Neuro-restorative Strategies for Stroke: Advancement beyond the Hyperactue Phase

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Guest Editor
Dr. Carli Lorraine Roulston
Department of Medicine, University of Melbourne, Australia 3065
Email: carlir@unimelb.edu.au

Manuscript Topics
Although studies suggest that the therapeutic window for thrombolysis after stroke might be extended, most patients do not receive treatment and there are no neuroprotective drugs in clinical use. Many survivors live with disabilities that impede their ability to carry out daily activities unassisted. New targeted treatments that promote recovery after stroke might therefor be a better strategy to support the majority of stroke survivors.

Decades of stroke research has been directed towards protecting the brain from injury during the hyperacute phase. Yet we know that the brain has a capacity for repair and remodelling and environmental enrichment strategies to support this process improve patient outcomes during rehabilitation. In addition to environmental enrichment, there have been major developments in recent years exploring the use of alternative treatment approaches to support the brain’s natural healing process. These include investigating signalling pathways that promote repair and remodelling, strategies to harness inflammation, and development of therapeutics designed to restore lost connectivity. These important developments designed to recovery the brain after injury deserves compilation in a special issue of AIMS Medical Science.

We invite scientists and researchers to contribute full text research articles, contemporary reviews or viewpoints regarding important advancements in therapeutic strategies that target recovery of the injured brain.

Topics include (but are not limited to)
• Signalling pathways important for brain rescue and remodelling
• Electrical stimulation strategies to awaken and reconnect surviving pathways
• The use of stem cells to support surviving neurons and reconstruct damaged pathways
• Treatments that target neurogenesis and neuronal differentiation

Paper submission
All manuscripts will be peer-reviewed before their acceptance for publication.
The deadline for manuscript submission is 30th August 2016.

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