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Lack of Association between Human µ-Opioid Receptor (OPRM1) Gene Polymorphisms and Heroin Addiction in A Sample of Southeast Iranian Population

Mansour Shakiba Mohammad Hashemi Zahra Rahbari Salah Mahdar Hiva Danesh Fatemeh Bizhani Gholamreza Bahari

*Corresponding author: Mohammad Hashemi mhd.hashemi@gmail.com; hashemim@zaums.ac.ir;

medicalScience2017,2,233doi:10.3934/medsci.2017.2.233

It has been proposed that genetic factors account for 30%–50% of the risk for cocaine and heroin addiction. The present study was aimed to find out the impact of µ-opioid receptor gene (OPRM1) rs1799971 A > G and rs9479757 polymorphisms on heroin dependence in a sample of southeast Iranian population. This case-control study was done on 123 heroin addicts and 140 non-addicts Iranian male. Genomic DNA was extracted from peripheral blood cells using salting out method. Genotyping of OPRM1 rs1799971 and rs9479757 polymorphisms were performed using PCR-RFLP method. Overall, our results did not support an association between OPRM1 variants and risk of heroin dependence in a sample of southeast Iranian population. Further studies with larges sample sizes and different ethnicities are required to validate our findings.

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