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Case report

Acute transverse myelitis (ATM) associated with COVID 19 infection and vaccination: A case report and literature review

  • Received: 01 December 2023 Revised: 27 May 2024 Accepted: 03 June 2024 Published: 11 June 2024
  • Acute transverse myelitis (ATM) is an inflammatory disorder caused by many etiologies, from postinfectious to autoimmune. Rarely, ATM cases have been reported after both COVID-19 infection and COVID-19 vaccination. We described our experience with ATM after COVID-19 infection and conducted a literature review.

    Case finding Methods 

    We reported a case of longitudinally extensive ATM after COVID 19 infection, who also received convalescent plasma therapy, and present a comprehensive literature review of ATM cases reported after COVID-19 infection and COVID-19 vaccination. The literature search was done using PubMed and Google scholar with keywords and selected peer-reviewed articles. The search included all cases from Jan 2020 to Sept 2022.

    Results 

    A total of 60 ATM cases reported association with post COVID 19 infection, and 23 ATM cases reported association with post COVID 19 vaccinations. Among post COVID 19 ATM cases, the mean age was 49 years and the youngest reported was 7-month-old. A total of 55% (33) were longitudinally extensive ATM. The most common symptom was lower extremity weakness. One case was reported as necrotizing myelitis on biopsy, and another case overlapped with syndrome of GBS and longitudinal ATM. No cases reported using convalescent plasma therapy after infection. Almost all the ATM cases were treated with steroids, but some cases needed additional treatment since not all responded adequately. Six cases (10%) responded with steroids plus plasmapheresis, and 5 cases (8%) responded with steroids + IVIG, especially in the pediatric age group. One case reported a positive response after treatment with eculizumab, and another with infliximab. Two cases (3%) remained paraparetic. Among post covid-19 vaccine ATM cases, 4 cases (17%) were reported as longitudinally extensive ATM. Five cases (21%) had symptom onset within a week after vaccination. Almost all reported a response to steroids except for one case which reported fatality after the 58th day after vaccination.

    Conclusion 

    ATM, in the setting of acute COVID-19 infection, has been described in multiple cases and is a rare complication of COVID-19 vaccination.

    Citation: Srinivas Medavarapu, Nitasha Goyal, Yaacov Anziska. Acute transverse myelitis (ATM) associated with COVID 19 infection and vaccination: A case report and literature review[J]. AIMS Neuroscience, 2024, 11(2): 178-187. doi: 10.3934/Neuroscience.2024011

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  • Acute transverse myelitis (ATM) is an inflammatory disorder caused by many etiologies, from postinfectious to autoimmune. Rarely, ATM cases have been reported after both COVID-19 infection and COVID-19 vaccination. We described our experience with ATM after COVID-19 infection and conducted a literature review.

    Case finding Methods 

    We reported a case of longitudinally extensive ATM after COVID 19 infection, who also received convalescent plasma therapy, and present a comprehensive literature review of ATM cases reported after COVID-19 infection and COVID-19 vaccination. The literature search was done using PubMed and Google scholar with keywords and selected peer-reviewed articles. The search included all cases from Jan 2020 to Sept 2022.

    Results 

    A total of 60 ATM cases reported association with post COVID 19 infection, and 23 ATM cases reported association with post COVID 19 vaccinations. Among post COVID 19 ATM cases, the mean age was 49 years and the youngest reported was 7-month-old. A total of 55% (33) were longitudinally extensive ATM. The most common symptom was lower extremity weakness. One case was reported as necrotizing myelitis on biopsy, and another case overlapped with syndrome of GBS and longitudinal ATM. No cases reported using convalescent plasma therapy after infection. Almost all the ATM cases were treated with steroids, but some cases needed additional treatment since not all responded adequately. Six cases (10%) responded with steroids plus plasmapheresis, and 5 cases (8%) responded with steroids + IVIG, especially in the pediatric age group. One case reported a positive response after treatment with eculizumab, and another with infliximab. Two cases (3%) remained paraparetic. Among post covid-19 vaccine ATM cases, 4 cases (17%) were reported as longitudinally extensive ATM. Five cases (21%) had symptom onset within a week after vaccination. Almost all reported a response to steroids except for one case which reported fatality after the 58th day after vaccination.

    Conclusion 

    ATM, in the setting of acute COVID-19 infection, has been described in multiple cases and is a rare complication of COVID-19 vaccination.



    1. Introduction

    With the development of wireless communication and positioning technology, more and more data about locations are collected and used for many applications, such as location-based services. In particular, the format of the data could be generalized to (location, time, texts), where the location represents the geo-coordinates where event happens (or some object lies), and time means the valid time when the event happens at location (or the object is at location), and texts are used to describe or record the state of the event (or object). For instance, someone publishes a micro-blog associated with geo-location tag at 6:30 pm, in which some comments about a restaurant are attached. Another example about real-estate advertising is that every advertisement contains geo-coordinates of the property, the publishing time and texts describing the property. Users are often interested in the spatial, temporal and textual attributes of the data, and retrieve useful information through the combination of these three dimensions. Such queries are called spatio-temporal keyword (STK) queries. For instance, find the users publishing micro-blogs containing words pasta and pizza in the range of this shopping mall yesterday.

    However, tens of billions of spatio-temporal data would be a serious problem for applications. HBase [1] is a distributed non-sql, key-value database, and is capable to store such a huge amount of data. However, due to the non-sql characteristics of HBase, it is inefficient to process spatio-temporal keyword queries using the built-in functions of HBase. Consequently, it is highly necessary to design efficient algorithms for processing spatio-temporal keyword queries in HBase. A previous work [9] about processing spatial or multi-attributes queries in HBase is different from ours, because they merely consider spatial dimension in query processing. To the best of our knowledge, this is the first work for processing spatio-temporal keyword queries in HBase.

    Our motivation is to adopt HBase to process STK queries efficiently. First, a space filling curve, Hilbert curve [8], is used to encode the spatial dimension into one-dimensional codes, i.e., for a location referred by geo-coordinates, it is represented by a number denoting the relative position in the original space. Based on this, we design a suitable access model for HBase, containing row keys for indexing spatio-temporal dimensions and Bloom filters [3] for fast detecting the existence of query keywords. After that, we develop two algorithms, one is suitable for the query with ordinary selectivity, the other is a parallel algorithm for the large range query. We evaluate our algorithms on a real dataset, and the results show that our algorithms are capable to handle spatio-temporal keyword queries efficiently. In summary, we make the following contributions:

    ● We propose spatio-temporal keyword queries processing problem in HBase, which is a new challenge for HBase platform.

    ● We design a novel access model for HBase to store spatial, temproal and textual information.

    ● We propose efficient algorithms for processing spatio-temporal keyword queries in HBase.

    The rest of this paper is organized as follows. Section 2 reviews related works on spatio-temporal queries and HBase queries. Section 3 formally defines spatio-temporal keyword problem. Section 4 presents an access model for HBase. Algorithms for spatio-temporal keyword queries are presented in section 5. And we experimentally evaluate our algorithms in section 6. Finally, section 7 concludes the paper with directions for future works.


    2. Related work

    To our knowledge, the state of the art for spatio-temporal keyword queries in HBase is less well studied. However, some researches focusing on distributed index could be referenced. As an attractive choice for large-scale data processing, Cloud storage system currently adopts a hash-like approach to retrieve data that only support simple keyword-based queries, but lacks various forms of information search. To overcome this disadvantage, Zhou et al. [10] propose a novel SkipNet and B+-tree based index structure, called SNB-index. SNB-index uses the B+-tree to construct efficient local index in the lower layer, while it selects local index nodes to form a SkipNet-based global overlay in the upper layer. SNB-index also can be employed in systems such as GFS and Hadoop [2], which ensures it scalable and flexible. Experimental results show that SNB-index is valid and can be an alternative approach for constructing an auxiliary index in Cloud computing systems.

    For supporting similarity search in cloud system, Cheng et al. [4] propose VF-CAN, a novel indexing scheme, which integrates content addressable network (CAN) based routing protocol and the improved vector approximation file (VA-file) index. There are two index levels in this scheme: global index and local index. In the local index, VA-file approximation vectors are clustered by k-means according to their degree of proximity. In the global index, storage nodes are organized into an overlay network CAN, and only clustering information of local index is issued to the entire overlay network through the CAN interface. The experimental results show that VF-CAN reduces the index storage space and improves query performance effectively.

    For multi-dimensional data applications, Nishimura et al. [9] proposes MD-HBase, a scalable multi-dimensional data store supporting efficient multi-dimensional range and nearest neighbor queries. MD-HBase layers a multi-dimensional index structure over a range partitioned key-value store. Using a design based on linearization, its implementation layers standard index structures like K-D trees and Quad trees.

    As we have mentioned above, many applications not only require finding objects closest to a specified location, but also that containing a set of keywords. Felipe et al. [6] present an efficient method to answer top-k spatial keyword queries. It adopts a structure called IR2-Tree (Information Retrieval R-Tree) which combines an R-Tree with superimposed text signatures. Algorithms are proposed to construct and maintain an IR2-Tree, and answer top-k spatial keyword queries. With experimentally comparison with current methods, superior performance and excellent scalability of the algorithms are shown.

    Cong et al. [5] propose a novel indexing framework for location top-k text retrieval. It integrates the inverted file for text retrieval and the R-tree for spatial proximity query. Several hybrid indexing approaches are explored within the framework. Algorithms utilize the proposed indexes to compute the top-k query by taking into account both text relevancy and location proximity to prune the search space.

    In practical applications, it is need to consider the nature of the movement of objects. Traditional indexes have good query performance but can not handle this data processing problem in that they are not efficient for update which is crucial for an index for moving objects, as they change their position frequently. Jensen et al. [7] represent moving-object locations as vectors that are time stamped based on their update time. Then B+-tree based data structure is adopted to index moving objects according to their time stamp and otherwise preserves spatial proximity. This method supports range and nearest neighbor queries, as well as continuous queries. Bx-tree which is based on the B+-tree, outperforms the TPR-tree in range queries and kNN queries concerning the current or near-future positions of the objects.


    3. Problem definition

    In this section, we first present the definitions for spatio-temporal keyword data and queries, and then describe the HBase logical table. For simplicity, only two-dimensional space is considered in this paper, however, our method can be directly extended into higher dimensional space.

    Spatio-temporal data. A record r of spatio-temporal data can be denoted as x, y, t, W, A, where (x, y) means the geo-location of the record, t means the valid time when the data is produced, W is a set of keywords, W = {w1, w2, , wn}, A represents other attributes, such as user-id, object's shape, etc.

    Spatio-temporal keyword query. Given a set Ust of records of spatio-temporal data, a spatio-temporal keyword (STK) query Q = Rq,ts,te,Wq, where Rq = (xl, yl, xu, yu) means a query range with lower-left coordinate (xl, yl) and upper-right coordinate (xu, yu), Wq = {wq1, wq2, , wqm} is a set of query keywords, aims to find a subset Sst = {rs | rs Ust} satisfying that:

    rs.(x,y)Rq
    rs.t[ts,te]
    rs.WWqϕ

    Logical view of HBase table. Without loss of generality, we give the descriptions for HBase table. HBase is a distributed key-value database which consists of a number of computing nodes cooperatively processing large-scale data. A physical table in HBase is partitioned into several regions each of which is maintained by a node. From the logical view, a table is similar to a grid, where a cell can be located by the given row identifier and column identifier. Row identifiers are implemented by row keys (rk) which are index by B+-tree, and the column identifier is represented by column family (cf) + column key (ck), where a column family consists of several column keys. The value in a cell can be referred to as the format (rk, cf:ck). Table 1 shows a logical view of a table in HBase. For instance, value v1 can be referred to as (rk1, cf1:ck1).

    Table 1. A HBase Logical Table.
    cf1cf2
    ck1ck2ck3ckackb
    rk1v1v2v3v4v5
    rk2v6v7v8v9v10
     | Show Table
    DownLoad: CSV

    4. Spatio-temporal keyword access model for HBase

    In this section, we describe a spatio-temporal keyword access (STKA) model for the logical view of HBase table. The model is built based on Hilbert curve and Bloom filter. We first introduce Hilbert curve, which maps high-dimensional data into one-dimensional space and then describe the access model.


    4.1. Hilbert curve

    Hilbert curve is a kind of space filling curve which maps multi-dimensional space into one-dimensional space. In particular, the whole space is partitioned into equal-size cells and then a curve is passed through each cell for only once in term of some sequence, so that every cell is assigned a sequence number. Different space filling curves are distinguished by different sequencing methods. Due to information loss in the transformation, different space filling curves are evaluated by the criteria, locality preservation, meaning that how much the change of proximities is from original space to one-dimensional space. Hilbert curve is proved to be the best locality preserved space filling curve. With Hilbert curve, any object in the original space is transformed into [0, 22λ1] space, where λ is called the order of Hilbert curve. Figure 1 shows four Hilbert curves in two-dimensional space with λ = 1, 2, 3 and 4. In Figure 1 (b), there are two points p1 and p2, and the sequence number 2 and 13 is obtained through the curve for them, respectively. Note that p1 and p2 are neighbors in the original space, but apart from each other by 11 unit distances in one-dimensional space.

    Figure 1. Hilbert Curves.

    We describe two functions for Hilbert curve, one is mapping a point in the original space to a value in one-dimensional space, the other is mapping a range window to a series of intervals. Specifically, for a Hilbert curve with order = λ,

    coorToCode(p). Given a point p = (x1, x2, , xn) in n-dimensional space S, coorToCode(p) returns a cell number (between 0 and 22λ1) referring the cell where p lies within S.

    rectToIntervals(R). Given a range window R = (xl1, xl2, , xln, xu1, xu2, , xun) in n-dimensional space S, where xli and xui (1in) are the lower and upper bound of the ith-dimension, respectively, rectToIntervals(R) returns a series of intervals representing the cells intersecting with R in S.

    For instance, in Figure 1 (b), coorToCode(p1) = 2, coorToCode(p2) = 13, and rectToIntervals(R1) = {[1,2], [7,8], [11,15]}.


    4.2. STKA model

    For each record r = x, y, t, W, A, the row key is generated as tcoorToCode(x,y). Note that for different records, they may share the same row key, which means a row key might correspond to several records. And we use Bloom filter to denote the union of keyword sets of records. A Bloom filter is a space-efficient probabilistic data structure which is used to test whether an element is a member of a set. If the returned value is false for testing whether element e belongs to set C, then it is definite that e is not in C. However, if the result is true, e may be in C, which means false-positives are possible and further inspection should be taken. In particular, for a set of records S = {r1, r2, , rm}, the Bloom filter BS = addSet({wi,j | wi,j Wi, 1j|Wi|, 1im}), where function addset() means inserting keyword list into Bloom filter structure, and Wi is the keyword set of ri (1im).

    The STKA model is rowkey, B, listof(x, y, W, A), where rowkey identifies a set of records S, each of which has tcoorToCode(x,y) = rowkey, and B is the Bloom filter of union of the keywords in S, and listof(x, y, W, A) is a list, each element in which contains geo-location, keyword set, and other attributes of each records in S.

    The STKA model is suitable for the logical view of HBase table. Table 2 shows an example of the model. For storing listof(x, y, W, A), multiple column groups (loc, wordlist, attr) are used.

    Table 2. STKA model for HBase.
    stdata
    bfloc1wordlist1attr1loc2wordlist2attr2
    rowkey1B1(x1,y1) W1A1(x2,y2) W2A2
    rowkeykBk(xm,ym) WmAm(xn,yn) WnAn
     | Show Table
    DownLoad: CSV

    5. Algorithms for STK queries

    In this section, we first describe the processing for STK queries on original model. Considering massive data processing, we use MapReduce [2] framework to design parallel algorithm for STK queries.


    5.1. STK queries

    For a STK query Q = Rq,ts,te,Wq, where Rq = (xl, yl, xu, yu) means a query range, Wq = {wq1, wq2, , wqm} is a set of query keywords, the basic idea for spatio-temporal range queries processing is to transform the spatial range and temproal range into a series of row keys, and using these row keys to retrieve the records and examin them whether they satisfy the query condition. To be more specific, firstly, the query spatial range is converted into a series of Hilbert value intervals. Then, according to row key design patterns, row keys are generated by time concatenating the Hilbert value. After that, we use scan, an interface of HBase, to retrieve the records within the row key range, and then we use Bloom filter to test whether these records intersect with the query keywords. Finally, to avoid false-positive, those satisfied records in the previous step must be further examined. Algorithm 1 describes the processing for STK queries in detail.

    Table . .
    Algorithm 1 Spatio-temporal Keyword Query
    Input:
    (ts,te) //temporal range of query
    Rq(xl,yl,xu,yu) //spatial range of query
    Wq //query keywords
    Output:
    Qlist //result list
    1: intervals = rectToIntervals(Rq);
    2: table=connectHTable(); //connect to table in HBase for query
    3: while ts<te do
    4: for each interval in intervals do
    5: startrowkey=ts+interval.Henter; //starting row key
    6: endrowkey=ts+interval.Hexit; //ending row key
    7: rowkeyRange=(startrowkey,endrowkey); //row key range for scanning
    8: Scan=scan(rowkeyRange); //scan table
    9: ResultScanner=table.getScanner(Scan); //results of scanning
    10: for each Result in ResultScanner do
    11: if Result.bf.intersect(Wq)null then
    12:while (str=Result.getNextSTRecord())null do
    13: if (str.locRq)(str.wordlistWqϕ) then
    14: Qlist.add(str); //add result to query result list
    15: end if
    16: end while
    17: end if
    18: end for
    19: end for
    20: ts=ts+1;
    21: end while
     | Show Table
    DownLoad: CSV

    For the sake of legibility, some functions and variables of the algorithm are explained below:

    1. rectToIntervals(R) returns a series of intervals, each of which is denoted as [Henter,Hexit];

    2. connectHTable() connects to HBase and returns the table;

    3. rowkeyRange is a range of row keys, represented by a starting row key and an ending row key;

    4. ResultScanner is a collection of rows retrieved by scanning table, whose row keys are in rowkeyRange;

    5. bf.intersect(Wq) is the function of Bloom filter bf to test whether bf intersects with Wq;

    6. getNextSTRecord() returns next spatio-temporal record in a row;

    7. Qlist is the result list for the query.

    In line 1, Rq is transformed into a series of intervals. From line 3 to 20, the involved rows are retrieved and examined. In line 9, a collection of rows ResultScanner is retrieved, corresponding to a time stamp in (ts,te) and an area in Rq. The Bloom filter of the union of keywords in each row is examined whether it intersects with Wq in line 11. If the intersection is not null, every spatio-temporal record in the row is further examined on location and word list (from line 12 to 16). For the satisfied record, the result is added into Qlist (line 14).


    5.2. Parallel STK queries

    As we have mentioned above, with the development of wireless communication and positioning technology, more and more data about locations are collected, so it is necessary to consider the problems of massive data processing. For a STK query with large range predicates, a great number of rows are retrieved, which is a bottleneck of performance. Consequently, it is necessary to design parallel algorithm which involved computing nodes to process the query simultaneously, so that throughput and efficiency increase. Based on MapReduce framework, we design a parallel algorithm for STK queries.

    The basic work flow is that, firstly, an intermediate file containing all the involved row key ranges for the query is generated, in which each record corresponds to a row key range in HBase. Then Map procedure reads the records in the file and outputs them to Reduce procedure. And then in the Reduce, corresponding nodes retrieve and examine rows simultaneously to get results. Algorithm 2 describes the parallel algorithm for STK queries based on MapReduce framework.

    Table . .
    Algorithm 2 Parallel Spatio-temporal Keyword Query
    Input:
    (ts,te) //temporal range of query
    Rq(xl,yl,xu,yu) //spatial range of query
    Wq //query keywords
    Output:
    Qlist //result list
    1: /*generating intermediate file Filerecord for Map and Reduce*/
    2: intervals = rectToIntervals(Rq);
    3: while ts<te do
    4: for each interval in intervals do
    5:startrowkey=ts+interval.Henter; //starting row key
    6:endrowkey=ts+interval.Hexit; //ending row key
    7:rowkeyRange=(startrowkey,endrowkey); //row key range for scanning
    8:Filerecord.write(rowkeyRange); //write rowkeyRange range to Filerecord
    9:end for
    10:ts=ts+1;
    11: end while
    12: /*Map input: file Filerecord */
    13: while (record=Filerecord.getNextRecord())null do
    14: context.write(record); //output the record
    15: end while
    16: /*Reduce input: output of Map */
    17: rowkeyRange=parse(record); //parse record into rowkey range
    18: table=connectHTable(); //connect to table in HBase for query
    19: Scan=scan(rowkeyRange); //start scanning
    20: ResultScanner=table.getScanner(Scan); //results of scanning
    21: for each Result in ResultScanner do
    22:if Result.bf.intersect(Wq)null then
    23:while (str=Result.getNextSTRecord())null do
    24:if (str.locRq)(str.wordlistWqϕ) then
    25:Qlist.add(str); //add result to query result list
    26:end if
    27:end while
    28:end if
    29:end for
     | Show Table
    DownLoad: CSV

    Pseudo-codes between line 2 and 11 describe the generation for the intermediate file Filerecord. In line 8, the row key range is written into the file in terms of file record in the loops in line 3 and 4. Map procedure is showed between line 13 and 15, and context.write(record) means outputting record to Reduce step. Pseudo-codes between line 2 and line 11 describe Reduce procedure. In line 17, the record passed by Map is parsed into the row key range. The remaining codes are similar to Algorithm 1.


    6. Experimental evaluation

    We evaluate our algorithms on a real dataset, which contains trajectories of taxis in Beijing. In particular, each record in the dataset contains vehicle ID, geo-location, recording time stamp, etc. For each record, we randomly assign it a list of keywords with size varied from 7 to 15 words. For comparison, we extract 5 datasets in different sizes from the original one in terms of temporal range. Table 3 shows the datasets in detail.

    Table 3. Dataset.
    Dataset Temporal Range Size (records)
    dataset10:00-0:48, Nov. 1st1 million
    dataset20:00-8:25, Nov. 1st10 million
    dataset30:00-23:59, Nov. 1st30 million
    dataset4Nov. 1st & Nov. 2nd60 million
    dataset5Nov. 1st, Nov. 2nd & Nov. 3rd100 million
     | Show Table
    DownLoad: CSV

    Our algorithms are implemented in Java, and run on a three-node cluster with Hadoop 2.5.1 and HBase 0.98.6, in which each node is equipped with Intel(R) Core(TM) i3 CPU @ 3.40GHz, 4GB main memory, and 500GB storage, and operating system is CentOS release 6.5 64bit, and network bandwidth is 10Mbps.


    6.1. STK queries

    First, we evaluate the algorithm for STK queries. And we introduce two parameters to test the algorithm under various conditions. One is selectivity θ defined as:

    θ=L(ts,te)LtARqAS

    where L(ts,te) means the length of query temporal range (ts,te), Lt means the length of temporal extent of the dataset, ARq means the area of query spatial range Rq, and AS means the area of the whole space. Selectivity specifies the size of the query range, and the larger θ is, the more spatio-temporal records are involved. The other parameter is the number of query keywords κ, and a larger κ will recall more records.

    Firstly, we fix κ = 5(in reality, the number of keywords users usually query is less than 5), and vary θ from 3 % to 50 %. For each value of θ, we issue 10 queries with different temporal ranges and spatial ranges, and collect the average response time as the measurement of performance. Figure 2 shows the results.

    Figure 2. Response Time vs. Selectivity (κ = 5).

    We can see that response time increases with θ for all the datasets. This is because a larger selectivity would access more records to be retrieved and examined, which increases the processing time. Furthermore, the response time grows linearly with θ. This can be explained by the transformation from spatio-temporal dimensions into one-dimensional space, and by the fast detection of Bloom filter for keywords matching. Another observation is that with the enlargement of dataset size(the amount of data from dataset1 to dataset5 increases), the response time also increases. The explanation is that for a fixed selectivity θ, STK query would recall more records with the increase of data amount.

    We fix θ = 15 %, and vary κ from 3 to 10. The average response time is computed similarly to the previous one. Figure 3 shows the results.

    Figure 3. Response Time vs. Number of Query Keywords (θ = 15 %).

    Similarly, the response time increases with κ. The explanation is similar to the previous case, i.e., a larger κ would involve more records to be accessed.


    6.2. Parallel STK queries

    After studying the performance of STK queries, we compare parallel STK query with the original one to observe the improvement. For both of them, we issue 5 different queries on dataset 1, and Table 4 shows the conditions in detail.

    Table 4. Query Conditions.
    Conditions Temporal Range(min) Spatial Range(km) Number of Keywords Number of Scanned Records
    c110133987
    c2202518786
    c3303542457
    c4404799789
    c550510108040
     | Show Table
    DownLoad: CSV

    Figure 4 shows the results. We can see that at the beginning, i.e, the number of scanned records is not much, STK query is faster than the parallel one, because the cost of writing and parsing the intermediate file in the MapReduce procedure impacts the performance. However, with the query range enlarged, the parallel STK query is more efficient than the original one. This can be explained by the parallelism of processing the query, making accessing and comparing to operate simultaneously. Therefore, the parallel STK queries are applicable for the condition with large selectivity.

    Figure 4. STK Query vs. Parallel STK Query.

    7. Conclusion

    In this paper, we propose the spatio-temporal keyword queries in HBase, which is a new problem for HBase platform. We devise a proper access model for HBase, utilized Hilbert curve and Bloom filter. Two algorithms are developed suitable for ordinary and large query selectivities, respectively. We conduct experiments on a real dataset, and the results show our methods are capable for large scale spatio-temporal keyword queries.

    In the future, we plan to extend our work to the inner structure of HBase index table, in order to improve efficiency of spatio-temporal keyword queries.


    Acknowledgments

    This work is supported by NSF of China grant 61303062. We would like to thank Peijun He for helping with the implementation.



    Acknowledgments



    None.

    Funding



    No funding or grant support.

    Conflicts of interest



    The following authors have no financial disclosures: NG, SM, SM, IL.

    Authorship



    All authors attest that they meet the current ICMJE criteria for Authorship.

    [1] Simone CG, Emmady PD (2023) Transverse Myelitis. StatPearls [Internet] . Treasure Island (FL): StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559302/
    [2] Ackerman T (2021) Acute Transverse Myelitis (ATM): An Unexpectedly Frequent Complication of COVID-19. COVID-19, NEUROLOGY & NEUROSURGERY .
    [3] “WHO Coronavirus (COVID-19) Dashboard.”. World Health Organization . Available from: https://data.who.int/dashboards/covid19/data [Accessed 9 June 2023]
    [4] Sriwastava S, Tandon M, Podury S, et al. (2021) COVID-19 and neuroinflammation: a literature review of relevant neuroimaging and CSF markers in central nervous system inflammatory disorders from SARS-COV2. J Neurol 268: 4448-4478. https://doi.org/10.1007/s00415-021-10611-9
    [5] Bösel YL (2021) Neurological manifestations of COVID-19 – an approach to categories of pathology. Neurol Res Pract 3. https://doi.org/10.1186/s42466-021-00138-9
    [6] Roy D, Ghosh R, Dubey S, et al. (2021) Neurological and Neuropsychiatric Impacts of COVID-19 Pandemic. Can J Neurol Sci 48: 9-24. https://doi.org/10.1017/cjn.2020.173
    [7] Liotta EM, Batra A, Clark JR, et al. (2020) Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients. Ann Clin Transl Neurol 7: 2221-2230. https://doi.org/10.1002/acn3.51210
    [8] Ahmad I, Rathore FA (2020) Neurological manifestations and complications of COVID-19: A literature review. J Clin Neurosci 77: 8-12. https://doi.org/10.1016/j.jocn.2020.05.017
    [9] Maury A, Lyoubi A, Peiffer-Smadja N, et al. (2021) Neurological manifestations associated with SARS-CoV-2 and other coronaviruses: A narrative review for clinicians. Rev Neurol (Paris) 177: 51-64. https://doi.org/10.1016/j.neurol.2020.10.001
    [10] Li X, Raventós B, Roel E, et al. (2022) Association between covid-19 vaccination, SARS-CoV-2 infection, and risk of immune mediated neurological events: population based cohort and self-controlled case series analysis. BMJ 376: e068373. https://doi.org/10.1136/bmj-2021-068373
    [11] Garg RK, Paliwal VK (2022) Spectrum of neurological complications following COVID-19 vaccination. Neurol Sci 43: 3-40. https://doi.org/10.1007/s10072-021-05662-9
    [12] West TW, Hess C, Cree BA (2012) Acute transverse myelitis: demyelinating, inflammatory, and infectious myelopathies. Semin Neurol 32: 97-113. https://doi.org/10.1055/s-0032-1322586
    [13] Greenberg BM, Krishnan C, Harder R (2019) New onset transverse myelitis diagnostic accuracy and patient experiences. Mult Scler Relat Disord 30: 42-44. https://doi.org/10.1016/j.msard.2019.01.046
    [14] Maroufi SF, Behdani FN, Rezania F, et al. (2022) Longitudinally extensive transverse myelitis after Covid-19 vaccination: case report and review of literature. Hum Vaccin Immunother 18. https://doi.org/10.1080/21645515.2022.2040239
    [15] Mao L, Jin H, Wang M, et al. (2020) Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China. JAMA Neurol 77: 1-9. https://doi.org/10.1001/jamaneurol.2020.1127
    [16] Román GC, Gracia F, Torres A, et al. (2021) Acute Transverse Myelitis (ATM): Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222). Front Immunol 12: 653786. https://doi.org/10.3389/fimmu.2021.653786
    [17] Hsiao Y-T, Tsai M-J, Chen Y-H, et al. (2021) Acute Transverse Myelitis after COVID-19 Vaccination. Medicina 57. https://doi.org/10.3390/medicina57101010
    [18] Voysey M, Clemens SAC, Madhi SA, et al. (2021) Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 397: 99-111. https://doi.org/10.1016/S0140-6736(20)32661-1
    [19] Eom H, Kim SW, Kim M, et al. (2022) Case Reports of Acute Transverse Myelitis Associated With mRNA Vaccine for COVID-19. J Korean Med Sci 37. https://doi.org/10.3346/jkms.2022.37.e52
    [20] Advani S, Hosseini SM, Zali A, et al. (2021) Transverse myelitis after SARS-CoV-2 infection: Report of two cases with COVID-19. Clin Case Rep 9: e05196. https://doi.org/10.1002/ccr3.5196
    [21] Qazi R, Memon A, Mohamed AS, et al. (2021) Post-COVID-19 Acute Transverse Myelitis: A Case Report and Literature Review. Cureus 13: e20628. https://doi.org/10.7759/cureus.20628
    [22] Brisca G, Sotgiu S, Pirlo D, et al. (2022) Longitudinally Extensive Transverse Myelitis (LETM) and Myopericarditis in a 7-Month-Old Child with SARs-CoV-2 Infection. Neuropediatrics 53: 61-64. https://doi.org/10.1055/s-0041-1732364
    [23] Alrubaye R, Bondugula V, Baleguli V, et al. (2022) A possible Guillain-Barré syndrome/transverse myelitis overlap syndrome after recent COVID-19. BMJ Case Rep 15: e246967. https://doi.org/10.1136/bcr-2021-246967
    [24] Arslan D, Acar-Ozen P, Gocmen R, et al. (2022) Post-COVID-19 longitudinally extensive transverse myelitis: is it a new entity?. Neurol Sci 43: 1569-1573. https://doi.org/10.1007/s10072-021-05640-1
    [25] Baghbanian SM, Namazi F (2021) Post COVID-19 longitudinally extensive transverse myelitis (LETM)-a case report. Acta Neurol Belg 121: 1875-1876. https://doi.org/10.1007/s13760-020-01497-x
    [26] Lu IF, Cornish JS, Ashok A, et al. (2022) Early SARS-CoV-2-associated acute transverse myelitis: A case for neurotropism?. J Intern Med 292: 679-683. https://doi.org/10.1111/joim.13542
    [27] Guada L, Cabrero FR, Baldwin NL, et al. (2022) Acute Ascending Necrotizing Myelitis After COVID-19 Infection: A Clinicopathologic Report. Neurol Clin Pract 12: e28-e32. https://doi.org/10.1212/CPJ.0000000000001175
    [28] Fonseca JP, Coelho A, Lourenço AC, et al. (2022) Longitudinally extensive transverse myelitis (LETM) secondary to SARS-CoV-2 infection: A recent reality in spinal cord injury rehabilitation. Clin Case Rep 10: e05876. https://doi.org/10.1002/ccr3.5876
    [29] Mbonu C, Molokwu N, Matelski A (2022) A COVID Constellation: A Case of Transverse Myelitis and Acquired von Willebrand Syndrome. J Consum Cult 10: 296-316. https://doi.org/10.1177/1469540518787584
    [30] Koc ER, Turan ÖF, Mengüç B (2022) Covid-19 Infection as a Possible Risk Factor for Longitudinally Extensive Transverse Myelitis!. Int J Neurosci 134: 193-196. https://doi.org/10.1080/00207454.2022.2098731
    [31] Prete S, McShannic JD, Fertel BS, et al. (2022) Acute Transverse Myelitis Progressing to Permanent Quadriplegia Following Covid-19 Infection. Am J Emerg Med 56: 391.e1-391.e3. https://doi.org/10.1016/j.ajem.2022.02.038
    [32] Quiles LEP, Tiongson JJA, Buensalido MJOV, et al. (2022) Transverse Myelitis as Neurologic Sequelae in a COVID-19 Recovered Patient. Neuroimmunol Rep 2: 100055. https://doi.org/10.1016/j.nerep.2022.100055
    [33] Kara S, Candelore T, Youssef P, et al. (2021) Evidence of Post-COVID-19 Transverse Myelitis Demyelination. Cureus 13: e19087. https://doi.org/10.7759/cureus.19087
    [34] Pourmoghaddas Z, Sadeghizadeh A, Tara SZ, et al. (2021) Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report. J Neuroimmunol 360: 577704. https://doi.org/10.1016/j.jneuroim.2021.577704
    [35] Chow CCN, Magnussen J, Ip J, et al. (2020) Acute transverse myelitis in COVID-19 infection. BMJ Case Rep 13: e236720. https://doi.org/10.1136/bcr-2020-236720
    [36] Khan E, Shrestha AK, Colantonio MA, et al. (2022) Acute transverse myelitis following SARS-CoV-2 vaccination: a case report and review of literature. J Neurol 269: 1121-1132. https://doi.org/10.1007/s00415-021-10785-2
    [37] Erdem NŞ, Demirci S, Özel T, et al. (2021) Acute transverse myelitis after inactivated COVID-19 vaccine. Ideggyogy Sz 74: 273-276. https://doi.org/10.18071/isz.74.0273
    [38] Gao JJ, Tseng HP, Lin CL, et al. (2021) Acute Transverse Myelitis Following COVID-19 Vaccination. Vaccines (Basel) 9: 1008. https://doi.org/10.3390/vaccines9091008
    [39] Finsterer J (2022) SARS-CoV-2 vaccinations complicated by transverse myelitis. Hum Vaccin Immunother 18: 2057162. https://doi.org/10.1080/21645515.2022.2057162
    [40] Nguyen S, Bastien E, Chretien B, et al. (2022) Transverse Myelitis Following SARS-CoV-2 Vaccination: A Pharmacoepidemiological Study in the World Health Organization's Database. Ann Neurol 92: 1080-1089. https://doi.org/10.1002/ana.26494
    [41] Maroufi SF, Naderi Behdani F, Rezania F, et al. (2022) Longitudinally extensive transverse myelitis after Covid-19 vaccination: case report and review of literature. Hum Vaccin Immunother 18: 2040239. https://doi.org/10.1080/21645515.2022.2040239
    [42] Tan WY, Yusof Khan AHK, Mohd Yaakob MN, et al. (2021) Longitudinal extensive transverse myelitis following ChAdOx1 nCOV-19 vaccine: a case report. BMC Neurol 21: 395. https://doi.org/10.1186/s12883-021-02427-x
    [43] Eom H, Kim SW, Kim M, et al. (2022) Case Reports of Acute Transverse Myelitis Associated With mRNssA Vaccine for COVID-19. J Korean Med Sci 37: e52. https://doi.org/10.3346/jkms.2022.37.e52
    [44] Nakano H, Yamaguchi K, Kawabata K, et al. (2022) Acute transverse myelitis after BNT162b2 vaccination against COVID-19: Report of a fatal case and review of the literature. J Neurol Sci 434: 120102. https://doi.org/10.1016/j.jns.2021.120102
    [45] Miyaue N, Yoshida A, Yamanishi Y, et al. (2022) Refractory Longitudinally Extensive Transverse Myelitis after Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in a Japanese Man. Intern Med 61: 739-742. https://doi.org/10.2169/internalmedicine.8747-21
    [46] Shetty AJ, Rastogi A, Jha V, et al. (2022) Longitudinally extensive transverse myelitis following ChAdOx1 nCoV-19 vaccine. J Postgrad Med 68: 179-181. https://doi.org/10.4103/jpgm.jpgm_1047_21
    [47] Maroufi SF, Behdani FN, Rezania F, et al. (2022) Longitudinally extensive transverse myelitis after covid vaccination: Response to letter. Hum Vaccin Immunother 18. https://doi.org/10.1080/21645515.2022.2096378
    [48] Hirose S, Hara M, Koda K, et al. (2021) Acute autoimmune transverse myelitis following COVID-19 vaccination: A case report. Medicine (Baltimore) 100: e28423. https://doi.org/10.1097/MD.0000000000028423
    [49] Pagenkopf C, Südmeyer M (2021) A case of longitudinally extensive transverse myelitis following vaccination against Covid-19. J Neuroimmunol 358: 577606. https://doi.org/10.1016/j.jneuroim.2021.577606
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