Valorization of bioinspired adhesives via enhanced graft copolymerization for biomedicals: recent challenges, implications and potential solutions

Victor Ugbetan Agbogo; Emmanuel Rotimi Sadiku; Lucey Mapula Mavhungu; Moipone Linda Teffo; Victor Ugbetan Agbogo; Emmanuel Rotimi Sadiku; Lucey Mapula Mavhungu; Moipone Linda Teffo

doi:10.3934/bioeng.2025015

AIMS Bioengineering

2025, Volume 12, Issue 3: 314-356. doi: 10.3934/bioeng.2025015

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Review

Valorization of bioinspired adhesives via enhanced graft copolymerization for biomedicals: recent challenges, implications and potential solutions

Department of Chemical, Metallurgical, and Materials Engineering (Polymer Division) & Institute of Nano-Engineering Research (INER), Tshwane University of Technology, Pretoria 0001, South Africa

Received: 10 April 2025 Revised: 19 May 2025 Accepted: 12 June 2025 Published: 16 July 2025

Bioinspired adhesives, polymeric materials derived from renewable natural sources, offer sustainable and functional alternatives for bonding surfaces, especially in biomedical applications. While their use has fluctuated over the decades, rising environmental regulations and demands for biocompatible materials are renewing interest. In this review, we highlight recent advances in biomolecular adhesives and the pivotal role of graft copolymerization in enhancing their functional, mechanical, and biocompatibility properties. We focused on starch-based modifications, additive strategies, and nanofiller integration to address water resistance, viscosity stabilization, and adhesion enhancement. Key biomedical applications were examined alongside current engineering challenges and proposed solutions. This work provides a comprehensive framework for valorizing bioinspired adhesives to meet future clinical and environmental demands.
- Bioinspired adhesives,
- graft copolymerization,
- nanofillers integration,
- chemical modification,
- valorization
Citation: Victor Ugbetan Agbogo, Emmanuel Rotimi Sadiku, Lucey Mapula Mavhungu, Moipone Linda Teffo. Valorization of bioinspired adhesives via enhanced graft copolymerization for biomedicals: recent challenges, implications and potential solutions[J]. AIMS Bioengineering, 2025, 12(3): 314-356. doi: 10.3934/bioeng.2025015

Related Papers:

Abstract

Bioinspired adhesives, polymeric materials derived from renewable natural sources, offer sustainable and functional alternatives for bonding surfaces, especially in biomedical applications. While their use has fluctuated over the decades, rising environmental regulations and demands for biocompatible materials are renewing interest. In this review, we highlight recent advances in biomolecular adhesives and the pivotal role of graft copolymerization in enhancing their functional, mechanical, and biocompatibility properties. We focused on starch-based modifications, additive strategies, and nanofiller integration to address water resistance, viscosity stabilization, and adhesion enhancement. Key biomedical applications were examined alongside current engineering challenges and proposed solutions. This work provides a comprehensive framework for valorizing bioinspired adhesives to meet future clinical and environmental demands.

Acknowledgments

This research was supported by Tshwane University of Technology, Pretoria, South Africa.

Conflict of interest

The authors state that none of the work described in this study could have been influenced by any known competing financial interests or personal relationships.

Author contributions

Dr. Agbogo: Writing – writing – original draft, conceptualization, editing. Prof. Sadiku: review, Supervision. Dr. Mavhungu: Project administration and investigation. Dr. Teffo: Visualization.

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