Review

Periostin – an unexplored tumor marker of oral squamous cell carcinoma

  • Received: 04 October 2020 Accepted: 15 December 2020 Published: 16 December 2020
  • Cancer is a multi-hit multi-step process that ultimately leads to malignant transformation. Genes encoding for extracellular matrix, proteins of epidermal development, and cell adhesion molecules are mostly altered in oral squamous cell carcinoma. Of late, the paradigm for diagnosis has shifted from clinical status to molecular one. This is because molecular changes occur immediately, whereas clinical changes take a long time to show up. Hence, by evaluating various markers of cancer, its progression, severity, resistance, and prognosis can be predicted way before the clinical signs occur. These markers are present either in the tumors or hosts and help to distinguish between normal and dysplastic tissue. They generally increase during the disease progression or relapse, and decrease when the disease goes into remission. They can also be detected in blood, plasma and saliva apart from tissues. Periostin is one such molecule that gets altered, and hence can be used as a marker. Studies on the expression of periostin in oral cancer are very few; therefore, an attempt is made to throw some light on this novel protein and its role in oral cancer. It can be used in target therapy solely or as an adjunct in treating oral squamous cell carcinoma.

    Citation: Khushboo Desai, Dolly Patel, Parth Desai, Rakesh Rawal, Himanshu Pandya. Periostin – an unexplored tumor marker of oral squamous cell carcinoma[J]. AIMS Molecular Science, 2020, 7(4): 383-395. doi: 10.3934/molsci.2020019

    Related Papers:

  • Cancer is a multi-hit multi-step process that ultimately leads to malignant transformation. Genes encoding for extracellular matrix, proteins of epidermal development, and cell adhesion molecules are mostly altered in oral squamous cell carcinoma. Of late, the paradigm for diagnosis has shifted from clinical status to molecular one. This is because molecular changes occur immediately, whereas clinical changes take a long time to show up. Hence, by evaluating various markers of cancer, its progression, severity, resistance, and prognosis can be predicted way before the clinical signs occur. These markers are present either in the tumors or hosts and help to distinguish between normal and dysplastic tissue. They generally increase during the disease progression or relapse, and decrease when the disease goes into remission. They can also be detected in blood, plasma and saliva apart from tissues. Periostin is one such molecule that gets altered, and hence can be used as a marker. Studies on the expression of periostin in oral cancer are very few; therefore, an attempt is made to throw some light on this novel protein and its role in oral cancer. It can be used in target therapy solely or as an adjunct in treating oral squamous cell carcinoma.


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    Conflict of interest



    All authors declare no conflicts of interest in this paper.

    [1] Kumar V, Cotran RS, Stanley L (2003) Robbins with illustrations by James A. Perkins. Robbins Basic Pathology Philadelphia: Saunders.
    [2] Varshitha A (2015) Prevalence of oral cancer in India. J Pharm Sci Res 7: 845-848.
    [3] Andrabi SASMedia report. Indian Council of Medical Research in news (2019) .2 Feb to 8 Feb.
    [4] Mehrotra R, Yadav S (2006) Oral Squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations. Indian J Cancer 43: 60-66. doi: 10.4103/0019-509X.25886
    [5] India state-level Disease Burden Initiative Cancer Collaborators (2018) The burden of cancers and their variations across the states of India: the Global Burden of Disease Study 1990–2016. Lancet Oncol 19: 1289-1306.
    [6] Lin JW, Jiang RS, Wu SH, et al. (2011) Smoking, Alcohol and Betel Quid and Oral Cancer: A Prospective Cohort Study. J Oncol Article ID: 525976.
    [7] Gerstner AO (2008) Early detection in head and neck cancer – current state and future perspectives. GMS Curr Top Otorhinolaryngol Head Neck Surg 7: Doc06.
    [8] Mishra A, Verma M (2010) Cancer Biomarkers: Are We Ready for the Prime Time? Cancers 2: 190-208. doi: 10.3390/cancers2010190
    [9] Pratheepa L, Ramani P, Sherlin HJ, et al. (2012) Expression of Emerging Novel Tumor markers in Oral Squamous cell carcinoma and their Clinical and Pathological correlation to determine the Prognosis and Usefulness as a Therapeutic target – A Systematic Review. J Nat Sci Res 2: 57-66.
    [10] Spencer KR, Ferguson JW, Wiesenfeld D (2002) Current concepts in the management of oral squamous cell carcinoma. Aust Dent J 47: 284-289. doi: 10.1111/j.1834-7819.2002.tb00539.x
    [11] Bhatt AN, Mathur R, Farooque A, et al. (2010) Cancer biomarkers ̶ current perspectives. Indian J Med Res 132: 129-149.
    [12] Choi P, Chen C (2005) Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma. Cancer 104: 1113-1128. doi: 10.1002/cncr.21293
    [13] Morra L, Moch H (2011) Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update. Virchows Arch 459: 465-475. doi: 10.1007/s00428-011-1151-5
    [14] Ratajczak-Wielgomas K, Dziegiel P (2015) The role of periostin in neoplastic processes. Folia Histochem Cytobiol 53: 120-132. doi: 10.5603/FHC.a2015.0014
    [15] Kudo A (2011) Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell. Cell Mol Life Sci 68: 3201-3207. doi: 10.1007/s00018-011-0784-5
    [16] Coutu DL, Wu JH, Monette A, et al. (2008) Periostin, a member of a novel family of vitamin K–dependent proteins, is expressed by mesenchymal stromal cells. J Biol Chem 283: 17991-18001. doi: 10.1074/jbc.M708029200
    [17] Conway SJ, Izuhara K, Kudo Y, et al. (2014) The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci 71: 1279-1288. doi: 10.1007/s00018-013-1494-y
    [18] Wong GS, Rustgi AK (2013) Matricellular proteins: priming the tumor microenvironment for cancer development and metastasis. Br J Cancer 108: 755-761. doi: 10.1038/bjc.2012.592
    [19] Liu Y, Huang Z, Cui D, et al. (2019) The multiaspect functions of periostin in tumor progression. Periostin. Advances in Experimental Medicine and Biology Singapore: Springer, 125-136. doi: 10.1007/978-981-13-6657-4_13
    [20] Orecchia P, Conte R, Balza E, et al. (2011) Identification of a novel cell binding site of periostin involved in tumor growth. Eur J Cancer 47: 2221-2229. doi: 10.1016/j.ejca.2011.04.026
    [21] Qin X, Yan M, Zhang J, et al. (2016) TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis. Sci Rep 6: 20587. doi: 10.1038/srep20587
    [22] Kudo A (2017) Introductory review: Periostin - gene and protein structure. Cell Mol Life Sci 74: 4259-4268. doi: 10.1007/s00018-017-2643-5
    [23] Guan WQ, Li Q, Ouyang QM (2019) Expression and Significance of Periostin in Tissues and Serum in Oral Leukoplakia and Squamous Cell Carcinoma. Cancer Biother Radiopharm 34: 444-450. doi: 10.1089/cbr.2018.2764
    [24] Gonzalez-Gonzalez L, Alonso L (2018) Periostin: A matricellular protein with multiple functions in cancer development and progression. Front Oncol 8: 225. doi: 10.3389/fonc.2018.00225
    [25] Tilman G, Mattiussi M, Brasseur F, et al. (2007) Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by stromal and melanoma cells. Mol Cancer 6: 80. doi: 10.1186/1476-4598-6-80
    [26] Liu AY, Zheng H, Ouyang G (2014) Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol 37: 150-156. doi: 10.1016/j.matbio.2014.04.007
    [27] Siriwardena BS, Kudo Y, Ogawa I, et al. (2006) Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. Br J Cancer 95: 1396-1403. doi: 10.1038/sj.bjc.6603431
    [28] Hu WW, Chen PC, Chen JM, et al. (2017) Periostin promotes epithelial-mesenchymal transition via the MAPK/miR-381 axis in lung cancer. Oncotarget 8: 62248-62260. doi: 10.18632/oncotarget.19273
    [29] Ye D, Shen ZS, Qiu SJ, et al. (2017) Role and underlying mechanisms of the interstitial protein periostin in the diagnosis and treatment of malignant tumors. Oncol Lett 14: 5099-5106.
    [30] Lv YJ, Wang W, Ji CS, et al. (2017) Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance. Oncol Lett 14: 376-382. doi: 10.3892/ol.2017.6124
    [31] Routray S, Rahman J (2017) Periostin (POSTN). Encyclopedia of Signaling Molecules New York (NY): Springer, 1-5.
    [32] Wang W, Sun QK, He YF, et al. (2014) Overexpression of periostin is significantly correlated to the tumor angiogenesis and poor prognosis in patients with esophageal Squamous cell carcinoma. Int J Clin Exp Pathol 7: 593-601.
    [33] Yu B, Wu K, Wang X, et al. (2018) Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7. Cell Death Dis 9: 1082. doi: 10.1038/s41419-018-1116-6
    [34] Yang T, Deng Z, Pan Z, et al. (2020) Prognostic value of periostin in multiple solid cancers: A systematic review with meta-analysis. J Cell Physiol 235: 2800-2808. doi: 10.1002/jcp.29184
    [35] Kang Y, Wang X, Zhang Y, et al. (2019) Periostin serves an important role in the pathogenesis of oral squamous cell carcinoma. Oncol Lett 17: 1292-1298.
    [36] Kudo Y, Siriwardena BS, Hatano H, et al. (2007) Periostin: Novel diagnostic and therapeutic target for cancer. Histol Histopathol 22: 1167-1174.
    [37] Sundar S, Ramani P, Sherlin HJ, et al. (2018) Role of periostin in oral squamous cell carcinoma: A systematic review. Int J Orofac Biol 2: 35-40. doi: 10.4103/ijofb.ijofb_2_19
    [38] Wong GS, Lee JS, Park YY, et al. (2013) Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment. Oncogenesis 2: e59. doi: 10.1038/oncsis.2013.17
    [39] Ruan K, Bao S, Ouyang G (2009) The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci 66: 2219-2230. doi: 10.1007/s00018-009-0013-7
    [40] Wang W, Ma JL, Jia WD, et al. (2011) Periostin: a putative mediator involved in tumor resistance to anti-angiogenic therapy? Cell Biol Int 35: 1085-1088. doi: 10.1042/CBI20110171
    [41] Schmitz S, Ang KK, Vermorken J, et al. (2014) Targeted therapies for squamous cell carcinoma of the head and neck: current knowledge and future directions. Cancer Treat Rev 40: 390-404. doi: 10.1016/j.ctrv.2013.09.007
    [42] Siriwardena SBSM, Tsunematsu T, Qi G, et al. (2018) Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma – A Review. Int J Mol Sci 19: 1462. doi: 10.3390/ijms19051462
    [43] Kudo Y, Ogawa I, Kitajima S, et al. (2006) Periostin Promotes Invasion and Anchorage-Independent Growth in the Metastatic Process of Head and Neck Cancer. Cancer Res 66: 6928-6935. doi: 10.1158/0008-5472.CAN-05-4540
    [44] Kim GE, Lee JS, Park MH, et al. (2017) Epithelial periostin expression is correlated with poor survival in patients with invasive breast carcinoma. Plos One 12: e0187635. doi: 10.1371/journal.pone.0187635
    [45] Choi P, Jordan CD, Mendez E, et al. (2008) Examination of oral cancer biomarkers by tissue microarray analysis. Arch Otolaryngol Head Neck Surg 134: 539-546. doi: 10.1001/archotol.134.5.539
    [46] Deraz EM, Kudo Y, Yoshida M, et al. (2011) MMP-10/ Stromelysin-2 promotes invasion of head and neck cancer. Plos One 6: e25438. doi: 10.1371/journal.pone.0025438
    [47] Kudo Y, Iizuka S, Yoshida M, et al. (2012) Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer. Plos One 7: e44488. doi: 10.1371/journal.pone.0044488
    [48] Gawish GEH, Alomer HA (2013) The role of periostin in regulation of early tumorgenesis in oral squamous cell carcinomas. Biochem Anal Biochem 2: 4.
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