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Mathematical Biosciences and Engineering

2004, Volume 1, Issue 1: 147-159. doi: 10.3934/mbe.2004.1.147
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Biological computing with diffusion and excitable calcium stores

  • 1.
    Department of Physics, Emory University, Maths/Science Center, 400 Dowman Drive, Atlanta, GA 30322
  • 2.
    Department of Physiology and Biophysics, Dalhousie University, Halifax NS
  • 3.
    Department of Physics, Emory University, Atlanta, GA 30322
  • Received: 01 February 2004 Accepted: 29 June 2018 Published: 01 March 2004

  • MSC : 92C05, 92C55.

  • Intracellular signaling often employs excitable stores of calcium coupled by diffusion. We investigate the ability of various geometric configurations of such excitable stores to generate a complete set of logic gates for computation. We also describe how the mechanism of excitable calcium-induced calcium release can be used for constructing coincidence detectors for biological signals.

    Citation: H. G. E. Hentschel, Alan Fine, C. S. Pencea. Biological computing with diffusion and excitable calcium stores[J]. Mathematical Biosciences and Engineering, 2004, 1(1): 147-159. doi: 10.3934/mbe.2004.1.147

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  • Intracellular signaling often employs excitable stores of calcium coupled by diffusion. We investigate the ability of various geometric configurations of such excitable stores to generate a complete set of logic gates for computation. We also describe how the mechanism of excitable calcium-induced calcium release can be used for constructing coincidence detectors for biological signals.


  • This article has been cited by:

    1. Richard Mayne, Andrew Adamatzky, Konradin Metze, On the Computing Potential of Intracellular Vesicles, 2015, 10, 1932-6203, e0139617, 10.1371/journal.pone.0139617
    2. Joshua Bongard, Michael Levin, There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines, 2023, 8, 2313-7673, 110, 10.3390/biomimetics8010110
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  • © 2004 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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