Research article

Global stability of an age-structured infection model in vivo with two compartments and two routes


  • Received: 11 January 2022 Revised: 21 June 2022 Accepted: 23 June 2022 Published: 02 August 2022
  • In this paper, for an infection age model with two routes, virus-to-cell and cell-to-cell, and with two compartments, we show that the basic reproduction ratio $ R_0 $ gives the threshold of the stability. If $ R_0 > 1 $, the interior equilibrium is unique and globally stable, and if $ R_0 \le 1 $, the disease free equilibrium is globally stable. Some stability results are obtained in previous research, but, for example, a complete proof of the global stability of the disease equilibrium was not shown. We give the proof for all the cases, and show that we can use a type reproduction number for this model.

    Citation: Tsuyoshi Kajiwara, Toru Sasaki, Yoji Otani. Global stability of an age-structured infection model in vivo with two compartments and two routes[J]. Mathematical Biosciences and Engineering, 2022, 19(11): 11047-11070. doi: 10.3934/mbe.2022515

    Related Papers:

  • In this paper, for an infection age model with two routes, virus-to-cell and cell-to-cell, and with two compartments, we show that the basic reproduction ratio $ R_0 $ gives the threshold of the stability. If $ R_0 > 1 $, the interior equilibrium is unique and globally stable, and if $ R_0 \le 1 $, the disease free equilibrium is globally stable. Some stability results are obtained in previous research, but, for example, a complete proof of the global stability of the disease equilibrium was not shown. We give the proof for all the cases, and show that we can use a type reproduction number for this model.



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