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AIMS Biophysics

2025, Volume 12, Issue 1: 43-53. doi: 10.3934/biophy.2025004
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Research article

Thyroid function and hematological alterations in cardiac catheterization workers: a pre-post observational study on x-ray exposure

  • 1.
    Department of Anatomy, Biology, and Histology, College of Medicine, University of Duhok, Duhok, 42001, Iraq
  • 2.
    Department of Medical Physiology and Pharmacology, College of Medicine, University of Duhok, Duhok, 42001, Iraq
  • 3.
    Department of Medicine, College of Medicine, University of Duhok, Duhok, 42001, Iraq
  • 4.
    Department of Anesthesia, College of Health Sciences, University of Duhok, Duhok, 42001, Iraq
  • 5.
    Department of Water Resources, College of Engineering, University of Duhok, Duhok, 42001, Iraq
  • 6.
    Department of Pathology, College of Medicine, University of Duhok, Duhok, 42001, Iraq
  • Received: 25 December 2024 Revised: 01 February 2025 Accepted: 11 February 2025 Published: 17 February 2025

  • Ionizing radiation is a common health risk encountered by healthcare professionals. Previous studies highlighted the potential adverse effects of X-ray exposure, such as metabolic dysfunctions, radiation-induced biological changes, and a susceptibility to infection. The present study examined the long-term effects of radiation exposure on the hematopoietic system and thyroid functions. A cohort of 40 healthcare professionals of various professions working in the cardiac catheterization center at Azadi Teaching Hospital were recruited for this study. After their consent, the necessary data were taken, and blood specimens were collected for the laboratory investigations. The recruits were divided based on x-ray exposure into pre- and post-exposure groups. Concerning the hematological parameters, no significant differences were observed between the groups, except MCH, which was statistically elevated in the post-exposure group (p = 0.000). Among the thyroid hormones, only free T4 was significantly increased in the post-exposed subjects (p = 0.000) as compared to non-exposed controls. Moreover, a positive correlation was observed between the ionizing radiation exposure dosage and T4 elevation (r = 0.362, p = 0.02). The findings collectively highlight the remarkable impact of long-term radiation exposure on thyroid functions and some hematological parameters. Therefore, regular monitoring of health professionals is suggested to avoid the detrimental effects of radiation on human health.

    Citation: Haliz Hussein, Hazhmat Ali, Zeki Mohamed, Majeed Mustafa, Khairi Abdullah, Asaad Alasady, Mayada Yalda. Thyroid function and hematological alterations in cardiac catheterization workers: a pre-post observational study on x-ray exposure[J]. AIMS Biophysics, 2025, 12(1): 43-53. doi: 10.3934/biophy.2025004

    Related Papers:

  • Ionizing radiation is a common health risk encountered by healthcare professionals. Previous studies highlighted the potential adverse effects of X-ray exposure, such as metabolic dysfunctions, radiation-induced biological changes, and a susceptibility to infection. The present study examined the long-term effects of radiation exposure on the hematopoietic system and thyroid functions. A cohort of 40 healthcare professionals of various professions working in the cardiac catheterization center at Azadi Teaching Hospital were recruited for this study. After their consent, the necessary data were taken, and blood specimens were collected for the laboratory investigations. The recruits were divided based on x-ray exposure into pre- and post-exposure groups. Concerning the hematological parameters, no significant differences were observed between the groups, except MCH, which was statistically elevated in the post-exposure group (p = 0.000). Among the thyroid hormones, only free T4 was significantly increased in the post-exposed subjects (p = 0.000) as compared to non-exposed controls. Moreover, a positive correlation was observed between the ionizing radiation exposure dosage and T4 elevation (r = 0.362, p = 0.02). The findings collectively highlight the remarkable impact of long-term radiation exposure on thyroid functions and some hematological parameters. Therefore, regular monitoring of health professionals is suggested to avoid the detrimental effects of radiation on human health.



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    Conflict of interest


    The authors have no conflict of interest to declare.

    Author contributions


    Haliz Hussein and Hazhmat Ali conducted the experiments and drafted the manuscript. Zeki Mohamed analyzed the data. Majeed Mustafa and Khairi Abdullah collected data and recruited patients for the study. Asaad Alasady and Mayada Yalda conceptualized the study, performed critical analysis, and edited the manuscript. Hazhmat Ali supervised the project.

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