AIMS Molecular Science

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• Oxidative stress, innate immunity, and age-related macular degeneration

  Peter X. Shaw, Travis Stiles, Christopher Douglas, Daisy Ho, Wei Fan, Hongjun Du, Xu Xiao

  2016, 3(2): 196-221. doi: 10.3934/molsci.2016.2.196

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• Electrospun biodegradable polymers loaded with bactericide agents

  Luís J. del Valle, Lourdes Franco, Ramaz Katsarava, Jordi Puiggalí

  2016, 3(1): 52-87. doi: 10.3934/molsci.2016.1.52

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• The Roles of Primary cilia in Polycystic Kidney Disease

  Sarmed H. Kathem, Ashraf M. Mohieldin, Surya M. Nauli

  2014, 1(1): 27-46. doi: 10.3934/molsci.2013.1.27

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• Triclosan antimicrobial polymers

  Richard C. Petersen

  2016, 3(1): 88-103. doi: 10.3934/molsci.2016.1.88

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• The mitotic checkpoint complex (MCC): looking back and forth after 15 years

  Song-Tao Liu, Hang Zhang

  2016, 3(4): 597-634. doi: 10.3934/molsci.2016.4.597

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• Short-term and rapid effects of lysophosphatidic acid on human adipose cell lipolytic and glucose uptake activities

  Christian Carpéné, Jean Galitzky, Jean Sébastien Saulnier-Blache

  2016, 3(2): 222-237. doi: 10.3934/molsci.2016.2.222

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• Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways

  Valentina Contrò, John R. Basile, Patrizia Proia

  2015, 2(3): 294-310. doi: 10.3934/molsci.2015.3.294

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• Oxidative stress, cellular senescence and ageing

  Akshaj Pole, Manjari Dimri, Goberdhan P. Dimri

  2016, 3(3): 300-324. doi: 10.3934/molsci.2016.3.300

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• Drugs and drug delivery systems targeting amyloid-β in Alzheimer's disease

  Morgan Robinson, Brenda Yasie Lee, Zoya Leonenko

  2015, 2(3): 332-358. doi: 10.3934/molsci.2015.3.332

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• Current status of lectin-based cancer diagnosis and therapy

  Fohona S. Coulibaly, Bi-Botti C. Youan

  2017, 4(1): 1-27. doi: 10.3934/molsci.2017.1.1

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• Androgen receptor and prostate cancer

  Karen E. Livermore, Jennifer Munkley, David J. Elliott

  2016, 3(2): 280-299. doi: 10.3934/molsci.2016.2.280

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• Approaches in biotechnological applications of natural polymers

  Priscilla B.S. Albuquerque, Luana C.B.B. Coelho, José A. Teixeira, Maria G. Carneiro-da-Cunha

  2016, 3(3): 386-425. doi: 10.3934/molsci.2016.3.386

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• Amyloid misfolding, aggregation, and the early onset of protein deposition diseases: insights from AFM experiments and computational analyses

  Yuri L. Lyubchenko

  2015, 2(3): 190-210. doi: 10.3934/molsci.2015.3.190

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• SUMO modulation of protein aggregation and degradation

  Marco Feligioni, Serena Marcelli, Erin Knock, Urooba Nadeem, Ottavio Arancio, Paul E. Fraser

  2015, 2(4): 382-410. doi: 10.3934/molsci.2015.4.382

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• Role of nucleolar dysfunction in neurodegenerative disorders: a game of genes?

  Rosanna Parlato, Holger Bierhoff

  2015, 2(3): 211-224. doi: 10.3934/molsci.2015.3.211

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• Redox-regulated transcription in plants: Emerging concepts

  Jehad Shaikhali, Gunnar Wingsle

  2017, 4(3): 301-338. doi: 10.3934/molsci.2017.3.301

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• microRNA as a new agent for regulating neuronal glutathione synthesis and metabolism

  Chisato Kinoshita, Koji Aoyama, Toshio Nakaki

  2015, 2(2): 124-143. doi: 10.3934/molsci.2015.2.124

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• Mitochondrial dynamics in neurodegeneration: from cell death to energetic states

  Mireille Khacho, Ruth S. Slack

  2015, 2(2): 161-174. doi: 10.3934/molsci.2015.2.161

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• Current insights into the molecular systems pharmacology of lncRNA-miRNA regulatory interactions and implications in cancer translational medicine

  Sujit Nair

  2016, 3(2): 104-124. doi: 10.3934/molsci.2016.2.104

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• Regulation of vesicular trafficking by Parkinson's disease-associated genes

  Tsuyoshi Inoshita, Yuzuru Imai

  2015, 2(4): 461-475. doi: 10.3934/molsci.2015.4.461

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• Implication of bidirectional promoters containing duplicated GGAA motifs of mitochondrial function-associated genes

  Fumiaki Uchiumi, Makoto Fujikawa, Satoru Miyazaki, Sei-ichi Tanuma

  2014, 1(1): 1-26. doi: 10.3934/molsci.2013.1.1

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• Simulation of lipid-protein interactions with the CgProt force field

  Jacob Fosso-Tande, Cody Black, Stephen G. Aller, Lanyuan Lu, Ronald D. Hills Jr

  2017, 4(3): 352-369. doi: 10.3934/molsci.2017.3.352

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• Application of fluorescently labelled lectins for the study of polysaccharides in biofilms with a focus on biofouling of nanofiltration membranes

  Mohamed Amine Ben Mlouka, Thomas Cousseau, Patrick Di Martino

  2016, 3(3): 338-356. doi: 10.3934/molsci.2016.3.338

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• The aliphatic counterpart of PET, PPT and PBT aromatic polyesters: effect of the molecular structure on thermo-mechanical properties

  Morgane Albanese, Justine Boyenval, Paola Marchese, Simone Sullalti, Annamaria Celli

  2016, 3(1): 32-51. doi: 10.3934/molsci.2016.1.32

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• Epochal neuroinflammatory role of high mobility group box 1 in central nervous system diseases

  Seidu A. Richard, Wu Min, Zhaoliang Su, Hua-Xi Xu

  2017, 4(2): 185-218. doi: 10.3934/molsci.2017.2.185

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• Glutamate/NMDA excitotoxicity and HMGB1/TLR4 neuroimmune toxicity converge as components of neurodegeneration

  Jian Zou, Fulton T. Crews

  2015, 2(2): 77-100. doi: 10.3934/molsci.2015.2.77

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• The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer's disease

  Ann De Vos, Tine Bynens, Joëlle Rosseels, Catherina Coun, Julia Ring, Frank Madeo, Marie-Christine Galas, Joris Winderickx, Vanessa Franssens

  2015, 2(2): 144-160. doi: 10.3934/molsci.2015.2.144

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• Oxidative stress and CCN1 protein in human skin connective tissue aging

  Zhaoping Qin, Patrick Robichaud, Taihao Quan

  2016, 3(2): 269-279. doi: 10.3934/molsci.2016.2.269

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• Intracellular calcium excess as one of the main factors in the etiology of prostate cancer

  Vladimir Zaichick, Sofia Zaichick, Maxim Rossmann

  2016, 3(4): 635-647. doi: 10.3934/molsci.2016.4.635

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• Cell ageing: a flourishing field for neurodegenerative diseases

  Dora Brites

  2015, 2(3): 225-258. doi: 10.3934/molsci.2015.3.225

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• A proteomic analysis of the interactions between poly(L-lactic acid) nanofibers and SH-SY5Y neuronal-like cells

  Ana Marote, Nathalie Barroca, Rui Vitorino, Raquel M. Silva, Maria H.V. Fernandes, Paula M. Vilarinho, Odete A.B. da Cruz e Silva, Sandra I. Vieira

  2016, 3(4): 661-682. doi: 10.3934/molsci.2016.4.661

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• Identifying the Enzymatic Mode of Action for Cellulase Enzymes by Means of Docking Calculations and a Machine Learning Algorithm

  Somisetti V. Sambasivarao, David M. Granum, Hua Wang, C. Mark Maupin

  2014, 1(1): 59-80. doi: 10.3934/molsci.2014.1.59

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• Characterisation of the salmon cystic fibrosis transmembrane conductance regulator protein for structural studies

  Naomi L. Pollock, Oscar Moran, Debora Baroni, Olga Zegarra-Moran, Robert C. Ford

  2014, 1(4): 141-161. doi: 10.3934/molsci.2014.4.141

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• Role of sphingosine 1-phosphate (S1P) and effects of fingolimod, an S1P receptor 1 functional antagonist in lymphocyte circulation and autoimmune diseases

  Kenji Chiba, Yasuhiro Maeda, Noriyasu Seki, Hirotoshi Kataoka, Kunio Sugahara

  2014, 1(4): 162-182. doi: 10.3934/molsci.2014.4.162

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• Protein clearance mechanisms and their demise in age-related neurodegenerative diseases

  Isabel Saez, David Vilchez

  2015, 1(1): 1-21. doi: 10.3934/molsci.2015.1.1

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• How nitric oxide donors can protect plants in a changing environment: what we know so far and perspectives

  Amedea B. Seabra, Halley C. Oliveira

  2016, 3(4): 692-718. doi: 10.3934/molsci.2016.4.692

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• Forskolin sensitizes pancreatic cancer cells to gemcitabine via Stat3 and Erk1/2 inhibition

  Michela Illiano, Luigi Sapio, Ilaria Caiafa, Emilio Chiosi, Annamaria Spina, Silvio Naviglio

  2017, 4(2): 224-240. doi: 10.3934/molsci.2017.2.224

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• Controlled and selective placement of boron subphthalocyanines on either chain end of polymers synthesized by nitroxide mediated polymerization

  Benoît H. Lessard, Timothy P. Bender

  2015, 2(4): 411-426. doi: 10.3934/molsci.2015.4.411

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• Cigarette smoke may be an exacerbation factor in nonalcoholic fatty liver disease via modulation of the PI3K/AKT pathway

  Mayuko Ichimura, Akari Minami, Noriko Nakano, Yasuko Kitagishi, Toshiyuki Murai, Satoru Matsuda

  2015, 2(4): 427-439. doi: 10.3934/molsci.2015.4.427

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• Calcium homeostasis and signaling in fungi and their relevance for pathogenicity of yeasts and filamentous fungi

  Renata Tisi, Marco Rigamonti, Silvia Groppi, Fiorella Belotti

  2016, 3(4): 505-549. doi: 10.3934/molsci.2016.4.505

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• Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease

  Tara P. Hurst, Caroline Coleman-Vaughan, Indu Patwal, Justin V. McCarthy

  2016, 3(2): 138-157. doi: 10.3934/molsci.2016.2.138

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• The role of melatonin in autoimmune and atopic diseases

  J.R. Calvo, M.D. Maldonado

  2016, 3(2): 158-186. doi: 10.3934/molsci.2016.2.158

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• Theory of partial agonist activity of steroid hormones

  Carson C. Chow, Karen M. Ong, Benjamin Kagan, S. Stoney Simons Jr.

  2015, 2(2): 101-123. doi: 10.3934/molsci.2015.2.101

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• Nanoparticles and potential neurotoxicity: focus on molecular mechanisms

  Davide Lovisolo, Marianna Dionisi, Federico A. Ruffinatti, Carla Distasi

  2018, 5(1): 1-13. doi: 10.3934/molsci.2018.1.1

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• Apomorphine-induced pathway perturbation in MPP⁺-treated SH-SY5Y cells

  Jin Hwan Do

  2017, 4(3): 271-287. doi: 10.3934/molsci.2017.3.271

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• The role of PSMD9 in human disease: future clinical and therapeutic implications

  Joanne L. Hopper, Natasha Begum, Laura Smith, Thomas A. Hughes

  2015, 2(4): 476-484. doi: 10.3934/molsci.2015.4.476

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• Possible molecular basis for macromolecular antigen attachment to host cells: their immune complex with plasma antibodies have unoccupied binding sites enabling binding to smaller ligands

  Genu George, Sumita K. Chellappan, Mandagini Geetha, Padinjaradath S. Appukuttan

  2017, 4(1): 91-102. doi: 10.3934/molsci.2017.1.91

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• Phytochemical comparison with quantitative analysis between two flower phenotypes of Mentha aquatica L.: pink-violet and white

  Alessandro Venditti, Claudio Frezza, Diana Celona, Fabio Sciubba, Sebastiano Foddai, Maurizio Delfini, Mauro Serafini, Armandodoriano Bianco

  2017, 4(3): 288-300. doi: 10.3934/molsci.2017.3.288

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• Autism and neuro-immune-gut link

  Dario Siniscalco, Anna Lisa Brigida, Nicola Antonucci

  2018, 5(2): 166-172. doi: 10.3934/molsci.2018.2.166

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• Secondary metabolites with ecologic and medicinal implications in Anthemis cretica subsp. petraea from Majella National Park

  Alessandro Venditti, Claudio Frezza, Giacomo Rossi, Mirella Di Cecco, Giampiero Ciaschetti, Mauro Serafini, Armandodoriano Bianco

  2016, 3(4): 648-660. doi: 10.3934/molsci.2016.4.648

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• Headmasters: Microglial regulation of learning and memory in health and disease

  Laetitia Weinhard, Paolo dErrico, Tuan Leng Tay

  2018, 5(1): 63-89. doi: 10.3934/molsci.2018.1.63

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• Virtual target screening to rapidly identify potential protein targets of natural products in drug discovery

  Yuri Pevzner, Daniel N. Santiago, Jacqueline L. von Salm, Rainer S. Metcalf, Kenyon G. Daniel, Laurent Calcul, H. Lee Woodcock, Bill J. Baker, Wayne C. Guida, Wesley H. Brooks

  2014, 1(2): 81-98. doi: 10.3934/molsci.2014.2.81

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• Sphingosine kinase 1 in murine dorsal root ganglia

  Dimitra Beroukas, Maurice Selhorst, Stuart M. Pitson, Dusan Matusica, Ian L. Gibbins, Michaela Kress, Rainer V. Haberberger

  2015, 1(1): 22-33. doi: 10.3934/molsci.2015.1.22

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• Molecular mechanisms involved in taste learning and memory

  Andrés Molero-Chamizo, Guadalupe Nathzidy Rivera-Urbina

  2017, 4(4): 389-398. doi: 10.3934/molsci.2017.4.389

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• Characterization and immobilization of engineered sialidases from Trypanosoma rangeli for transsialylation

  Birgitte Zeuner, Isabel González-Delgado, Jesper Holck, Gabriel Morales, María-José López-Muñoz, Yolanda Segura, Anne S. Meyer, Jørn Dalgaard Mikkelsen

  2017, 4(2): 140-163. doi: 10.3934/molsci.2017.2.140

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• The critical role of lipid rafts nanodomains in the cross-talk between calcium and reactive oxygen and nitrogen species in cerebellar granule neurons apoptosis by extracellular potassium deprivation

  Carlos Gutierrez-Merino, Dorinda Marques-da-Silva, Sofia Fortalezas, Alejandro K. Samhan-Arias

  2016, 3(1): 12-29. doi: 10.3934/molsci.2016.1.12

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• Critical function of Siah2 in tumorigenesis

  Kazunobu Baba, Tadaaki Miyazaki

  2017, 4(4): 415-423. doi: 10.3934/molsci.2017.4.415

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• The skeletal proteome of the brittle star Ophiothrix spiculata identifies C-type lectins and other proteins conserved in echinoderm skeleton formation

  Rachel L. Flores, Kayla Gonzales, Ryan W. Seaver, Brian T. Livingston

  2016, 3(3): 357-367. doi: 10.3934/molsci.2016.3.357

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• In vitro activity of some flavonoid derivatives on human leukemic myeloid cells: evidence for aminopeptidase-N (CD13) inhibition, antiproliferative and cell death properties

  Sandrine Bouchet, Marion Piedfer, Santos Susin, Daniel Dauzonne, Brigitte Bauvois

  2016, 3(3): 368-385. doi: 10.3934/molsci.2016.3.368

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• Actin nitrosylation and its effect on myosin driven motility

  Heather M. Bansbach, William H. Guilford

  2016, 3(3): 426-438. doi: 10.3934/molsci.2016.3.426

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• Regulation of CCK-induced ERK1/2 activation by PKC epsilon in rat pancreatic acinar cells

  Chenwei Li, John A. Williams

  2017, 4(4): 463-477. doi: 10.3934/molsci.2017.4.463

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• N-formylpyrazolines and N-benzoylpyrazolines as potential inhibitors cathepsin L

  S. Garg, N. Raghav

  2016, 3(3): 454-465. doi: 10.3934/molsci.2016.3.454

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• Dexamethasone enhances glutamine synthetase activity and reduces N-methyl-D-aspartate neurotoxicity in mixed cultures of neurons and astrocytes

  Edith Debroas, Carine Ali, Dominique Duval

  2015, 2(2): 175-189. doi: 10.3934/molsci.2015.2.175

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• Genome-wide transcriptional comparison of MPP⁺ treated human neuroblastoma cells with the state space model

  Jin Hwan Do

  2015, 2(4): 440-460. doi: 10.3934/molsci.2015.4.440

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• Age-related protein and mRNA expression of glutathione peroxidases (GPx) and Hsp-70 in different regions of rat kidney with and without stressor

  Noor Riyadh Thiab, Nicola King, Mary McMillan, Amer Almashhadany, Graham L Jones

  2016, 3(2): 125-137. doi: 10.3934/molsci.2016.2.125

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• The potential role of transforming growth factor beta family ligand interactions in prostate cancer

  Kit P. Croxford, Karen L. Reader, Helen D. Nicholson

  2017, 4(1): 41-61. doi: 10.3934/molsci.2017.1.41

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• The changing paradigm: estrogen receptor α recognition on DNA and within the dynamic nature of nucleosomes

  William M. Scovell, Sachindra R. Joshi

  2015, 2(2): 48-63. doi: 10.3934/molsci.2015.2.48

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• Regulation of zebrafish gonadal sex differentiation

  Ajay Pradhan, Per-Erik Olsson

  2016, 3(4): 567-584. doi: 10.3934/molsci.2016.4.567

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• Skin aging and oxidative stress

  Sayeeda Ahsanuddin, Minh Lam, Elma D. Baron

  2016, 3(2): 187-195. doi: 10.3934/molsci.2016.2.187

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