Functional evaluation of saclipins A and B derived from the edible cyanobacterium <i>Aphanothece sacrum</i>: New bioactivities for anti-wrinkle and anti-hypertension

Yoshie Uchida; Masaki Honda; Rungaroon Waditee-Sirisattha; Hakuto Kageyama; Yoshie Uchida; Masaki Honda; Rungaroon Waditee-Sirisattha; Hakuto Kageyama

doi:10.3934/molsci.2025007

AIMS Molecular Science

2025, Volume 12, Issue 2: 113-121. doi: 10.3934/molsci.2025007

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Research article Special Issues

Functional evaluation of saclipins A and B derived from the edible cyanobacterium Aphanothece sacrum: New bioactivities for anti-wrinkle and anti-hypertension

1.
Graduate School of Environmental and Human Sciences, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, 468-8502, Japan
2.
Department of Chemistry, Faculty of Science and Technology, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya, Aichi 468-8502, Japan
3.
Department of Microbiology, Faculty of Science, Chulalongkorn University, Payathai Road, Pathumwan, Bangkok 10330, Thailand

Received: 15 January 2025 Revised: 26 March 2025 Accepted: 07 April 2025 Published: 14 April 2025

Saclipin A and saclipin B are bioactive oxylipin compounds derived from an edible cyanobacterium, Aphanothece sacrum. Saclipins have been shown to have potent anti-aging properties, including antioxidative, antiglycative, anti-wrinkle, and skin-whitening activities. In this study, we demonstrate that the anti-collagenase and anti-hyaluronidase activities of saclipins are additional anti-wrinkle properties of these compounds. Furthermore, we reveal that saclipins exert angiotensin-converting enzyme (ACE) inhibitory activities, which can mitigate hypertension. These results suggest that saclipins are promising natural products with applications not only for skincare products but also as medical supplements.
- saclipin,
- cyanobacteria,
- Aphanothece sacrum,
- angiotensin-converting enzyme inhibition,
- collagenase inhibition,
- hyaluronidase inhibition
Citation: Yoshie Uchida, Masaki Honda, Rungaroon Waditee-Sirisattha, Hakuto Kageyama. Functional evaluation of saclipins A and B derived from the edible cyanobacterium Aphanothece sacrum: New bioactivities for anti-wrinkle and anti-hypertension[J]. AIMS Molecular Science, 2025, 12(2): 113-121. doi: 10.3934/molsci.2025007

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Abstract

Saclipin A and saclipin B are bioactive oxylipin compounds derived from an edible cyanobacterium, Aphanothece sacrum. Saclipins have been shown to have potent anti-aging properties, including antioxidative, antiglycative, anti-wrinkle, and skin-whitening activities. In this study, we demonstrate that the anti-collagenase and anti-hyaluronidase activities of saclipins are additional anti-wrinkle properties of these compounds. Furthermore, we reveal that saclipins exert angiotensin-converting enzyme (ACE) inhibitory activities, which can mitigate hypertension. These results suggest that saclipins are promising natural products with applications not only for skincare products but also as medical supplements.

Acknowledgments

This work was supported by the Japan Society for the Promotion of Science KAKENHI Grants 24K08623, the Research Fund of the Naito Science and Engineering Foundation (to H.K.).

Conflict of interest

Rungaroon Waditee-Sirisattha and Hakuto Kageyama are the Guest Editor of special issue “Recent advances in exploring bioactive natural products from cyanobacteria and microalgae” for AIMS Molecular Science. Rungaroon Waditee-Sirisattha and Hakuto Kageyama were not involved in the editorial review and the decision to publish this article. All authors declare no conflicts of interest in this paper.

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