Dynamic Multidrug Therapies for HIV: Optimal and STI Control Approaches
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Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC 27695
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Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC 27695-8212
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Accepted:
29 June 2018
Published:
01 July 2004
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MSC :
34H05, 37M05, 49K15, 65L05, 92B05, 92C60.
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We formulate a dynamic mathematical model that describes the
interaction of the immune system with the human immunodeficiency
virus (HIV) and that permits drug ''cocktail'' therapies. We
derive HIV therapeutic strategies by formulating and analyzing an
optimal control problem using two types of dynamic treatments
representing reverse transcriptase (RT) inhibitors and protease
inhibitors (PIs). Continuous optimal therapies are found by
solving the corresponding optimality systems. In addition, using
ideas from dynamic programming, we formulate and derive suboptimal
structured treatment interruptions (STI) in antiviral therapy that
include drug-free periods of immune-mediated control of HIV. Our
numerical results support a scenario in which STI therapies can
lead to long-term control of HIV by the immune response system
after discontinuation of therapy.
Citation: B. M. Adams, H. T. Banks, Hee-Dae Kwon, Hien T. Tran. Dynamic Multidrug Therapies for HIV: Optimal and STI Control Approaches[J]. Mathematical Biosciences and Engineering, 2004, 1(2): 223-241. doi: 10.3934/mbe.2004.1.223
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Abstract
We formulate a dynamic mathematical model that describes the
interaction of the immune system with the human immunodeficiency
virus (HIV) and that permits drug ''cocktail'' therapies. We
derive HIV therapeutic strategies by formulating and analyzing an
optimal control problem using two types of dynamic treatments
representing reverse transcriptase (RT) inhibitors and protease
inhibitors (PIs). Continuous optimal therapies are found by
solving the corresponding optimality systems. In addition, using
ideas from dynamic programming, we formulate and derive suboptimal
structured treatment interruptions (STI) in antiviral therapy that
include drug-free periods of immune-mediated control of HIV. Our
numerical results support a scenario in which STI therapies can
lead to long-term control of HIV by the immune response system
after discontinuation of therapy.
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