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Immunotherapy for synovial sarcoma

  • Received: 21 January 2019 Accepted: 14 July 2019 Published: 13 August 2019
  • Synovial sarcoma (SS) is a relatively common subtype of soft tissue sarcoma that typically affects young adults. Nearly all tumors harbor a translocation between SS18 and SSX1/SSX2 and the vast majority express the cancer testis antigen (CTA) NY-ESO-1. While patients with small, non-metastatic tumors are often cured surgically, outcomes remain poor for patients with locally advanced or metastatic disease, even when aggressive chemotherapy and radiotherapy are employed. Therefore, innovative systemic therapies that target the biology of the disease are needed to improve outcomes for these higher risk patients. One such category is tumor-directed immune therapies. In this review, we will discuss the current status of immunotherapy for SS, including the recent trial results, ongoing challenges, and future directions.

    Citation: Catherine M. Albert, Seth Pollack. Immunotherapy for synovial sarcoma[J]. AIMS Medical Science, 2019, 6(3): 191-200. doi: 10.3934/medsci.2019.3.191

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  • Synovial sarcoma (SS) is a relatively common subtype of soft tissue sarcoma that typically affects young adults. Nearly all tumors harbor a translocation between SS18 and SSX1/SSX2 and the vast majority express the cancer testis antigen (CTA) NY-ESO-1. While patients with small, non-metastatic tumors are often cured surgically, outcomes remain poor for patients with locally advanced or metastatic disease, even when aggressive chemotherapy and radiotherapy are employed. Therefore, innovative systemic therapies that target the biology of the disease are needed to improve outcomes for these higher risk patients. One such category is tumor-directed immune therapies. In this review, we will discuss the current status of immunotherapy for SS, including the recent trial results, ongoing challenges, and future directions.


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    Conflict of interest



    Dr. Pollack receives research funding from Merck, EMD Serono, Incyte, Presage, Janssen, Oncosec and Juno. He receives honoraria from Seattle Genetics, Bayer, Tempus, Daiichi Sankyo and Blueprint Medicine.

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