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Numerical prediction of thrombosis risk in left atrium under atrial fibrillation

1 State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, China
2 Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3 Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
4 Key Laboratory of Cardiovascular Medicine of Zhejiang Province, Hangzhou, China
The authors contribute equally.

Special Issues: Computational Techniques for Bio-Hemodynamics and Heat Transfer

The remodeling of the left atrial morphology and function caused by atrial fibrillation (AF) can exacerbate thrombosis in the left atrium (LA) even spike up the risk of stroke within AF patients. This study explored the effect of the AF on hemodynamic and thrombosis in LA. We reconstructed the patient-specific anatomical shape of the LA and considered the non-Newtonian property of the blood. The thrombus model was applied in the LA models to simulate thrombosis. Our results indicate that AF can aggravate thrombosis which mainly occurs in the left atrial appendage (LAA). Thrombosis first forms on the LAA wall then expands toward the internal LAA. The proposed computational model also shows the potential application of numerical analyses to help assess the risk of thrombosis in AF patients.
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Keywords atrial fibrillation; left atrium; left atrial appendage; thrombosis risk; non-Newtonian; computational fluid dynamics

Citation: Yan Wang, Yonghui Qiao, Yankai Mao, Chenyang Jiang, Jianren Fan, Kun Luo. Numerical prediction of thrombosis risk in left atrium under atrial fibrillation. Mathematical Biosciences and Engineering, 2020, 17(3): 2348-2360. doi: 10.3934/mbe.2020125

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