Ozonated olive oil effects in dentistry: A randomized clinical trial systematic review

Cesare D'Amico; Francesca Gorassini; Fulvia Galletti; Vincenzo Ronsivalle; Toufiq Noor; Felix Amekpor; Gabriele Cervino; Cesare D'Amico; Francesca Gorassini; Fulvia Galletti; Vincenzo Ronsivalle; Toufiq Noor; Felix Amekpor; Gabriele Cervino

doi:10.3934/jdms.2025003

Journal of Dentistry and Multidisciplinary Sciences

2025, Volume 1, Issue 1: 13-30. doi: 10.3934/jdms.2025003

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Review

Ozonated olive oil effects in dentistry: A randomized clinical trial systematic review

1.
Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98100 Messina, Italy
2.
Department of Dental Research Cell, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, (Deemed-to-be-University) Pune 411018, India
3.
FiDent, Centro Medico Odontoiatrico, 89121 Reggio di Calabria, Italy
4.
Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", 80121 Naples, Italy
5.
Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Via S. Sofia 78, 95124 Catania, Italy
6.
Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana

Received: 26 December 2024 Revised: 05 June 2025 Accepted: 18 June 2025 Published: 09 July 2025

Background
Ozonated olive oil (OOO) is emerging as a significant therapeutic agent in dentistry, leveraging its antimicrobial, anti-inflammatory, and healing properties to enhance oral health outcomes. This review synthesizes findings from recent randomized controlled trials to assess the efficacy of OOO in various dental applications, including managing peri-implant mucositis, caries, periodontal disease, and endodontic infections.
Methods
According to the PRISMA guidelines, five studies were included in this systematic review, having met our inclusion criteria.
Results
The studies collectively demonstrate that OOO effectively reduces clinical parameters such as bleeding on probing and probing depth and enhances microbial control in periodontal therapy and root canal treatments. Additionally, OOO's application has significantly improved dentin hypersensitivity, particularly when combined with calcium sodium phosphosilicate.
Conclusions
The results emphasize OOO's promise as a supplementary treatment option, showcasing its capacity to enhance tissue healing while reducing dependence on conventional antibiotics. Further research is necessary to confirm these findings and establish standardized treatment protocols aimed at optimizing the use of OOO in clinical settings.
- olive oil,
- randomized controlled trial,
- ozone therapy,
- oral health
Citation: Cesare D'Amico, Francesca Gorassini, Fulvia Galletti, Vincenzo Ronsivalle, Toufiq Noor, Felix Amekpor, Gabriele Cervino. Ozonated olive oil effects in dentistry: A randomized clinical trial systematic review[J]. Journal of Dentistry and Multidisciplinary Sciences, 2025, 1(1): 13-30. doi: 10.3934/jdms.2025003

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Abstract

Background

Ozonated olive oil (OOO) is emerging as a significant therapeutic agent in dentistry, leveraging its antimicrobial, anti-inflammatory, and healing properties to enhance oral health outcomes. This review synthesizes findings from recent randomized controlled trials to assess the efficacy of OOO in various dental applications, including managing peri-implant mucositis, caries, periodontal disease, and endodontic infections.

Methods

According to the PRISMA guidelines, five studies were included in this systematic review, having met our inclusion criteria.

Results

The studies collectively demonstrate that OOO effectively reduces clinical parameters such as bleeding on probing and probing depth and enhances microbial control in periodontal therapy and root canal treatments. Additionally, OOO's application has significantly improved dentin hypersensitivity, particularly when combined with calcium sodium phosphosilicate.

Conclusions

The results emphasize OOO's promise as a supplementary treatment option, showcasing its capacity to enhance tissue healing while reducing dependence on conventional antibiotics. Further research is necessary to confirm these findings and establish standardized treatment protocols aimed at optimizing the use of OOO in clinical settings.

References

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