ∗(s3+s4−1Cϑϑ∑ν=1φνμν,δ1)⪯Ψ∗(s3,δ1)+Ψ∗(s4,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(μν,δ1)−ϑ∑ν=1ℏ∘(φνCϑ)[Ψ∗(μν−s3,δ1)+Ψ∗(s4−μν,δ1)]−ϑ∑ν=1ℏ∘(φνCϑ)Ψ∗(|μν−1Cϑϑ∑ν=1φνμν|,δ1), | (2.15) |
and
(2.16) |
Bridging (2.15) and (2.16) through Pseudo ordering, we acquire the fuzzy-valued Jensen-Mercer inequality.
Remark 2.2. For different substitution of , we get fuzzy number-valued Jensen-Mercer inequalities for different classes of super-quadraticity. By taking and in Theorem 2.2, we get Jensen-Mercer inequality, and that is proved in [17].
Theorem 2.5. If , then
Proof. Since is a fuzzy interval-valued -super-quadratic mapping, we first consider , then we get
The above inequality can be transformed as
(2.17) |
Integrating with respect to on , we get
By similar arguments, we have
This implies that,
(2.18) |
Since , then
(2.19) |
and
(2.20) |
Adding (2.19) and (2.20), we have
This can be transformed as
(2.21) |
Integrating (2.21) with respect to on ,
(2.22) |
Through a similar strategy, we acquire
(2.23) |
Combining inequalities (2.25) and (2.26), we recapture the desired result. So, the result is accomplished.
Now, we present some deductions of Theorem 2.5.
● Taking , we recapture
● Taking , we recapture
● Taking , we recapture
● Taking , we recapture
Remark 2.3. We can a get a blend of new Hermite-Hadamard's type inequalities for different values of and by taking and in Theorem 2.5, we get the classical Hermite-Hadamard inequality for super-quadratic mappings, which is derived in [15].
Example 2.2. Let be a fuzzy valued super-quadratic mapping, which is defined as
and its level cuts are . It fulfils the condition of Theorem 2.5, then
To visualize the above formulations, we fix and vary .
Note that L.L.F, L.U.F, M.L.F, M.U.F, R.L.F, and R.U.F are specifying the endpoint mappings of left, middle, and right terms of Theorem 2.5.
0.140625 | 0.796875 | 0.2250 | 1.2750 | 0.3600 | 2.0400 | |
0.411938 | 1.64775 | 0.6591 | 2.6364 | 1.05456 | 4.21824 | |
0.791016 | 2.37305 | 1.26563 | 3.79688 | 2.025 | 6.0750 | |
0.1870 | 3.2805 | 3.4992 | 5.2488 | 5.59872 | 8.39808 |
Theorem 2.6. If and is a symmetric mapping, then
Proof. Since is a fuzzy interval-valued -super-quadratic mapping, then by multiplying (2.17) by and integrating with respect to on , we get
Since is a symmetric mapping about , then . Using this fact in the above inequality, we get
This implies that
Similarly, we have
Combining the last two inequalities in the Pseudo ordering relation, we have
Finally, we can write
(2.24) |
Multiplying (2.21) by and integrating with respect to on , we get
We can write
(2.25) |
Also,
(2.26) |
Combining (2.25) and (2.26), we achieve the required inequality. Hence, the result is completed.
Remark 2.4. By selecting in Theorem 2.6, we get Hermite-Hadamard-Fejer's inequalities for different classes of super-quadraticity. If we take in Theorem 2.6, we obtain the Hermite-Hadamard's inequality. Also by taking and in Theorem 2.6, we obtain the Hermite-Hadamard-Fejer inequality.
Example 2.3. Let be fuzzy valued super-quadratic mapping, which is defined as
and its level cuts are . Also is a symmetric integrable mapping and is defined as . Both mappings fulfill the condition of Theorem 2.6, then
To visualize the above formulations, we fix and vary .
Note that L.L.F, L.U.F, M.L.F, M.U.F, R.L.F, and R.U.F are specifying the endpoint mappings of left, middle, and right terms of Theorem 2.6.
0.05625 | 0.31875 | 0.1800 | 1.0200 | 0.1800 | 1.0200 | |
0.24881 | 0.995241 | 0.702557 | 2.81023 | 0.785476 | 3.1419 | |
0.553711 | 1.66113 | 1.36875 | 4.10625 | 1.73229 | 5.19688 | |
1.71461 | 2.57191 | 3.28719 | 4.93079 | 5.30129 | 7.95193 |
This section contains fractional trapezoidal-like inequalities incorporated with - super-quadratic mappings.
Lemma 3.1. If , then
Proof. Let be -super-quadraticity, and we have
We can break the above inequality as
and
Furthermore, we can write:
(3.1) |
Moreover, we have
(3.2) |
Comparing (3.1) and (3.2), we achieve the final result.
Lemma 3.2. If , then
Proof. Assume that is a - super-quadratic mapping on , then
Substitute , then
(3.3) |
Replacing by in (3.3), we get
(3.4) |
Adding (3.3) and (3.4), we have
(3.5) |
Similarly,
(3.6) |
Comparison of (3.5) and (3.6) through Pseudo ordering relation, we get our final outcome.
Theorem 3.1. If , then
(3.7) |
(3.8) |
Proof. Since is an super-quadratic mapping, then
Through Lemma 3.1, we can interpret
(3.9) |
From (3.9), we have
(3.10) |
Also,
(3.11) |
Combining (3.10) and (3.11) via pseudo order relation, we acquire the first inequality of (3.7). From Lemma 3.2, we can write
(3.12) |
Similarly, we have
(3.13) |
Comparing (3.12) and (3.13) through Pseudo ordering relation, we achieve our desired result.
Remark 3.1. For , the Theorem 3.1 transformed into Theorem 2.5. By selecting in Theorem 3.1, we get various fractional Hermite-Hadamard's inequalities for different classes of super-quadraticity. Also by taking and in Theorem 3.1, we obtain the fractional Hermite-Hadamard's inequality for –super-quadratic mappings, which is given in [59].
Example 3.1. Let be a fuzzy valued super-quadratic mapping which is defined as
and its level cuts are . It fulfills the condition of Theorem 3.1, then
To visualize the above formulations, we fix and vary .
Note that L.L.F, L.U.F, M.L.F, M.U.F, R.L.F, and R.U.F are specifying the endpoint mappings of left, middle, and right terms of Theorem 3.1.
2.50084 | 14.1714 | 4.32 | 24.48 | 6.01143 | 34.0648 | |
3.0000 | 12.0000 | 4.8000 | 19.2000 | 5.7600 | 30.7200 | |
3.69468 | 11.084 | 5.82857 | 17.4857 | 9.54805 | 28.6442 | |
6.0000 | 9.0000 | 9.6000 | 14.4000 | 15.3600 | 23.0400 |
Now, we prove the weighted Hermite-Hadamard's inequality for symmetric mappings.
Theorem 3.2. If and is a nonnegative integrable symmetric mapping about , then
Proof. Since is a fuzzy interval-valued -super-quadratic mapping, then by multiplying (2.17) by and applying integration with respect to on , we get
Since is symmetric mapping about , then . Using this fact in the above inequality, we get
After some simple computations, we have the following inequality
(3.14) |
By following a similar procedure, we get
(3.15) |
Implementing the pseudo ordering relation on (3.14) and (3.15) results in the following relation
(3.16) |
Now, we establish our second inequality. Multiplying (2.21) by and integrating with respect to on , we get
After performing some computations, we get
(3.17) |
Similarly, we have
(3.18) |
Inequalities (3.17) and (3.18) produce the following relation
(3.19) |
Finally, bridging inequalities (3.16) and (3.19), we achieve the Hermite-Hadmard-Fejer inequality.
Now we discuss some special scenarios of Theorem 3.2.
● By setting in Theorem 3.2, we have
● By setting in Theorem 3.2, we have
● By setting in Theorem 3.2, we have
Remark 3.2. For , the Theorem 3.2 transformed into Theorem 2.6. By selecting in Theorem 3.1, we get various fractional Hermite-Hadamard-Fejer's inequalities for different classes of super-quadraticity. Also by taking and in Theorem 3.2, we obtain the fractional Hermite-Hadamard-Fejer's inequality for –super-quadratic mappings.
Example 3.2. Let be a fuzzy valued super-quadratic mapping, which is defined as
and its level cuts are . Also is a symmetric integrable mapping and is defined as . Both mappings fulfill the condition of Theorem 3.2, then
To visualize the above formulations, we fix and vary .
Note that L.L.F, L.U.F, M.L.F, M.U.F, R.L.F, and R.U.F are specifying the endpoint mappings of left, middle, and right terms of Theorem 3.2.
0.548152 | 3.1062 | 2.67429 | 15.1543 | 7.00699 | 46.3796 | |
0.4000 | 1.6000 | 2.2400 | 8.9600 | 2.4000 | 9.6000 | |
0.451568 | 1.3547 | 2.58701 | 7.76104 | 2.68392 | 8.05175 | |
0.8000 | 1.2000 | 4.4800 | 6.7200 | 4.8000 | 7.2000 |
Now, we give some applications of our proposed results. First, we recall the binary means of positive real numbers.
The arithmetic mean:
The generalized -mean:
Proposition 4.1. For , then
Proof. This result is acquired by applying on Theorem 2.5.
Note that Proposition 4.1 provides the bounds for generalized logarithmic mean. Next, we give the refinements of the triangular inequality.
Proposition 4.2. Let be an increasing positive sequence. Then from Theorem 2.2, we have
and
Proof. Since and are super-quadratic mappings, by applying these mappings on Theorem 2.2 by taking , , , and , we acquire our desired inequalities.
Proposition 4.3. Let be an increasing positive sequence. Then, from Theorem 2.2, we have
Particularly, we have
Proof. Since where is super-quadratic mapping, by applying on Theorem 2.2, and taking , , , and , we acquire our desired inequalities.
Proposition 4.4. Let be an increasing positive sequence. Then, from Theorem 2.4, we have
and
Proof. Since and for are super-quadratic mappings, by applying these mappings on Theorem 2.4, and taking , , , and , we acquire our desired inequalities.
The theory of inequalities is the main source used to investigate the various mapping classes. We've talked about the idea of a fuzzy number-valued super-quadratic mapping that works with the LR partially ordered ranking relation, -levels mappings, and a nonnegative mapping . This class is novel and new in literature; it reduces to several mapping classes of super-quadraticity, like fuzzy-valued super-quadratic mappings, fuzzy-valued super-quadratics, fuzzy-valued Godunova super-quadratic mappings, and many more. Also, results obtained from this class of mappings refined classical inequalities. We have developed several Jensen's and Hadamard's-like inequalities pertaining to this class of mappings. This study is significant due to various aspects because the first-time idea of super-quadratic mapping in a fuzzy environment is investigated. The proposed definition is novel due to its unified nature and strengthening the properties of the class of fuzzy numbered valued mappings. Also, this is the first study exploring the fuzzy numbered valued Hermite-Hadamard-Fejer type inequalities for strong convexity. The obtained results provides the better approximation as compared to existing results. In the future, we will try to address these inequalities by leveraging the concepts of generalized fractional operators, quantum, and symmetric quantum calculus to analyze the bounds for error inequalities like the Ostrowski inequality, Simpson's inequality, Bullen's and Boole's inequality, etc. By utilizing this class of mappings, Hausdorff-Pompeiu distance, and generalized differentiability of mappings based on Hukuhara differences as well as adopting a similar technique, one can introduce more general function classes and their applicable aspects in different domains. We will also talk about fuzzy-valued inequalities for totally ordered fuzzy-valued super-quadratic mappings and how they can be used in optimization. We hope the strategy, techniques, and ideas developed in our study will create new sights for research.
Muhammad Zakria Javed: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Writing-original draft, Writing-review and editing, Visualization; Muhammad Uzair Awan: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Writing-review and editing, Visualization, Supervision; Loredana Ciurdariu: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Writing-review and editing, Visualization; Omar Mutab Alsalami: Conceptualization, Software, Validation, Formal analysis, Investigation, Writing-review and editing, Visualization. All authors have read and agreed for the publication of this manuscript.
The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.
This research was funded by TAIF University, TAIF, Saudi Arabia, Project No. (TU-DSPP-2024-258).
The authors are thankful to the editor and anonymous reviewers for their valuable comments and suggestions. The authors extend their appreciation to TAIF University, Saudi Arabia, for supporting this work through project number (TU-DSPP-2024-258).
The authors declare no conflicts of interest.
[1] |
Kotha RR, Luthria DL (2019) Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules 24: 2930. https://doi.org/10.3390/molecules24162930 ![]() |
[2] |
Priyadarsini KI (2014) The chemistry of curcumin: From extraction to therapeutic agent. Molecules 19: 20091-20112. https://doi.org/10.3390/molecules191220091 ![]() |
[3] |
Nelson KM, Dahlin JL, Bisson J, et al. (2017) The essential medicinal chemistry of curcumin. J Med Chem 60: 1620-1637. https://doi.org/10.1021/acs.jmedchem.6b00975 ![]() |
[4] |
Salehi B, Stojanović-Radić Z, Matejić J, et al. (2019) The therapeutic potential of curcumin: A review of clinical trials. Eur J Med Chem 163: 527-545. https://doi.org/10.1016/j.ejmech.2018.12.016 ![]() |
[5] |
Yeung AWK, Horbańczuk M, Tzvetkov NT, et al. (2019) Curcumin: Total-scale analysis of the scientific literature. Molecules 24: 1393. https://doi.org/10.3390/molecules24071393 ![]() |
[6] |
Li H, Sureda A, Devkota HP, et al. (2020) Curcumin, the golden spice in treating cardiovascular diseases. Biotechnol Adv 38: 107343. https://doi.org/10.1016/j.biotechadv.2019.01.010 ![]() |
[7] |
Kwiecien S, Magierowski M, Majka J, et al. (2019) Curcumin: A potent protectant against esophageal and gastric disorders. Int J Mol Sci 20: 1477. https://doi.org/10.3390/ijms20061477 ![]() |
[8] | Heidari S, Mahdiani S, Hashemi M, et al. (2020) Recent advances in neurogenic and neuroprotective effects of curcumin through the induction of neural stem cells. Biotechnol Appl Biochem 67: 430-441. https://doi.org/10.1002/bab.1891 |
[9] |
Scazzocchio B, Minghetti L, D'Archivio M, et al. (2020) Interaction between gut microbiota and curcumin: A new key of understanding for the health effects of curcumin. Nutrients 12: 2499. https://doi.org/10.3390/nu12092499 ![]() |
[10] |
Chen Y, Lu Y, Lee RJ, et al. (2020) Nano encapsulated curcumin: And its potential for biomedical applications. Int J Nanomedicine 15: 3099-3120. https://doi.org/10.2147/IJN.S210320 ![]() |
[11] |
Kabir MT, Rahman MH, Akter R, et al. (2021) Potential role of curcumin and its nanoformulations to treat various types of cancers. Biomolecules 11: 392. https://doi.org/10.3390/biom11030392 ![]() |
[12] |
Tagde P, Tagde P, Islam F, et al. (2021) The multifaceted role of curcumin in advanced nanocurcumin form in the treatment and management of chronic disorders. Molecules 26: 7109. https://doi.org/10.3390/molecules26237109 ![]() |
[13] |
Tang W, Du M, Zhang S, et al. (2021) Therapeutic effect of curcumin on oral diseases: A literature review. Phytother Res 35: 2287-2295. https://doi.org/10.1002/ptr.6943 ![]() |
[14] |
Sharifi S, Fathi N, Memar MY, et al. (2020) Anti-microbial activity of curcumin nanoformulations: New trends and future perspectives. Phytother Res 34: 1926-1946. https://doi.org/10.1002/ptr.6658 ![]() |
[15] |
Kumbar VM, Peram MR, Kugaji MS, et al. (2021) Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis. Odontology 109: 18-28. https://doi.org/10.1007/s10266-020-00514-y ![]() |
[16] |
Soares JM, Yakovlev VV, Blanco KC, et al. (2024) Photodynamic inactivation and its effects on the heterogeneity of bacterial resistance. Sci Rep 14: 28268. https://doi.org/10.1038/s41598-024-79743-y ![]() |
[17] | Sha AM, Garib BT (2019) Antibacterial effect of curcumin against clinically isolated Porphyromonas gingivalis and connective tissue reactions to curcumin gel in the subcutaneous tissue of rats. Biomed Res Int 2019: 6810936. https://doi.org/10.1155/2019/6810936 |
[18] |
Adeyemi OS, Obeme-Imom JI, Akpor BO, et al. (2020) Altered redox status, DNA damage and modulation of L-tryptophan metabolism contribute to antimicrobial action of curcumin. Heliyon 6: e03495. https://doi.org/10.1016/j.heliyon.2020.e03495 ![]() |
[19] |
Trigo-Gutierrez JK, Vega-Chacón Y, Soares AB, et al. (2021) Antimicrobial activity of curcumin in nanoformulations: A comprehensive review. Int J Mol Sci 22: 7130. https://doi.org/10.3390/ijms22137130 ![]() |
[20] | Teow SY, Liew K, Ali SA, et al. (2016) Antibacterial action of curcumin against staphylococcus aureus: A brief review. J Trop Med 2016: 2853045. https://doi.org/10.1155/2016/28530 |
[21] |
Wray R, Iscla I, Blount P (2021) Curcumin activation of a bacterial mechanosensitive channel underlies its membrane permeability and adjuvant properties. PLoS Pathog 17: e1010198. https://doi.org/10.1371/journal.ppat.1010198 ![]() |
[22] |
Javed F, Romanos GE (2013) Does photodynamic therapy enhance standard antibacterial therapy in dentistry?. Photomed Laser Surg 31: 512-518. https://doi.org/10.1089/pho.2012.3329 ![]() |
[23] |
Alves LVGL, Curylofo-Zotti FA, Borsatto MC, et al. (2019) Influence of antimicrobial photodynamic therapy in carious lesion. Randomized split-mouth clinical trial in primary molars. Photodiagn Photodyn 26: 124-130. https://doi.org/10.1016/j.pdpdt.2019.02.018 ![]() |
[24] |
Jia Q, Song Q, Li P, et al. (2019) Rejuvenated photodynamic therapy for bacterial infections. Adv Healthc Mater 8: e1900608. https://doi.org/10.1002/adhm.201900608 ![]() |
[25] |
Saitawee D, Teerakapong A, Morales NP, et al. (2018) Photodynamic therapy of Curcuma longa extract stimulated with blue light against Aggregatibacter actinomycetemcomitans. Photodiagn Photodyn 22: 101-105. https://doi.org/10.1016/j.pdpdt.2018.03.001 ![]() |
[26] |
Pan H, Wang D, Zhang F (2020) In vitro antimicrobial effect of curcumin-based photodynamic therapy on Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Photodiagn Photodyn 32: 102055. https://doi.org/10.1016/j.pdpdt.2020.102055 ![]() |
[27] |
Zhang G, Yang Y, Shi J, et al. (2021) Near-infrared light II-assisted rapid biofilm elimination platform for bone implants at mild temperature. Biomaterials 269: 120634. https://doi.org/10.1016/j.biomaterials.2020.120634 ![]() |
[28] |
Ferrisse TM, Dias LM, De Oliveira AB, et al. (2022) Efficacy of curcumin-mediated antibacterial photodynamic therapy for oral antisepsis: A systematic review and network meta-analysis of randomized clinical trials. Photodiagn Photodyn 39: 102876. https://doi.org/10.1016/j.pdpdt.2022.102876 ![]() |
[29] |
Nima G, Soto-Montero J, Alves LA, et al. (2021) Photodynamic inactivation of Streptococcus mutans by curcumin in combination with EDTA. Dent Mater 37: e1-e14. https://doi.org/10.1016/j.dental.2020.09.015 ![]() |
[30] |
Cusicanqui Méndez DA, Gutierres E, Dionisio EJ, et al. (2018) Curcumin-mediated antimicrobial photodynamic therapy reduces the viability and vitality of infected dentin caries microcosms. Photodiagn Photodyn 24: 102-108. https://doi.org/10.1016/j.pdpdt.2018.09.007 ![]() |
[31] |
Girisa S, Kumar A, Rana V, et al. (2021) From simple mouth cavities to complex oral mucosal disorders-Curcuminoids as a promising therapeutic approach. ACS Pharmacol Transl Sci 4: 647-665. https://doi.org/10.1021/acsptsci.1c00017 ![]() |
[32] |
Dashper SG, Liu SW, Walsh KA, et al. (2013) Streptococcus mutans biofilm disruption by κ-casein glycopeptide. J Dent 41: 521-527. https://doi.org/10.1016/j.jdent.2013.03.010 ![]() |
[33] |
Pourhajibagher M, Omrani LR, Noroozian M, et al. (2021) In vitro antibacterial activity and durability of a nano-curcumin-containing pulp capping agent combined with antimicrobial photodynamic therapy. Photodiagn Photodyn 33: 102150. https://doi.org/10.1016/j.pdpdt.2020.102150 ![]() |
[34] |
Méndez DAC, Gutierrez E, Lamarque GCC, et al. (2019) The effectiveness of curcumin-mediated antimicrobial photodynamic therapy depends on pre-irradiation and biofilm growth times. Photodiagn Photodyn 27: 474-480. https://doi.org/10.1016/j.pdpdt.2019.07.011 ![]() |
[35] |
Wenzler JS, Wurzel SC, Falk W, et al. (2024) Bactericidal effect of different photochemical-based therapy options on implant surfaces-An in vitro Sstudy. J Clin Med 13: 4212. https://doi.org/10.3390/jcm13144212 ![]() |
[36] |
Lamarque GCC, Méndez DAC, Matos AA, et al. (2021) In vitro effect of curcumin-mediated antimicrobial photodynamic therapy on fibroblasts: Viability and cell signaling for apoptosis. Lasers Med Sci 36: 1169-1175. https://doi.org/10.1007/s10103-020-03150-8 ![]() |
[37] |
Sakko M, Tjäderhane L, Rautemaa-Richardson R (2016) Microbiology of root canal infections. Prim Dent J 5: 84-89. https://doi.org/10.1308/205016816819304231 ![]() |
[38] |
Pileggi G, Wataha JC, Girard M, et al. (2013) Blue light-mediated inactivation of Enterococcus faecalis in vitro. Photodiag Photodyn 10: 134-140. https://doi.org/10.1016/j.pdpdt.2012.11.002 ![]() |
[39] |
Neelakantan P, Cheng CQ, Ravichandran V, et al. (2015) Photoactivation of curcumin and sodium hypochlorite to enhance antibiofilm efficacy in root canal dentin. Photodiagn Photodyn 12: 108-114. https://doi.org/10.1016/j.pdpdt.2014.10.011 ![]() |
[40] |
Guo Q, Li P, Zhang Y, et al. (2024) Polydopamine-curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties. Photochem Photobiol 100: 699-711. https://doi.org/10.1111/php.13870 ![]() |
[41] | Pourhajibagher M, Chiniforush N, Monzavi A, et al. (2018) Inhibitory effects of antimicrobial photodynamic therapy with curcumin on biofilm-associated gene expression profile of aggregatibacter actinomycetemcomitans. J Dent (Tehran) 15: 169-177. |
[42] |
Ivanaga CA, Miessi DMJ, Nuernberg MAA, et al. (2019) Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: A randomized and controlled split-mouth clinical trial. Photodiagn Photodyn 27: 388-395. https://doi.org/10.1016/j.pdpdt.2019.07.005 ![]() |
[43] |
Böcher S, Wenzler JS, Falk W, et al. (2019) Comparison of different laser-based photochemical systems for periodontal treatment. Photodiagn Photodyn 27: 433-439. https://doi.org/10.1016/j.pdpdt.2019.06.009 ![]() |
[44] |
Pérez-Pacheco CG, Fernandes NAR, Primo FL, et al. (2021) Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial. Clin Oral Invest 25: 3217-3227. https://doi.org/10.1007/s00784-020-03652-3 ![]() |
[45] |
Negahdari R, Ghavimi MA, Barzegar A, et al. (2021) Antibacterial effect of nanocurcumin inside the implant fixture: An in vitro study. Clin Exp Dent Res 7: 163-169. https://doi.org/10.1002/cre2.348 ![]() |
[46] |
Mahdizade-Ari M, Pourhajibagher M, Bahador A (2019) Changes of microbial cell survival, metabolic activity, efflux capacity, and quorum sensing ability of Aggregatibacter actinomycetemcomitans due to antimicrobial photodynamic therapy-induced bystander effects. Photodiagn Photodyn 26: 287-294. https://doi.org/10.1016/j.pdpdt.2019.04.021 ![]() |
[47] |
Narayanan VS, Muddaiah S, Shashidara R, et al. (2020) Variable antifungal activity of curcumin against planktonic and biofilm phase of different candida species. Indian J Dent Res 31: 145-148. https://doi.org/10.4103/ijdr.IJDR_521_17 ![]() |
[48] |
Ambreen G, Duse L, Tariq I, et al. (2020) Sensitivity of papilloma virus-associated cell lines to photodynamic therapy with curcumin-loaded liposomes. Cancers 12: 3278. https://doi.org/10.3390/cancers12113278 ![]() |
[49] |
Jordão CC, De Sousa TV, Klein MI, et al. (2020) Antimicrobial photodynamic therapy reduces gene expression of Candida albicans in biofilms. Photodiagn Photodyn 31: 101825. https://doi.org/10.1016/j.pdpdt.2020.101825 ![]() |
[50] |
de Cassia Rodrigues Picco D, Cavalcante LLR, Trevisan RLB, et al. (2019) Effect of curcumin-mediated photodynamic therapy on Streptococcus mutans and Candida albicans: A systematic review of in vitro studies. Photodiagn Photodyn 27: 455-461. https://doi.org/10.1016/j.pdpdt.2019.07.010 ![]() |
[51] |
Anwar SK, Elmonaem SNA, Moussa E, et al. (2023) Curcumin nanoparticles: The topical antimycotic suspension treating oral candidiasis. Odontology 111: 350-359. https://doi.org/10.1007/s10266-022-00742-4 ![]() |
[52] |
Jennings MR, Parks RJ (2020) Curcumin as an antiviral agent. Viruses 12: 1242. https://doi.org/10.3390/v12111242 ![]() |
[53] |
Šudomová M, Hassan STS (2021) Nutraceutical curcumin with promising protection against herpesvirus infections and their associated inflammation: Mechanisms and pathways. Microorganisms 9: 292. https://doi.org/10.3390/microorganisms9020292 ![]() |
[54] |
Liczbiński P, Michałowicz J, Bukowska B (2020) Molecular mechanism of curcumin action in signaling pathways: Review of the latest research. Phytother Res 34: 1992-2005. https://doi.org/10.1002/ptr.6663 ![]() |
[55] |
Hasanzadeh S, Read MI, Bland AR, et al. (2020) Curcumin: An inflammasome silencer. Pharmacol Res 159: 104921. https://doi.org/10.1016/j.phrs.2020.104921 ![]() |
[56] |
Sinjari B, Pizzicannella J, D'aurora M, et al. (2019) Curcumin/liposome nanotechnology as delivery platform for anti-inflammatory activities via NFkB/ERK/pERK pathway in human dental pulp treated with 2-HydroxyEthyl MethAcrylate (HEMA). Front Physiol 10: 633. https://doi.org/10.3389/fphys.2019.00633 ![]() |
[57] |
Breschi L, Maravic T, Cunha SR, et al. (2018) Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications. Dent Mater 34: 78-96. https://doi.org/10.1016/j.dental.2017.11.005 ![]() |
[58] |
Liu Y, Tjäderhane L, Breschi L, et al. (2011) Limitations in bonding to dentin and experimental strategies to prevent bond degradation. J Dent Res 90: 953-968. https://doi.org/10.1177/0022034510391799 ![]() |
[59] |
Seseogullari-Dirihan R, Mutluay MM, Vallittu P, et al. (2015) Effect of pretreatment with collagen crosslinkers on dentin protease activity. Dent Mater 31: 941-947. https://doi.org/10.1016/j.dental.2015.05.002 ![]() |
[60] |
Seseogullari-Dirihan R, Apollonio F, Mazzoni A, et al. (2016) Use of crosslinkers to inactivate dentin MMPs. Dent Mater 32: 423-432. https://doi.org/10.1016/j.dental.2015.12.012 ![]() |
[61] |
Seseogullari-Dirihan R, Mutluay MM, Pashley DH, et al. (2017) Is the inactivation of dentin proteases by crosslinkers reversible?. Dent Mater 33: e62-e68. https://doi.org/10.1016/j.dental.2016.09.036 ![]() |
[62] |
Xiao C, Yu X, Xie J, et al. (2018) Protective effect and related mechanisms of curcumin in rat experimental periodontitis. Head Face Med 14: 12. https://doi.org/10.1186/s13005-018-0169-1 ![]() |
[63] |
Guimarães MR, De Aquino SG, Coimbra LS, et al. (2012) Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats. Innate Immun 18: 155-163. https://doi.org/10.1177/1753425910392935 ![]() |
[64] |
Toraya S, Uehara O, Hiraki D, et al. (2020) Curcumin inhibits the expression of proinflammatory mediators and MMP-9 in gingival epithelial cells stimulated for a prolonged period with lipopolysaccharides derived from Porphyromonas gingivalis. Odontology 108: 16-24. https://doi.org/10.1007/s10266-019-00432-8 ![]() |
[65] |
Anitha V, Rajesh P, Shanmugam M, et al. (2015) Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: A clinical and microbiological study. Indian J Dent Res 26: 53-56. https://doi.org/10.4103/0970-9290.156806 ![]() |
[66] |
Zhang L, Tan J, Liu Y, et al. (2024) Curcumin relieves arecoline-induced oral submucous fibrosis via inhibiting the LTBP2/NF-κB axis. Oral Dis 30: 2314-2324. https://doi.org/10.1111/odi.14656 ![]() |
[67] |
Chatterjee A, Debnath K, Rao NKH (2017) A comparative evaluation of the efficacy of curcumin and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A double-blinded randomized controlled clinical study. J Indian Soc Periodontol 21: 132-137. https://doi.org/10.4103/jisp.jisp_136_17 ![]() |
[68] |
Malekzadeh M, Kia SJ, Mashaei L, et al. (2021) Oral nano-curcumin on gingival inflammation in patients with gingivitis and mild periodontitis. Clin Exp Dent Res 7: 78-84. https://doi.org/10.1002/cre2.330 ![]() |
[69] |
Saran G, Umapathy D, Misra N, et al. (2018) A comparative study to evaluate the efficacy of lycopene and curcumin in oral submucous fibrosis patients: A randomized clinical trial. Indian J Dent Res 29: 303-312. https://doi.org/10.4103/ijdr.IJDR_551_16 ![]() |
[70] |
Ali FM, Aher V, Prasant MC, et al. (2013) Oral submucous fibrosis: Comparing clinical grading with duration and frequency of habit among areca nut and its products chewers. J Cancer Res Ther 9: 471-476. https://doi.org/10.4103/0973-1482.119353 ![]() |
[71] |
Hande AH, Chaudhary MS, Gawande MN, et al. (2019) Oral submucous fibrosis: An enigmatic morpho-insight. J Cancer Res Ther 15: 463-469. https://doi.org/10.4103/jcrt.JCRT_522_17 ![]() |
[72] |
Srivastava A, Agarwal R, Chaturvedi TP, et al. (2015) Clinical evaluation of the role of tulsi and turmeric in the management of oral submucous fibrosis: A pilot, prospective observational study. J Ayurveda Integr Med 6: 45-49. ![]() |
[73] |
Nerkar Rajbhoj A, Kulkarni TM, Shete A, et al. (2021) A comparative study to evaluate efficacy of curcumin and aloe vera gel along with oral physiotherapy in the management of oral submucous fibrosis: A randomized clinical trial. Asian Pac J Cancer Prev 22: 107-112. https://doi.org/10.31557/apjcp.2021.22.s1.107 ![]() |
[74] |
Ara SA, Mudda JA, Lingappa A, et al. (2016) Research on curcumin: A meta-analysis of potentially malignant disorders. J Cancer Res Ther 12: 175-181. https://doi.org/10.4103/0973-1482.171370 ![]() |
[75] |
Gupta S, Ghosh S, Gupta S, et al. (2017) Effect of curcumin on the expression of p53, transforming growth factor-β, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study. J Invest Clin Dent 8: e12252. https://doi.org/10.1111/jicd.12252 ![]() |
[76] | Al-Maweri SA (2019) Efficacy of curcumin for management of oral submucous fibrosis: A systematic review of randomized clinical trials. Oral Surg Oral Med O 127: 300-308. https://doi.org/10.1016/j.oooo.2019.01.010 |
[77] | Chandrashekar A, Annigeri RG, Va U, et al. (2021) A clinicobiochemical evaluation of curcumin as gel and as buccal mucoadhesive patches in the management of oral submucous fibrosis. Oral Surg Oral Med O 131: 428-434. https://doi.org/10.1016/j.oooo.2020.12.020 |
[78] |
Chen D, Xi Y, Zhang S, et al. (2022) Curcumin attenuates inflammation of Macrophage-derived foam cells treated with Poly-L-lactic acid degradation via PPARγ signaling pathway. J Mater Sci Mater Med 33: 33. https://doi.org/10.1007/s10856-022-06654-7 ![]() |
[79] |
Rai A, Qazi S, Raza K (2022) In silico analysis and comparative molecular docking study of FDA approved drugs with transforming growth factor beta receptors in oral submucous fibrosis. Indian J Otolaryngol Head Neck Surgery 74: 2111-2121. https://doi.org/10.1007/s12070-020-02014-5 ![]() |
[80] |
Klopfleisch R, Jung F (2017) The pathology of the foreign body reaction against biomaterials. J Biomed Mater Res A 105: 927-940. https://doi.org/10.1002/jbm.a.35958 ![]() |
[81] |
Wu J, Deng J, Theocharidis G, et al. (2024) Adhesive anti-fibrotic interfaces on diverse organs. Nature 630: 360-367. https://doi.org/10.1038/s41586-024-07426-9 ![]() |
[82] |
Yang C, Zhu K, Yuan X, et al. (2020) Curcumin has immunomodulatory effects on RANKL-stimulated osteoclastogenesis in vitro and titanium nanoparticle-induced bone loss in vivo. J Cell Mol Med 24: 1553-1567. https://doi.org/10.1111/jcmm.14842 ![]() |
[83] |
Khezri K, Dizaj SM, Saadat YR, et al. (2021) Osteogenic differentiation of mesenchymal stem cells via curcumin-containing nanoscaffolds. Stem Cells Int 2021: 1520052. https://doi.org/10.1155/2021/1520052 ![]() |
[84] |
Chen S, Liang H, Ji Y, et al. (2021) Curcumin modulates the crosstalk between macrophages and bone mesenchymal stem cells to ameliorate osteogenesis. Front Cell Dev Biol 9: 634650. https://doi.org/10.3389/fcell.2021.634650 ![]() |
[85] |
Liu B, Zhou C, Zhang Z, et al. (2021) Antimicrobial property of halogenated catechols. Chem Eng J 403: 126340. https://doi.org/10.1016/j.cej.2020.126340 ![]() |
[86] |
Jiang C, Luo P, Li X, et al. (2020) Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation. Cell Stress Chaperon 25: 395-406. https://doi.org/10.1007/s12192-020-01079-z ![]() |
[87] |
Chen D, Yu C, Ying Y, et al. (2022) Study of the osteoimmunomodulatory properties of curcumin-modified copper-bearing titanium. Molecules 27: 3205. https://doi.org/10.3390/molecules27103205 ![]() |
[88] |
Wusiman P, Maimaitituerxun B, Guli, et al. (2020) Epidemiology and pattern of oral and maxillofacial trauma. J Craniofac Surg 31: e517-e520. https://doi.org/10.1097/scs.0000000000006719 ![]() |
[89] |
Lam R (2016) Epidemiology and outcomes of traumatic dental injuries: A review of the literature. Aust Dent J 61: 4-20. https://doi.org/10.1111/adj.12395 ![]() |
[90] | Lynham A, Tuckett J, Warnke P (2012) Maxillofacial trauma. Aust Fam Physician 41: 172-180. |
[91] |
Falanga V (2005) Wound healing and its impairment in the diabetic foot. Lancet 366: 1736-1743. https://doi.org/10.1016/s0140-6736(05)67700-8 ![]() |
[92] |
Barchitta M, Maugeri A, Favara G, et al. (2019) Nutrition and wound healing: An overview focusing on the beneficial effects of curcumin. Int J Mol Sci 20: 1119. https://doi.org/10.3390/ijms20051119 ![]() |
[93] |
Velnar T, Bailey T, Smrkolj V (2009) The wound healing process: An overview of the cellular and molecular mechanisms. J Int Med Res 37: 1528-1542. https://doi.org/10.1177/147323000903700531 ![]() |
[94] |
Keihanian F, Saeidinia A, Bagheri RK, et al. (2018) Curcumin, hemostasis, thrombosis, and coagulation. J Cell Physiol 233: 4497-4511. https://doi.org/10.1002/jcp.26249 ![]() |
[95] |
Tabeshpour J, Hashemzaei M, Sahebkar A (2018) The regulatory role of curcumin on platelet functions. J Cell Biochem 119: 8713-8722. https://doi.org/10.1002/jcb.27192 ![]() |
[96] |
Hunter CJ, De Plaen IG (2014) Inflammatory signaling in NEC: Role of NF-κB, cytokines and other inflammatory mediators. Pathophysiology 21: 55-65. https://doi.org/10.1016/j.pathophys.2013.11.010 ![]() |
[97] |
Gopinath D, Ahmed MR, Gomathi K, et al. (2004) Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials 25: 1911-1917. https://doi.org/10.1016/s0142-9612(03)00625-2 ![]() |
[98] |
Tapia E, Sánchez-Lozada LG, García-Niño WR, et al. (2014) Curcumin prevents maleate-induced nephrotoxicity: Relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Free Radical Res 48: 1342-1354. https://doi.org/10.3109/10715762.2014.954109 ![]() |
[99] |
Chaushu L, Gavrielov MR, Chaushu G, et al. (2021) Curcumin promotes primary oral wound healing in a rat model. J Med Food 24: 422-430. https://doi.org/10.1089/jmf.2020.0093 ![]() |
[100] |
Mohanty C, Das M, Sahoo SK (2012) Sustained wound healing activity of curcumin loaded oleic acid based polymeric bandage in a rat model. Mol Pharm 9: 2801-2811. https://doi.org/10.1021/mp300075u ![]() |
[101] |
Akbik D, Ghadiri M, Chrzanowski W, et al. (2014) Curcumin as a wound healing agent. Life Sci 116: 1-7. https://doi.org/10.1016/j.lfs.2014.08.016 ![]() |
[102] |
Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341: 738-746. https://doi.org/10.1056/nejm199909023411006 ![]() |
[103] |
Habiboallah G, Nasroallah S, Mahdi Z, et al. (2008) Histological evaluation of Curcuma longa-ghee formulation and hyaluronic acid on gingival healing in dog. J Ethnopharmacol 120: 335-341. https://doi.org/10.1016/j.jep.2008.09.011 ![]() |
[104] |
Murgia D, Angellotti G, Conigliaro A, et al. (2020) Development of a multifunctional bioerodible nanocomposite containing metronidazole and curcumin to apply on L-PRF clot to promote tissue regeneration in dentistry. Biomedicines 8: 425. https://doi.org/10.3390/biomedicines8100425 ![]() |
[105] | Mitie A, Todorovic K, Stojiljkovic N, et al. (2017) Beneficial effects of curcumin on the wound-healing process after tooth extraction. Nat Prod Commun 12: 1905-1908. https://doi.org/10.1177/1934578X1701201223 |
[106] |
Rujirachotiwat A, Suttamanatwong S (2021) Curcumin promotes collagen type I, keratinocyte growth factor-1, and epidermal growth factor receptor expressions in the in vitro wound healing model of human gingival fibroblasts. Eur J Dent 15: 63-70. https://doi.org/10.1055/s-0040-1715781 ![]() |
[107] | Thakur A, Kumar A, Hasan S, et al. (2019) Curcumin in oral mucosal lesions: An update. Asian J Pharm Clin Res 12: 32-43. https://doi.org/10.22159/ajpcr.2019.v12i2.22458 |
[108] |
Bashang H, Tamma S (2020) The use of curcumin as an effective adjuvant to cancer therapy: A short review. Biotechnol Appl Biochem 67: 171-179. https://doi.org/10.1002/bab.1836 ![]() |
[109] | Wang Y, Lu J, Jiang B, et al. (2020) The roles of curcumin in regulating the tumor immunosuppressive microenvironment. Oncol Lett 19: 3059-3070. https://doi.org/10.3892/ol.2020.11437 |
[110] |
Radhika T, Jeddy N, Nithya S, et al. (2016) Salivary biomarkers in oral squamous cell carcinoma-An insight. J Oral Biol Craniofac Res 6: S51-S54. https://doi.org/10.1016/j.jobcr.2016.07.003 ![]() |
[111] |
Nagel-Wolfrum K, Buerger C, Wittig I, et al. (2004) The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Mol Cancer Res 2: 170-182. https://doi.org/10.1158/1541-7786.170.2.3 ![]() |
[112] |
Ma C, Zhuang Z, Su Q, et al. (2020) Curcumin has anti-proliferative and pro-apoptotic effects on tongue cancer in vitro: A study with bioinformatics analysis and in vitro experiments. Drug Des Devel Ther 14: 509-518. https://doi.org/10.2147/dddt.s237830 ![]() |
[113] |
Liao F, Liu L, Luo E, et al. (2018) Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma. Arch Oral Biol 92: 32-37. https://doi.org/10.1016/j.archoralbio.2018.04.015 ![]() |
[114] | Zhen L, Fan D, Yi X, et al. (2014) Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. Int J Clin Exp Pathol 7: 6438-6446. https://doi.org/10.1158/1541-7786.MCR-04-0010 |
[115] |
Yaguchi T, Sumimoto H, Kudo-Saito C, et al. (2011) The mechanisms of cancer immunoescape and development of overcoming strategies. Int J Hematol 93: 294-300. https://doi.org/10.1007/s12185-011-0799-6 ![]() |
[116] |
Lee H, Jeong AJ, Ye SK (2019) Highlighted STAT3 as a potential drug target for cancer therapy. BMB Rep 52: 415-423. https://doi.org/10.5483/BMBRep.2019.52.7.152 ![]() |
[117] | Ohnishi Y, Sakamoto T, Zhengguang L, et al. (2020) Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-Met blockade. Oncol Lett 19: 4177-4182. https://doi.org/10.3892/ol.2020.11523 |
[118] |
Hu A, Huang JJ, Li RL, et al. (2015) Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1. Sci Rep 5: 13429. https://doi.org/10.1038/srep13429 ![]() |
[119] |
Srivastava S, Mohammad S, Pant AB, et al. (2018) Co-delivery of 5-fluorouracil and curcumin nanohybrid formulations for improved chemotherapy against oral squamous cell carcinoma. J Maxillofac Oral Surg 17: 597-610. https://doi.org/10.1007/s12663-018-1126-z ![]() |
[120] |
Molla S, Hembram KC, Chatterjee S, et al. (2020) PARP inhibitor olaparib enhances the apoptotic potentiality of curcumin by increasing the DNA damage in oral cancer cells through inhibition of BER cascade. Pathol Oncol Res 26: 2091-2103. https://doi.org/10.1007/s12253-019-00768-0 ![]() |
[121] |
Gupta N, Verma K, Nalla S, et al. (2020) Free radicals as a double-edged sword: The cancer preventive and therapeutic roles of curcumin. Molecules 25: 5390. https://doi.org/10.3390/molecules25225390 ![]() |
[122] |
Kia SJ, Basirat M, Saedi HS, et al. (2021) Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucositis in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial. BMC Complement Med Ther 21: 232. https://doi.org/10.1186/s12906-021-03400-4 ![]() |
[123] |
Srivastava S, Mohammad S, Gupta S, et al. (2018) Chemoprotective effect of nanocurcumin on 5-fluorouracil-induced-toxicity toward oral cancer treatment. Natl J Maxillofac Surg 9: 160-166. https://doi.org/10.4103/njms.NJMS_27_18 ![]() |
[124] |
Hegde MN, Gatti P, Hegde ND (2019) Protection of wear resistance behaviour of enamel against electron beam irradiation. BDJ Open 5: 11. https://doi.org/10.1038/s41405-019-0021-0 ![]() |
[125] |
Delavarian Z, Pakfetrat A, Ghazi A, et al. (2019) Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers. Spec Care Dentist 39: 166-172. https://doi.org/10.1111/scd.12358 ![]() |
[126] |
Antonazzo IC, Gribaudo G, La Vecchia A, et al. (2024) Cost and cost effectiveness of treatments for psoriatic arthritis: An updated systematic literature review. Pharmacoeconomics 42: 1329-1343. https://doi.org/10.1007/s40273-024-01428-1 ![]() |
[127] |
Ulmansky M, Michelle R, Azaz B (1995) Oral psoriasis: Report of six new cases. J Oral Pathol Med 24: 42-45. https://doi.org/10.1111/j.1600-0714.1995.tb01128.x ![]() |
[128] |
Zargari O (2006) The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients. Clin Exp Dermatol 31: 192-195. https://doi.org/10.1111/j.1365-2230.2005.02028.x ![]() |
[129] |
Ogueta CI, Ramírez PM, Jiménez OC, et al. (2019) Geographic tongue: What a dermatologist should know. Actas Dermo-Sifiliográficas 110: 341-346. https://doi.org/10.1016/j.ad.2018.10.022 ![]() |
[130] |
Lowes MA, Suárez-Fariñas M, Krueger JG (2014) Immunology of psoriasis. Annu Rev Immunol 32: 227-255. https://doi.org/10.1146/annurev-immunol-032713-120225 ![]() |
[131] |
Rendon A, Schäkel K (2019) Psoriasis pathogenesis and treatment. Int J Mol Sci 20: 1475. https://doi.org/10.3390/ijms20061475 ![]() |
[132] |
Panahi Y, Fazlolahzadeh O, Atkin SL, et al. (2019) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review. J Cell Physiol 234: 1165-1178. https://doi.org/10.1002/jcp.27096 ![]() |
[133] |
Kang D, Li B, Luo L, et al. (2016) Curcumin shows excellent therapeutic effect on psoriasis in mouse model. Biochimie 123: 73-80. https://doi.org/10.1016/j.biochi.2016.01.013 ![]() |
[134] |
Tziotzios C, Lee JYW, Brier T, et al. (2018) Lichen planus and lichenoid dermatoses: Clinical overview and molecular basis. J Am Acad Dermatol 79: 789-804. https://doi.org/10.1016/j.jaad.2018.02.010 ![]() |
[135] |
Eisen D, Carrozzo M, Sebastian JVB, et al. (2005) Number V Oral lichen planus: Clinical features and management. Oral Dis 11: 338-349. https://doi.org/10.1111/j.1601-0825.2005.01142.x ![]() |
[136] |
Roopashree MR, Gondhalekar RV, Shashikanth MC, et al. (2010) Pathogenesis of oral lichen planus—A review. J Oral Pathol Med 39: 729-734. https://doi.org/10.1111/j.1600-0714.2010.00946.x ![]() |
[137] |
Bombeccari GP, Giannì AB, Spadari F (2017) Oral Candida colonization and oral lichen planus. Oral Dis 23: 1009-1010. https://doi.org/10.1111/odi.12681 ![]() |
[138] |
Salehi B, Lopez-Jornet P, López EPF, et al. (2019) Plant-derived bioactives in oral mucosal lesions: A key emphasis to curcumin, lycopene, chamomile, aloe vera, green tea and coffee properties. Biomolecules 9: 106. https://doi.org/10.3390/biom9030106 ![]() |
[139] |
Kia SJ, Basirat M, Mortezaie T, et al. (2020) Comparison of oral nano-curcumin with oral prednisolone on oral lichen planus: A randomized double-blinded clinical trial. BMC Complement Med Ther 20: 328. https://doi.org/10.1186/s12906-020-03128-7 ![]() |
[140] |
White CM, Chamberlin K, Eisenberg E (2019) Curcumin, a turmeric extract, for oral lichen planus: A systematic review. Oral Dis 25: 720-725. https://doi.org/10.1111/odi.13034 ![]() |
[141] |
Lv KJ, Chen TC, Wang GH, et al. (2019) Clinical safety and efficacy of curcumin use for oral lichen planus: A systematic review. J Dermatol Treat 30: 605-611. https://doi.org/10.1080/09546634.2018.1543849 ![]() |
[142] |
Li H, Yue L, Xu H, et al. (2019) Curcumin suppresses osteogenesis by inducing miR-126a-3p and subsequently suppressing the WNT/LRP6 pathway. Aging 11: 6983-6998. https://doi.org/10.18632/aging.102232 ![]() |
[143] |
Yang Q, Leong SA, Chan KP, et al. (2021) Complex effect of continuous curcumin exposure on human bone marrow-derived mesenchymal stem cell regenerative properties through matrix metalloproteinase regulation. Basic Clin Pharmacol Toxicol 128: 141-153. https://doi.org/10.1111/bcpt.13477 ![]() |
[144] |
Yang M, Liu J, Liu C, et al. (2025) Programmable food-derived peptide coassembly strategies for boosting targeted colitis therapy by enhancing oral bioavailability and restoring gut microenvironment homeostasis. ACS Nano 19: 600-620. https://doi.org/10.1021/acsnano.4c11108 ![]() |
[145] |
Nguyen MH, Yu H, Kiew TY, et al. (2015) Cost-effective alternative to nano-encapsulation: Amorphous curcumin–chitosan nanoparticle complex exhibiting high payload and supersaturation generation. Eur J Pharm Biopharm 96: 1-10. https://doi.org/10.1016/j.ejpb.2015.07.007 ![]() |
[146] |
Pei Z, Chen S, Ding L, et al. (2022) Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis. J Control Release 352: 211-241. https://doi.org/10.1016/j.jconrel.2022.10.023 ![]() |
[147] |
Fernandez-Fernandez A, Manchanda R, Rodrigues JMC, et al. (2023) State-of-the-art rational nanodesign: From screening to theranostics and from bench to clinic. Front Pharmacol 14: 1210185. https://doi.org/10.3389/fphar.2023.1210185 ![]() |
[148] |
Szymusiak M, Hu X, Plata PAL, et al. (2016) Bioavailability of curcumin and curcumin glucuronide in the central nervous system of mice after oral delivery of nano-curcumin. Int J Pharm 511: 415-423. https://doi.org/10.1016/j.ijpharm.2016.07.027 ![]() |
[149] |
Bakhshi M, Mahboubi A, Jaafari M R, et al. (2022) Comparative efficacy of 1% curcumin nanomicelle gel and 2% curcumin gel for treatment of recurrent aphthous stomatitis: a double-blind randomized clinical trial. J Evid Based Dent Pract 22: 101708. https://doi.org/10.1016/j.jebdp.2022.101708 ![]() |
[150] |
Hafez Ghoran S, Calcaterra A, Abbasi M, et al. (2022) Curcumin-based nanoformulations: A promising adjuvant towards cancer treatment. Molecules 27: 5236. https://doi.org/10.3390/molecules27165236 ![]() |
[151] |
Yallapu MM, Jaggi M, Chauhan SC (2012) Curcumin nanoformulations: A future nanomedicine for cancer. Drug Discov Today 17: 71-80. https://doi.org/10.1016/j.drudis.2011.09.009 ![]() |
[152] |
Zheng Y, Jia R, Li J, et al. (2025) Expression of concern: Curcumin-and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma. J Nanobiotechnol 23: 288. https://doi.org/10.1186/s12951-025-03361-7 ![]() |
[153] |
Wang J, Zhang T, Gu R, et al. (2024) Development and evaluation of reconstructed nanovesicles from turmeric for multifaceted obesity intervention. ACS Nano 18: 23117-23135. https://doi.org/10.1021/acsnano.4c05309 ![]() |
[154] |
Sahyon HBS, da Silva PP, de Oliveira MS, et al. (2019) Influence of curcumin photosensitizer in photodynamic therapy on the mechanical properties and push-out bond strength of glass-fiber posts to intraradicular dentin. Photodiagn Photodyn 25: 376-381. https://doi.org/10.1016/j.pdpdt.2019.01.025 ![]() |
[155] |
Al Ahdal K, Al Deeb L, Al-Hamdan RS, et al. (2020) Influence of different photosensitizers on push-out bond strength of fiber post to radicular dentin. Photodiagn Photodyn 31: 101805. https://doi.org/10.1016/j.pdpdt.2020.101805 ![]() |
[156] |
Strazzi-Sahyon HB, Da Silva PP, Nakao JM, et al. (2021) Influence of two photodynamic therapy sessions and different photosensitizers on the bond strength of glass-fiber posts in different regions of intraradicular dentin. Photodiagn Photodyn 33: 102193. https://doi.org/10.1016/j.pdpdt.2021.102193 ![]() |
0.140625 | 0.796875 | 0.2250 | 1.2750 | 0.3600 | 2.0400 | |
0.411938 | 1.64775 | 0.6591 | 2.6364 | 1.05456 | 4.21824 | |
0.791016 | 2.37305 | 1.26563 | 3.79688 | 2.025 | 6.0750 | |
0.1870 | 3.2805 | 3.4992 | 5.2488 | 5.59872 | 8.39808 |
0.05625 | 0.31875 | 0.1800 | 1.0200 | 0.1800 | 1.0200 | |
0.24881 | 0.995241 | 0.702557 | 2.81023 | 0.785476 | 3.1419 | |
0.553711 | 1.66113 | 1.36875 | 4.10625 | 1.73229 | 5.19688 | |
1.71461 | 2.57191 | 3.28719 | 4.93079 | 5.30129 | 7.95193 |
2.50084 | 14.1714 | 4.32 | 24.48 | 6.01143 | 34.0648 | |
3.0000 | 12.0000 | 4.8000 | 19.2000 | 5.7600 | 30.7200 | |
3.69468 | 11.084 | 5.82857 | 17.4857 | 9.54805 | 28.6442 | |
6.0000 | 9.0000 | 9.6000 | 14.4000 | 15.3600 | 23.0400 |
0.548152 | 3.1062 | 2.67429 | 15.1543 | 7.00699 | 46.3796 | |
0.4000 | 1.6000 | 2.2400 | 8.9600 | 2.4000 | 9.6000 | |
0.451568 | 1.3547 | 2.58701 | 7.76104 | 2.68392 | 8.05175 | |
0.8000 | 1.2000 | 4.4800 | 6.7200 | 4.8000 | 7.2000 |
0.140625 | 0.796875 | 0.2250 | 1.2750 | 0.3600 | 2.0400 | |
0.411938 | 1.64775 | 0.6591 | 2.6364 | 1.05456 | 4.21824 | |
0.791016 | 2.37305 | 1.26563 | 3.79688 | 2.025 | 6.0750 | |
0.1870 | 3.2805 | 3.4992 | 5.2488 | 5.59872 | 8.39808 |
0.05625 | 0.31875 | 0.1800 | 1.0200 | 0.1800 | 1.0200 | |
0.24881 | 0.995241 | 0.702557 | 2.81023 | 0.785476 | 3.1419 | |
0.553711 | 1.66113 | 1.36875 | 4.10625 | 1.73229 | 5.19688 | |
1.71461 | 2.57191 | 3.28719 | 4.93079 | 5.30129 | 7.95193 |
2.50084 | 14.1714 | 4.32 | 24.48 | 6.01143 | 34.0648 | |
3.0000 | 12.0000 | 4.8000 | 19.2000 | 5.7600 | 30.7200 | |
3.69468 | 11.084 | 5.82857 | 17.4857 | 9.54805 | 28.6442 | |
6.0000 | 9.0000 | 9.6000 | 14.4000 | 15.3600 | 23.0400 |
0.548152 | 3.1062 | 2.67429 | 15.1543 | 7.00699 | 46.3796 | |
0.4000 | 1.6000 | 2.2400 | 8.9600 | 2.4000 | 9.6000 | |
0.451568 | 1.3547 | 2.58701 | 7.76104 | 2.68392 | 8.05175 | |
0.8000 | 1.2000 | 4.4800 | 6.7200 | 4.8000 | 7.2000 |