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Research article

Role of parental age in newborn telomere length prolongation

  • Telomere length, a marker of biological aging, can be altered by parental telomere genetics. In this study, we aimed to find an association between parental age and newborn telomere length (TL) and deterioration patterns in parents and newborns. This was a cross-sectional study on 204 parent–newborn pairs from September 2021 to July 2022. Quantitative polymerase chain reaction (qPCR) was used to measure the telomere length (T/S ratio). A correlation and linear regression were used for the association between newborn TL and parental age. There was a positive correlation (r = 0.185, p = 0.007) between the fathers' age and newborn TL. However, regression analysis highlighted an association between the mother's as well as the father's age and newborn TL (B = 0.032, 0.04; p = 0.09, 0.009). The old-age mothers (35.1–40 years old) had newborn girls with longer TL; however, old-age fathers (35.1–45 years old) had boys with longer TL (1.94 ± 0.72, 2.48 ± 1.22) (p = 0.23). Therefore, longer telomere length was seen in newborns of older parents. Moreover, parental age, especially the father's age, showed an association with newborns' telomere genetics.

    Citation: Sadia Farrukh, Saeeda Baig, Aliya Irshad Sani. Role of parental age in newborn telomere length prolongation[J]. AIMS Molecular Science, 2024, 11(2): 140-149. doi: 10.3934/molsci.2024009

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  • Telomere length, a marker of biological aging, can be altered by parental telomere genetics. In this study, we aimed to find an association between parental age and newborn telomere length (TL) and deterioration patterns in parents and newborns. This was a cross-sectional study on 204 parent–newborn pairs from September 2021 to July 2022. Quantitative polymerase chain reaction (qPCR) was used to measure the telomere length (T/S ratio). A correlation and linear regression were used for the association between newborn TL and parental age. There was a positive correlation (r = 0.185, p = 0.007) between the fathers' age and newborn TL. However, regression analysis highlighted an association between the mother's as well as the father's age and newborn TL (B = 0.032, 0.04; p = 0.09, 0.009). The old-age mothers (35.1–40 years old) had newborn girls with longer TL; however, old-age fathers (35.1–45 years old) had boys with longer TL (1.94 ± 0.72, 2.48 ± 1.22) (p = 0.23). Therefore, longer telomere length was seen in newborns of older parents. Moreover, parental age, especially the father's age, showed an association with newborns' telomere genetics.



    Rectifying curves have been studied a lot in three-dimensional Euclidean space. Rectifying curve whose definition and equivalent definitions are provided in [1]. Chen and Dillen revealed the relationship between the center point of the spatial curve and the rectifying curve in [2]. Rectifying curves have many properties in Euclidean space [3]. In four-dimensional Euclidean space, İşbilir and Tosun [4] studied rectifying curves. Many scholars studied the properties of multiple curves in three-dimensional Minkowski space [5,6]. There have also been studies about rectifying curves, such as three-dimensional Minkowski space [7,8], three-dimensional hyperbolic space [9], and three-dimensional spheres [10]. There is a new article about rectifying curves [11]. These are all valuable geometric information obtained by analyzing the curvature and the torsion of the regular rectifying curve and the Frenet-Serret formula. If the curve has singularities, then other methods need to be used for research. The definition of framed curves has been given in [12]. Framed curves are spatial curves that have moving frames. The framed base curve may have singularities. Next, the rectifying curve was studied by the adapted frame in [13].

    Inspired by the above work, we study non-lightlike framed rectifying curves. We define the non-lightlike framed rectifying curves, study the construction of the non-lightlike framed rectifying curves, and obtain valuable geometric information.

    In Section 2, we review the basic knowledge of non-lightlike framed curves. In Section 3, the non-lightlike framed rectifying curves are defined and their equivalent definitions are given. In Section 4, a method for constructing non-lightlike framed rectifying curves is provided, and examples of regular curves and singular curves are also provided. In Section 5, we define non-lightlike framed helices to obtain the relationship between them and non-lightlike framed rectifying curves. The centrodes of non-lightlike framed rectifying curves are also studied.

    All maps and manifolds considered here are differentiable of class C.

    Let R31 be Minkowski 3-space with the pseudo scalar product ,, the pseudo vector product , and the norm ||||. The pseudo scalar product is equipped with the signature (,+,+).

    For any nonzero vector aR31, it is called spacelike, timelike, or lightlike if a,a is positive, negative, or zero, respectively. We say the regular curve γ:IR31 is spacelike, timelike, or lightlike if the vector γ(t) is spacelike, timelike or lightlike for all tI, respectively. For nR31{0}, define a set P={aR31|a,n=0}. It is obvious that P is a plane in R31. The vector n is called the pseudo normal vector of the plane P. The plane P is called spacelike, timelike, or lightlike if the vector n is timelike, spacelike, or lightlike, respectively.

    There are three pseudo spheres in R31:

    S21={aR31|a,a=1},
    LC={aR31{0}|a,a=0}

    and

    H20={aR31|a,a=1}.

    We call them de Sitter 2-space, (open) lightcone, and hyperbolic 2-space, respectively. Let Δ={(β1,β2)R31×R31|β1,β2=0,||β1||=1,||β2||=1} and γ:IR31 be a non-lightlike curve.

    Definition 2.1. We call (γ,β1,β2):IR31×Δ a non-lightlike framed curve if γ(t),β1(t)=0, γ(t),β2(t)=0 for any tI. We call γ:IR31 a non-lightlike framed base curve if there exists (β1,β2):IΔ such that (γ,β1,β2) is a non-lightlike framed curve.

    Define μ(t)=β1(t)β2(t). There exists a function α:IR satisfying γ(t)=α(t)μ(t). {β1(t),β2(t),μ(t)} is a moving frame along γ. Frenet-type formulas are

    (β1(t)β2(t)μ(t))=(0l1(t)l2(t)σl1(t)0l3(t)σδl2(t)δl3(t)0)(β1(t)β2(t)μ(t)),
    γ(t)=α(t)μ(t),

    where

    σ=μ(t),μ(t),δ=β1(t),β1(t),l1(t)=σδβ1(t),β2(t),l2(t)=σβ1(t),μ(t),l3(t)=σβ2(t),μ(t),α(t)=σγ(t),μ(t).

    (l1,l2,l3,α):IR4 is called the curvature of (γ,β1,β2). If μ(t) is spacelike (timelike), we call γ a spacelike (timelike) framed base curve.

    We know t0 is a singular point of γ if and only if α(t0)=0.

    Proposition 2.2. γ:IR31 is a non-lightlike regular curve, and (γ,β1,β2):IR31×Δ is a non-lightlike framed curve. The relations between the curvature (l1,l2,l3,α) of (γ,β1,β2) and the curvature κ and the torsion τ of γ are

    (|α|κ)(t)=|l22σl23|(t),
    (δα(l22σl23)τ)(t)=(l2l3l3l2+σl1l22l1l23)(t).

    We assume l22(t)σl23(t) and denote ε=sgn(l22σl23)(t).

    Definition 2.3. (γ,β1,β2):IR31×Δ is a non-lightlike framed curve, and its curvature is (l1,l2,l3,α). Let

    (¯β1(t)¯β2(t))=1ε(l22σl23)(t)(εl2(t)εσl3(t)l3(t)l2(t))(β1(t)β2(t)).

    We call ¯β1 direction the principal normal direction of (γ,β1,β2) and ¯β2 direction the binormal direction of (γ,β1,β2).

    We have μ(t)=¯β1(t)¯β2(t). {¯β1(t),¯β2(t),μ(t)} is called the Frenet-type frame along γ. Frenet-type formulas are

    (¯β1(t)¯β2(t)μ(t))=(0L1(t)L2(t)σL1(t)00σεδL2(t)00)(¯β1(t)¯β2(t)μ(t)),
    γ(t)=α(t)μ(t),

    where

    L1(t)=ε(l2l3l3l2l22σl23(t)+σl1(t)),L2(t)=ε(l22(t)σl23(t)).

    Then (L1,L2,0,α) is the curvature of (γ,¯β1,¯β2).

    Remark 2.4. (γ,β1,β2):IR31×Δ is a non-lightlike framed curve, and its curvature is (l1,l2,0,α). If l2(t)>0, then ¯β1(t)=β1(t) and ¯β2(t)=β2(t). If l2(t)<0, then ¯β1(t)=β1(t) and ¯β2(t)=β2(t).

    In this article, we only study the non-lightlike framed curve (γ,¯β1,¯β2) and its frame is the Frenet-type frame {¯β1(t),¯β2(t),μ(t)}.

    Remark 2.5. γ:IR31 is a non-lightlike regular curve and (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve. Let l3=0 be in Proposition 2.2. We have the relations among the curvature κ, the torsion τ of γ and the curvature (L1,L2,0,α) of (γ,¯β1,¯β2) are

    κ(t)=L2|α|(t),τ(t)=σδL1α(t)

    For a non-lightlike framed curve (γ,¯β1,¯β2):IR31×Δ, the rectifying plane of γ at t0 is the plane through γ(t0) and spanned by ¯β2(t0) and μ(t0).

    Definition 3.1. (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve. We call (γ,¯β1,¯β2) a non-lightlike framed rectifying curve if γ satisfies

    γ(t)=(ψμ+ϕ¯β2)(t)

    for two functions ψ(t),ϕ(t):IR. γ is called a base curve of a non-lightlike framed rectifying curve (Figure 1).

    Figure 1.  γ is a base curve of a non-lightlike framed rectifying curve.

    We call f(t)=γ(t),γ(t) the distance squared function of a non-lightlike framed curve (γ,¯β1,¯β2).

    Theorem 3.2. (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve. The following statements are equivalent.

    (1) γ(t),μ(t)=σα(t).

    (2) The distance squared function satisfies

    f(t)=σγ(t),μ(t)2ϕ2σεδ.

    (3) γ(t),¯β2(t)=ϕεδ,ϕR{0}.

    (4) γ(t) is a base curve of a non-lightlike framed rectifying curve.

    Proof. Let γ(t) be a base curve of a non-lightlike framed rectifying curve. We know there exist two functions ψ(t) and ϕ(t) such that

    γ(t)=(ψμ+ϕ¯β2)(t). (3.1)

    According to the Frenet-type formulas and deriving (3.1), we have

    (αμ)(t)=(ψμ+(σεδψL2+σϕL1)¯β1+ϕ¯β2)(t).

    Then

    ψ(t)=α(t),(σεδψL2)(t)=(σϕL1)(t),ϕ(t)=0. (3.2)

    From the first equation of (3.2), we obtain γ,μ(t)=σψ(t)=σα(t). This proves the statement (1).

    By (3.1) and (3.2), we can obtain that

    γ,γ(t)=(σψ2ϕ2σεδ)(t)=(σγ,μ2ϕ2σεδ)(t),

    If ϕ=0, then ψ(t)=0 and γ(t) is a point. So ϕ0. This proves statements (2) and (3).

    Conversely, we assume the statement (1) holds, then

    γ,μ(t)=(αμ,μ+γ,σεδL2¯β1)(t)=σα(t).

    By assumption, we obtain γ(t),¯β1(t)=0. So γ(t) is a base curve of a non-lightlike framed rectifying curve.

    If the statement (2) holds, then

    γ,γ(t)=(σγ,μ2ϕ2σεδ)(t).

    Then,

    2γ,αμ(t)=(2σγ,μσα+γ,σεδL2¯β1)(t).

    So we get γ(t),¯β1(t)=0.γ(t) is a base curve of a non-lightlike framed rectifying curve.

    If the statement (3) holds, γ(t),¯β2(t)=ϕσεδ. By taking the derivative, we have

    (αμ,¯β2+γ,σL1¯β1)(t)=0.

    So γ(t),¯β1(t)=0.γ(t) is a base curve of a non-lightlike framed rectifying curve.

    Remark 3.3. (γ,¯β1,¯β2) is a non-lightlike framed rectifying curve. If the base curve of a non-lightlike framed rectifying curve γ is singular at t0, then from Eq (3.2) and the statement (2) in Theorem 3.2, we have

    L1L2(t)=σδψϕ(t),(L1L2(t))=σδαϕ(t).

    So (L1(t0)L2(t0))=0. Moreover, we know

    f(t)=(2αγ,μ)(t).

    So f(t0)=0.

    Theorem 4.1. (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed rectifying curve. γ(t) is a base curve of a non-lightlike framed rectifying curve if and only if γ(t) can be expressed as one of the following two equations

    γ(t)=ρ(sec(||y(t)||dt+M))y(t),

    where M is a constant, ρR{0} and y(t) is a spacelike framed base curve on S21. Or

    γ(t)=2ϕe||y(t)||dt+12M|1e2||y(t)||dt+M|y(t),

    where M is a constant, ϕR{0} and y(t) is a spacelike (timelike) framed base curve on H20 (S21).

    Proof. First, we prove the first equation. Let γ(t) be a base curve of a spacelike framed rectifying curve, which has a spacelike rectifying plane. So γ,γ(t)=(ψ2(t)+ρ2)(t), where ρR{0}. Let y(t)=(1(ψ2+ρ2)12γ)(t) be a spacelike framed base curve on S21. We have

    γ(t)=(ψα(ψ2+ρ2)12y+(ψ2+ρ2)12y)(t).

    Since γ(t)=α(t)μ(t) and y(t) is orthogonal to y(t), we can obtain

    γ,γ(t)=(ψ2α2ψ2+ρ2+(ψ2+ρ2)y,y)(t).

    So

    ||y(t)||=(|ρα|ψ2+ρ2)(t).

    We only consider ρα(t)0, and it is similar for ρα(t)0. Then

    ||y(t)||dt+M=arctanψ(t)ρ.

    That is

    ψ(t)=ρtan(||y(t)||dt+M).

    So

    γ(t)=ρ(sec(||y(t)||dt+M))y(t).

    Conversely, let (y,βy1,βy2) be a spacelike framed curve and γ(t) be defined by

    γ(t)=ρ(sec(||y(t)||dt+M))y(t).

    Let ¯ψ(t)=ρ(tan2(||y(t)||dt+M)) and ¯α(t)=¯ψ(t). Then

    γ(t)=((¯ψ2+ρ2)12y)(t),
    γ(t)=(¯ψ¯α(¯ψ2+ρ2)12y+(¯ψ2+ρ2)12y)(t).

    Since y(t) is also a spacelike framed curve, we define that y(t)=ψ(t)μy(t), where μy(t)=βy1(t)βy2(t). We can obtain

    ||y(t)||dt+M=arctan¯ψ(t)ρ

    and

    ||y(t)||=(|ρ¯α|¯ψ2+ρ2)(t).

    Therefore, we denote that y(t)=(ρ¯α¯ψ2+ρ2μy)(t). That is y(t)=(ρ¯α¯ψ2(t)+ρ2)(t). Then we have

    γ(t)=(¯α¯ψ(¯ψ2+ρ2)12y+ρ(¯ψ2+ρ2)12μy)(t)=(¯αμ)(t).

    Hence, we can calculate that γ,μ2(t)=¯ψ(t). Since γ,γ(t)=(¯ψ2+ρ2)(t), we have

    γ,γ(t)=(γ,μ2+ρ2)(t).

    It indicates that the function satisfies the statement (2) in Theorem 3.2. So γ(t) is a base curve of a spacelike framed rectifying curve.

    Next we prove the second equation. Let γ(t) be the base curve of a spacelike framed rectifying curve, which has a timelike rectifying plane and a spacelike position vector. (We only prove this case, and the proof for other cases is similar to it.) So γ,γ(t)=(ψ2ϕ2)(t), where ϕR{0}. Let y(t)=(1(ψ2ϕ2)12γ)(t) be a spacelike framed base curve on S21. We have

    γ(t)=(ψα(ψ2ϕ2)12y+(ψ2ϕ2)12y)(t),

    Since γ(t)=(αμ)(t) and y(t) is orthogonal to y(t),

    γ,γ(t)=α2(t)=(ψ2α2ψ2ϕ2+(ψ2ϕ2)y,y)(t).

    So

    ||y(t)||=|ϕαψ(t)2ϕ2|(t)

    and

    ||y(t)||dt+M=12ln|ψ(t)ϕψ(t)+ϕ|.

    Then,

    ψ(t)=ϕ1+e2||y(t)||dt+M1e2||y(t)||dt+M.

    So

    γ(t)=2ϕe||y(t)||dt+12M|1e2||y(t)||dt+M|y(t).

    Conversely, we can obtain the proof of this section by referring to the proof of the first equation.

    Remark 4.2. If γ(t) is a base curve of a spacelike framed rectifying curve, which has a timelike rectifying plane and a lightlike position vector, then γ(t),γ(t)=0. That means ψ2(t)=ϕ2, α(t)=0, then γ(t) is a point. So γ(t) does not exist.

    Example 4.3. Let y1(t)=(32,72cos2t,72sin2t),t(π23,π23) be a curve on S21. We have ||y1(t)||=7. Let ρ=1 and M=0. We have the curve

    γ1(t)=(sec7t)(32,72cos2t,72sin2t)

    is a base curve of a non-lightlike framed rectifying curve in R31 (Figure 2).

    Figure 2.  The curve γ1(t) is a non-lightlike framed rectifying curve.

    Example 4.4. Let y2(t)=(sinht2,cosht2,0),t(π2,π2) be a curve on S21. We have ||y2(t)||=2|t|. Let ρ=1 and M=0. We have the curve

    γ2(t)=sect2(sinht2,cosht2,0)

    is a base curve of a non-lightlike framed rectifying curve with a singular point R31 (Figure 3).

    Figure 3.  The curve γ2(t) is a base curve of a non-lightlike framed rectifying curve with a singular point. The black point is the singular point of the curve, whose two segments coincide.

    Definition 5.1. (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve. γ is called a non-lightlike framed helix if there exists a fixed unit vector η satisfying

    μ(t),η=p,

    where pR{0}.

    Remark 5.2. For a non-lightlike framed curve (γ,β1,β2), we can also call γ a non-lightlike framed helix if there exists a fixed unit vector η satisfying

    μ(t),η=p,

    where pR{0}.

    (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve with the curvature (L1,L2,0,α). γ is a non-lightlike framed helix. We consider the ratio L1(t)L2(t).

    Since

    μ,η(t)=(σεδL2¯β1,η(t)=0.

    Then

    ¯β1(t),η=0. (5.1)

    η is located in the plane, and the plane has basis vectors μ(t) and ¯β2(t). Since μ(t),η=p, we have ¯β2(t),η is a constant, denoted by p1. If p1=0, then μ(t)=σpη. At this point, γ is a segment of a straight line. So we always assume p10. We take the derivative of (5.1), so

    L2μ+L1¯β2,η(t)=0.

    Then

    L1L2(t)=pp1.

    By Theorem 3.2, we can obtain γ(t) is a base curve of the non-lightlike framed rectifying curve if and only if

    L1L2(t)=c1α(t)dt+c2,

    where c1,c2R, c10.

    Proposition 5.3. (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve and its curvature is (L1,L2,0,α). The curvature satisfies (L1(t)L2(t))=c1α(t).

    (1) If c1=0, then (γ,¯β1,¯β2) is a non-lightlike framed helix.

    (2) If c10, then (γ,¯β1,¯β2) is a non-lightlike framed rectifying curve.

    Definition 5.4. (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve and its curvature is (L1,L2,0,α). We call d(t) the centrode of (γ,¯β1,¯β2) if

    d(t)=(L1μ+L2¯β2)(t).

    Proposition 5.5. (γ,¯β1,¯β2):IR31×Δ is a non-lightlike framed curve, and its curvature is (L1,L2,0,α). Where L1(t) is a nonzero constant and L2(t) is a nonconstant function.

    (1) Let d(t)=(L1μ+L2¯β2)(t) be the centrode of (γ,¯β1,¯β2). Then d(t) is a base curve of a non-lightlike framed rectifying curve.

    (2) The base curve of any non-lightlike framed rectifying curve in R31 is the centrode of some non-lightlike framed curve.

    Future research could extend the concept of non-lightlike framed rectifying curves to high-dimensional Minkowski space or it could study lightlike framed rectifying curves. This provides assistance in studying the properties and classification of higher-dimensional non-lightlike framed rectifying curves.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    This work was supported by the National Natural Science Foundation of China (Grant No. 11671070).

    The authors declare that there is no conflict of interest.


    Acknowledgments



    The authors would like to thank the Ziauddin Hospitals (Clifton, Kemari) paramedical staff for their help in data and sample collection. Special thanks to the laboratory assistants for the accomplishment of molecular genetics work.

    Conflict of interest



    All authors declare no conflicts of interest in this paper.

    [1] Blackburn EH, Epel ES, Lin J (2015) Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science 350: 1193-1198. https://doi.org/10.1126/science.aab3389
    [2] Aunan JR, Watson MM, Hagland HR, et al. (2016) Molecular and biological hallmarks of ageing. Brit J Surg 103: e29-e46. https://doi.org/10.1002/bjs.10053
    [3] Srinivas N, Rachakonda S, Kumar R (2020) Telomeres and telomere length: A general overview. Cancers 12: 558. https://doi.org/10.3390/cancers12030558
    [4] Zhu Y, Armstrong JL, Tchkonia T, et al. (2014) Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Curr Opin Clin Nutr Metab Care 17: 324-328. https://doi.org/10.1097/mco.0000000000000065
    [5] Lee SP, Hande P, Yeo GS, et al. (2017) Correlation of cord blood telomere length with birth weight. BMC Res Notes 10: 469. https://doi.org/10.1186/s13104-017-2791-6
    [6] Feiler MO, Patel D, Li H, et al. (2018) The association between early-life relative telomere length and childhood neurodevelopment. NeuroToxicology 65: 22-27. https://doi.org/10.1016/j.neuro.2018.01.005
    [7] Weng Q, Du J, Yu F, et al. (2016) The known genetic loci for telomere length may be involved in the modification of telomeres length after birth. Sci Rep 6: 38729. https://doi.org/10.1038/srep38729
    [8] Whittemore K, Vera E, Martínez-Nevado E, et al. (2019) Telomere shortening rate predicts species life span. PNAS 116: 15122-15127. https://doi.org/10.1073/pnas.1902452116
    [9] Razgonova MP, Zakharenko AM, Golokhvast KS, et al. (2020) Telomerase and telomeres in aging theory and chronographic aging theory (Review). Mol Med Rep 22: 1679-1694. https://doi.org/10.3892/mmr.2020.11274
    [10] De Meyer T, Rietzschel ER, De Buyzere ML, et al. (2007) Paternal age at birth is an important determinant of offspring telomere length. Hum Mol Genet 16: 3097-3102. https://doi.org/10.1093/hmg/ddm271
    [11] Eisenberg DTA, Hayes MG, Kuzawa CW (2012) Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants. PNAS 109: 10251-10256. https://doi.org/10.1073/pnas.1202092109
    [12] Entringer S, de Punder K, Buss C, et al. (2018) The fetal programming of telomere biology hypothesis: An update. Phil. Trans R. Soc B 373: 20170151. https://doi.org/10.1098/rstb.2017.0151
    [13] Farrukh S, Baig S, Hussain R, et al. (2022) Parental genetics communicate with intrauterine environment to reprogram newborn telomeres and immunity. Cells 11: 3777. https://doi.org/10.3390/cells11233777
    [14] Rossiello F, Jurk D, Passos JF, et al. (2022) Telomere dysfunction in ageing and age-related diseases. Nat Cell Biol 24: 135-147. https://doi.org/10.1038/s41556-022-00842-x
    [15] Chen L, Tan KML, Gong M, et al. (2022) Variability in newborn telomere length is explained by inheritance and intrauterine environment. BMC Med 20: 20. https://doi.org/10.1186/s12916-021-02217-9
    [16] Ozturk S, Sozen B, Demir N (2014) Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species. Mol Hum Reprod 20: 15-30. https://doi.org/10.1093/molehr/gat055
    [17] Farrukh S, Baig S, Hussain R, et al. (2019) Telomere reprogramming during fetal life in low socioeconomic mothers. Egypt J Med Hum Genet 20: 9. https://doi.org/10.1186/s43042-019-0007-4
    [18] Garcia-Martin I, Janssen AB, Jones RE, et al. (2017) Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59: 61-68. https://doi.org/10.1016/j.placenta.2017.09.007
    [19] Martens DS, Sleurs H, Dockx Y, et al. (2022) Association of newborn telomere length with blood pressure in childhood. JAMA Netw Open 5: e2225521. https://doi.org/10.1001/jamanetworkopen.2022.25521
    [20] Puterman E, Lin J, Krauss J, et al. (2014) Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter. Mol Psychiatry 20: 529-535. https://doi.org/10.1038/mp.2014.70
    [21] Martens DS, Plusquin M, Gyselaers W, et al. (2016) Maternal pre-pregnancy body mass index and newborn telomere length. BMC Med 14: 148. https://doi.org/10.1186/s12916-016-0689-0
    [22] Biswas SK (2016) Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?. Oxid Med Cell Longev 2016: 569893. https://doi.org/10.1155/2016/5698931
    [23] Hjelmborg JB, Dalgård C, Mangino M, et al. (2015) Paternal age and telomere length in twins: The germ stem cell selection paradigm. Aging Cell 14: 701-703. https://doi.org/10.1111/acel.12334
    [24] Benetos A, Dalgård C, Labat C, et al. (2014) Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins. Int J Epidemiol 43: 1799-1805. https://doi.org/10.1093/ije/dyu146
    [25] Cariati F, Jaroudi S, Alfarawati S, et al. (2016) Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality. Reprod BioMed Online 33: 404-411. https://doi.org/10.1016/j.rbmo.2016.06.006
    [26] Fagan E, Sun F, Bae H, et al. (2017) Telomere length is longer in women with late maternal age. Menopause 24: 497-501. https://doi.org/10.1097/GME.0000000000000795
    [27] Wulaningsih W, Hardy R, Wong A, et al. (2018) Parental age and offspring leukocyte telomere length and attrition in midlife: Evidence from the 1946 British birth cohort. Experimental Gerontology 112: 92-96. https://doi.org/10.1016/j.exger.2018.09.008
    [28] Broer L, Codd V, Nyholt DR, et al. (2013) Meta-analysis of telomere length in 19713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet 21: 1163-1168. https://doi.org/10.1038/ejhg.2012.303
    [29] Eisenberg DTA (2013) Inconsistent inheritance of telomere length (TL): Is offspring TL more strongly correlated with maternal or paternal TL?. Eur J Hum Genet 22: 8-9. https://doi.org/10.1038/ejhg.2013.202
    [30] de Frutos C, López-Cardona AP, Fonseca Balvís N, et al. (2016) Spermatozoa telomeres determine telomere length in early embryos and offspring. Reproduction 151: 1-7. https://doi.org/10.1530/rep-15-0375
    [31] Fielder E, Tweedy C, Wilson C, et al. (2020) Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice. Aging Cell 19: e13188. https://doi.org/10.1111/acel.13188
    [32] Gruber HJ, Semeraro MD, Renner W, et al. (2021) Telomeres and age-related diseases. Biomedicines 9: 1335. https://doi.org/10.3390/biomedicines9101335
    [33] Send TS, Gilles M, Codd V, et al. (2017) Telomere length in newborns is related to maternal stress during pregnancy. Neuropsychopharmacology 42: 2407-2413. https://doi.org/10.1038/npp.2017.73
    [34] Jafri MA, Ansari SA, Alqahtani MH, et al. (2016) Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Med 8: 69. https://doi.org/10.1186/s13073-016-0324-x
    [35] Wang R, Metayer C, Morimoto L, et al. (2017) Parental age and risk of pediatric cancer in the offspring: A population-based record-linkage study in California. Am J Epidemiol 186: 843-856. https://doi.org/10.1093/aje/kwx160
    [36] Ujvari B, Raven N, Madsen T, et al. (2022) Telomeres, the loop tying cancer to organismal life-histories. Mol Ecol 31: 6273-6285. https://doi.org/10.1111/mec.16488
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