The rapid emergence and global spread of multi-drug resistant (MDR) bacteria have rendered many conventional antibiotics ineffective, posing an unprecedented challenge to public health and modern medicine. Resolving this crisis requires innovative treatment strategies that can effectively address the root causes and bring new hope to public health and modern medicine. The escalation of microbial infections and the concurrent rise in antibiotic resistance pose a formidable challenge to global health. Amidst the dwindling efficacy of traditional antibiotics, antimicrobial peptides (AMPs) have emerged as promising therapeutic agents due to their broad-spectrum activity and unique mechanisms of action that offer potential solutions to antibiotic resistance. In this review, we aim to emphasize the significant progress made in the field of antimicrobial peptide research. We particularly emphasize the novel and creative strategies adopted in the key aspects of antimicrobial peptides, namely their design, optimization, and delivery. By doing so, we help shape the future of antimicrobial therapy with innovative methods and help combat infections. We adopt a novel perspective by integrating insights into antibiotics, antimicrobial peptides mechanisms of action with advanced strategies in peptide engineering, and delivery systems, highlighting synergies between antimicrobial peptides and conventional antibiotics. Unlike other researchers, we provide a forward-looking discussion on the translational challenges and opportunities in AMP-based therapies and display it in tabular form, offering actionable guidance for future research and development.
Citation: Yue Xu, Fulei Zhang, Kairui Zhu, Ying Liu, Xuejuan Wang, Yunqi Ma. Novel antimicrobial strategies against infections[J]. AIMS Bioengineering, 2025, 12(1): 22-49. doi: 10.3934/bioeng.2025002
The rapid emergence and global spread of multi-drug resistant (MDR) bacteria have rendered many conventional antibiotics ineffective, posing an unprecedented challenge to public health and modern medicine. Resolving this crisis requires innovative treatment strategies that can effectively address the root causes and bring new hope to public health and modern medicine. The escalation of microbial infections and the concurrent rise in antibiotic resistance pose a formidable challenge to global health. Amidst the dwindling efficacy of traditional antibiotics, antimicrobial peptides (AMPs) have emerged as promising therapeutic agents due to their broad-spectrum activity and unique mechanisms of action that offer potential solutions to antibiotic resistance. In this review, we aim to emphasize the significant progress made in the field of antimicrobial peptide research. We particularly emphasize the novel and creative strategies adopted in the key aspects of antimicrobial peptides, namely their design, optimization, and delivery. By doing so, we help shape the future of antimicrobial therapy with innovative methods and help combat infections. We adopt a novel perspective by integrating insights into antibiotics, antimicrobial peptides mechanisms of action with advanced strategies in peptide engineering, and delivery systems, highlighting synergies between antimicrobial peptides and conventional antibiotics. Unlike other researchers, we provide a forward-looking discussion on the translational challenges and opportunities in AMP-based therapies and display it in tabular form, offering actionable guidance for future research and development.
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Figures(2) / Tables(1)
Yue Xu, Fulei Zhang, Kairui Zhu, Ying Liu, Xuejuan Wang, Yunqi Ma. Novel antimicrobial strategies against infections[J]. AIMS Bioengineering, 2025, 12(1): 22-49. doi: 10.3934/bioeng.2025002
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