SARS-CoV-2; from vaccine development to drug discovery and prevention guidelines

Amir Khodavirdipour; Fariba Keramat; Seyed Hamid Hashemi; Mohammad Yousef Alikhani; Amir Khodavirdipour; Fariba Keramat; Seyed Hamid Hashemi; Mohammad Yousef Alikhani

doi:10.3934/molsci.2020013

AIMS Molecular Science

2020, Volume 7, Issue 3: 281-291. doi: 10.3934/molsci.2020013

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Review

SARS-CoV-2; from vaccine development to drug discovery and prevention guidelines

1.
Department of Biology, Faculty of Natural sciences, University of Tabriz, Tabriz, Iran
2.
Division of Human Genetics, Department of Anatomy, St. John's Hospital, Bangalore, India
3.
Department of Infectious Diseases, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4.
Department of Microbiology, Hamadan University of Medical Sciences, Hamadan, Iran
These authors contributed equally to this work.

Received: 15 June 2020 Accepted: 21 July 2020 Published: 23 July 2020

All species of coronavirus may cause infections in birds which is known to us since the 60s, but recently, from Nov 2019, the disease emerged in humans from the seafood market in Wuhan city. The previous viral outbreaks like SARS-CoV and MERS-CoV have also shown a greater mortality rate when transmitted to humans than other animals. An emerging concern in the 2019 novel coronavirus (SARS-CoV-2) is in terms of developing vaccine or discovery of new drugs to overcome the current viral pandemic. In this rapid-review, we aim to update the available data on coronavirus with the latest findings and achievements. So far, great steps have been taken such as hrsACE2 by a Swedish team from Karolinska Institute. Monash University announced the efficacy of Ivermectin to overcome COVID-19. The CRISPR/Cas13d as a new innovative therapeutics based might overcome the challenge of COVID-19. those strains of virus which lacking E protein-encoding regions are the perfect choice for vaccine development.
- COVID-19,
- vaccine,
- drug discovery,
- hrsACE2,
- ivermectin,
- famotidine
Citation: Amir Khodavirdipour, Fariba Keramat, Seyed Hamid Hashemi, Mohammad Yousef Alikhani. SARS-CoV-2; from vaccine development to drug discovery and prevention guidelines[J]. AIMS Molecular Science, 2020, 7(3): 281-291. doi: 10.3934/molsci.2020013

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Abstract

All species of coronavirus may cause infections in birds which is known to us since the 60s, but recently, from Nov 2019, the disease emerged in humans from the seafood market in Wuhan city. The previous viral outbreaks like SARS-CoV and MERS-CoV have also shown a greater mortality rate when transmitted to humans than other animals. An emerging concern in the 2019 novel coronavirus (SARS-CoV-2) is in terms of developing vaccine or discovery of new drugs to overcome the current viral pandemic. In this rapid-review, we aim to update the available data on coronavirus with the latest findings and achievements. So far, great steps have been taken such as hrsACE2 by a Swedish team from Karolinska Institute. Monash University announced the efficacy of Ivermectin to overcome COVID-19. The CRISPR/Cas13d as a new innovative therapeutics based might overcome the challenge of COVID-19. those strains of virus which lacking E protein-encoding regions are the perfect choice for vaccine development.

Conflict of interest

The authors confirm that there is no conflict of interest.

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