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The use of biomonitoring equivalents for interpreting blood concentrations in population studies: a case for polychlorinated biphenyls

  • Received: 01 December 2014 Accepted: 26 January 2015 Published: 02 February 2015
  • A number of exposure guideline values for environmental contaminants are established by various agencies for risk assessment purposes. Biomonitoring equivalents are conversions of external guideline values to internal doses, against which biomonitoring data can be directly compared. Several biomonitoring equivalents have been developed for the interpretation of blood concentrations of environmental contaminants, but none has yet been developed for polychlorinated biphenyls (PCBs). In this paper, we describe information needed to develop biomonitoring equivalents for PCBs and discuss anticipated challenges. We provide a broad overview of PCB absorption, distribution, metabolism and excretion, PCB guideline values, and PCB pharmacokinetic modeling efforts in animals and humans. We also provide strategies to address anticipated challenges in deriving biomonitoring equivalents for this complex contaminant. Biomonitoring equivalents will be useful for the interpretation of the PCB biomonitoring data that is currently available for populations around the globe through national surveys and research of specific populations.

    Citation: Kavita Singh, Andy Nong, Mark Feeley, Hing Man Chan. The use of biomonitoring equivalents for interpreting blood concentrations in population studies: a case for polychlorinated biphenyls[J]. AIMS Environmental Science, 2015, 2(1): 21-41. doi: 10.3934/environsci.2015.1.21

    Related Papers:

  • A number of exposure guideline values for environmental contaminants are established by various agencies for risk assessment purposes. Biomonitoring equivalents are conversions of external guideline values to internal doses, against which biomonitoring data can be directly compared. Several biomonitoring equivalents have been developed for the interpretation of blood concentrations of environmental contaminants, but none has yet been developed for polychlorinated biphenyls (PCBs). In this paper, we describe information needed to develop biomonitoring equivalents for PCBs and discuss anticipated challenges. We provide a broad overview of PCB absorption, distribution, metabolism and excretion, PCB guideline values, and PCB pharmacokinetic modeling efforts in animals and humans. We also provide strategies to address anticipated challenges in deriving biomonitoring equivalents for this complex contaminant. Biomonitoring equivalents will be useful for the interpretation of the PCB biomonitoring data that is currently available for populations around the globe through national surveys and research of specific populations.


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    [1] U.S. Environmental Protection Agency. Terminology Sevices. Available from: http://ofmpub.epa.gov/sor_internet/registry/termreg/home/overview/home.do.
    [2] U.S. Environmental Protection Agency. Exposure Factors Handbook Glossary of Terms, 2011. Available from: http://www.epa.gov/ncea/efh/report.html.
    [3] Agency for Toxic Substances and Disease Registry. Toxic Substances Portal. Minimal Risk Levels (MRLs), 2014. Available from: http://www.atsdr.cdc.gov/mrls/index.asp.
    [4] Health Canada.Health-Based Tolerable Daily Intakes/Concentrations and Tumorigenic Doses/Concentrations for Priority Substances, 1996. Available from: http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/hbct-jact/index-eng.php.
    [5] Agency for Toxic Substances and Disease Registry (ATSDR) (2000) Toxicological profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
    [6] U.S. Environmental Protection Agency (EPA). Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment. National Center for Environmental Assessment, Washington, DC; EPA/600/R-05/043F, 2006. Available from: National Technical Information Service, Springfield, VA, and online at http://epa.gov/ncea.
    [7] Hays SM, Becker RA, Leung HW, et al. (2007) Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective. Regul Toxicol Pharmacol 47: 96-109. doi: 10.1016/j.yrtph.2006.08.004
    [8] Hays SM, Aylward LL, LaKind JS, et al. (2008) Guidelines for the derivation of biomonitoring equivalents: report from the biomonitoring equivalents expert workshop. Regul Toxicol Pharmacol 51: S4-15. doi: 10.1016/j.yrtph.2008.05.004
    [9] Krishnan K, Adamou T, Aylward LL, et al. (2011) Biomonitoring equivalents for 2,2',4,4',5-pentabromodiphenylether (PBDE-99). Regul Toxicol Pharmacol 60: 165-171. doi: 10.1016/j.yrtph.2011.03.011
    [10] Kirman CR, Aylward LL, Hays SM, et al. (2011) Biomonitoring equivalents for DDT/DDE. Regul Toxicol Pharmacol 60: 172-180. doi: 10.1016/j.yrtph.2011.03.012
    [11] Aylward LL, Barton HA, Hays SM. (2008) Biomonitoring Equivalents (BE) dossier for toluene (CAS No. 108-88-3). Regul Toxicol Pharmacol 51: S27-36. doi: 10.1016/j.yrtph.2008.05.009
    [12] Aylward LL, Hays SM, Gagné M, et al. (2010) Biomonitoring equivalents for hexachlorobenzene. Regul Toxicol Pharmacol 58: 25-32. doi: 10.1016/j.yrtph.2010.06.003
    [13] Aylward LL, Hays SM. (2008) Biomonitoring Equivalents (BE) dossier for 2,4-dichlorophenoxyacetic acid (2,4-D) (CAS No. 94-75-7). Regul Toxicol Pharmacol 51: S37-48. doi: 10.1016/j.yrtph.2008.05.006
    [14] Porta M, Zumeta E. (2002) Implementing the Stockholm Treaty on Persistent Organic Pollutants. Occup Environ Med 59: 651-653. doi: 10.1136/oem.59.10.651
    [15] Breivik K, Alcock R, Li YF, et al. (2004) Primary sources of selected POPs: regional and global scale emission inventories. Environ Pollut 128: 3-16. doi: 10.1016/j.envpol.2003.08.031
    [16] Breivik K, Sweetman A, Pacyna JM, et al. (2002) Towards a global historical emission inventory for selected PCB congeners—a mass balance approach 1. Global production and consumption. Sci Total Environ 290: 181-198.
    [17] U.S. Environmental Protection Agency (EPA) (2003) Non-dioxin-like PCBs: Effects and consideration in ecological risk assessment. Experimental Toxicology Division National Health and Environmental Effects Research Laboratory Office of Research and Development (NCEA-C-1340. ERASC-003. June).
    [18] IARC monographs on the evaluation of carcinogenic risks to humans. Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42. Supplement 7, 1987. Available from: http://monographs.iarc.fr/ENG/Monographs/suppl7/index.php.
    [19] Van Oostdam J, Donaldson SG, Feeley M, et al. (2005) Human health implications of environmental contaminants in Arctic Canada: a review. Sci Total Environ  351-352: 165-246.
    [20] Laird BD, Goncharov AB, Chan HM. (2013) Body burden of metals and persistent organic pollutants among Inuit in the Canadian Arctic. Environ Int 59: 33-40. doi: 10.1016/j.envint.2013.05.010
    [21] Agency for Toxic Substances and Disease Registry (ATSDR) (2011) Addendum to the Toxicological profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
    [22] Health Canada. Report on Human Biomonitoring of Environmental Chemicals in Canada, 2010. Available from: http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/chms-ecms/section8-eng.php#n8_3.
    [23] U.S. Environmental Protection Agency (EPA). Integrated Risk Information System (IRIS). Aroclor 1016 (CASRN 12674-11-2), 1993. Available from: http://www.epa.gov/iris/subst/0462.htm.
    [24] Joint FAO/WHO Expert Committee on Food Additives. Meeting (67th : 2006 : Rome, Italy) Evaluation of certain food additives and contaminants : sixty-seventh report of the Joint FAO/WHO Expert Committee on Food Additives, 2007. Available from: http://www.who.int/ipcs/publications/jecfa/reports/trs940.pdf.
    [25] Centers for Disease Control and Prevention. Polychlorinated Biphenyls (PCBs). DHHS (NIOSH) Publication Number 86-111, 1986. Available: http://www.cdc.gov/niosh/docs/86-111/.
    [26] French Agency for Food, Environmental and Occupational Health and Safety (ANSES). What are the critical blood concentration levels for PCBs?, 2013. Available from: https://www.anses.fr/en/content/what-are-critical-blood-concentration-levels-pcbs.
    [27] Health Canada. Part II: Health Canada Toxicological Reference Values (TRVs) and Chemical-Specific Factors, Version 2.0, 2010.
    [28] European Food Safety Authority (EFSA). Opinion of the scientific panel on contaminants in the food chain on a request from the Commission related to the presence of non dioxin-like polychlorinated biphenyls (PCB) in feed and food, 2005. Available from: http://www.efsa.europa.eu/en/efsajournal/pub/284.htm.
    [29] French Agency for Food, Environmental and Occupational Health and Safety (ANSES). Opinion of the French Food Safety Agency on the establishment of relevant maximum levels for non dioxin-like polychlorobiphenyls (NDL-PCB) in some foodstuffs, 2007. Available from: https://www.anses.fr/sites/default/files/documents/RCCP2006sa0305EN.pdf.
    [30] Weijs L, Roach AC, Yang RSH, et al. (2014) Lifetime PCB 153 bioaccumulation and pharmacokinetics in pilot whales: Bayesian population PBPK modeling and Markov chain Monte Carlo simulations. Chemosphere 94: 91-96. doi: 10.1016/j.chemosphere.2013.09.019
    [31] Weijs L, Covaci A, Yang RSH, et al. (2011) A non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises. Toxicol Appl Pharmacol 256: 136-145. doi: 10.1016/j.taap.2011.07.020
    [32] Weijs L, Yang RSH, Covaci A, et al. (2010) Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises (Phocoena phocoena): model development and evaluation. Environ Sci Technol 44: 7023-7030. doi: 10.1021/es101688h
    [33] Czub G, McLachlan MS. (2007) Influence of the temperature gradient in blubber on the bioaccumulation of persistent lipophilic organic chemicals in seals. Environ Toxicol Chem 26: 1600-1605. doi: 10.1897/06-548R.1
    [34] Klanjscek T, Nisbet RM, Caswell H, et al. (2007) A model for energetics and bioaccumulation in marine mammals with applications to the right whale. Ecol Appl 17: 2233-2250. doi: 10.1890/06-0426.1
    [35] Hickie B, Mackay D, De Koning J. (1999) Lifetime pharmacokinetic model for hydrophobic contaminants in marine mammals. Environ Toxicol Chem 18: 2622-2633. doi: 10.1002/etc.5620181132
    [36] Drouillard KG, Norstrom RJ, Fox GA, et al. (2003) Development and validation of a herring gull embryo toxicokinetic model for PCBs. Ecotoxicology 12: 55-68. doi: 10.1023/A:1022588913171
    [37] Drouillard KG, Fernie KJ, Smits JE, et al. (2001) Bioaccumulation and toxicokinetics of 42 polychlorinated biphenyl congeners in American kestrels (Falco sparverius). Environ Toxicol Chem 20: 2514-2522. doi: 10.1002/etc.5620201117
    [38] Sonne C, Gustavson K, Rigét FF, et al. (2009) Reproductive performance in East Greenland polar bears (Ursus maritimus) may be affected by organohalogen contaminants as shown by physiologically-based pharmacokinetic (PBPK) modelling. Chemosphere 77: 1558-1568. doi: 10.1016/j.chemosphere.2009.09.044
    [39] Lohitnavy M, Lu Y, Lohitnavy O, et al. (2008) A possible role of multidrug resistance-associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling. Toxicol Sci 104: 27-39. doi: 10.1093/toxsci/kfn026
    [40] Lee SK, Ou YC, Andersen ME, et al. (2007) A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice. Arch Toxicol 81: 101-111. doi: 10.1007/s00204-006-0130-0
    [41] Emond C, Charbonneau M, Krishnan K. (2005) Physiologically based modeling of the accumulation in plasma and tissue lipids of a mixture of PCB congeners in female Sprague-Dawley rats. J Toxicol Environ Health Part A 68: 1393-1412. doi: 10.1080/15287390590956551
    [42] Lee SK, Ou YC, Yang RSH. (2002) Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modeling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups. Toxicol Sci 65: 26-34. doi: 10.1093/toxsci/65.1.26
    [43] Tuey D, Matthews B. (1977) Pharmacokinetics of 3,3',5,5'-tetrachlorobiphenyl in the male rat. Drug Metab Dispos 5: 444-450.
    [44] Lutz R, Dedrick R, Matthews H, et al. (1977) A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat. Drug Metab Dispos 5: 386-396.
    [45] Nichols JW, Fitzsimmons PN, Whiteman FW, et al. (2004) A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish I. Feeding studies with 2,2',5,5'-tetrachlorobiphenyl. Toxicol Sci 77: 206-218.
    [46] Karara A, Mcfarland V. (1992) A pharmacokinetic analysis of the uptake of polychlorinated biphenyls (PCBs) by golden shiners. Environ Toxicol Chem 11: 315-320. doi: 10.1002/etc.5620110305
    [47] Kulkarni MG, Karara AH. (1990) A pharmacokinetic model for the disposition of polychlorinated biphenyls ( PCBs ) in channel catfish. Aquat Toxicol 16: 141-150. doi: 10.1016/0166-445X(90)90083-2
    [48] Pizza JC, Connor JMO. (1983) PCB dynamics in Hudson River striped bass II. Accumulation from dietary sources. Aquat Toxicol 3: 313-327.
    [49] Borchard RE, Hansen LG, Huber WG, et al. (1974) Pharmacokinetics of Aroclor 1254 components after intravenous administration to swine and sheep. Arch Environ Contam 2: 179-192. doi: 10.1007/BF01975471
    [50] Van Eijkeren JCH, Zeilmaker MJ, Kan CA, et al. (2006) A toxicokinetic model for the carry-over of dioxins and PCBs from feed and soil to eggs. Food Addit Contam 23: 509-517. doi: 10.1080/02652030500512045
    [51] Yu KN, Lam PKS, Cheung CCC, et al. (2002) Mathematical modeling of PCB bioaccumulation in Perna viridis. Mar Pollut Bull 45: 332-338. doi: 10.1016/S0025-326X(02)00099-1
    [52] Verner M, Mcdougall R, Glynn A, et al. (2013) Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics? Environ Health Perspect 121: 1219-1225.
    [53] Ulaszewska MM, Ciffroy P, Tahraoui F, et al. (2012) Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women. J Expo Sci Environ Epidemiol 22: 601-609. doi: 10.1038/jes.2012.36
    [54] Trnovec T, Dedík L, Jusko TA, et al. (2011) Assessment of exposure to PCB 153 from breast feeding and normal food intake in individual children using a system approach model. Chemosphere 85: 1687-1693. doi: 10.1016/j.chemosphere.2011.09.013
    [55] Redding LE, Sohn MD, McKone TE, et al. (2008) Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results. Environ Health Perspect 116: 1629-1634. doi: 10.1289/ehp.11519
    [56] Gascon M, Verner MA, Guxens M, et al. (2013) Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children. Neurotoxicology 34: 9-15. doi: 10.1016/j.neuro.2012.10.006
    [57] Verner MA, Plusquellec P, Muckle G, et al. (2010) Alteration of infant attention and activity by polychlorinated biphenyls: unravelling critical windows of susceptibility using physiologically based pharmacokinetic modeling. Neurotoxicology 31: 424-431. doi: 10.1016/j.neuro.2010.05.011
    [58] Verner MA, Ayotte P, Muckle G, et al. (2009) A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies. Environ Health Perspect 117: 481-487. doi: 10.1289/ehp.0800047
    [59] Verner MA, Bachelet D, McDougall R, et al. (2011) A case study addressing the reliability of polychlorinated biphenyl levels measured at the time of breast cancer diagnosis in representing early-life exposure. Cancer Epidemiol Biomarkers Prev 20: 281-286. doi: 10.1158/1055-9965.EPI-10-0992
    [60] Verner MA, Charbonneau M, López-Carrillo L, et al. (2008) Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. Environ Health Perspect 116: 886-892. doi: 10.1289/ehp.10917
    [61] Sonne C, Gustavson K, Rigét FF, et al. (2014) Physiologically based pharmacokinetic modeling of POPs in Greenlanders. Environ Int 64: 91-97. doi: 10.1016/j.envint.2013.12.006
    [62] Abass K, Huusko A, Nieminen P, et al. (2013) Estimation of health risk by using toxicokinetic modelling: a case study of polychlorinated biphenyl PCB153. J Hazard Mater 261: 1-10. doi: 10.1016/j.jhazmat.2013.07.011
    [63] Ayotte P, Dewailly E, Bruneau S, et al. (1995) Arctic air pollution and human health: what effects should be expected? Sci Total Environ 160-161: 529-537. doi: 10.1016/0048-9697(95)04387-G
    [64] Broding HC, Schettgen T, Göen T, et al. (2007) Development and verification of a toxicokinetic model of polychlorinated biphenyl elimination in persons working in a contaminated building. Chemosphere 68: 1427-1434. doi: 10.1016/j.chemosphere.2007.04.014
    [65] Arnot JA, Brown TN, Wania F. (2014) Estimating screening-level organic chemical half-lives in humans. Environ Sci Technol 48: 723-730. doi: 10.1021/es4029414
    [66] Tonnelier A, Coecke S, Zaldívar JM. (2012) Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model. Arch Toxicol 86: 393-403. doi: 10.1007/s00204-011-0768-0
    [67] Ritter R, Scheringer M, MacLeod M, et al. (2011) Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom. Environ Health Perspect 119: 225-231.
    [68] Alcock RE, Sweetman AJ, Juan CY, et al. (2000) A generic model of human lifetime exposure to persistent organic contaminants: development and application to PCB-101. Environ Pollut 110: 253-265. doi: 10.1016/S0269-7491(99)00298-5
    [69] Aylward LL, Green E, Porta M, et al. (2014) Population variation in biomonitoring data for persistent organic pollutants (POPs): an examination of multiple population-based datasets for application to Australian pooled biomonitoring data. Environ Int 68: 127-138. doi: 10.1016/j.envint.2014.03.026
    [70] Becker K, Kaus S, Krause C, et al. (2002) German Environmental Survey 1998 (GerES III): Environmental pollutants in blood of the German population. Int J Hyg Environ Health 205: 297-308. doi: 10.1078/1438-4639-00155
    [71] Porta M, Gasull M, Puigdomènech E, et al. (2010) Distribution of blood concentrations of persistent organic pollutants in a representative sample of the population of Catalonia. Environ Int 36: 655-664. doi: 10.1016/j.envint.2010.04.013
    [72] Koppen G, Den Hond E, Nelen V, et al. (2009) Organochlorine and heavy metals in newborns: Results from the Flemish Environment and Health Survey (FLEHS 2002-2006). Environ Int 35: 1015-1022. doi: 10.1016/j.envint.2009.05.002
    [73] Schoeters G, Den Hond E, Colles A, et al. (2012) Concept of the Flemish human biomonitoring programme. Int J Hyg Environ Health 215: 102-108. doi: 10.1016/j.ijheh.2011.11.006
    [74] Schade G, Heinzow BU. (1998) Organochlorine pesticides and polychlorinated biphenyls in human milk of mothers living in northern Germany: Current extent of contamination , time trend from 1986 to 1997 and factors that influence the levels of contamination. Sci Total Environ 215: 31-39. doi: 10.1016/S0048-9697(98)00008-4
    [75] Ritter R, Scheringer M, MacLeod M, et al. (2009) A multi-individual pharmacokinetic model framework for interpreting time trends of persistent chemicals in human populations: application to a postban situation. Environ Health Perspect 117: 1280-1286. doi: 10.1289/ehp.0900648
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