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A model of drug resistance with infection by health care workers

Avner Friedman Najat Ziyadi Khalid Boushaba

*Corresponding author:  

MBE2010,4,779doi:10.3934/mbe.2010.7.779

Antibiotic resistant organisms (ARO) pose an increasing serious threat in hospitals. One of the most life threatening ARO is methicillin-resistant staphylococcus aureus (MRSA). In this paper, we introduced a new mathematical model which focuses on the evolution of two bacterial strains, drug-resistant and non-drug resistant, residing within the population of patients and health care workers in a hospital. The model predicts that as soon as drug is administered, the average load of the non-resistant bacteria will decrease and eventually (after 6 weeks of the model's simulation) reach a very low level. However, the average load of drug-resistant bacteria will initially decrease, after treatment, but will later bounce back and remain at a high level. This level can be made lower if larger amount of drug is given or if the contact between health care workers and patients is reduced.

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Article ID   1551-0018_2010_4_779
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