Order reprints

Role of some epigenetic factors in DNA damage response pathway

Mrinalini Tiwari Suhel Parvez Paban K Agrawala

*Corresponding author: Paban K Agrawala paban@inmas.drdo.in


The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review.

Please supply your name and a valid email address you yourself

Fields marked*are required

Article URL   http://www.aimspress.com/Genetics/article/1344.html
Article ID   genetics-04-00069
Editorial Email  
Your Name *
Your Email *
Quantity *

Copyright © AIMS Press All Rights Reserved