Aging and immunity

Ken S. Rosenthal; Ken S. Rosenthal

doi:10.3934/Allergy.2026002

AIMS Allergy and Immunology

2026, Volume 10, Issue 1: 16-20. doi: 10.3934/Allergy.2026002

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Editorial

Aging and immunity

Ken S. Rosenthal ^,

Professor of Immunology, Augusta University/University of Georgia Medical Partnership, Athens GA; Adjunct Professor, Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA; Emeritus Professor, Northeast Ohio Medical University, Rootstown, OH

Received: 05 January 2026 Revised: 05 January 2026 Accepted: 06 January 2026 Published: 06 January 2026

Citation: Ken S. Rosenthal. Aging and immunity[J]. AIMS Allergy and Immunology, 2026, 10(1): 16-20. doi: 10.3934/Allergy.2026002

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Conflicts of interest

Ken S. Rosenthal is a member of the editorial board of the Allergy and Immunology and was not involved in the editorial review or the decision to publish this article. The author declares no conflict of interest.

References

[1]	Rosenthal KS, Baker JB (2022) The immune system through the ages. AIMS Allergy Immunol 6: 170-187. https://doi.org/10.3934/Allergy.2022013
[2]	Arachchige AS (2023) Aging and immunity: Unraveling the complex relationship. AIMS Allergy Immunol 7: 213-221. https://doi.org/10.3934/Allergy.2023015
[3]	Azzi T, Lünemann A, Murer A, et al. (2014) Role for early-differentiated natural killer cells in infectious mononucleosis. Blood 16: 2533-2543. https://doi.org/10.1182/blood-2014-01-553024
[4]	Johnson C, Baldwin A, Bruner LP, et al. (2024) Sex, gender, and other factors that influence infections for men and women. Infect Dis Clin Pract 32: 1405. https://doi.org/10.1097/IPC.0000000000001405
[5]	Sharma S, Gibbons A, Ollmann Saphire E (2025) Sex differences in tissue-specific immunity and immunology. Science 389: 599-603. https://doi.org/10.1126/science.adx4381
[6]	Forsyth KS, Jiwrajka N, Lovell CD, et al. (2024) The conneXion between sex and immune responses. Nat Rev Immunol 24: 487-502. https://doi.org/10.1038/s41577-024-00996-9
[7]	Sandstedt M, Chung R, Skoglund C, et al. (2023) Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8⁺ T cells in a Swedish middle-aged population. Immun Ageing 20: 45. https://doi.org/10.1186/s12979-023-00371-7
[8]	Elyahu Y, Monsonego A (2021) Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair. Ageing Res Rev 65: 101231. https://doi.org/10.1016/j.arr.2020.101231
[9]	Khan N, Shariff N, Cobbold M, et al. (2002) Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 169: 1984-1992. https://doi.org/10.4049/jimmunol.169.4.1984
[10]	Brauning A, Rae M, Zhu G, et al. (2022) Aging of the immune system: Focus on natural killer cells phenotype and functions. Cells 11: 1017. https://doi.org/10.3390/cells11061017
[11]	Su TY, Hauenstein J, Somuncular E, et al. (2024) Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets. Nat Commun 15: 7966. https://doi.org/10.1038/s41467-024-52318-1
[12]	Liu Z, Hu X, Liang Y, et al. (2022) Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche. Nat Immunol 23: 1086-1097. https://doi.org/10.1038/s41590-022-01244-9
[13]	Ahuja SK, Manoharan MS, Lee GC, et al. (2023) Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection. Nat Commun 14: 3286. https://doi.org/10.1038/s41467-023-38238-6
[14]	Ganesan A, Moore AR, Zheng H, et al. (2025) A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response. Immunity 58: 2104-2119.e5. https://doi.org/10.1016/j.immuni.2025.05.020
[15]	Scott D, Bond M, Manning TH, et al. (2023) How are older adults different than other adults for infections?. Infect Dis Clin Pract 31: e119. https://doi.org/10.1097/IPC.0000000000001197
[16]	Quiros-Roldan E, Sottini A, Natali PG, et al. (2024) The impact of immune system aging on infectious diseases. Microorganisms 12: 775. https://doi.org/10.3390/microorganisms12040775
[17]	Gong Q, Sharma M, Glass MC, et al. (2025) Multi-omic profiling reveals age-related immune dynamics in healthy adults. Nature 648: 696-706. https://doi.org/10.1038/s41586-025-09686-5
[18]	Gustafson CE, Kim C, Weyand CM, et al. (2020) Influence of immune aging on vaccine responses. J Allergy Clin Immunol 145: 1309-1321. https://doi.org/10.1016/j.jaci.2020.03.017
[19]	Silva-Moraes V, Reis LR, Ross TM (2025) Comparative analysis of cellular immune responses to four seasonal inactivated influenza vaccines in younger and older adults. J Immunol 2025: vkaf286. https://doi.org/10.1093/jimmun/vkaf286
[20]	Wrona MV, Ghosh R, Coll K, et al. (2024) The 3 I's of immunity and aging: immunosenescence, inflammaging, and immune resilience. Front Aging 5: 1490302. https://doi.org/10.3389/fragi.2024.1490302
[21]	Monti D, Ostan R, Borelli V, et al. (2017) Inflammaging and human longevity in the omics era. Mech Ageing Dev 165: 129-138. https://doi.org/10.1016/j.mad.2016.12.008
[22]	García-Domínguez M (2025) Pathological and inflammatory consequences of aging. Biomolecules 15: 404. https://doi.org/10.3390/biom15030404
[23]	Yu W, Yu Y, Sun S, et al. (2024) Immune alterations with aging: Mechanisms and intervention strategies. Nutrients 16: 3830. https://doi.org/10.3390/nu16223830
[24]	Ayoub M, Abou Jaoude C, Ayoub M, et al. (2026) The immune system and cellular senescence: A complex interplay in aging and disease. Immunology 177: 149-169. https://doi.org/10.1111/imm.70036
[25]	Roark KM, Iffland PH (2025) Rapamycin for longevity: The pros, the cons, and future perspectives. Front Aging 6: 1628187. https://doi.org/10.3389/fragi.2025.1628187
[26]	Widjaja AA, Lim WW, Viswanathan S, et al. (2024) Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632: 157-165. https://doi.org/10.1038/s41586-024-07701-9
[27]	Amor C, Fernández-Maestre I, Chowdhury S, et al. (2024) Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nat Aging 4: 336-349. https://doi.org/10.1038/s43587-023-00560-5

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