Editorial

Biocomplexes in bioengineering: advances in bone repair and regeneration

  • Published: 18 June 2026
  • Citation: Rogério Leone Buchaim. Biocomplexes in bioengineering: advances in bone repair and regeneration[J]. AIMS Bioengineering, 2026, 13(2): 257-260. doi: 10.3934/bioeng.2026011

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    [1] Mangano C, Paino F, d'Aquino R, et al. (2011) Human dental pulp stem cells hook into biocoral scaffold forming an engineered biocomplex. PLoS One 6: e18721. https://doi.org/10.1371/journal.pone.0018721
    [2] Aimetti M, Ferrarotti F, Mariani GM, et al. (2015) Use of dental pulp stem cells/collagen sponge biocomplex in the treatment of non-contained intrabony defects: a case series. Clin Adv Periodontics 5: 104-109. https://doi.org/10.1902/cap.2013.130047
    [3] d'Aquino R, De Rosa A, Lanza V, et al. (2009) Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 18: 75-83. https://doi.org/10.22203/eCM.v018a07
    [4] Petridis X, Diamanti E, Trigas GCh, et al. (2015) Bone regeneration in critical-size calvarial defects using human dental pulp cells in an extracellular matrix-based scaffold. J Craniomaxillofac Surg 43: 483-490. https://doi.org/10.1016/j.jcms.2015.02.003
    [5] Reis CHB, Buchaim RL, Pomini KT, et al. (2022) Effects of a biocomplex formed by two scaffold biomaterials, hydroxyapatite/tricalcium phosphate ceramic and fibrin biopolymer, with photobiomodulation, on bone repair. Polymers 14: 2075. https://doi.org/10.3390/polym14102075
    [6] Buchaim DV, Andreo JC, Pomini KT, et al. (2022) A biocomplex to repair experimental critical size defects associated with photobiomodulation therapy. J Venom Anim Toxins Incl Trop Dis 28: e20210056. https://doi.org/10.1590/1678-9199-JVATITD-2021-0056
    [7] Apatzidou DA, Bakopoulou AA, Kouzi-Koliakou K, et al. (2021) A tissue-engineered biocomplex for periodontal reconstruction: a proof-of-principle randomized clinical study. J Clin Periodontol 48: 1111-1125. https://doi.org/10.1111/jcpe.13474
    [8] Rossi JdO, Araujo EMC, Camargo MEC, et al. (2024) Effectiveness of the association of fibrin scaffolds, nanohydroxyapatite, and photobiomodulation with simultaneous low-level red and infrared lasers in bone repair. Materials 17: 4351. https://doi.org/10.3390/ma17174351
    [9] Buchaim CHB, de Matos BTL, Bueno CRdS, et al. (2026) Biofunctional response of a synthetic ceramic of 99.9% tricalcium phosphate associated with a heterologous fibrin biopolymer and infrared photobiomodulation. Front Bioeng Biotechnol 13: 1748343. https://doi.org/10.3389/fbioe.2025.1748343
    [10] Rossi JO, Rossi GT, Camargo MEC, et al. (2023) Effects of the association between hydroxyapatite and photobiomodulation on bone regeneration. AIMS Bioeng 10: 466-490. https://doi.org/10.3934/bioeng.2023027
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  • © 2026 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
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