Export file:

Format

  • RIS(for EndNote,Reference Manager,ProCite)
  • BibTex
  • Text

Content

  • Citation Only
  • Citation and Abstract

Comparative anatomy of the mouse and human ankle joint using Micro-CT: Utility of a mouse model to study human ankle sprains

1 Orthopedic Institute, Medical College, Soochow University, Suzhou, China
2 Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China

Special Issues: Advanced Computer Methods and Programs in Biomedicine

The use of mouse models as a tool to study ankle sprain requires a basic understanding of the similarities and differences between human and mouse ankle joint anatomy. However, few studies have been conducted that address the merits and drawbacks of these differences in the functioning of joints. Twenty hindfoot specimens were obtained from 10 male C57BL/6J mice and scanned using micro-CT. The foot and ankle skeletal structures were reconstructed in three dimensions. Morphological parameters were then measured using a plane projection method and normalized data were compared with those of human ankles. There was no significant difference in the malleolar width, maximal tibial thickness, tibial arc length, trochlea tali arc length or trochlea tali width of the mouse specimens compared with the human model. However, a groove was observed on the talar dome in the mouse specimens which was not observed in humans, the talar dome being more symmetric. The mouse ankle was to a large extent able to mimic the mechanism of a human ankle and so a mouse model could be appropriate for expanding our understanding of ankle biomechanics in general. However, the structural differences in the talar dome in the mouse and human should not be ignored. Although there are some differences in the mouse and human ankle that cannot be ignored, compared to other animals, the human ankle is more similar to that of the mouse.
  Figure/Table
  Supplementary
  Article Metrics

Keywords talocrural joint; musculoskeletal anatomy; talar dome; rodent; foot biomechanics

Citation: Chao Gao, Zhi Chen, Yu Cheng, Junkun Li, Xiaowei Huang, Liangyi Wei, FanHe, Zong-ping Luo, Hongtao Zhang, Jia Yu. Comparative anatomy of the mouse and human ankle joint using Micro-CT: Utility of a mouse model to study human ankle sprains. Mathematical Biosciences and Engineering, 2019, 16(4): 2959-2972. doi: 10.3934/mbe.2019146

References

  • 1. X. Li, D. Fong and K. M. Chan, Kinematic analysis of ankle eversion sprain in sports: two cases during the FIFA world cup, J. Orthop. Transl., 7 (2016), 135.
  • 2. J. M. Conn, J. L. Annest and J. Gilchrist, Sports and recreation related injury episodes in the US population, 1997-99, Inj. Prev., 9 (2003), 117.
  • 3. B. R. Waterman, B. D. Owens, S. Davey, et al., The epidemiology of ankle sprains in the United States., J. Bone Joint Surg. Am., 92 (2010), 2279.
  • 4. W. Niu, J. Yao, Z. W. Chu, et al., Effects of Ankle Eversion, Limb Laterality, and Ankle Stabilizers on Transient Postural Stability During Unipedal Standing, J. Med. Biol. Eng., 35 (2015), 69–75.
  • 5. R. Bahr, F. Pena, J. Shine, et al., Mechanics of the anterior drawer and talar tilt tests. A cadaveric study of lateral ligament injuries of the ankle, Acta Orthop. Scand., 68 (1997), 435.
  • 6. C. M. Gorehamvoss, T. O. Mckinley and T. D. Brown, A finite element exploration of cartilage stress near an articular incongruity during unstable motion, J. Biomech., 40 (2007), 3438–3447.
  • 7. F. Bonnel, E. Toullec and C. Mabit, Chronic ankle instability: Biomechanics and pathomechanics of ligaments injury and associated lesions, Orthop. Traumatol. Surg. Res., 96 (2010), 424–432.
  • 8. H. Fang and F. Beier, Mouse models of osteoarthritis: modelling risk factors and assessing outcomes, Nat. Rev. Rheumatol., 10 (2014), 413–421.
  • 9. K. Lampropoulouadamidou, P. Lelovas, E. V. Karadimas, et al., Papaioannou, Useful animal models for the research of osteoarthritis, Eur. J. Orthop. Surg. Traumatol., 24 (2014), 263–271.
  • 10. P. Fleckman, K. Jaeger, K. A. Silva, et al., Comparative anatomy of mouse and human nail units, Anat. Rec., 296 (2013), 521–532.
  • 11. T. Hubbard-Turner, E. A. Wikstrom, S. Guderian, et al., Acute ankle sprain in a mouse model, Med. Sci. Sports Exerc., 45 (2013), 1623–1628.
  • 12. S. H. Chang, T. Yasui, S. Taketomi, et al., Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability, Osteoarth. Cartil., 24 (2015), 688–697.
  • 13. H. Y. Kim, J. Wang, K. Chung, et al., A surgical ankle sprain pain model in the rat: Effects of morphine and indomethacin, Neurosci. Lett., 442 (2008),161–164.
  • 14. E. A. Wikstrom, T. Hubbardturner, S. Woods, et al., Developing a mouse model of chronic ankle instability, Med. Sci. Sports Exerc., 47 (2015), 866–872.
  • 15. A. Hayes, Y. Tochigi and C. L. Saltzman, Ankle morphometry on 3D-CT images, Iowa Orthop. J., 26 (2006), 1–4.
  • 16. K. I. Vadakkan, Y. H. Jia and M. Zhuo, A behavioral model of neuropathic pain induced by ligation of the common peroneal nerve in mice., J. Pain, 6 (2005), 747–756.
  • 17. M. H. Fessy, J. P. Carret and J. Béjui, Morphometry of the talocrural joint, Surg. Radiol. Anat., 19 (1997), 299–302.
  • 18. R. Stagni, A. Leardini, A. Ensini, et al., Ankle morphometry evaluated using a new semi-automated technique based on X-ray pictures, Clin. Biomech., 20 (2005), 307–311.
  • 19. W. D. Hazelton, G. Goodman, W. N. Rom, et al., Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers, Math. Biosci., 240 (2012), 20–34.
  • 20. S. P. Chakrabarty, F. B. Hanson, Distributed parameters deterministic model for treatment of brain tumors using Galerkin finite element method, Math. Biosci., 219 (2009),129–141.
  • 21. C. C. Kuo, H. L. Lu, A. Leardini, et al., Three-dimensional computer graphics-based ankle morphometry with computerized tomography for total ankle replacement design and positioning, Clin. Anat., 27 (2014), 659.
  • 22. A. Lundberg, I. Goldie, B. Kalin, et al., Kinematics of the ankle/foot complex: plantarflexion and dorsiflexion, Foot Ankle, 9 (1989), 194.
  • 23. J. Yu, W. C. Wong, H. Zhang, et al., The influence of high-heeled shoes on strain and tension force of the anterior talofibular ligament and plantar fascia during balanced standing and walking, Med. Eng. Phys., 38 (2016), 1152–1156.
  • 24. J. P. Charles, O. Cappellari, A. J. Spence, et al., Musculoskeletal geometry, muscle architecture and functional specialisations of the mouse hindlimb, PLOS ONE, 11 (2016), e147669.
  • 25. A. Delaurier, N. Burton, M. Bennett, et al., The Mouse Limb Anatomy Atlas: an interactive 3D tool for studying embryonic limb patterning, BMC Dev. Biol., 8 (2008), 83.
  • 26. W. L. Johnson, D. L. Jindrich, R. R. Roy, et al., A three-dimensional model of the rat hindlimb: musculoskeletal geometry and muscle moment arms, J. Biomech., 41 (2008), 610–619.
  • 27. T. R. Olson and M. R. Seidel, The evolutionary basis of some clinical disorders of the human foot: a comparative survey of the living primates, Foot Ankle, 3 (1983), 322.
  • 28. W. C. H. Parr, C. Soligo, J. Smaers, et al., Three-dimensional shape variation of talar surface morphology in hominoid primates, J. Anat., 225 (2014), 42–59.
  • 29. S. Duce, L. Madrigal, K. Schmidt, et al., Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot, J. Anat., 216 (2010), 108.
  • 30. D. Youlatos and J. Meldrum, Locomotor diversification in new world monkeys: running, climbing, or clawing along evolutionary branches, Anat. Rec., 294 (2011), 1991–2012.
  • 31. Q. Huang, X. Huang, L. Liu, et al., A case-oriented web-based training system for breast cancer diagnosis, Comput. Meth. Prog. Bio.
  • 32. V. Kuhn, N. Ivanovic and W. Recheis, High resolution 3D-printing of trabecular bone based on micro-CT data, J. Orthop. Transl., 2 (2014), 238.

 

Reader Comments

your name: *   your email: *  

© 2019 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

Download full text in PDF

Export Citation

Copyright © AIMS Press All Rights Reserved