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Monitoring serum PCB levels in the adult population of the Canary Islands (Spain)

1 Grupo de Investigación en Toxicología Clínica, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España, Facultad de Ciencias de la Salud, Universidad Europea de Canarias, La Orotava, Tenerife, Spain;
2 Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBER ObN) and Instituto Canario de Investigación del Cáncer (ICIC) Plaza Dr. Pasteur s/n 35016-Las Palmas de Gran Canaria, Spain;
3 Urology Service, Complejo Hospitalario Universitario Insular-Materno Infantil, Avda. Marítima del Sur, 35016-Las Palmas de Gran Canaria, and Instituto Canario de Investigación del Cáncer (ICIC), Spain

The first and second authors have contributed equally to this work and, therefore, they should be considered indistinctly as first authors.

Special Issues: Human biomonitoring and health impacts of existing and emerging environmental contaminants

Polychlorinated biphenyls (PCBs) are persistent organic chemicals that have been detected in human serum or tissues all over the world. These pollutants could exert a number of deleterious effects on humans and wildlife, including carcinogenic processes. The Spanish population of the Canary Islands was evaluated with respect to PCB levels more than ten years ago showing lower levels than other Western populations. The objective of our study was to assess the current level of contamination by PCBs showed by this population. We measured serum PCBs in a sample of healthy adult subjects (206 serum samples from subjects with an average age of 66 years old) to evaluate the potential modification of PCB serum levels in this population during the last decade. PCB congeners (28, 52, 77, 81, 101, 105, 114, 118, 123, 126, 138, 153, 156, 157, 167, 169, 180, and 189) were measured by gas chromatography-mass spectrometry (GC/MS). Our results showed that PCB residues were found in 84% of serum samples analyzed, the congeners 28, 153 and 180 being the most frequently detected and at the highest median values (0.1 ng/mL). In addition, the median concentration of the sum of those PCBs considered as markers of environmental contamination by these chemicals (Marker-PCBs) was 0.6 ng/mL, reaching values as high as as 2.6 ng/mL in the 95th percentile. Levels of the sum of PCBs with toxic effects similar to dioxins (dioxin-like PCBs) reached median values of 0.4 ng/mL in the 95th percentile. The reported levels are similar to those described previously in this population more than ten years ago, in the sense that the inhabitants of the Canary Archipelago show levels of PCB contamination lower than the majority of populations from developed countries. These findings suggest that currently there is not any active source of these chemicals in this archipelago. Nevertheless, as foods seem to be a relevant source for these compounds, Public Health authorities should monitor the presence of PCB residues in foods available in the market of these Islands.
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Keywords polychlorobiphenyls; POPs; serum samples; adult subjects; biomonitoring; gas chromatography/mass spectrometry

Citation: Guillermo Burillo-Putze, Luis D. Boada, Luis Alberto Henríquez-Hernández, Patricio Navarro, Manuel Zumbado, María Almeida-González, Ana Isabel Dominguez-Bencomo, María Camacho, Octavio P. Luzardo. Monitoring serum PCB levels in the adult population of the Canary Islands (Spain). AIMS Environmental Science, 2015, 2(2): 345-352. doi: 10.3934/environsci.2015.2.345


  • 1. Safe SH (1994) Polychlorinatedbiphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24: 87-149.    
  • 2. Headrick ML, Hollinger K, Lovell RA, et al (1999) PBBs, PCBs, and dioxins in food animals, their public health implications. Vet Clin North Am Food Anim Pract 15:109-131.
  • 3. United Nations Environmental Program (2001) “Stockholm Convention on persistent organic pollutants. Available from: http://chm.pops.int/Programmes/NewPOPs/tabid/672/language/en-US/Default.aspx
  • 4. Tanabe S (1988) PCB problems in the future: foresight from current knowledge. Environ Pollut50: 5-28.
  • 5. Henriquez-Hernandez LA, Luzardo OP, Almeida-Gonzalez M, et al. (2011) Background levels of polychlorinated biphenyls in the population of the Canary Islands (Spain). Environ Res 111:10-16.    
  • 6. Rodriguez-Hernöndez A, Boada LD, Almeida-Gonzölez M, et al. (2015) An estimation of the carcinogenic risk associated with the intake of multiple relevant carcinogens found in meat and charcuterie products. Sci Total Environ 514C: 33-41.
  • 7. Hagmar L (2003) Polychlorinated biphenyls and thyroid status in humans: a review. Thyroid 13:1021-1028.    
  • 8. Longnecker MP, Wolff MS, Gladen BC, et al. (2003) Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environ Health Perspect 111: 65-70.
  • 9. Fitzgerald EF, Belanger EE, Gomez MI, et al. (2008) Polychlorinated biphenyl exposure and neuropsychological status among older residents of upper Hudson River communities. Environ Health Perspect 116: 209-215.
  • 10. Philibert A, Schwartz H, Mergler D (2009) An exploratory study of diabetes in a first nation community with respect to serum concentrations of p,p’-DDE and PCBs and fish consumption. Int J Environ Res Public Health 6: 3179-3189.    
  • 11. IARC (2002) “IARC Monographs on the evaluation of carcinogenic risk to humans”. Available from: http://monographs.iarc.fr/ENG/Monographs/vol82/mono82.pdf
  • 12. Van denBerg M, DeJongh J, Poiger H, et al. (1994).The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol 24: 1-74.    
  • 13. Buck Louis GM, Dmochowski J, Lynch C, et al. (2009) Polychlorinated biphenyl serum concentrations, lifestyle and time-to-pregnancy. Hum Reprod 24: 451-458.    
  • 14. Zumbado M, Goethals M, Álvarez-León EE, et al. (2005) Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain). Sci Total Environ 339: 49-62.    
  • 15. Luzardo OP, Goethals M, Zumbado M, et al. (2006) Increasing serum levels of non-DDT-derivative organochlorine pesticides in the younger population of the Canary Islands (Spain). Sci Total Environ 367: 129-138.    
  • 16. Boada LD, Henríquez-Hernöndez LA, Navarro P, et al. (2015) Exposure to polycyclic aromatic hydrocarbons (PAHs) and bladder cancer: evaluation from a gene-environment perspective in a hospital-based case-control study in the Canary Islands (Spain). Int J Occup Environ Health 21:23-30.    
  • 17. Luzardo OP, Mahtani V, Troyano JM, et al. (2009) Determinants of organochlorine levels detectable in the amniotic fluid of Women from Tenerife Island (Canary Islands, Spain). Environ Res109: 607-613.
  • 18. Almeida-Gonzölez M, Luzardo OP, Zumbado M, et al. (2012) Levels of organochlorine contaminants in organic and conventional cheeses and their impact on the health of consumers: an independent study in the Canary Islands (Spain). Food Chem Toxicol 50: 4325-4332.    
  • 19. Luzardo OP, Almeida-Gonzölez M, Henríquez-Hernöndez LA, et al. (2012) Polychlorobiphenyls and organochlorine pesticides in conventional and organic brands of milk: occurrence and dietary intake in the population of the Canary Islands (Spain). Chemosphere 88: 307-315.    
  • 20. Van denBerg M, Birnbaum LS, Denison M, et al. (2006) The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93: 223-241.    
  • 21. Luzardo OP, Rodríguez-Hernöndez A, Quesada-Tacoronte Y, et al. (2013). Influence of the method of production of eggs on the daily intake of polycyclic aromatic hydrocarbons and organochlorine contaminants: an independent study in the Canary Islands (Spain). Food Chem Toxicol 60: 455-462.    
  • 22. Bocio A, Domingo JL, Falco G, et al. (2007) Concentrations of PCDD/PCDFs and PCBs in fish and sea food from the Catalan (Spain) market: estimated human intake. Environ Int 33: 170-175.    
  • 23. Gomara B, Bordajandi LR, Fernandez MA, et al. (2005) Levels and trends of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (PCBs) in Spanish commercial fish and shellfish products,1995–2003. J Agric FoodChem 53: 8406-8413.    
  • 24. Bordajandi LR, Martın I, Abad E, et al. (2006) Organochlorine compounds (PCBs, PCDDs and PCDFs) in sea fish and sea food from the Spanish Atlantic Southwest Coast. Chemosphere 64:1450-1457.    
  • 25. Serra Majem L (2000) Evaluación del estado nutricional de la población canaria (1997–1998). Sociedad Latinoamericana de Nutrición, Caracas, Venezuela.
  • 26. Welch AA, Lund E, Amiano P, et al. (2002) Variability of fish consumption within the 10 European countries participating in the European investigation into cancer and nutrition (EPIC) study. Public Health Nutr 5: 1273-1285.    


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