
Vestibular Migraine (VM) is a complex neurological disorder characterized by episodic vertigo and migraine-like symptoms and is often misdiagnosed due to overlapping features with other vestibular and neurological conditions. In this review, we systematically explored the efficacy of exogenous (e.g., repetitive transcranial magnetic stimulation (rTMS) and transient DC Stimulation (tDCS)) and endogenous (e.g., EEG and infra-low frequency neurofeedback) neuromodulation techniques in diagnosing and managing vestibular disorders and migraines, with its relevance to VM. Analysis of 30 selected studies demonstrated promising outcomes in symptom reduction, with notable effectiveness in refractory and chronic cases. Studies involving both neuromodulation techniques improve various symptoms of vestibular disorders and migraine, positioning neuromodulation as a valuable adjunct to the available standard care being employed with patients. Given the pathophysiological overlap between migraine and vestibular dysfunction, particularly involving cortical excitability, GABAergic inhibition, and hypothalamic-trigeminal dysregulation, neuromodulation offers a non-invasive, safe, and targeted approach for long-term VM management. Further high-quality clinical trials are warranted to establish standardized protocols and confirm the long-term efficacy of these neuromodulation modalities.
Citation: Dinesh Bhatia, Koyel Das, Tania Acharjee, Henry Benson Nongrum. Exploring the effectiveness of neuromodulation techniques in the diagnosis and management of vestibular disorders and migraine and its relevance to vestibular migraine[J]. AIMS Biophysics, 2025, 12(2): 221-258. doi: 10.3934/biophy.2025013
[1] | Jaouhra Cherif, Anis Raddaoui, Ghofrane Ben Fraj, Asma Laabidi, Nada Souissi . Escherichia coli's response to low-dose ionizing radiation stress. AIMS Biophysics, 2024, 11(2): 130-141. doi: 10.3934/biophy.2024009 |
[2] | Zubaidah Ningsih, James W.M. Chon, Andrew H.A. Clayton . A Microfluidic Device for Spatiotemporal Delivery of Stimuli to Cells. AIMS Biophysics, 2015, 2(2): 58-72. doi: 10.3934/biophy.2015.2.58 |
[3] | Michael R Hamblin . Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophysics, 2017, 4(3): 337-361. doi: 10.3934/biophy.2017.3.337 |
[4] | Aaron Lerner, Torsten Matthias . Don’t forget the exogenous microbial transglutaminases: it is immunogenic and potentially pathogenic. AIMS Biophysics, 2016, 3(4): 546-552. doi: 10.3934/biophy.2016.4.546 |
[5] | Dr. P. Esther Rani, B.V.V.S.R.K.K. Pavan . Multi-class EEG signal classification with statistical binary pattern synergic network for schizophrenia severity diagnosis. AIMS Biophysics, 2023, 10(3): 347-371. doi: 10.3934/biophy.2023021 |
[6] | Judit Faus-Garriga, Isabel Novoa, Andrés Ozaita . mTOR signaling in proteostasis and its relevance to autism spectrum disorders. AIMS Biophysics, 2017, 4(1): 63-89. doi: 10.3934/biophy.2017.1.63 |
[7] | Etimad Alattar, Khitam Alwasife, Eqbal Radwan . Effects of treated water with neodymium magnets (NdFeB) on growth characteristics of pepper (Capsicum annuum). AIMS Biophysics, 2020, 7(4): 267-290. doi: 10.3934/biophy.2020021 |
[8] | Etimad Alattar, Khitam Elwasife, Eqbal Radwan . Effects of magnetic field treated water on some growth parameters of corn (Zea mays) plants. AIMS Biophysics, 2021, 8(3): 267-280. doi: 10.3934/biophy.2021021 |
[9] | Yun Chen, Bin Liu, Lei Guo, Zhong Xiong, Gang Wei . Enzyme-instructed self-assembly of peptides: Process, dynamics, nanostructures, and biomedical applications. AIMS Biophysics, 2020, 7(4): 411-428. doi: 10.3934/biophy.2020028 |
[10] | Marek K. Korzeniowski, Barbara Baird, David Holowka . STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain. AIMS Biophysics, 2016, 3(1): 99-118. doi: 10.3934/biophy.2016.1.99 |
Vestibular Migraine (VM) is a complex neurological disorder characterized by episodic vertigo and migraine-like symptoms and is often misdiagnosed due to overlapping features with other vestibular and neurological conditions. In this review, we systematically explored the efficacy of exogenous (e.g., repetitive transcranial magnetic stimulation (rTMS) and transient DC Stimulation (tDCS)) and endogenous (e.g., EEG and infra-low frequency neurofeedback) neuromodulation techniques in diagnosing and managing vestibular disorders and migraines, with its relevance to VM. Analysis of 30 selected studies demonstrated promising outcomes in symptom reduction, with notable effectiveness in refractory and chronic cases. Studies involving both neuromodulation techniques improve various symptoms of vestibular disorders and migraine, positioning neuromodulation as a valuable adjunct to the available standard care being employed with patients. Given the pathophysiological overlap between migraine and vestibular dysfunction, particularly involving cortical excitability, GABAergic inhibition, and hypothalamic-trigeminal dysregulation, neuromodulation offers a non-invasive, safe, and targeted approach for long-term VM management. Further high-quality clinical trials are warranted to establish standardized protocols and confirm the long-term efficacy of these neuromodulation modalities.
Auditory Brainstem Evoked Potential;
Anterior Inferior Cerebellar Artery;
Central motor conduction time;
Cerebrospinal Fluid;
Cortical Stimulation Silent Period;
Cortical Spreading Depression;
Deep brain stimulation;
Dizziness Handicap Index;
Dorsolateral Prefrontal Cortex;
Electromyography;
International Classification of Headache Disorders;
Motor-evoked potentials;
Mal de debarquement syndrome;
Migraine Disability Assessment Scale;
Magnetic Vestibular Stimulation;
Superior Olivary Complex;
Repetitive Transcranial Magnetic Stimulation;
Resting motor threshold;
Persistent post-concussion syndrome;
Just above the occipital point;
Randomized Controlled Trials;
Single-Pulse Transcranial Magnetic Stimulation;
Transcranial Direct Current Stimulation;
Trigeminovascular system;
Traumatic Brain Injury;
Transcranial Electromagnetic Stimulation;
Trigeminovascular system;
Vestibular Migraine;
Vestibular Rehabilitation Therapy;
Ventral Posteriomedial Nucleus;
Videonystagmography;
Infra-Low frequency
It is universally acknowledged that multi-agent cooperative control has a lot of applications, such as unmanned air vehicles, traffic control, animal groups and automated highway systems [1,2,3,4]. The cooperative control consensus that has received a lot of attention can be roughly divided into leader-follower consensus and leaderless consensus [5,6]. Most of the research aims have been to design a consensus protocol to make agents exchange local information with their neighbors, so that a cluster of agents are capable of achieving the consistent state.
As a paradigmatic instance, a digital microprocessor is installed in each agent of the system, which is responsible for gathering information from its neighboring agents and updating the controller accordingly. The majority of research studies utilize continuous measurement signals, yet continuous communication in a constrained energy exchange network is not feasible. In order to avoid continuous communication, some studies have introduced sampling data control [7,8,9], and each agent transmits the corresponding data at the sampling instants. Control using periodic sampling data often requires estimation of an optimal sampling period since improper selection can result in either excessively frequent or infrequent sampling, both of which can be detrimental to system performance. Stochastic sampling can better solve this problem. Stochastic sampling has been gaining increasing attention due to its flexibility in terms of dynamically switching sampling periods between different values. In [10], the authors investigated the leaderless multi-agent consensus problem under stochastic sampling, where the sampling period was chosen randomly at a given value.
Compared to the conventional time-triggered mechanism, the utilization of an event-triggered mechanism presents a significant advantage in terms of improving the efficiency of communication resource allocation. Research on event-triggered mechanisms has been extensively conducted in various fields, including cyber-physical systems [11], cyber-control systems [12] and multi-agent systems [13,14,15,16]. To solve the high-order multi-agent consensus problem, in [16], Wu et al. presented by estimating the state of neighbor agents, a novel event-triggered protocol. For further research, many scholars put forward dynamic event-triggered protocol [17,18,19,20,21]. In [17], a dynamic event-triggered protocol was proposed for individual agents, which established a distributed adaptive consensus protocol. This protocol involves updating the coupling strength to achieve consensus among the agents. A dynamic event-triggered protocol was proposed in [20] for the investigation of consensus in multi-agent systems. This protocol involved internal dynamic variables, and the elimination of Zeno behavior played an important role. In [21], Du et al. studied the multi-agent problem of leader-follower consensus based on a dynamic event-triggered mechanism. However, since event-triggered control has its own limitation, there is a need for continuous event detection. To loosen that constraint, many researchers designed an event-triggered protocol based on sampling data [22,23,24]. The authors presented research on event-triggered consensus strategies for multi-agent systems in [25] and [26]. Specifically, Su et al. investigated sampled data-based leader-follower multi-agent systems with input delays, with a focus on making sampling-based mechanisms for event detection more realistic. Meanwhile, He et al. focused on mean-square leaderless consensus for networked non-linear multi-agent systems and presented an efficiently distributed event-triggered mechanism that reduces communication costs and controller updates for random sampling-based systems. In [27], Ruan et al. studied the consensus problem with bounded external disturbances under an event-triggered scheme based on two independent dynamic thresholds in the context of leader-follower dynamics. The authors presented a nonlinear dynamic event-triggered control strategy for achieving prescribed-time synchronization in networks of piecewise smooth systems in [28].
The above studies are mostly the ones based on the fixed topology of multiple agents. A large number of switching topologies, some of which are studied by establishing Markov models, can be observed in our real world [29,30,31]. In [29], Hu et al. investigated the multi-agent consensus of Markov jump systems based on event-triggered strategies. In [30,31], the scholars studied consensus issues in multi-agent systems with a Markov network structure. Nevertheless, the application of time-varying topology based on Markov processes has certain limitations, primarily due to the exponential distribution of jump times in Markov chains. Some researchers have focused on semi-Markovian jump topologies [32,33,34,35,36]. This is because the sojourn time in the semi-Markovian exchange topology is a generic continuous random variable. Its probability distribution is general. The H∞ consensus problem for multi-agent systems in a semi-Markov switching topology with incomplete known transmission rates was investigated in [35]. In a related research study by Xie et al. [36], the consensus problem of multi-agent systems was investigated under an attack scenario in which both the semi-Markov switching topology and network were susceptible to attacks, with the possibility of recovery. In [37], the authors presented a study on achieving cluster synchronization in finite/fixed time for semi-Markovian switching T−S fuzzy complex dynamical networks with discontinuous dynamic nodes.
Building upon the aforementioned literature review, this research article is focused on the development and analysis of an event-triggered mechanism for the stochastic sampling of leader-follower multi-agent systems. The key contributions of this study can be summarized as follows:
(1). This paper proposes a novel event-triggered methodology by utilizing stochastic sampling, which is capable of significantly reducing the frequency of control updates and communication overhead among agents. Furthermore, the proposed mechanism ensures the avoidance of Zeno behavior.
(2). The dynamic system switching investigated in this paper is modeled by using the semi-Markov jump process. A sufficient condition for mean-square consensus is derived.
(3). The sampling period of stochastic sampling is randomly selected from a finite set. Stochastic sampling differs from the periodic sampling and stochastic sampling in the literature [26,29].
The subsequent sections of this article are organized as follows. Section Ⅱ presents the problem formulation and introductory suggestions. Section Ⅲ reports the major findings. The numerical tests in Section Ⅳ validate the accuracy of the theoretical conclusions. Section Ⅴ concludes with final remarks.
Notations: The n-dimensional identity matrix is denoted by In. A zero matrix of appropriate dimension is represented by O. A positive (negative) definite matrix A is denoted by A>0 (A<0). The element implied by the symmetry of a matrix is denoted by ∗. The function C([a,b],Rn) maps the interval [a,b] to a continuous vector-valued function Rn. The Euclidean norm of a vector is represented by |⋅|. A superscript T and the symbol ⊗ indicate matrix transposition and the Kronecker product, respectively. Let IN={1,2,…,N} denote a finite index set.
We consider a directed graph, denoted by G={V,E,A}, where V represents a set of vertices {1,2,…,N}, E denotes a set of directed edges and A is a weighted adjacency matrix of size N×N. The elements of A, denoted by aij, are positive if there exists a directed edge going from vertex i to vertex j, and zero otherwise. We can refer to the set of neighbors of vertex i as Ni, which is defined as Ni={j∈V:(j,i)∈E}. The degree matrix D is defined as a diagonal matrix of size N×N, where the diagonal entries di represent the weighted degree of vertex i. Specifically, di=∑j∈Niaij. The Laplacian matrix of G is defined as L=D−A=(lij)N×N. The diagonal entries of L are given by lii=−∑j∈Nilij, and the off-diagonal entries are defined as follows: lij=−aij if (i,j) is an edge in G; otherwise, lij=0.
Consider a multi-agent system that has a leader and N followers. Label them respectively as 0 and 1,2,3,…,N. The dynamic equations for each agent are illustrated below:
{˙xi(t)=A(r(t))xi(t)+B(r(t))ui(t),i∈IN,˙x0(t)=A(r(t))x0(t). | (2.1) |
The control input and state for the ith state are denoted by ui(t)∈Rn and xi∈Rn, respectively. A state of x0(t)∈Rn indicates the leader agent. The constant matrices A(r(t)) and B(r(t)) have the appropriate dimensions. The semi-Markov chain {r(t),t≥0} is a right-continuous process defined on the complete probability space (Ω,F,P), where its values belong to the finite state space D=IM and its generators are denoted by λ=(λmn(v))M×M. The transition probabililty is
Pr{r(t+v)=n∣r(t)=m}={λmn(v)v+o(v)m≠n,1+λmn(v)v+o(v)m=n. | (2.2) |
v is the time interval, which stands for the amount of time that passes between two successive jumps. The transition rate from mode m at time t to mode n at time t+v is denoted by λmn(v), and it satisfies λmn(v)≥0. o(v) can be defined as limv→0+o(v)v=0. λmm(v)=−∑m≠nλmn(v).
Remark 1: The dwell time v is the time elapsed from the last jump of the system, and it is distinct from the time t. When the system jumps, v resets to 0 and the transition probability λmn(v) only depends on v.
A consensus protocol for event-triggered consensus that is grounded in the stochastic sampling of data is presented. Assuming that the sampling time is 0=t0<t1<t2<⋯<ts<⋯, the sampling period is h=ts+1−ts, in which h is selected from a random finite set h1,h2,⋯,hl. The probability is described as Pr{h=hs}=πs, s∈Il, πs∈[0,1], and ∑ls=1πs=1. For the sake of generality, we can set 0=h0<h1<h2<⋯<hs<⋯<hl,l>1.
Assuming that the ith agent has a K-time event-triggered time of tik, {tik}∞k=0 represents the event-triggered time sequence of the ith agent, tik∈{ts,s∈N}, ti0=0. tik+1represents the next event-triggering time of the ith agent, which is determined by the following formula
tik+1=mints>tk{ts:(ei(ts))TΦ(ei(ts))>σi(zi(ts))TΦ(zi(ts))}. | (2.3) |
The threshold parameter is represented in this case by σi>0. A positive definite event-triggered matrix is the intended matrix of matrix Φ. ei(ts)=xi(tik)−xi(ts) and zi(ts)=∑Nj=1aij(xi(tik)−xj(tjk′))+bi(xi(tik)−x0(ts)), where ts∈[tik,tik+1). tik′ is the latest transmitted sampled data of its neighbors before tik, that is tjk′=max{tjk∣tjk≤tik}, k′=0,1,2,⋯.
Remark 2: The stochastic sampling sequence is 0=t0<t1<t2<⋯<ts<⋯. The sampling period is h=ts+1−ts, where h is selected from a random finite set {h1,h2,⋯,hl}, where 0=h0<h1<h2<⋯<hl. This stochastic sampling differs from the periodic sampling and stochastic sampling in the literature [26,29]. They represent the special form of stochastic sampling when h is constant and l equals 2.
Remark 3: In accordance with the event-triggered condition (2.3), the ith agent broadcasts the most recent sampled data to its neighbors. The sampling sequence includes the event-triggered sequence because the sampling period h=ts+1−ts is stochastic in the set of {h1,h2,⋯,hl},h>0. Zeno behavior is precisely precluded.
Remark 4: It should be noted that in an attempt to decrease unnecessary communication between agents, a stochastic sampling static event-triggered protocol is proposed.
The following consensus protocol should be taken into consideration in light of the discussion above:
ui(t)=−K(r(t))[N∑j=1aij(xi(tik)−xj(tjk′))+bi(xi(tik)−x0(ts))]. | (2.4) |
Remark 5: The consensus protocol relies upon the stochastic sampling of event-triggered conditions as well as upon a semi-Markov switching system, where the feedback gain K(r(t)) depends on r(t), which will be given by a theorem later. When the ith agent and its neighbor agents satisfy the trigger conditions, the controller will be updated. With a zero-order holder, ui(t) remains constant between two successive event instants.
Define
ei(ts)=xi(tik)−xi(ts),ej(ts)=xj(tjk′)−xj(ts),δi(ts)=xi(ts)−x0(ts). | (2.5) |
Submitting (2.5) into (2.4), we can obtain
ui(t)=−K(r(t))[N∑j=1lij(ej(ts)+δj(ts))+bi(ei(ts)+δi(ts))]. | (2.6) |
Define τ(t)=t−ts, where τ(t) is a piecewise linear function with a slope of ˙τ(t)=1 for all t∈[ts,ts+1), except at time ts. The control protocol (2.6) may be expressed as
ui(t)=−K(r(t))[N∑j=1lij(ej(t−τ(t))+δj(t−τ(t)))+bi(ei(t−τ(t))+δi(t−τ(t)))]. | (2.7) |
A new stochastic variable is introduced as follows:
βs(t)={1ts−1≤τ(t)<ts,s=1,2,⋯,l0 otherwise. | (2.8) |
In this way, we can obtain
Pr{βs(t)=1}=Pr{ts−1≤τ(t)<ts}=l∑i=sπihi−hi−1hi=βs. | (2.9) |
The Bernoulli distribution is satisfied by βs(t), given that E{βs(t)}=βs and E{βs(t)−β2s}=βs(1−βs) respectively. We can obtain the calculation of the following formula from the above study:
˙δ(t)=(IN⊗A(r(t)))δ(t)−l∑s=1βs(t)(H⊗B(r(t))K(r(t)))e(t−τs(t))−l∑s=1βs(t)(H⊗B(r(t))K(r(t)))δ(t−τs(t)), | (2.10) |
where δ=diag{δ1,δ2,⋯,δN}, H=L+B1, B1=diag{b1,b2,⋯,bN}.
According to the initial conditions of Equation (2.10), let δ(t)=ϕ(t),−hl≤t≤0, ϕ(t)=[ϕT1(t),ϕT2(t),⋯,ϕTN(t)] and ϕi(t)∈C([−hl,0],Rn).
Definition 1 [34]. Under semi-Markov switching topologies, the leader-follower consensus of multi-agent system (2.1) with the consensus protocol is said to be achieved if limt→∞E‖xi(t)−x0(t)‖=0, i∈IN holds for any initial distribution r0∈D and any initial condition ϕ(t),∀t∈[−hl,0].
Assumption 1. The directed spanning tree in the network graph G has the leader's root.
Lemma 1 [34]. For symmetric matrices R>0 and X and any scalar μ, the following inequality holds:
−XR−1X≤μ2R−2μX. |
Theorem 1. Under Assumption 1 and utilizing the protocol given by (2.7), the constants provided are 0=h0<h1<⋯<hs<⋯<hl and πi∈[0,1], σi>0, i∈IN. Consensus can be achieved in the mean-square sense for the multi-agent system (2.10) by employing the stochastic sampling event-triggered strategy given by (2.3), provided that constant metrics are present, namely P(m)>0,Qs>0,Rs>0,Ws>0,m∈Dands∈Il. In such a way, the inequality below holds:
(ΞFT(m)Σ(m,v)∗Ψ0∗∗−X2(m))<0, | (3.1) |
where
Ξ=ℵ1+ℵ2+ℵ3+ℵ4+ℵ5+ℵ6.
ℵ1=FT(m)(IN⊗P(m))ε1+εT1(IN⊗P(m))F(m)+M∑n=1λmn(v)(εT1(IN⊗P(n))ε1).
ℵ2=β1εT1(IN⊗Qs)ε1−β1εTl+1(IN⊗Qs)εi+1+l∑s=2βs(εTl+s(IN⊗Qs)εl+s−εTl+s+1(IN⊗Qs)εl+s+1).
ℵ3=−l∑s=1βs1hs−hs−1((εTl+s−εTl+s+1)×(IN⊗(Rs+Ws))(εl+s−εl+s+1)).
ℵ4=εT1(IN⊗P(m))ε1.
ℵ5=−∑ls=1βsεTs+1Φεs+1.
ℵ6=(εs+1+ε2l+s+1)T(HTΛH⊗Φ)(εs+1+ε2l+s+1).
F(m)=(IN⊗A(m))ε1−l∑s=1βs(H⊗B(m)K(m))ε2l+s+1−l∑s=1βs(H⊗B(m)K(m))εs+1.
Φ=diag{Φ1,Φ2,⋯,ΦN}, Σ(m,v)=λ(m,v)X1(m).
Ψ=−(∑ls=1βs(hs−hs−1)(IN⊗(Rs+Ws)))−1.
λ(m,v)=(√λm1(v),√λm2(v),⋯,√λmm−1(v),√λmm+1(v),⋯,√λmM(v)).
X1(m)=diag{IN⊗P(m),⋯,IN⊗P(m)}M−1.
X2(m)=diag{IN⊗P(1),IN⊗P(2),⋯,IN⊗P(m−1),IN⊗P(m+1),⋯,IN⊗P(M)}M−1.
A(m)=A(r(t)=m),P(m)=P(r(t)=m) and βs is defined the same way as in (2.10). Define εs as a block matrix consisting of 3l+1 block elements. The s-th block element is an Nn×Nn identity matrix, denoted by INn, while all other block elements are zero matrices. Therefore, εs can be expressed as εs=[0,0,⋯,INn,0,0,⋯,0]∈RNn×(3l+1)Nn for s=1,2,⋯,3l+1.
Proof of Theorem 1. Think about the Lyapunov-Krasovskii functional presented as follows:
V(t,δt,˙δt,r(t))=3∑i=1Vi(t,δt,˙δt,r(t)),t∈[ts,ts+1], | (3.2) |
where
V1(t,δt,˙δt,r(t))=δT(t)(IN⊗P(r(t)))δ(t), | (3.3) |
V2(t,δt,˙δt)=l∑s=1βs∫t−hs−1t−hsδT(μ)×(IN⊗Qs)δ(μ)dμ, | (3.4) |
V3(t,δt,˙δt)=l∑s=1βs∫−hs−1−hs∫tt+v˙δT(μ)(IN⊗(Rs+Ws))˙δ(μ)dμdv. | (3.5) |
Consider the weak infinitesimal generator
ℑV(t,zt)=limΔ→0+1Δ{E{V(t+Δ,δt+Δ,˙δt+Δ,r(t+Δ))∣δt,r(t)=m}−V(t,δt,˙δt,r(t))}. | (3.6) |
Introduce y(t)=(δT(t),δT(t−τ1(t)),⋯,δT(t−τl(t)),δT(t−h1),⋯, δT(t−hl),eT(t−τ1(t)),⋯,eT(t−τl(t))),y(t)∈R(3l+1)Nn, A(m)=A(r(t)=m),P(m)=P(r(t)=m),∀m∈D.
Thus, we obtain
E[ℑV1(t,δt,˙δt,r(t))]=E[limΔ→0+1Δ{E{V1(t+Δ,δt+Δ,˙δt+Δ,r(t+Δ)∣δt,r(t)=m)}−V1(t,δi,˙δi,r(t))}]=E[yT(t)(FT(m)(IN⊗P(m))ε1+ετ1(IN⊗P(m))F(m)+M∑n=1λmn(v)ετ1(IN⊗P(n))ε1)y(t)], | (3.7) |
where
F(m)=(IN⊗A(m))ε1−l∑s=1βs(H⊗B(m)K(m))ε2l+s+1−l∑s=1βs(H⊗B(m)K(m))εs+1. |
E[ℑV2(t,δi,˙δt)]=E{yT(t)(β1δT(t−h0)(IN⊗Q1)δ(t−h0)−β1δT(t−h1)(IN⊗Q1)δ(t−h1)+l∑s=2βs(δT(t−hs−1)(IN⊗Qs)δ(t−hs−1)−δT(t−hs)(IN⊗Qs)δ(t−hs)))y(t)}, | (3.8) |
and
E[ℑV3(t,δt,˙δt)]=E[l∑s=1βs(hs−hs−1)˙δT(t)(IN⊗(Rs+Ws))˙δ(t)−l∑s=1βs∫t−hs−1t−hs˙δT(v)(IN⊗(Rs+Ws))˙δ(v)dv]. | (3.9) |
According to Jensen's inequality, it can be obtained that
−l∑s=1βs∫t−hs−1t−hs˙δT(ν)(IN⊗(Rs+Ws))˙δ(ν)dν≤−l∑s=1βs1hs−hs−1∫t−hs−1t−hs˙δT(ν)dν×(IN⊗(Rs+Ws))∫t−hs−1t−hs˙δ(ν)dν. | (3.10) |
Submit (2.10) and (3.10) into (3.9), and we can obtain
E[ℑV3(t,δt,˙δt,r(t))]≤yT(t)[l∑s=1βs(hs−hs−1)×FT(m)(IN⊗(Rs+Ws))F(m)−l∑s=1βs1hs−hs−1(εTl+s−εTl+s+1)×(IN⊗(Rs+Ws))(εTl+s−εTl+s+1)]y(t). | (3.11) |
From (2.3), we can obtain
eT(t−τs)Φe(t−τs)≤zT(t−τs)(Λ⊗Φ)z(t−τs)=(δ(t−τs)+e(t−τs))T(HTΛH⊗Φ)×(δ(t−τs)+e(t−τs)), | (3.12) |
where e(t−τs)=col{e1(t−τs),e2(t−τs),⋯,eN(t−τs)}, Λ=diag{σ1,σ2,⋯,σN}. Additionally, z(t−τs)=col{z1(t−τs),z2(t−τs),⋯,zN(t−τs)}.
Thus, combine (3.8–3.10) with (3.11), and we can obtain
E[ℑV(t,δt,˙δt,r(t))]≤E[yT(t)l∑s=1βs(Ξ−ETs+1ΦEs+1+(Es+1+E2l+s+1)T(HTΛH⊗Φ)(Es+1+E2l+s+1)]y(t), | (3.13) |
and
E[ℑV(t,δt,˙δt,r(t))]≤E[yT(t)l∑s=1βs(Ξ−ETs+1ΦEs+1+(Es+1+E2l+s+1)T(HTΛH⊗Φ)(Es+1+E2l+s+1)]y(t). | (3.14) |
Applying the Schur complement and (3.1) leads to the conclusion that
E[ℑV(t,δt,˙δt,r(t))]<0, | (3.15) |
where
Ξ=ℵ1+ℵ2+ℵ3+ℵ4+ℵ5+ℵ6. |
Hence, the consensus (3.1) of the multi-agent system can be attained in a mean squared sense under the event-triggered method given by (2.3).
Keeping Theorem 1's results in mind, this method provides an efficient approach to design consensus controller gains.
Theorem 2. Under Assumption 1, and by utilizing the protocol given by (2.7), we have the following constants 0=h0<h1<⋯<hs<⋯<hl,πi∈[0,1],σi>0,i∈IN and μ>0. The multi-agent system consensus (2.10) can be achieved in the mean-square sense with the stochastic sampled even-triggered strategy (2.3) if there exist the matrices ˆP(m)>0,ˆQs>0,ˆRs>0,ˆWs>0 and ˆΦ>0 and the matrices ˆK(m),m∈D and s∈Il satisfy the following inequality:
(ˆΞ(hm−h(m−1))ˆFT(m)ˆΣ(m,v)∗ˆΨO∗∗−ˆX2(m))<0, | (3.16) |
where ˆΞ=ˆℵ1+ˆℵ2+ˆℵ3+ˆℵ4+ˆℵ5+ˆℵ6.
ˆℵ1=ˆFT(m)ε1+εT1ˆF(m)+εT1λmm(v)(IN⊗ˆP(m))ε1.
ˆℵ2=β1εT1(IN⊗ˆQ1)ε1−β1εTl+1(IN⊗ˆQ1)εl+1 +l∑s=2βs(εTl+s(IN⊗ˆQs)εl+s−εTl+s+1(IN⊗ˆQs)εl+s+1).
ˆℵ3=−l∑s=1βs1hs−hs−1((εTl+s−εTl+s+1)(IN⊗(ˆRs+ˆWs))(εl+s−εl+s+1)).
ˆℵ4=εT1(IN⊗ˆP(m))ε1.
ˆℵ5=−∑ls=1βsεTs+1(ˆΦ)εs+1.
ˆℵ6=(εs+1+ε2l+s+1)T(HTΛH⊗ˆΦ)(εs+1+ε2l+s+1).
ˆF(m)=(IN⊗A(m)ˆP(m))ε1−l∑s=1βs(H⊗B(m)ˆK(m))ε2l+s+1−l∑s=1βs(H⊗B(m)ˆK(m))εs+1.
ˆΦ=diag{ˆΦ1,ˆΦ2,⋯,ˆΦN},ˆΦi=ˆP(m)ΦiˆP(m),ˆP(m)=P−1(m), ˆΦs=ˆP(m)ΦsˆP(m).
ˆΨ=l∑s=1(βs(hs−hs−1))−1(μ2(IN⊗(Rs+Ws))−2μ(IN⊗ˆP(m))).
ˆRs=ˆP(m)RsˆP(m),ˆWs=ˆP(m)WsˆP(m),ˆΣ(m,v)=λ(m,v)ˆX1(m).
λ(m,v)=(√λm1(v),√λm2(v),⋯,√λmm−1(v),√λmm+1(v),⋯,√λmM(v),0,⋯,0).
ˆX1(m)=diag{IN⊗ˆP(m),⋯,IN⊗ˆP(m),O,⋯,O}.
ˆX2(m)=diag{IN⊗ˆP(1),IN⊗ˆP(2),⋯,IN⊗ˆP(m−1),IN⊗ˆP(m+1),⋯,IN⊗ˆP(M),O,⋯,O}.
In addition, the feedback gain is supplied by K(m)=ˆK(m)ˆP−1(m) and the event-triggered parameter matrix is given by Φ(m)=ˆP−1(m)ˆΦ(m)ˆP−1(m).
Proof of Theorem 2. Here we present the definitions of matrix variables K(m)=ˆK(m)ˆP−1(m),ˆP(m)=P−1(m) and ˆΦ(m)=ˆP(m)Φ(m)ˆP(m). We pre- and post-multiply both sides of (3.3) by the matrix diag{IN⊗P−1(m),IN⊗P−1(m),IN⊗P−1(m),InN}, and both sides of (3.2) by the matrix diag{IN⊗P−1(m),IN⊗P−1(m)}, respectively.
Lemma 1 enables one to derive the subsequent inequality.
−(IN⊗ˆP(m))(∑ls=1β(hs−hs−1)(IN⊗(Rs+Ws)))−1×(IN⊗ˆP(m))
≤μ2(∑ls=1β(hs−hs−1)(IN⊗(Rs+Ws)))−2μ(IN⊗ˆP(m));
we can get
(ˆΞ(hm−h(m−1))ˆFT(m)ˆΣ(m,v)∗ˆΨO∗∗−ˆX2(m))<0, | (3.17) |
where ˆΞ=ˆℵ1+ˆℵ2+ˆℵ3+ˆℵ4+ˆℵ5+ˆℵ6,
ˆℵ1=ˆFT(m)ε1+εT1ˆF(m)+εT1λmm(v)(IN⊗ˆP(m))ε1,
ˆℵ2=β1εT1(IN⊗ˆQ1)ε1−β1εTl+1(IN⊗ˆQ1)εl+1+l∑s=2βs(εTl+s(IN⊗ˆQs)εl+s −εTl+s+1(IN⊗ˆQs)εl+s+1),
ˆℵ3=−l∑s=1βs1hs−hs−1((εTl+s−εTl+s+1)(IN⊗(ˆRs+ˆWs))(εl+s−εl+s+1)),
ˆℵ4=εT1(IN⊗ˆP(m))ε1,
ˆℵ5=−∑ls=1βsεTs+1(ˆΦ)εs+1,
ˆℵ6=(εs+1+ε2l+s+1)T(HTΛH⊗ˆΦ)(εs+1+ε2l+s+1),
ˆF(m)=(IN⊗A(m)ˆP(m))ε1−l∑s=1βs(H⊗B(m)ˆK(m))ε2l+s+1−l∑s=1βs(H⊗B(m)ˆK(m))εs+1,
ˆΦ=diag{ˆΦ1,ˆΦ2,⋯,ˆΦN}, ˆΦi=ˆP(m)ΦiˆP(m), ˆP(m)=P−1(m), ˆΦs=ˆP(m)ΦsˆP(m),
ˆΨ=l∑s=1(βs(hs−hs−1))−1(μ2(IN⊗(Rs+Ws))−2μ(IN⊗ˆP(m))),
ˆRs=ˆP(m)RsˆP(m), ˆWs=ˆP(m)WsˆP(m), ˆΣ(m,v)=λ(m,v)ˆX1(m),
λ(m,v)=(√λm1(v),√λm2(v),⋯,√λmm−1(v),√λmm+1(v),⋯,√λmM(v),0,⋯,0),
ˆX1(m)=diag{IN⊗ˆP(m),⋯,IN⊗ˆP(m),O,⋯,O},
ˆX2(m)=diag{IN⊗ˆP(1),IN⊗ˆP(2),⋯,IN⊗ˆP(m−1),
IN⊗ˆP(m+1),⋯,IN⊗ˆP(M),O,⋯,O}.
The proof is therefore complete.
In Theorems 1 and 2, we establish sufficient conditions for achieving consensus in event-triggered semi-Markov jump multi-agent systems through stochastic sampling. But the sufficient conditions do not satisfy linear matrix inequality (LMI) conditions, because λ(m,v) is time-varying. As a result, the problems cannot be directly solved by using the LMI toolbox in MATLAB. Nevertheless, we can establish lower and upper bounds for the transition rate and apply the theorem presented below to overcome this issue.
Theorem 3. Under Assumption 1, and by utilizing the protocol given by (2.7), we have the following constants 0=h0<h1<⋯<hs<⋯<hl,πi∈[0,1],σi>0,i∈IN and μ>0. By utilizing the stochastic sampled event-triggered strategy (2.3) and assuming the existence of positive matrices ˆP(m),ˆQs,ˆRs,ˆWs,ˆΦ, consensus of the multi-agent system (2.10) can be achieved in a mean square sense. This is subject to the condition that the matrices ˆK(m),m∈D and s∈Il satisfy the following inequality:
(ˆΞ_(hm−h(m−1))ˆFT(m)ˆΣ_(m)∗ˆΨO∗∗−ˆX2)<0, | (3.18) |
(¯ˆΞ(hm−h(m−1))ˆFT(m)¯ˆΣ(m)∗ˆΨO∗∗−ˆX2)<0, | (3.19) |
where ˆΞ_=ˆℵ_1+ˆℵ2+ˆℵ3+ˆℵ4+ˆℵ5+ˆℵ6,
ˆℵ_1=ˆFT(m)ε1+εT1ˆF(m)+εT1λ_mm(IN⊗ˆP(m))ε1,
¯ˆΞ=¯ˆℵ1+ˆℵ2+ˆℵ3+ˆℵ4+ˆℵ5+ˆℵ6,
¯ˆℵ1=ˆFT(m)ε1+εT1ˆF(m)+εT1¯λmm(IN⊗ˆP(m))ε1,
ˆΣ_(m)=λ_(m)ˆX1(m), ¯ˆΣ(m)=ˉλ(m)ˆX1(m),
λ_(m)=(√λ_m1,√λ_m2,⋯,√λ_mm−1,√λ_mm+1,⋯,√λ_mM,0,⋯,0),
¯λ(m)=(√¯λm1,√¯λm2,⋯,√¯λmm−1,√¯λmm+1,⋯,√¯λmM,0,⋯,0).
The definitions of Theorem 2 are applicable to the remaining terms in the inequalities. By using the same strategy for proof as Theorem 2 of [35], the theorem may be simply constructed. Therefore, it is omitted here.
Remark 6. It is worth mentioning that Theorem 3's conclusion is relatively conservative. To decrease conservativeness, the sojourn-time division method is used by dividing the sojourn time υ by J and denoting the pth segment as ¯λnm,p and λ_nm,p to represent the upper and lower bounds on the transmission probability, respectively. The conclusions drawn are relatively lenient.
Corollary 1. Under Assumption 1 and the protocol (2.7), where 0=h0<h1<⋯<hs<⋯<hl, πi∈[0,1], σi>0,i∈IN and μ>0, the multi-agent system consensus (2.10) can be achieved in a mean-square sense with the stochastic sampled event-triggered strategy (2.3). This can be achieved if there exists a positive matrix ˆP(m), and positive matrices ˆQs,ˆRs,ˆWs,ˆΦ, along with the matrices ˆK(m),m∈D,s∈Il, which satisfy the following LMI:
(ˆΞ_(m,p)(hm−h(m−1))ˆFT(m,p)ˆΣ_(m,p)∗ˆΨ(m,p)O∗∗−ˆX2(m,p))<0, |
(¯ˆΞ(m,p)(hm−h(m−1))ˆFT(m,p)¯ˆΣ(m,p)∗ˆΨ(m,p)O∗∗−ˆX2(m,p))<0, |
in which ˆΞ_(m,p),¯ˆΞ(m,p),ˆΣ_(m,p),¯ˆΣ(m,p),ˆF(m,p),ˆP(m,p), ˆX2(m,p),ˆΨ(m,p),ˆΥ1(m,p) and ˆΥ2(m,p) are similarly defined as in Theorem 3, with the exception that (m) is substituted by (m,p). Furthermore, the feedback gain is given by K(m,p)=ˆK(m,p)ˆP−1(m,p). Moreover, the expression for the feedback gain is defined as K(m,p)=ˆK(m,p)ˆP−1(m,p). The parameter matrix for the event-triggered strategy is denoted as Φ(m,p)=ˆP−1(m,p)ˆΦ(m,p)ˆP−1(m,p), where ˆΦ(m,p) is an estimated parameter and m is an element in the set D while p is an element in the index set IJ.
Within this part, we will provide a numerical illustration to showcase the efficacy of the suggested design methodology. For consideration of a {semi-Markov jump multi-agent system}, which contains a leader and five followers, we assume that the model is described in formula (2.1). The coefficient matrices of the system equation are Ar, Br, Cr, r=1,2,3. A(1)=(−14−18−11−28), A(2)=(−16−16−15−23), A(3)=(−13−18−11−20), B(1)=(172), B(2)=(612), B(3)=(68). The topology of the network is shown in Figure 1. The corresponding Laplacian matrix L and the leader adjacency matrix B can be derived in the manner shown as follows:
L=(1−100000000−1010000−11000−101), B=diag(1,1,0,0,0).
Let the event-trigged parameters be σ1=6.353,σ2=7.163,σ3=6.093,σ4=7.533 and σ5=6.312. The stochastic sampling period h takes values from the set {h1,h2}={0.1s,0.2s} with probabilities of occurrence π1=Pr{h=h1}=0.2 and θ2=Pr{h=h2}=0.8. With these values, we can obtain that ρ1=0.6, ρ2=0.4. By utilizing MATLAB's LMI toolbox, we can verify the feasibility of solutions to LMIs} (3.18, 3.19) for μ=4 in Theorem 3. The event-triggered parameter metrics are derived as follows: Φ1=(3.11590.01890.01893.1294), Φ2=(3.11530.01950.01963.1279), and Φ3=(3.11490.01950.01953.1279). The consensus feedback matrices are as follows: K(1)=(0.0058−0.0038), K(2)=(0.0027−0.0011), K(3)=(0.0048−0.0023). The initial states of the leader and followers were selected as follows: x0(0)=(10), x1(0)=(3.5479.553), x2(0)=(−6.1545.902), x3(0)=(3.594−7.611), x4(0)=(9.3417.841), x5(0)=(2.30112.24). The tracking errors between the leader and the followers are shown in Figures 2 and 3.
Figure 4 illustrates the point in time at which an event is triggered. It indicates that the triggering of the event occurs at a lower frequency than the sampling rate.
Furthermore, the stochastic sampling period h is shown in Figure 6.
We can compare our simulation example with that in [34]. Both our article and [34] share the same state equations. However, [34] adopted a static event-triggered protocol, while we added a process of stochastic sampling to its event-triggered protocol. Compared with the figure in [34], the multi-agent system controlled by stochastic sampling event-triggered control has a faster convergence rate and smaller steady-state error. Thus, this example validates the validity of Theorem 3.
The paper presented a study on the mean-square consensus of a semi-Markov jump multi-agent system based on event-triggered stochastic sampling. We have proposed a novel approach to improve the efficiency of multi-agent systems for consensus control.
The results of the study showed that the proposed approach was effective in achieving mean-square consensus in multi-agent systems. The use of event-triggering via stochastic sampling reduced the communication frequency and improved the computational efficiency of the system. The semi-Markov jump model provided a more accurate representation of the state transitions in the system.
However, there are some limitations to this study. The numerical examples presented in the paper were relatively small, and it is unclear how the proposed approach would scale to larger multi-agent systems. Additionally, the study assumed perfect knowledge of the system parameters, which may not be the case in real-world scenarios.
Future research can further investigate the robustness of the proposed approach against uncertainties and disturbances in the system. The scalability of the approach can also be explored in more details, and the approach can be tested on more complex multi-agent systems.
The study presented in this article focuses on the use of multi-agent systems for the leader-follower consensus control topic. We have proposed a novel event-triggered stochastic sampling approach and investigated the use of a semi-Markov switching system architecture. We have also developed appropriate measures for mean-square consensus in multi-agent systems.
The results of the numerical example presented in this study demonstrate the accuracy of the theoretical computations. The proposed approach has the potential to improve the efficiency of multi-agent systems for consensus control in various applications.
The authors declare that they have not used artificial intelligence tools in the creation of this article.
This work was supported by the College Students' Innovation and Entrepreneurship Program of the Ministry of Education (202211306068), Excellent Scientific Research and Innovation Team of Anhui Colleges (2022AH010098), Innovation and Entrepreneurship Training Program for College Students in Anhui Province (S202211306114, S202211306134), Quality Engineering Project of Chizhou University (2022XXSKC09), Chizhou University Introducing Doctoral Research Startup Project (CZ2022YJRC08), and Key Research Project of Chizhou University (CZ2021ZR03, CZ2023ZRZ04).
The authors declare that there is no conflict of interest.
[1] | Strupp M, Dlugaiczyk J, Ertl-Wagner BB, et al. (2020) Vestibular disorders. Deutsch Ärztebl Int 117: 300-310. https://doi.org/10.3238/arztebl.2020.0300 |
[2] |
Dieterich M, Obermann M, Celebisoy N, et al. (2016) VM: the most frequent entity of episodic vertigo. J Neurol 263: 82-89. https://doi.org/10.1007/s00415-015-7905-2 ![]() |
[3] |
Shen Y, Qi X (2022) Update on diagnosis and differential diagnosis of VM. Neurol Sci 43: 1659-1666. https://doi.org/10.1007/s10072-022-05872-9 ![]() |
[4] |
Lempert T, Neuhauser H (2009) Epidemiology of vertigo, migraine, and VM. J Neurol 256: 333-338. https://doi.org/10.1007/s00415-009-0149-2 ![]() |
[5] | (2013) Headache Classification Committee of the International Headache Society (IHS)The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 629-808. Available from: https://doi.org/10.1177/0333102413485658 |
[6] |
Alghadir AH, Anwer S (2018) Effects of vestibular rehabilitation in the management of a VM: a review. Front Neurol 9: 440. https://doi.org/10.3389/fneur.2018.00440 ![]() |
[7] |
Lempert T, Olesen J, Furman J, et al. (2021) Vestibular migraine: diagnostic criteria (Update)1. J Vestibul Res 32: 1-6. https://doi.org/10.3233/ves-201644 ![]() |
[8] |
Langhagen T, Lehrer N, Borggraefe I, et al. (2015) VM in children and adolescents: clinical findings and laboratory tests. Front Neurol 5: 292. https://doi.org/10.3389/fneur.2014.00292 ![]() |
[9] |
Dieterich M, Staab JP, Brandt T (2016) Functional (psychogenic) dizziness. Handbook of Clinical Neurology : 447-468. https://doi.org/10.1016/B978-0-12-801772-2.00037-0 ![]() |
[10] |
Luan S, Williams I, Nikolic K, et al. (2014) Neuromodulation: present and emerging methods. Front Neuroeng 7: 27. https://doi.org/10.3389/fneng.2014.00027 ![]() |
[11] |
Staab JP, Rohe DE, Eggers SD, et al. (2014) Anxious, introverted personality traits in patients with chronic subjective dizziness. J Psychosom Res 76: 80-83. https://doi.org/10.1016/j.jpsychores.2013.11.008 ![]() |
[12] | Othmer S, Othmer SF (2024) Endogenous neuromodulation at infra-low frequency: method and theory. Preprints . https://doi.org/10.20944/preprints202310.1085.v2 |
[13] |
Noda T, Nishikawa M, Matsuda Y, et al. (2025) Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation for bipolar depression: a study protocol for a multicenter, double-blind, randomized, sham-controlled trial. Front Psychiatry 16: 1393605. https://doi.org/10.3389/fpsyt.2025.1393605 ![]() |
[14] | Hallet M (2007) Transcranial magnetic stimulation: a primer. Neuron 55: 187199. https://doi.org/10.1016/j.neuron.2007.06.026 |
[15] | Wassermann E, Epstein C, Ziemann U, et al. (2008) Oxford Handbook of Transcranial Stimulation. Oxford: Oxford University Press. https://doi.org/10.1093/oxfordhb/9780198568926.001.0001 |
[16] |
Cowey A (2004) The Ferrier Lecture 2004 What can transcranial magnetic stimulation tell us about how the brain works?. Philosophical Transactions of the Royal Society B: Biological Sciences 360: 1185-1205. https://doi.org/10.1098/rstb.2005.1658 ![]() |
[17] |
Huerta PT, Volpe BT (2009) Transcranial magnetic stimulation, synaptic plasticity, and network oscillations. J Neuroeng Rehabil 6: 7. https://doi.org/10.1186/1743-0003-6-7 ![]() |
[18] |
Walsh V, Pascual-Leone A (2003) Transcranial Magnetic Stimulation: A Neurochronometrics of Mind. Cambridge: The MIT Press. https://doi.org/10.7551/mitpress/6896.001.0001 ![]() |
[19] |
Allen EA, Pasley BN, Duong T, et al. (2007) Transcranial magnetic stimulation elicits coupled neural and hemodynamic consequences. Science 317: 1918-1921. https://doi.org/10.1126/science.1146426 ![]() |
[20] | Nitsche MA, Paulus W (2011) Transcranial direct current stimulation–update 2011. Restor Neurol Neurosci 29: 463492. https://doi.org/10.3233/rnn-2011-0618 |
[21] |
Thair H, Holloway AL, Newport R, et al. (2017) Transcranial direct current stimulation (tDCS): a beginner's guide for design and implementation. Front Neurosci 11: 641. https://doi: 10.3389/fnins.2017.00641 ![]() |
[22] |
Fertonani A, Pirulli C, Miniussi C (2011) Random noise stimulation improves neuroplasticity in perceptual learning. J Neurosci 31: 15416-15423. https://doi.org/10.1523/jneurosci.2002-11.2011 ![]() |
[23] |
Berthelot N, Lemieux R, Garon Bissonnette J, et al. (2020) Uptrend in distress and psychiatric symptomatology in pregnant women during the coronavirus disease 2019 pandemic. Acta Obstet Gyn Scan 99: 848-855. https://doi.org/10.1111/aogs.13925 ![]() |
[24] |
Cui X, Bray S, Reiss AL (2009) Functional near-infrared spectroscopy (NIRS) signal improvement based on negative correlation between oxygenated and deoxygenated hemoglobin dynamics. NeuroImage 49: 3039-3046. https://doi.org/10.1016/j.neuroimage.2009.11.050 ![]() |
[25] |
Merzagora AC, Foffani G, Panyavin I, et al. (2010) Prefrontal hemodynamic changes produced by anodal direct current stimulation. NeuroImage 49: 2304-2310. https://doi.org/10.1016/j.neuroimage.2009.10.044 ![]() |
[26] |
Emre M, Aarsland D, Albanese A, et al. (2004) Rivastigmine for dementia associated with Parkinson's disease. New Engl J Med 351: 2509-2518. https://doi.org/10.1056/nejmoa041470 ![]() |
[27] |
Stonsaovapak C, Hemrungroj S, Terachinda P, et al. (2020) Effect of anodal transcranial direct current stimulation at the right dorsolateral prefrontal cortex on the cognitive function in patients with mild cognitive impairment: a randomized double-blind controlled trial. Arch Phys Med Rehab 101: 1279-1287. https://doi.org/10.1016/j.apmr.2020.03.023 ![]() |
[28] |
Han BI, Song HS, Kim JS (2011) Vestibular rehabilitation therapy: review of indications, mechanisms, and key exercises. J Clin Neurol 7: 184. https://doi.org/10.3988/jcn.2011.7.4.184 ![]() |
[29] |
Cha YH, Cui Y, Baloh R, et al. (2013) Repetitive transcranial magnetic stimulation for mal de debarquement syndrome. Otol Neurotol 34: 175-179. https://doi.org/10.1097/mao.0b013e318278bf7c ![]() |
[30] |
Tarnutzer AA, Ward BK, Shaikh AG, et al. (2023) Novel ways to modulate the vestibular system: Magnetic vestibular stimulation, deep brain stimulation, and transcranial magnetic stimulation / transcranial direct current stimulation. J Neurol Sci 445: 120544. https://doi.org/10.1016/j.jns.2023.120544 ![]() |
[31] |
Koganemaru S, Goto F, Arai M, et al. (2017) Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: an exploratory study. Brain Stimul 10: 576-578. https://doi.org/10.1016/j.brs.2017.02.005 ![]() |
[32] |
Paxman E, Stilling J, Mercier L, et al. (2018) Repetitive transcranial magnetic stimulation (rTMS) as a treatment for chronic dizziness following mild traumatic brain injury. BMJ Case Rep 2018: 226698. https://doi.org/10.1136/bcr-2018-226698 ![]() |
[33] |
Moussavi Z, Suleiman A, Rutherford G, et al. (2019) A pilot randomised double-blind study of the tolerability and efficacy of repetitive transcranial magnetic stimulation on persistent post-concussion syndrome. Sci Rep 9: 5498. https://doi.org/10.1038/s41598-019-41923-6 ![]() |
[34] |
Buard I, Lopez-Esquibel N, Schoeneberger S, et al. (2020) Transcranial magnetic stimulation as treatment for mal de debarquement syndrome: case report and literature review. Cogn Behav Neurol 33: 145-153. https://doi.org/10.1097/wnn.0000000000000224 ![]() |
[35] |
Saki N, Bayat A, Nikakhlagh S, et al. (2022) Vestibular rehabilitation therapy in combination with transcranial direct current stimulation (tDCS) for treatment of chronic vestibular dysfunction in the elderly: a double-blind randomized controlled trial. Braz J Otorhinolar 88: 758-766. https://doi.org/10.1016/j.bjorl.2020.11.004 ![]() |
[36] |
Maertens de Noordhout A, Pepin JL, Schoenen J, et al. (1992) Percutaneous magnetic stimulation of the motor cortex in migraine. Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section 85: 110-115. https://doi.org/10.1016/0168-5597(92)90076-n ![]() |
[37] |
Bettucci D, Cantello R, Gianelli M, et al. (1922) Menstrual migraine without aura: cortical excitability to magnetic stimulation. J Head Face Pain 32: 345-347. https://doi.org/10.1111/j.1526-4610.1992.hed3207345.x ![]() |
[38] |
Van Der Kamp W, Van Den Brink AM (1996) Interictal cortical hyperexcitability in migraine patients demonstrated with transcranial magnetic stimulation. J Neurol Sci 139: 106-110. https://doi.org/10.1016/s0022-510x(96)00044-5 ![]() |
[39] |
Brighina F, Piazza A, Vitello G, et al. (2004) rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci 227: 67-71. https://doi.org/10.1016/j.jns.2004.08.008 ![]() |
[40] |
Brighina F, Palermo A, Fierro B (2009) Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine. J Headache Pain 10: 77-84. https://doi.org/10.1007/s10194-008-0095-x ![]() |
[41] |
Cosentino G, Fierro B, Vigneri S, et al. (2014) Cyclical changes of cortical excitability and metaplasticity in migraine: evidence from a repetitive transcranial magnetic stimulation study. Pain 155: 1070-1078. https://doi.org/10.1016/j.pain.2014.02.024 ![]() |
[42] |
Afra J, Proietti Cecchini A, Sándor PS, et al. (2000) Comparison of visual and auditory evoked cortical potentials in migraine patients between attacks. Clin Neurophysiol 111: 1124-1129. https://doi.org/10.1016/s1388-2457(00)00271-6 ![]() |
[43] |
Gerwig M, Kastrup O, Meyer BU, et al. (2003) Evaluation of cortical excitability by motor and phosphene thresholds in transcranial magnetic stimulation. J Neurol Sci 215: 75-78. https://doi.org/10.1016/s0022-510x(03)00228-4 ![]() |
[44] |
Young WB, Oshinsky ML, Shechter, et al. (2004) Consecutive transcranial magnetic stimulation: phosphene thresholds in migraineurs and controls. J Head Face Pain 44: 131-135. https://doi.org/10.1111/j.1526-4610.2004.04028.x ![]() |
[45] |
Chadaide Z, Arlt S, Antal A, et al. (2007) Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Cephalalgia 27: 833-839. https://doi.org/10.1111/j.1468-2982.2007.01337.x ![]() |
[46] |
Zeugin D, Ionta S (2021) Anatomo-functional origins of the cortical silent period: spotlight on the basal ganglia. Brain Sci 11: 705. https://doi.org/10.3390/brainsci11060705 ![]() |
[47] |
Paci M, Di Cosmo G, Perrucci MG, et al. (2021) Cortical silent period reflects individual differences in action-stopping performance. Sci Rep 11: 15158. https://doi.org/10.1038/s41598-021-94494-w ![]() |
[48] |
Aurora SK, al-Sayeed F, Welch KM, et al. (1999) The cortical silent period is shortened in migraine with aura. Cephalalgia 19: 708-712. https://doi.org/10.1046/j.1468-2982.1999.019008708.x ![]() |
[49] |
Bohotin V, Fumal A, Vandenheede M, et al. (2002) Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine. Brain 125: 912-922. https://doi.org/10.1093/brain/awf081 ![]() |
[50] |
Yuksel H, Topalkara KK (2021) Increased cortical excitability in female migraineurs: a transcranial magnetic stimulation study conducted in the preovulatory phase. J Clin Neurol 17: 236. https://doi.org/10.3988/jcn.2021.17.2.236 ![]() |
[51] |
Lan L, Zhang X, Li X, et al. (2017) The efficacy of transcranial magnetic stimulation on migraine: a meta-analysis of randomized controlled trials. J Headache Pain 18: 86. https://doi.org/10.1186/s10194-017-0792-4 ![]() |
[52] |
Narmashiri A, Akbari F (2023) The effects of transcranial direct current stimulation (TDCS) on the cognitive functions: a systematic review and meta-analysis. Neuropsychol Rev 35: 126-152. https://doi.org/10.1007/s11065-023-09627-x ![]() |
[53] |
Teepker M, Hötzel J, Timmesfeld N, et al. (2010) Low-frequency rTMS of the vertex in the prophylactic treatment of migraine. Cephalalgia 30: 137-144. https://doi.org/10.1111/j.1468-2982.2009.01911.x ![]() |
[54] |
Misra UK, Kalita J, Bhoi SK, et al. (2013) High-rate repetitive transcranial magnetic stimulation in migraine prophylaxis: a randomized, placebo-controlled study. J Neurol 260: 2793-2801. https://doi.org/10.1007/s00415-013-7072-2 ![]() |
[55] |
Hammad AB, Elsharkawy RE, Abdel Azim GS, et al. (2021) Repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine. Egypt J Neurol Psychiatry Neurosurg 57: 5. https://doi.org/10.1186/s41983-020-00254-4 ![]() |
[56] |
Brighina F, Giglia G, Scalia S, et al. (2005) Facilitatory effects of 1 Hz rTMS in the motor cortex of patients affected by migraine with aura. Exp Brain Res 161: 34-38. https://doi.org/10.1007/s00221-004-2042-7 ![]() |
[57] |
Molgat CV, Patten SB (2005) Comorbidity of major depression and migraine—A Canadian population-based study. Can J Psychiat 50: 832-837. https://doi.org/10.1177/070674370505001305 ![]() |
[58] |
Dussor G (2019) Discoveries in migraine mechanisms and therapeutic targets. Curr Opin Physiol 11: 116-124. https://doi.org/10.1016/j.cophys.2019.10.013 ![]() |
[59] |
Borsook D, Maleki N, Becerra L, et al. (2012) Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load. Neuron 73: 219-234. https://doi.org/10.1016/j.neuron.2012.01.001 ![]() |
[60] |
Carboni L, Khoury AE, Beiderbeck D (2022) Neuropeptide Y, calcitonin gene-related peptide, and neurokinin a in brain regions of HAB rats correlate with anxiety-like behaviours. Eur Neuropsychopharm 57: 1-14. https://doi.org/10.1016/j.euroneuro.2021.12.011 ![]() |
[61] |
Kauppila E, Vanninen E, Kaurijoki S, et al. (2013) Influence of serotonin transporter gene polymorphism (5-HTTLPR Polymorphism) on the relation between brain 5-HT transporter binding and heart rate-corrected cardiac repolarization interval. Plos One 8: e50303. https://doi.org/10.1371/journal.pone.0050303 ![]() |
[62] |
Furman JM, Marcus DA, Balaban CD (2013) VM: clinical aspects and pathophysiology. Lancet Neurol 12: 706-715. https://doi.org/10.1016/s1474-4422(13)70107-8 ![]() |
[63] |
Pistoia F, Salfi F, Saporito G, et al. (2022) Behavioral and psychological factors in individuals with migraine without psychiatric comorbidities. J Headache Pain 23: 110. https://doi.org/10.1186/s10194-022-01485-x ![]() |
[64] |
Powers SW, Kashikar-Zuck SM, et al. (2013) Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents. JAMA 310: 2622. https://doi.org/10.1001/jama.2013.282533 ![]() |
[65] |
Bottiroli S, De Icco R, Vaghi G, et al. (2021) Psychological predictors of negative treatment outcome with Erenumab in chronic migraine: data from an open-label long-term prospective study. J Headache Pain 22: 114. https://doi.org/10.1186/s10194-021-01333-4 ![]() |
[66] |
Schwartz WJ, Klerman EB (2019) Circadian neurobiology and the physiologic regulation of sleep and wakefulness. Neurol Clin 37: 475-486. https://doi.org/10.1016/j.ncl.2019.03.001 ![]() |
[67] |
Hastings MH, Maywood ES, Brancaccio M, et al. (2018) Generation of circadian rhythms in the suprachiasmatic nucleus. Nat Rev Neurosci 19: 453. https://doi.org/10.1038/s41583-018-0026-z ![]() |
[68] |
Stokes DA, Lappin MS (2010) Neurofeedback and biofeedback with 37 migraineurs: a clinical outcome study. Behav Brain Funct 6: 9. https://doi.org/10.1186/1744-9081-6-9 ![]() |
[69] |
Legarda SB, Michas-Martin PA, McDermott D (2022) Remediating intractable headache: an effective nonpharmacological approach employing infralow frequency neuromodulation. Front Hum Neurosci 16: 894856. https://doi.org/10.3389/fnhum.2022.894856 ![]() |
[70] |
Sasu R (2022) Infra-low frequency neurofeedback in persistent postural-perceptual dizziness—Case report. Front Hum Neurosci 16: 959579. https://doi.org/10.3389/fnhum.2022.959579 ![]() |
[71] |
Arina M, Zhao H, Rasgado-Toledo J (2022) Infralow neurofeedback for tension-type headache: a randomized, crossover sham-controlled study. Front Human Neurosci 16: 891323. https://doi.org/10.3389/fnhum.2022.891323 ![]() |
[72] |
Kirsch V, Keeser D, Hergenroeder T, et al. (2016) Structural and functional connectivity mapping of the vestibular circuitry from human brainstem to cortex. Brain Struct Funct 221: 1291-1308. https://doi.org/10.1007/s00429-014-0971-x ![]() |
[73] | Young A, Cornejo J, Spinner A Auditory brainstem response (2023). |
[74] |
Yamada T, Dickins QS, Arensdorf K, et al. (1986) Basilar migraine: polarity-dependent alteration of brainstem auditory evoked potential. Neurology 36: 1256-1260. https://doi.org/10.1212/wnl.36.9.1256 ![]() |
[75] | Yoo H, Mihaila DM Neuroanatomy, vestibular pathways (2022). |
[76] |
Ricci A, Rubino E, Pietro Serra G, et al. (2024) Concerning neuromodulation as treatment of neurological and neuropsychiatric disorders: insights gained from selective targeting of the subthalamic nucleus, para-subthalamic nucleus, and zona incerta in rodents. Neuropharmacology 256: 110003. https://doi.org/10.1016/j.neuropharm.2024.110003 ![]() |
[77] |
Walsh GS (2021) Dynamics of modular neuromotor control of walking and running during single and dual task conditions. Neuroscience 465: 1-10. https://doi.org/10.1016/j.neuroscience.2021.04.004 ![]() |
[78] | Taslim S, Shadmani S, Saleem A, et al. (2024) Neuropsychiatric disorders: bridging the gap between neurology and psychiatry. Cureus 16: e51655. https://doi.org/10.7759/cureus.51655 |
[79] |
Fletcher JL, Murray SS, Xiao J (2018) Brain-derived neurotrophic factor in central nervous system myelination: a new mechanism to promote myelin plasticity and repair. Int J Mol Sci 19: 4131. https://doi.org/10.3390/ijms19124131 ![]() |
[80] |
Fischer M, Wille G, Klien S, et al. (2012) Brain-derived neurotrophic factor in primary headaches. J Headache Pain 13: 469-475. https://doi.org/10.1007/s10194-012-0454-5 ![]() |
[81] |
Bliss TV, Cooke SF (2011) Long-term potentiation and long-term depression: a clinical perspective. Clinics 66: 3-17. https://doi.org/10.1590/s1807-59322011001300002 ![]() |
[82] |
Meldrum BS (2000) Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 130: 1007S-1015S. https://doi.org/10.1093/jn/130.4.1007s ![]() |
[83] | Jewett BE, Thapa B Physiology, NMDA receptor (2022). |
[84] | Blanke ML, VanDongen AM Activation mechanisms of the NMDA receptor (2009). |
[85] |
Chervyakov AV, Chernyavsky AY, Sinitsyn DO, et al. (2015) Possible mechanisms underlying the therapeutic effects of transcranial magnetic stimulation. Front Human Neurosci 9: 303. https://doi.org/10.3389/fnhum.2015.00303 ![]() |
[86] |
Wu X, Han S, Yang Y, et al. (2022) Decreased brain GABA levels in patients with migraine without aura: an exploratory proton magnetic resonance spectroscopy study. Neuroscience 488: 10-19. https://doi.org/10.1016/j.neuroscience.2022.02.010 ![]() |
[87] |
Tremblay R, Lee S, Rudy B (2016) GABAergic interneurons in the neocortex: from cellular properties to circuits. Neuron 91: 260-292. https://doi.org/10.1016/j.neuron.2016.06.033 ![]() |
[88] |
Caparelli E, Backus W, Telang F, et al. (2012) Is 1 Hz RTMS always inhibitory in healthy individuals?. Open Neuroimag J 6: 69-74. https://doi.org/10.2174/1874440001206010069 ![]() |
[89] |
Phylactou P, Pham T, Narskhani N, et al. (2024) Phosphene and motor transcranial magnetic stimulation thresholds are correlated: a meta-analytic investigation. Prog Neuro-Psychoph 133: 111020. https://doi.org/10.1016/j.pnpbp.2024.111020 ![]() |
[90] |
Zuniga SA, Adams ME (2021) Efficient use of vestibular testing. Otolaryng Clin N Am 54: 875-891. https://doi.org/10.1016/j.otc.2021.05.011 ![]() |
[91] | Peterchev AV, Murphy DL, Goetz SM (2015) Quiet transcranial magnetic stimulation: status and future directions. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society : 226-229. https://doi.org/10.1109/EMBC.2015.7318341 |
[92] |
Rossi S, Antal A, Bestmann S, et al. (2021) Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: expert guidelines. Clin Neurophysiol 132: 269-306. https://doi.org/10.1016/j.clinph.2020.10.003 ![]() |
[93] |
Matsumoto H, Ugawa Y (2016) Adverse events of tDCS and tACS: a review. Clin Neurophys Pract 2: 19-25. https://doi.org/10.1016/j.cnp.2016.12.003 ![]() |
[94] |
Magnezi R, Aminov E (2016) Comparison between neurostimulation techniques, repetitive transcranial magnetic stimulation vs electroconvulsive therapy for the treatment of resistant depression: patient preference and cost-effectiveness. Patient Prefer Adher 10: 1481-1487. https://doi.org/10.2147/PPA.S105654 ![]() |
[95] |
Xia Y, Xu Y, Li Y, et al. (2022) Comparative efficacy of different repetitive transcranial magnetic stimulation protocols for stroke: a network meta-analysis. Front Neurol 13: 918786. https://doi.org/10.3389/fneur.2022.918786 ![]() |