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Role of actin cytoskeleton at multiple levels of T cell activation

Martina Huranova Ondrej Stepanek

*Corresponding author: Ondrej Stepanek ondrej.stepanek@img.cas.cz

Molecular2016,4,585doi:10.3934/molsci.2016.4.585

Actin cytoskeleton is an essential cellular structure that is involved in many physiological aspects, including T cell antigenic responses. In has been proposed that actin modulates biophysical parameters of the antigen recognition, forms a barrier inhibiting spontaneous signaling in resting T cells, facilitates TCR signal transduction, stabilizes contacts between T cells and antigen presenting cells, and contributes to the establishment of the antigen affinity threshold. In this review, we discuss the role of actin cytoskeleton at these particular levels of T cell activation.

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