The COVID-19 pandemic has caused a worldwide health crisis and economic recession. Effective prevention and treatment methods are urgently required to control the pandemic. However, the emergence of novel SARS-CoV-2 variants challenges the effectiveness of currently available vaccines and therapeutic antibodies. In this study, through the assessment of binding free energies, we analyzed the mutational effects on the binding affinity of the coronavirus spike protein to neutralizing antibodies, patient-derived antibodies, and artificially designed antibody mimics. We designed a scoring method to assess the immune evasion ability of viral variants. We also evaluated the differences between several targeting sites on the spike protein of antibodies. The results presented herein might prove helpful in the development of more effective therapies in the future.
Citation: Ke An, Xiaohong Zhu, Junfang Yan, Peiyi Xu, Linfeng Hu, Chen Bai. A systematic study on the binding affinity of SARS-CoV-2 spike protein to antibodies[J]. AIMS Microbiology, 2022, 8(4): 595-611. doi: 10.3934/microbiol.2022038
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The COVID-19 pandemic has caused a worldwide health crisis and economic recession. Effective prevention and treatment methods are urgently required to control the pandemic. However, the emergence of novel SARS-CoV-2 variants challenges the effectiveness of currently available vaccines and therapeutic antibodies. In this study, through the assessment of binding free energies, we analyzed the mutational effects on the binding affinity of the coronavirus spike protein to neutralizing antibodies, patient-derived antibodies, and artificially designed antibody mimics. We designed a scoring method to assess the immune evasion ability of viral variants. We also evaluated the differences between several targeting sites on the spike protein of antibodies. The results presented herein might prove helpful in the development of more effective therapies in the future.
Let C denote the complex plane and Cn the n-dimensional complex Euclidean space with an inner product defined as ⟨z,w⟩=∑nj=1zj¯wj. Let B(a,r)={z∈Cn:|z−a|<r} be the open ball of Cn. In particular, the open unit ball is defined as B=B(0,1).
Let H(B) denote the set of all holomorphic functions on B and S(B) the set of all holomorphic self-mappings of B. For given φ∈S(B) and u∈H(B), the weighted composition operator on or between some subspaces of H(B) is defined by
Wu,φf(z)=u(z)f(φ(z)). |
If u≡1, then Wu,φ is reduced to the composition operator usually denoted by Cφ. If φ(z)=z, then Wu,φ is reduced to the multiplication operator usually denoted by Mu. Since Wu,φ=Mu⋅Cφ, Wu,φ can be regarded as the product of Mu and Cφ.
If n=1, B becomes the open unit disk in C usually denoted by D. Let Dm be the mth differentiation operator on H(D), that is,
Dmf(z)=f(m)(z), |
where f(0)=f. D1 denotes the classical differentiation operator denoted by D. As expected, there has been some considerable interest in investigating products of differentiation and other related operators. For example, the most common products DCφ and CφD were extensively studied in [1,10,11,12,13,23,25,26], and the products
MuCφD,CφMuD,MuDCφ,CφDMu,DMuCφ,DCφMu | (1.1) |
were also extensively studied in [14,18,22,27]. Following the study of the operators in (1.1), people naturally extend to study the operators (see [5,6,30])
MuCφDm,CφMuDm,MuDmCφ,CφDmMu,DmMuCφ,DmCφMu. |
Other examples of products involving differentiation operators can be found in [7,8,19,32] and the related references.
As studying on the unit disk becomes more mature, people begin to become interested in exploring related properties on the unit ball. One method for extending the differentiation operator to Cn is the radial derivative operator
ℜf(z)=n∑j=1zj∂f∂zj(z). |
Naturally, replacing D by ℜ in (1.1), we obtain the following operators
MuCφℜ,CφMuℜ,MuℜCφ,CφℜMu,ℜMuCφ,ℜCφMu. | (1.2) |
Recently, these operators have been studied in [31]. Other operators involving radial derivative operators have been studied in [21,33,34].
Interestingly, the radial derivative operator can be defined iteratively, namely, ℜmf can be defined as ℜmf=ℜ(ℜm−1f). Similarly, using the radial derivative operator can yield the related operators
MuCφℜm,CφMuℜm,MuℜmCφ,CφℜmMu,ℜmMuCφ,ℜmCφMu. | (1.3) |
Clearly, the operators in (1.3) are more complex than those in (1.2). Since CφMuℜm=Mu∘φCφℜm, the operator MuCφℜm can be regarded as the simplest one in (1.3) which was first studied and denoted as ℜmu,φ in [24]. Recently, it has been studied again because people need to obtain more properties about spaces to characterize its properties (see [29]).
To reconsider the operator CφℜmMu, people find the fact
CφℜmMu=m∑i=0Cimℜi(ℜm−iu)∘φ,φ. | (1.4) |
Motivated by (1.4), people directly studied the sum operator (see [2,28])
Sm→u,φ=m∑i=0MuiCφℜi, |
where ui∈H(B), i=¯0,m, and φ∈S(B). Particularly, if we set u0≡⋯≡um−1≡0 and um=u, then Sm→u,φ=MuCφℜm; if we set u0≡⋯≡um−1≡0 and um=u∘φ, then Sm→u,φ=CφMuℜm. In [28], Stević et al. studied the operators Sm→u,φ from Hardy spaces to weighted-type spaces on the unit ball and obtained the following results.
Theorem A. Let m∈N, uj∈H(B), j=¯0,m, φ∈S(B), and μ a weight function on B. Then, the operator Sm→u,φ:Hp→H∞μ is bounded and
supz∈Bμ(z)|uj(φ(z))||φ(z)|<+∞,j=¯1,m, | (1.5) |
if and only if
I0=supz∈Bμ(z)|u0(z)|(1−|φ(z)|2)np<+∞ |
and
Ij=supz∈Bμ(z)|uj(z)||φ(z)|(1−|φ(z)|2)np+j<+∞,j=¯1,m. |
Theorem B. Let m∈N, uj∈H(B), j=¯0,m, φ∈S(B), and μ a weight function on B. Then, the operator Sm→u,φ:Hp→H∞μ is compact if and only if it is bounded,
lim|φ(z)|→1μ(z)|u0(z)|(1−|φ(z)|2)np=0 |
and
lim|φ(z)|→1μ(z)|uj(z)||φ(z)|(1−|φ(z)|2)np+j=0,j=¯1,m. |
It must be mentioned that we find that the necessity of Theorem A requires (1.5) to hold. Inspired by [2,28], here we use a new method and technique without (1.5) to study the sum operator Sm→u,φ from logarithmic Bergman-type space to weighted-type space on the unit ball. To this end, we need to introduce the well-known Bell polynomial (see [3])
Bm,k(x1,x2,…,xm−k+1)=∑m!∏m−k−1i=1ji!m−k−1∏i=1(xii!)ji, |
where all non-negative integer sequences j1, j2,…,jm−k+1 satisfy
m−k+1∑i=1ji=kandm−k+1∑i=1iji=m. |
In particular, when k=0, one can get B0,0=1 and Bm,0=0 for any m∈N. When k=1, one can get Bi,1=xi. When m=k=i, Bi,i=xi1 holds.
In this section, we need to introduce logarithmic Bergman-type space and weighted-type space. Here, a bounded positive continuous function on B is called a weight. For a weight μ, the weighted-type space H∞μ consists of all f∈H(B) such that
‖f‖H∞μ=supz∈Bμ(z)|f(z)|<+∞. |
With the norm ‖⋅‖H∞μ, H∞μ becomes a Banach space. In particular, if μ(z)=(1−|z|2)σ(σ>0), the space H∞μ is called classical weighted-type space usually denoted by H∞σ. If μ≡1, then space H∞μ becomes the bounded holomorphic function space usually denoted by H∞.
Next, we need to present the logarithmic Bergman-type space on B (see [4] for the unit disk case). Let dv be the standardized Lebesgue measure on B. The logarithmic Bergman-type space Apwγ,δ consists of all f∈H(B) such that
‖f‖pApwγ,δ=∫B|f(z)|pwγ,δ(z)dv(z)<+∞, |
where −1<γ<+∞, δ≤0, 0<p<+∞ and wγ,δ(z) is defined by
wγ,δ(z)=(log1|z|)γ[log(1−1log|z|)]δ. |
When p≥1, Apwγ,δ is a Banach space. While 0<p<1, it is a Fréchet space with the translation invariant metric ρ(f,g)=‖f−g‖pApωγ,δ.
Let φ∈S(B), 0≤r<1, 0≤γ<∞, δ≤0, and a∈B∖{φ(0)}. The generalized counting functions are defined as
Nφ,γ,δ(r,a)=∑zj(a)∈φ−1(a)wγ,δ(zj(a)r) |
where |zj(a)|<r, counting multiplicities, and
Nφ,γ,δ(a)=Nφ,γ,δ(1,a)=∑zj(a)∈φ−1(a)wγ,δ(zj(a)). |
If φ∈S(D), then the function Nφ,γ,δ has the integral expression: For 1≤γ<+∞ and δ≤0, there is a positive function F(t) satisfying
Nφ,γ,δ(r,u)=∫r0F(t)Nφ,1(t,u)dt,r∈(0,1),u≠φ(0). |
When φ∈S(D) and δ=0, the generalized counting functions become the common counting functions. Namely,
Nφ,γ(r,a)=∑z∈φ−1(a),|z|<r(logr|z|)γ, |
and
Nφ,γ(a)=Nφ,γ(1,a)=∑z∈φ−1(a)(log1|z|)γ. |
In [17], Shapiro used the function Nφ,γ(1,a) to characterize the compact composition operators on the weighted Bergman space.
Let X and Y be two topological spaces induced by the translation invariant metrics dX and dY, respectively. A linear operator T:X→Y is called bounded if there is a positive number K such that
dY(Tf,0)≤KdX(f,0) |
for all f∈X. The operator T:X→Y is called compact if it maps bounded sets into relatively compact sets.
In this paper, j=¯k,l is used to represent j=k,...,l, where k,l∈N0 and k≤l. Positive numbers are denoted by C, and they may vary in different situations. The notation a≲b (resp. a≳b) means that there is a positive number C such that a≤Cb (resp. a≥Cb). When a≲b and b≳a, we write a≍b.
In this section, we obtain some properties on the logarithmic Bergman-type space. First, we have the following point-evaluation estimate for the functions in the space.
Theorem 3.1. Let −1<γ<+∞, δ≤0, 0<p<+∞ and 0<r<1. Then, there exists a positive number C=C(γ,δ,p,r) independent of z∈K={z∈B:|z|>r} and f∈Apwγ,δ such that
|f(z)|≤C(1−|z|2)γ+n+1p[log(1−1log|z|)]−δp‖f‖Apwγ,δ. | (3.1) |
Proof. Let z∈B. By applying the subharmonicity of the function |f|p to Euclidean ball B(z,r) and using Lemma 1.23 in [35], we have
|f(z)|p≤1v(B(z,r))∫B(z,r)|f(w)|pdv(w)≤C1,r(1−|z|2)n+1∫B(z,r)|f(w)|pdv(w). | (3.2) |
Since r<|z|<1 and 1−|w|2≍1−|z|2, we have
log1|w|≍1−|w|≍1−|z|≍log1|z| | (3.3) |
and
log(1−log1|w|)≍log(1−log1|z|). | (3.4) |
From (3.3) and (3.4), it follows that there is a positive constant C2,r such that wγ,δ(z)≤C2,rwγ,δ(w) for all w∈B(z,r). From this and (3.2), we have
|f(z)|p≤C1,rC2,r(1−|z|2)n+1wγ,δ(z)∫B(z,r)|f(w)|pwγ,δ(w)dv(w)≤C1,rC2,r(1−|z|2)n+1wγ,δ(z)‖f‖pApwγ,δ. | (3.5) |
From (3.5) and the fact log1|z|≍1−|z|≍1−|z|2, the following inequality is right with a fixed constant C3,r
|f(z)|p≤C1,rC2,rC3,r(1−|z|2)n+1+γ[log(1−1log|z|)]−δ‖f‖pApwγ,δ. |
Let C=C1,rC2,rC3,rp. Then the proof is end.
Theorem 3.2. Let m∈N, −1<γ<+∞, δ≤0, 0<p<+∞ and 0<r<1. Then, there exists a positive constant Cm=C(γ,δ,p,r,m) independent of z∈K and f∈Apwγ,δ such that
|∂mf(z)∂zi1∂zi2…∂zim|≤Cm(1−|z|2)γ+n+1p+m[log(1−1log|z|)]−δp‖f‖Apwγ,δ. | (3.6) |
Proof. First, we prove the case of m=1. By the definition of the gradient and the Cauchy's inequality, we get
|∂f(z)∂zi|≤|∇f(z)|≤˜C1supw∈B(z,q(1−|z|))|f(w)|1−|z|, | (3.7) |
where i=¯1,n. By using the relations
1−|z|≤1−|z|2≤2(1−|z|), |
(1−q)(1−|z|)≤1−|w|≤(q+1)(1−|z|), |
and
log(1−1log|z|)≍log(1−1log|w|), |
we obtain the following formula
|f(w)|≤˘C1(1−|z|2)γ+n+1p[log(1−1log|z|)]−δp‖f‖Apwγ,δ |
for any w∈B(z,q(1−|z|)). Then,
supw∈B(z,q(1−|z|))|f(w)|≤˘C1(1−|z|2)γ+n+1p[log(1−1log|z|)]−δp‖f‖Apwγ,δ. |
From (3.1) and (3.2), it follows that
|∂f(z)∂zi|≤ˆC1(1−|z|2)γ+n+1p+1[log(1−1log|z|)]−δp‖f‖Apwγ,δ. | (3.8) |
Hence, the proof is completed for the case of m=1.
We will use the mathematical induction to complete the proof. Assume that (3.6) holds for m<a. For convenience, let g(z)=∂a−1f(z)∂zi1∂zi2…∂zia−1. By applying (3.7) to the function g, we obtain
|∂g(z)∂zi|≤˜C1supw∈B(z,q(1−|z|))|g(w)|1−|z|. | (3.9) |
According to the assumption, the function g satisfies
|g(z)|≤ˆCa−1(1−|z|2)γ+n+1p+a−1[log(1−1log|z|)]−δp‖f‖Apwγ,δ. |
By using (3.8), the following formula is also obtained
|∂g(z)∂zi|≤ˆCa(1−|z|2)γ+n+1p+a[log(1−1log|z|)]−δp‖f‖Apwγ,δ. |
This shows that (3.6) holds for m=a. The proof is end.
As an application of Theorems 3.1 and 3.2, we give the estimate in z=0 for the functions in Apωγ,δ.
Corollary 3.1. Let −1<γ<+∞, δ≤0, 0<p<+∞, and 0<r<2/3. Then, for all f∈Apwγ,δ, it follows that
|f(0)|≤C(1−r2)γ+n+1p[log(1−1logr)]−δp‖f‖Apwγ,δ, | (3.10) |
and
|∂mf(0)∂zl1…∂zlm|≤Cm(1−r2)γ+n+1p+m[log(1−1logr)]−δp‖f‖Apwγ,δ, | (3.11) |
where constants C and Cm are defined in Theorems 3.1 and 3.2, respectively.
Proof. For f∈Apwγ,δ, from Theorem 3.1 and the maximum module theorem, we have
|f(0)|≤max|z|=r|f(z)|≤C(1−r2)γ+n+1p[log(1−1logr)]−δp‖f‖Apwγ,δ, |
which implies that (3.10) holds. By using the similar method, we also have that (3.11) holds.
Next, we give an equivalent norm in Apwγ,δ, which extends Lemma 3.2 in [4] to B.
Theorem 3.3. Let r0∈[0,1). Then, for every f∈Apwγ,δ, it follows that
‖f‖pApwγ,δ≍∫B∖r0B|f(z)|pwγ,δ(z)dv(z). | (3.12) |
Proof. If r0=0, then it is obvious. So, we assume that r0∈(0,1). Integration in polar coordinates, we have
‖f‖pApwγ,δ=2n∫10wγ,δ(r)r2n−1dr∫S|f(rζ)|pdσ(ζ). |
Put
A(r)=wγ,δ(r)r2n−1andM(r,f)=∫S|f(rζ)|pdσ(ζ). |
Then it is represented that
‖f‖pApwγ,δ≍∫r00+∫1r0M(r,f)A(r)dr. | (3.13) |
Since M(r,f) is increasing, A(r) is positive and continuous in r on (0,1) and
limr→0A(r)=limx→+∞xγ[log(1+1x)]δe−(2n−1)x=limx→+∞xγ−δe(2n−1)x=0, |
that is, there is a constant ε>0(ε<r0) such that A(r)<A(ε) for r∈(0,ε). Then we have
∫r00M(r,f)A(r)dr≤2r01−r0maxε≤r≤r0A(r)∫1+r02r0M(r,f)dr≤2r01−r0maxε≤r≤r0A(r)minr0≤r≤1+r02A(r)∫1+r02r0M(r,f)A(r)dr≲∫1r0M(r,f)A(r)dr. | (3.14) |
From (3.13) and (3.14), we obtain the inequality
‖f‖pApwγ,δ≲∫1r0M(r,f)A(r)dr. |
The inequality reverse to this is obvious. The asymptotic relationship (3.12) follows, as desired.
The following integral estimate is an extension of Lemma 3.4 in [4]. The proof is similar, but we still present it for completeness.
Lemma 3.1. Let −1<γ<+∞, δ≤0, β>γ−δ and 0<r<1. Then, for each fixed w∈B with |w|>r,
∫Bωγ,δ(z)|1−⟨z,w⟩|n+β+1dv(z)≲1(1−|w|)β−γ[log(1−1log|w|)]δ. |
Proof. Fix |w| with |w|>r0 (0<r0<1). It is easy to see that
log1r≍1−rforr0≤r<1. | (3.15) |
By applying Theorem 3.3 with
fw(z)=1(1−⟨z,w⟩)n+β+1 |
and using (3.15), the formula of integration in polar coordinates gives
∫B1|1−⟨z,w⟩|n+β+1ωγ,δ(z)dv(z)≲∫1r0M(r,fw)(1−r)γ[log(1−1logr)]δr2n−1dr. | (3.16) |
By Proposition 1.4.10 in [15], we have
M(r,fw)≍1(1−r2|w|2)β+1. | (3.17) |
From (3.16) and (3.17), we have
∫B1|1−⟨z,w⟩|β+2nωγ,δ(z)dv(z)≲∫1r01(1−r2|w|2)β+1(1−r)γ[log(1−1logr)]δr2n−1dr≲∫1r01(1−r|w|)β+1(1−r)γ[log(1−1logr)]δr2n−1dr≲∫|w|r01(1−r|w|)β+1(1−r)γ[log(1−1logr)]δr2n−1dr+∫1|w|1(1−r|w|)β+1(1−r)γ[log(1−1logr)]δr2n−1dr=I1+I2. |
Since [log(1−1logr)]δ is decreasing in r on [|w|,1], we have
I2=∫1|w|1(1−r|w|)β+1(1−r)γ[log(1−1logr)]δr2n−1dr≲1(1−|w|)β+1[log(1−1log|w|)]δ∫1|w|(1−r)γdr≍1(1−|w|)β−γ[log(1−1log|w|)]δ. | (3.18) |
On the other hand, we obtain
I1=∫|w|r01(1−r|w|)β+1(1−r)γ[log(1−1logr)]δr2n−1dr≲∫|w|r0(1−r)γ−β−1(log21−r)δdr. |
If δ=0 and β>γ, then we have
I1(0)≲(1−|w|)γ−β. |
If δ≠0, then integration by parts gives
I1(δ)=−1γ−β(1−|w|)γ−β(log21−|w|)δ+1γ−β(1−r0)γ−β(log21−r0)δ+δγ−βI1(δ−1). |
Since δ<0, γ−β<0 and
(log21−r)δ−1≤(log21−r)δforr0<r<|w|<1, |
we have
I1(δ)≤−1γ−β(1−|w|)γ−β(log21−|w|)δ+δγ−βI1(δ) |
and from this follows
I1(δ)≲(1−|w|)γ−β(log21−|w|)δ≍(1−|w|)γ−β[log(1−1log|w|)]δ |
provided γ−β−δ<0. The proof is finished.
The following gives an important test function in Apwγ,δ.
Theorem 3.4. Let −1<γ<+∞, δ≤0, 0<p<+∞ and 0<r<1. Then, for each t≥0 and w∈B with |w|>r, the following function is in Apwγ,δ
fw,t(z)=[log(1−1log|w|)]−δp(1−|w|2)−δp+t+1(1−⟨z,w⟩)γ−δ+n+1p+t+1. |
Moreover,
sup{w∈B:|w|>r}‖fw,t‖Apwγ,δ≲1. |
Proof. By Lemma 3.1 and a direct calculation, we have
‖fw,t‖pApwγ,δ=∫B|[log(1−1log|w|)]−δp(1−|w|2)−δp+t+1(1−⟨z,w⟩)γ−δ+n+1p+t+1|pwγ,δ(z)dA(z)=(1−|w|2)p(t+1)−δ[log(1−1log|w|)]−δ×∫B1|1−⟨z,w⟩|γ−δ+p(t+1)+n+1wγ,δ(z)dA(z)≲1. |
The proof is finished.
In this section, for simplicity, we define
Bi,j(φ(z))=Bi,j(φ(z),φ(z),…,φ(z)). |
In order to characterize the compactness of the operator Sm→u,φ:Apwγ,δ→H∞μ, we need the following lemma. It can be proved similar to that in [16], so we omit here.
Lemma 4.1. Let −1<γ<+∞, δ≤0, 0<p<+∞, m∈N, uj∈H(B), j=¯0,m, and φ∈S(B). Then, the bounded operator Sm→u,φ:Apwγ,δ→H∞μ is compact if and only if for every bounded sequence {fk}k∈N in Apwγ,δ such that fk→0 uniformly on any compact subset of B as k→∞, it follows that
limk→∞‖Sm→u,φfk‖H∞μ=0. |
The following result was obtained in [24].
Lemma 4.2. Let s≥0, w∈B and
gw,s(z)=1(1−⟨z,w⟩)s,z∈B. |
Then,
ℜkgw,s(z)=sPk(⟨z,w⟩)(1−⟨z,w⟩)s+k, |
where Pk(w)=sk−1wk+p(k)k−1(s)wk−1+...+p(k)2(s)w2+w, and p(k)j(s), j=¯2,k−1, are nonnegative polynomials for s.
We also need the following result obtained in [20].
Lemma 4.3. Let s>0, w∈B and
gw,s(z)=1(1−⟨z,w⟩)s,z∈B. |
Then,
ℜkgw,s(z)=k∑t=1a(k)t(t−1∏j=0(s+j))⟨z,w⟩t(1−⟨z,w⟩)s+t, |
where the sequences (a(k)t)t∈¯1,k, k∈N, are defined by the relations
a(k)k=a(k)1=1 |
for k∈N and
a(k)t=ta(k−1)t+a(k−1)t−1 |
for 2≤t≤k−1,k≥3.
The final lemma of this section was obtained in [24].
Lemma 4.4. If a>0, then
Dn(a)=|11⋯1aa+1⋯a+n−1a(a+1)(a+1)(a+2)⋯(a+n−1)(a+n)⋮⋮⋯⋮n−2∏k=0(a+k)n−2∏k=0(a+k+1)⋯n−2∏k=0(a+k+n−1)|=n−1∏k=1k!. |
Theorem 4.1. Let −1<γ<+∞, δ≤0, 0<p<+∞, m∈N, uj∈H(B), j=¯0,m, and φ∈S(B). Then, the operator Sm→u,φ:Apwγ,δ→H∞μ is bounded if and only if
M0:=supz∈Bμ(z)|u0(z)|(1−|φ(z)|2)γ+n+1p[log(1−1log|φ(z)|)]−δp<+∞ | (4.1) |
and
Mj:=supz∈Bμ(z)|∑mi=jui(z)Bi,j(φ(z))|(1−|φ(z)|2)γ+n+1p+j[log(1−1log|φ(z)|)]−δp<+∞ | (4.2) |
for j=¯1,m.
Moreover, if the operator Sm→u,φ:Apwγ,δ→H∞μ is bounded, then
‖Sm→u,φ‖Apwγ,δ→H∞μ≍m∑j=0Mj. | (4.3) |
Proof. Suppose that (4.1) and (4.2) hold. From Theorem 3.1, Theorem 3.2, and some easy calculations, it follows that
μ(z)|m∑i=0ui(z)ℜif(φ(z))|≤μ(z)m∑i=0|ui(z)||ℜif(φ(z))|=μ(z)|u0(z)||f(φ(z))|+μ(z)|m∑i=1i∑j=1(ui(z)n∑l1=1⋯n∑lj=1(∂jf∂zl1∂zl2⋯∂zlj(φ(z))∑k1,…,kjC(i)k1,…,kjj∏t=1φlt(z)))|=μ(z)|u0(z)f(φ(z))|+μ(z)|m∑j=1m∑i=j(ui(z)n∑l1=1⋯n∑lj=1(∂jf∂zl1∂zl2⋯∂zlj(φ(z))∑k1,…,kjC(i)k1,…,kjj∏t=1φlt(z)))|≲μ(z)|u0(z)|(1−|φ(z)|2)γ+n+1p[log(1−1log|φ(z)|)]−δp‖f‖Apwγ,δ+m∑j=1μ(z)|∑mi=jui(z)Bi,j(φ(z))|(1−|φ(z)|2)γ+n+1p+j[log(1−1log|φ(z)|)]−δp‖f‖Apwγ,δ=M0‖f‖Apwγ,δ+m∑j=1Mj‖f‖Apwγ,δ. | (4.4) |
By taking the supremum in inequality (4.4) over the unit ball in the space Apwγ,δ, and using (4.1) and (4.2), we obtain that the operator Sm→u,φ:Apwγ,δ→H∞μ is bounded. Moreover, we have
‖Sm→u,φ‖Apwγ,δ→H∞μ≤Cm∑j=0Mj, | (4.5) |
where C is a positive constant.
Assume that the operator Sm→u,φ:Apwγ,δ→H∞μ is bounded. Then there exists a positive constant C such that
‖Sm→u,φf‖H∞μ≤C‖f‖Apwγ,δ | (4.6) |
for any f∈Apwγ,δ. First, we can take f(z)=1∈Apwγ,δ, then one has that
supz∈Bμ(z)|u0(z)|<+∞. | (4.7) |
Similarly, take fk(z)=zjk∈Apwγ,δ, k=¯1,n and j=¯1,m, by (4.7), then
μ(z)|u0(z)φk(z)j+m∑i=j(ui(z)Bi,j(φk(z))))|<+∞ | (4.8) |
for any j∈{1,2,…,m}. Since φ(z)∈B, we have |φ(z)|≤1. So, one can use the triangle inequality (4.7) and (4.8), the following inequality is true
supz∈Bμ(z)|m∑i=jui(z)Bi,j(φ(z))|<+∞. | (4.9) |
Let w∈B and dk=γ+n+1p+k. For any j∈{1,2,…,m} and constants ck=c(j)k, k=¯0,m, let
h(j)w(z)=m∑k=0c(j)kfw,k(z), | (4.10) |
where fw,k is defined in Theorem 3.4. Then, by Theorem 3.4, we have
Lj=supw∈B‖h(j)w‖Apwγ,δ<+∞. | (4.11) |
From (4.6), (4.11), and some easy calculations, it follows that
Lj‖Sm→u,φ‖Apwγ,δ→H∞μ≥‖Sm→u,φh(j)φ(w)‖H∞μ=supz∈Bμ(z)|m∑i=0u0(z)h(j)φ(w)(φ(z))|≥μ(w)|u0(w)h(j)φ(w)(φ(w))+m∑i=1(ui(w)ℜih(j)φ(w)(φ(w)))|=μ(w)|u0(w)h(j)φ(w)(φ(w))+m∑i=1ui(w)m∑k=0c(j)kfφ(w),k(φ(w))|=μ(w)|u0(w)c0+c1+⋯+cm(1−|φ(z)|2)γ+n+1p+⟨m∑i=1ui(w)Bi,1(φ(w)),φ(w)⟩(d0c0+⋯+dmcm)(1−|φ(w)|2)γ+n+1p+1+⋯+⟨m∑i=jui(w)Bi,j(φ(w)),φ(w)j⟩(d0⋯dj−1c0+⋯+dm⋯dm+j−1cm)(1−|φ(w)|2)γ+n+1p+j+⋯+⟨um(w)Bm,m(φ(w)),φ(w)m⟩(d0⋯dm−1c0+⋯+dm⋯d2m−1cm)(1−|φ(w)|2)γ+n+1p+m|[log(1−1log|φ(w)|)]−δp. | (4.12) |
Since dk>0, k=¯0,m, by Lemma 4.4, we have the following linear equations
(11⋯1d0d1⋯dm⋮⋮⋱⋮j−1∏k=0dkj−1∏k=0dk+m⋯j−1∏k=0dk+m⋮⋮⋱⋮m−1∏k=0dkm−1∏k=0dk+m⋯m−1∏k=0dk+m)(c0c1⋮cj⋮cm)=(00⋮1⋮0). | (4.13) |
From (4.12) and (4.13), we have
Lj‖Sl→u,φ‖Apwγ,δ→H∞μ≥sup|φ(z)|>1/2μ(z)|∑mi=jui(z)Bi,j(φ(z))||φ(z)|j(1−|φ(z)|2)γ+n+1p+j[log(1−1log|φ(z)|)]−δp≳sup|φ(z)|>1/2μ(z)|∑mi=jui(z)Bi,j(φ(z))|(1−|φ(z)|2)γ+n+1p+j[log(1−1log|φ(z)|)]−δp. | (4.14) |
On the other hand, from (4.9), we have
sup|φ(z)|≤1/2μ(z)|∑mi=jui(z)Bi,j(φ(z))|(1−|φ(z)|2)γ+n+1p+j[log(1−1log|φ(z)|)]−δp≤supz∈B(43)γ+n+1p+j[log(1−1log12)]−δpμ(z)|m∑i=jui(z)Bi,j(φ(z))|<+∞. | (4.15) |
From (4.14) and (4.15), we get that (4.2) holds for j=¯1,m.
For constants ck=c(0)k, k=¯0,m, let
h(0)w(z)=m∑k=0c(0)kfw,k(z). | (4.16) |
By Theorem 3.4, we know that L0=supw∈B‖h(0)w‖Apwγ,δ<+∞. From this, (4.12), (4.13) and Lemma 4.4, we get
L0‖Sm→u,φ‖Apwγ,δ→H∞μ≥μ(z)|u0(z)|(1−|φ(z)|2)γ+n+1p[log(1−1log|φ(z)|)]−δp. |
So, we have M0<+∞. Moreover, we have
‖Sm→u,φ‖Apwγ,δ→H∞μ≥m∑j=0Mj. | (4.17) |
From (4.5) and (4.17), we obtain (4.3). The proof is completed.
From Theorem 4.1 and (1.4), we obtain the following result.
Corollary 4.1. Let m∈N, u∈H(B), φ∈S(B) and μ is a weight function on B. Then, the operator CφℜmMu:Apwγ,δ→H∞μ is bounded if and only if
I0:=supz∈Bμ(z)|ℜmu∘φ(z)|(1−|φ(z)|2)γ+n+1p[log(1−1log|φ(z)|)]−δp<+∞ |
and
Ij:=supz∈Bμ(z)|∑mi=jℜm−iu∘φ(z)Bi,j(φ(z))|(1−|φ(z)|2)γ+n+1p+j[log(1−1log|φ(z)|)]−δp<+∞ |
for j=¯1,m.
Moreover, if the operator CφℜmMu:Apwγ,δ→H∞μ is bounded, then
‖CφℜmMu‖Apwγ,δ→H∞μ≍m∑j=0Ij. |
Theorem 4.2. Let −1<γ<+∞, δ≤0, 0<p<+∞, m∈N, uj∈H(B), j=¯0,m, and φ∈S(B). Then, the operator Sm→u,φ:Apwγ,δ→H∞μ is compact if and only if the operator is bounded,
(4.18) |
for , and
(4.19) |
Proof. Assume that the operator is compact. It is obvious that the operator is bounded.
If , then it is clear that (4.18) and (4.19) are true. So, we suppose that . Let be a sequence in such that
where are defined in (4.10) for a fixed . Then, it follows that uniformly on any compact subset of as . Hence, by Lemma 4.1, we have
Then, we can find sufficiently large such that
(4.20) |
If , then (4.20) is true.
Now, we discuss the case of . Let , where is defined in (4.16). Then, we also have that and uniformly on any compact subset of as . Hence, by Lemma 4.1, one has that
(4.21) |
Then, by (4.21), we know that (4.18) is true.
Now, assume that is bounded, (4.18) and (4.19) are true. One has that
(4.22) |
and
(4.23) |
for any . By (4.18) and (4.19), for arbitrary , there is a , for any such that
(4.24) |
and
(4.25) |
Assume that is a sequence such that and uniformly on any compact subset of as . Then by Theorem 3.1, Theorem 3.2 and (4.22)–(4.25), one has that
(4.26) |
Since uniformly on any compact subset of as . By Cauchy's estimates, we also have that uniformly on any compact subset of as . From this and using the fact that is a compact subset of , by letting in inequality (4.26), one get that
Since is an arbitrary positive number, it follows that
By Lemma 4.1, the operator is compact.
As before, we also have the following result.
Corollary 4.2. Let , , and is a weight function on . Then, the operators is compact if and only if the operator is bounded,
and
for .
In this paper, we study and obtain some properties about the logarithmic Bergman-type space on the unit ball. As some applications, we completely characterized the boundedness and compactness of the operator
from the logarithmic Bergman-type space to the weighted-type space on the unit ball. Here, one thing should be pointed out is that we use a new method and technique to characterize the boundedness of such operators without the condition (1.5), which perhaps is the special flavour in this paper.
The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.
This work was supported by Sichuan Science and Technology Program (2022ZYD0010) and the Graduate Student Innovation Foundation (Y2022193).
The authors declare that they have no competing interests.
[1] | WHO Coronavirus (COVID-19) Dashboard. Available from: https://covid19.who.int. |
[2] | Campbell C, Park A (2020) Inside the global quest to trace the origins of COVID-19 and predict where it will go next. TIME Magazine 23. https://doi.org/https://time.com/5870481/coronavirus-origins. |
[3] |
Almagro JC, Mellado-Sanchez G, Pedraza-Escalona M, et al. (2022) Evolution of Anti-SARS-CoV-2 therapeutic antibodies. Int J Mol Sci 23: 9763. https://doi.org/10.3390/ijms23179763 ![]() |
[4] |
Aydogdu MO, Rohn JL, Jafari NV, et al. (2022) Severe Acute Respiratory Syndrome Type 2-Causing Coronavirus: Variants and Preventive Strategies. Adv Sci 9: e2104495. https://doi.org/10.1002/advs.202104495 ![]() |
[5] | WHO: SARS-CoV-2-variants. Available from: https://www.who.int/en/activities/tracking-SARS-CoV-2-variants. |
[6] |
Chuenkitmongkol S, Solante R, Burhan E, et al. (2022) Expert review on global real-world vaccine effectiveness against SARS-CoV-2. Expert Rev Vaccines 21: 1255-1268. https://doi.org/10.1080/14760584.2022.2092472 ![]() |
[7] |
Qu P, Faraone J, Evans JP, et al. (2022) Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants. N Engl J Med 386: 2526-2528. https://doi.org/10.1056/NEJMc2206725 ![]() |
[8] |
Yu J, Collier AY, Rowe M, et al. (2022) Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants. N Engl J Med 386: 1579-1580. https://doi.org/10.1056/NEJMc2201849 ![]() |
[9] |
Cao Y, Wang J, Jian F, et al. (2021) Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nat 602: 657-663. https://doi.org/10.1038/s41586-021-04385-3 ![]() |
[10] |
Liu L, Iketani S, Guo Y, et al. (2021) Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nat 602: 676-681. https://doi.org/10.1038/s41586-021-04388-0 ![]() |
[11] |
Planas D, Saunders N, Maes P, et al. (2021) Considerable escape of SARS-CoV-2 Omicron to antibody neutralization. Nat 602: 671-675. https://doi.org/10.1038/s41586-021-04389-z ![]() |
[12] |
Flemming A (2022) Omicron, the great escape artist. Nat Rev Immunol 22: 75. https://doi.org/10.1038/s41577-022-00676-6 ![]() |
[13] |
Tuekprakhon A, Nutalai R, Dijokaite-Guraliuc A, et al. (2022) Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. Cell 185: 2422-2433. https://doi.org/10.1016/j.cell.2022.06.005 ![]() |
[14] |
Takashita E, Kinoshita N, Yamayoshi S, et al. (2022) Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2. N Engl J Med 386: 1475-1477. https://doi.org/10.1056/NEJMc2201933 ![]() |
[15] |
Wang Q, Guo Y, Iketani S, et al. (2022) Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5. Nature 608: 603-608. https://doi.org/10.1038/s41586-022-05053-w ![]() |
[16] |
Corti D, Purcell LA, Snell G, et al. (2021) Tackling COVID-19 with neutralizing monoclonal antibodies. Cell 184: 3086-3108. https://doi.org/10.1016/j.cell.2021.05.005 ![]() |
[17] |
Zhang H, Penninger JM, Li Y, et al. (2020) Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med 46: 586-590. https://doi.org/10.1007/s00134-020-05985-9 ![]() |
[18] |
Xu C, Wang Y, Liu C, et al. (2021) Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Sci Adv 7: eabe5575. https://doi.org/10.1126/sciadv.abe5575 ![]() |
[19] |
Bai C, Warshel A (2020) Critical Differences between the Binding Features of the Spike Proteins of SARS-CoV-2 and SARS-CoV. J Phys Chem B 124: 5907-5912. https://doi.org/10.1021/acs.jpcb.0c04317 ![]() |
[20] |
Bai C, Wang J, Chen G, et al. (2021) Predicting Mutational Effects on Receptor Binding of the Spike Protein of SARS-CoV-2 Variants. J Am Chem Soc 143: 17646-17654. https://doi.org/10.1021/jacs.1c07965 ![]() |
[21] |
Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234: 779-815. https://doi.org/10.1006/jmbi.1993.1626 ![]() |
[22] |
Yin W, Xu Y, Xu P, et al. (2022) Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery. Science 375: 1048-1053. https://doi.org/10.1126/science.abn8863 ![]() |
[23] |
Zost SJ, Gilchuk P, Case JB, et al. (2020) Potently neutralizing and protective human antibodies against SARS-CoV-2. Nature 584: 443-449. https://doi.org/https://doi.org/10.1038/s41586-020-2548-6 ![]() |
[24] |
Loo Y-M, McTamney PM, Arends RH, et al. (2022) The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans. Sci Transl Med 14: eabl8124. https://doi.org/10.1126/scitranslmed.abl8124 ![]() |
[25] |
Kim C, Ryu D-K, Lee J, et al. (2021) A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein. Nat Commun 12: 1-10. https://doi.org/https://doi.org/10.1038/s41467-020-20602-5 ![]() |
[26] |
Kim JY, Jang YR, Hong JH, et al. (2021) Safety, virologic efficacy, and pharmacokinetics of CT-P59, a neutralizing monoclonal antibody against SARS-CoV-2 spike receptor-binding protein: two randomized, placebo-controlled, phase i studies in healthy individuals and patients with mild SARS-CoV-2 infection. Clin Ther 43: 1706-1727. https://doi.org/10.1016/j.clinthera.2021.08.009 ![]() |
[27] |
Gottlieb RL, Nirula A, Chen P, et al. (2021) Effect of bamlanivimab as monotherapy or in combination with etesevimab on viral load in patients with mild to moderate COVID-19: a randomized clinical trial. Jama 325: 632-644. https://doi.org/10.1001/jama.2021.0202 ![]() |
[28] |
Jones BE, Brown-Augsburger PL, Corbett KS, et al. (2021) The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates. Sci Transl Med 13: eabf1906. https://doi.org/10.1126/scitranslmed.abf1906 ![]() |
[29] |
Hansen J, Baum A, Pascal KE, et al. (2020) Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail. Science 369: 1010-1014. https://doi.org/10.1126/science.abd0827 ![]() |
[30] |
Pinto D, Park Y-J, Beltramello M, et al. (2020) Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Nature 583: 290-295. https://doi.org/https://doi.org/10.1038/s41586-020-2349-y ![]() |
[31] |
McCallum M, Czudnochowski N, Rosen LE, et al. (2022) Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. Science 375: 864-868. https://doi.org/10.1126/science.abn8652 ![]() |
[32] |
Ju B, Zhang Q, Ge J, et al. (2020) Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature 584: 115-119. https://doi.org/https://doi.org/10.1038/s41586-020-2380-z ![]() |
[33] |
Wang R, Zhang Q, Ge J, et al. (2021) Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species. Immun 54: 1611-1621. https://doi.org/10.1016/j.immuni.2021.06.003 ![]() |
[34] |
Zhang Q, Ju B, Ge J, et al. (2021) Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun 12: 1-12. https://doi.org/https://doi.org/10.1038/s41467-021-24514-w ![]() |
[35] |
Li T, Han X, Gu C, et al. (2021) Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nat Commun 12: 1-11. https://doi.org/https://doi.org/10.1038/s41467-021-26539-7 ![]() |
[36] |
Guo H, Gao Y, Li T, et al. (2022) Structures of Omicron spike complexes and implications for neutralizing antibody development. Cell Rep 39: 110770. https://doi.org/https://doi.org/10.1016/j.celrep.2022.110770 ![]() |
[37] |
Vicatos S, Rychkova A, Mukherjee S, et al. (2014) An effective coarse-grained model for biological simulations: recent refinements and validations. Proteins 82: 1168-1185. https://doi.org/10.1002/prot.24482 ![]() |
[38] |
Vorobyov I, Kim I, Chu ZT, et al. (2016) Refining the treatment of membrane proteins by coarse-grained models. Proteins 84: 92-117. https://doi.org/10.1002/prot.24958 ![]() |
[39] |
Lee M, Kolev V, Warshel A (2017) Validating a Coarse-Grained Voltage Activation Model by Comparing Its Performance to the Results of Monte Carlo Simulations. J Phys Chem B 121: 11284-11291. https://doi.org/10.1021/acs.jpcb.7b09530 ![]() |
[40] |
Lee FS, Chu ZT, Warshel A (1993) Microscopic and semimicroscopic calculations of electrostatic energies in proteins by the POLARIS and ENZYMIX programs. J Comput Chem 14: 161-185. https://doi.org/https://doi.org/10.1002/jcc.540140205 ![]() |
[41] |
Kamerlin SC, Vicatos S, Dryga A, et al. (2011) Coarse-grained (multiscale) simulations in studies of biophysical and chemical systems. Annu Rev Phys Chem 62: 41-64. https://doi.org/10.1146/annurev-physchem-032210-103335 ![]() |
[42] |
Krissinel E, Henrick K (2007) Inference of macromolecular assemblies from crystalline state. J Mol Biol 372: 774-797. https://doi.org/10.1016/j.jmb.2007.05.022 ![]() |
[43] |
Cameroni E, Bowen JE, Rosen LE, et al. (2022) Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift. Nat 602: 664-670. https://doi.org/10.1038/s41586-021-04386-2 ![]() |
[44] |
Li L, Liao H, Meng Y, et al. (2022) Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1. Cell 185: 2952-2960 e2910. https://doi.org/10.1016/j.cell.2022.06.023 ![]() |
[45] |
Cai Y, Zhang J, Xiao T, et al. (2021) Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Science 373: 642-648. https://doi.org/10.1126/science.abi9745 ![]() |
[46] |
McCallum M, Walls AC, Sprouse KR, et al. (2021) Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants. Science 374: 1621-1626. https://doi.org/10.1126/science.abl8506 ![]() |
[47] |
Starr TN, Czudnochowski N, Liu Z, et al. (2021) SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Nature 597: 97-102. https://doi.org/10.1038/s41586-021-03807-6 ![]() |
[48] |
Ghimire D, Han Y, Lu M (2022) Structural Plasticity and Immune Evasion of SARS-CoV-2 Spike Variants. Viruses 14: 1255. https://doi.org/10.3390/v14061255 ![]() |
[49] |
Ju B, Zhang Q, Ge J, et al. (2020) Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature 584: 115-119. https://doi.org/10.1038/s41586-020-2380-z ![]() |
[50] |
Zhang Q, Ju B, Ge J, et al. (2021) Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun 12: 4210. https://doi.org/10.1038/s41467-021-24514-w ![]() |
[51] |
Guo H, Gao Y, Li T, et al. (2022) Structures of Omicron spike complexes and implications for neutralizing antibody development. Cell Rep 39: 110770. https://doi.org/10.1016/j.celrep.2022.110770 ![]() |
[52] |
Glasgow A, Glasgow J, Limonta D, et al. (2020) Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci USA 117: 28046-28055. https://doi.org/10.1073/pnas.2016093117 ![]() |
[53] |
Higuchi Y, Suzuki T, Arimori T, et al. (2021) Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2. Nat Commun 12: 1-13. https://doi.org/https://doi.org/10.1038/s41467-021-24013-y ![]() |
[54] |
Cao L, Goreshnik I, Coventry B, et al. (2020) De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. Science 370: 426-431. https://doi.org/10.1126/science.abd9909 ![]() |
[55] |
Hunt AC, Case JB, Park YJ, et al. (2022) Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice. Sci Transl Med 14: eabn1252. https://doi.org/10.1126/scitranslmed.abn1252 ![]() |
[56] |
Callaway E, Ledford H (2021) How bad is Omicron? What scientists know so far. Nature 600: 197-199. https://doi.org/10.1038/d41586-021-03614-z ![]() |
[57] |
Kumar S, Thambiraja TS, Karuppanan K, et al. (2021) Omicron and Delta variant of SARS-CoV-2: A comparative computational study of spike protein. J Med Virol 94: 1641-1649. https://doi.org/10.1002/jmv.27526 ![]() |
[58] |
Zhang J, Cai Y, Lavine C, et al. (2022) Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep 39: 110729. https://doi.org/10.1016/j.celrep.2022.110729 ![]() |
[59] |
Dacon C, Tucker C, Peng L, et al. (2022) Broadly neutralizing antibodies target the coronavirus fusion peptide. Science 377: 728-735. https://doi.org/10.1126/science.abq3773 ![]() |
[60] |
Low JS, Jerak J, Tortorici MA, et al. (2022) ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies. Science 377: 735-742. https://doi.org/10.1126/science.abq2679 ![]() |
[61] |
Jackson CB, Farzan M, Chen B, et al. (2022) Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol 23: 3-20. https://doi.org/10.1038/s41580-021-00418-x ![]() |
[62] |
Lamers MM, Haagmans BL (2022) SARS-CoV-2 pathogenesis. Nat Rev Microbiol 20: 270-284. https://doi.org/10.1038/s41579-022-00713-0 ![]() |
![]() |
![]() |
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