Order reprints

Current status of lectin-based cancer diagnosis and therapy

Fohona S. Coulibaly Bi-Botti C. Youan

*Corresponding author: Bi-Botti C. Youan youanb@umkc.edu

Molecular2017,1,1doi:10.3934/molsci.2017.1.1

Lectins are carbohydrate recognizing proteins originating from diverse origins in nature, including animals, plants, viruses, bacteria and fungus. Due to their exceptional glycan recognition property, they have found many applications in analytical chemistry, biotechnology and surface chemistry. This manuscript explores the current use of lectins for cancer diagnosis and therapy. Moreover, novel drug delivery strategies aiming at improving lectin’s stability, reducing their undesired toxicity and controlling their non-specific binding interactions are discussed. We also explore the nanotechnology application of lectins for cancer targeting and imaging. Although many investigations are being conducted in the field of lectinology, there is still a limited clinical translation of the major findings reported due to lectins stability and toxicity concerns. Therefore, new investigations of safe and effective drug delivery system strategies for lectins are warranted in order to take full advantage of these proteins.

Please supply your name and a valid email address you yourself

Fields marked*are required

Article URL   http://www.aimspress.com/Molecular/article/1202.html
Article ID   molsci-04-00001
Editorial Email  
Your Name *
Your Email *
Quantity *

Copyright © AIMS Press All Rights Reserved