Stability and Hopf bifurcation analysis for a Lac operon model with nonlinear degradation rate and time delay

1.
Department of Mathematics, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
2.
Department of Mathematics, University of Thi-Qar, Nasiriyah, Iraq
3.
College of Mathematics and Information Sciences, Henan Normal University, Xinxiang 453007, Henan, P.R., China

Received: 19 November 2018 Accepted: 02 February 2019 Published: 04 March 2019

Abstract
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In this paper, we construct a discrete time delay Lac operon model with nonlinear degradation rate for mRNA, resulting from the interaction among several identical mRNA pieces. By taking a discrete time delay as bifurcation parameter, we investigate the nonlinear dynamical behaviour arising from the model, using mathematical tools such as stability and bifurcation theory. Firstly, we discuss the existence and uniqueness of the equilibrium for this system and investigate the effect of discrete delay on its dynamical behaviour. Absence or limited delay causes the system to have a stable equilibrium, which changes into a Hopf point producing oscillations if time delay is increased. These sustained oscillation are shown to be present only if the nonlinear degradation rate for mRNA satisfies specific conditions. The direction of the Hopf bifurcation giving rise to such oscillations is also determined, via the use of the so-called multiple time scales technique. Finally, numerical simulations are shown to validate and expand the theoretical analysis. Overall, our findings suggest that the degree of nonlinearity of the model can be used as a control parameter for the stabilisation of the system.
- Lac operon model,
- stability analysis,
- Hopf bifurcation,
- nonlinear degradation,
- gene expression
Citation: Zenab Alrikaby, Xia Liu, Tonghua Zhang, Federico Frascoli. Stability and Hopf bifurcation analysis for a Lac operon model with nonlinear degradation rate and time delay[J]. Mathematical Biosciences and Engineering, 2019, 16(4): 1729-1749. doi: 10.3934/mbe.2019083

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Abstract

In this paper, we construct a discrete time delay Lac operon model with nonlinear degradation rate for mRNA, resulting from the interaction among several identical mRNA pieces. By taking a discrete time delay as bifurcation parameter, we investigate the nonlinear dynamical behaviour arising from the model, using mathematical tools such as stability and bifurcation theory. Firstly, we discuss the existence and uniqueness of the equilibrium for this system and investigate the effect of discrete delay on its dynamical behaviour. Absence or limited delay causes the system to have a stable equilibrium, which changes into a Hopf point producing oscillations if time delay is increased. These sustained oscillation are shown to be present only if the nonlinear degradation rate for mRNA satisfies specific conditions. The direction of the Hopf bifurcation giving rise to such oscillations is also determined, via the use of the so-called multiple time scales technique. Finally, numerical simulations are shown to validate and expand the theoretical analysis. Overall, our findings suggest that the degree of nonlinearity of the model can be used as a control parameter for the stabilisation of the system.

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