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Comprehensive analysis of key lncRNAs in ischemic stroke

Chunxiang Fan Zouqin Huang Binbin Chen Baojin Chen Qi Wang Weidong Liu Donghai Yu

*Corresponding author: Weidong Liu, Donghai Yu liuwd8b@outlook.com;yudonghai71@sina.com,yudonghai0523@126.com


Ischemic stroke (IS) is a leading cause of mortality and disability worldwide. However, the treatments for ischemic stroke remained inadequate. The mechanisms underlying ischemic stroke are still not completely understood. the present study identified 19 lncRNAs related to stroke recovery by analyzing a public dataset GSE37587. A co-expression network included 24 lncRNAs, 1668 mRNAs and 3542 edges were constructed in the present study. Bioinformatics analysis showed these lncRNAs were involved in regulating multiple biological processes and pathways, such as mRNA nonsense-mediated decay, translation, cell-cell adhesion. Three lncRNAs, including DLEU1, LOC432369, and LOC338799, were identified as key lncRNAs in stroke. Bioinformatics showed DLEU1 was involved in regulating oxidative phosphorylation, and ubiquitin-mediated proteolysis. LOC432369 was associated with oxidative phosphorylation. LOC338799 was associated with clathrin-dependent endocytosis, the establishment of organelle localization and ribonucleoprotein complex assembly. We thought this study could provide useful information to understand the mechanisms underlying stroke progression.

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