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Autism and neuro-immune-gut link

Dario Siniscalco Anna Lisa Brigida Nicola Antonucci

*Corresponding author: Dario Siniscalco dariosin@uab.edu

Molecular2018,2,166doi:10.3934/molsci.2018.2.166

Recent evidences sustain the hypothesis that host-bacteria interactions play a critical role in regulating tissue and body homeostasis. Gut microbiota and the brain are strongly interconnected and share communication pathways. Modifications in gut bacteria compositions are correlated to changes in behaviors. Indeed, autism spectrum disorders (ASD) are linked to dysfunctions of the gut bacteria-brain axis. Possible therapeutic strategies in ASD management will aim to restore dysbiosis and gut bacteria imbalance.

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