Review

Recent advances on camel milk: Nutritional and health benefits and processing implications—A review

  • Received: 07 July 2022 Revised: 31 August 2022 Accepted: 16 September 2022 Published: 28 September 2022
  • Camels are important dairy animals and are better milk producers in arid and desert environments than other livestock kept in the same environment. They not only survive but also produce more milk for longer periods than other animals, such as cattle. Camel milk has unique properties and a number of advantages as compared to milk from other species. This paper reviews recent developments on camel (Camelus dromedarius) milk, its nutritional and health benefits. It also addresses the peculiar characteristics of camel milk and its implications on processing and development of camel dairy products. Camel milk has superior nutritional quality and purported medicinal properties against a range of human illnesses including antidiabetic, anti-autistic, anti-microbial, antihypertensive, anticarcinogenic, anticholesterolemic, antioxidant, anti-inflammatory, hypoallergenic, hepatoprotective and immune boosting effects. The claimed therapeutic property of camel milk is attributed to its possession of various bioactive compounds as well as generation of bioactive peptides from intact proteins during digestion and/or fermentation of the milk. Although available reports mainly based on in vitro studies and animal models indicate the therapeutic potential of camel milk, the clinical effectiveness and value of camel milk as a therapeutic agent has not been conclusively confirmed. Camel milk differs markedly from bovine milk in terms of structural and functional properties of the milk components, and composition of individual proteins and its colloidal structures. These differences present challenges for processing camel milk into products.

    Citation: Eyassu Seifu. Recent advances on camel milk: Nutritional and health benefits and processing implications—A review[J]. AIMS Agriculture and Food, 2022, 7(4): 777-804. doi: 10.3934/agrfood.2022048

    Related Papers:

  • Camels are important dairy animals and are better milk producers in arid and desert environments than other livestock kept in the same environment. They not only survive but also produce more milk for longer periods than other animals, such as cattle. Camel milk has unique properties and a number of advantages as compared to milk from other species. This paper reviews recent developments on camel (Camelus dromedarius) milk, its nutritional and health benefits. It also addresses the peculiar characteristics of camel milk and its implications on processing and development of camel dairy products. Camel milk has superior nutritional quality and purported medicinal properties against a range of human illnesses including antidiabetic, anti-autistic, anti-microbial, antihypertensive, anticarcinogenic, anticholesterolemic, antioxidant, anti-inflammatory, hypoallergenic, hepatoprotective and immune boosting effects. The claimed therapeutic property of camel milk is attributed to its possession of various bioactive compounds as well as generation of bioactive peptides from intact proteins during digestion and/or fermentation of the milk. Although available reports mainly based on in vitro studies and animal models indicate the therapeutic potential of camel milk, the clinical effectiveness and value of camel milk as a therapeutic agent has not been conclusively confirmed. Camel milk differs markedly from bovine milk in terms of structural and functional properties of the milk components, and composition of individual proteins and its colloidal structures. These differences present challenges for processing camel milk into products.



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    [1] Farah Z (2011) Camel milk. In: Fuquay JW, Fox PF, McSweeney PLH, Encyclopedia of Dairy Sciences, 2nd Ed., London, UK: Academic Press, 512–517. https://doi.org/10.1016/B978-0-12-374407-4.00317-4
    [2] Alhadrami A, Faye B (2022) Animals that produce dairy food: Camel. In: McSweeney PLH, McNamara JP, Encyclopedia of Dairy Science, 3rd Ed., USA: Elsevier Ltd., 48–64. https://doi.org/10.1016/B978-0-12-818766-1.00364-0
    [3] Chabeda EO (2002) The past, present and future extension on camel production in Kenya. In: Proceedings of the 8th Kenya Camel Forum. 12th–15th March, Kajiado District, Kenya.
    [4] Al Jassim R, Sejian V (2015) Climate change and camel production: Impact and contribution. J Camelid Sci 8: 1–17.
    [5] Field CR (2005) Where there is No Development Agency: A Manual for Pastoralists and their Promoters. Aylesford: Natural Resources International.
    [6] Cossins N (1986) Resource conservation and productivity improvement under communal land tenure. In: Rangelands: A Resource Under Siege: Proceedings of the Second International Rangelands Congress, held in Adelaide, Australia in May 1984, Cambridge: Cambridge University Press, 119–121.
    [7] Kamal-Eldin A, Ayyash M, Sobti B, et al. (2022) Non-bovine milks: Camel milk. In: McSweeney PLH, McNamara JP, Encyclopedia of Dairy Science, 3rd Ed., London, UK: Academic Press, 504–513. https://doi.org/10.1016/B978-0-12-818766-1.00327-5
    [8] Ho TM, Zou Z, Bansal N (2022) Camel milk: A review of its nutritional value, heat stability, and potential food products. Food Res Int 153: 110870. https://doi.org/10.1016/j.foodres.2021.110870 doi: 10.1016/j.foodres.2021.110870
    [9] Mbogo EN, Field CR, Ngeiywa KJ, et al. (2012) Origin and uses of camels. In: Younan M, Zaidi A, Sikuku P, et al., Camel Manual for Service Providers, Nairobi, Kenya: Kenya Camel Association and Kenya Agricultural Research Institute, 1–10.
    [10] Al haj OA, Al Kanhal HA (2010) Compositional, technological and nutritional aspects of dromedary camel milk. Int Dairy J 20: 811–821. https://doi.org/10.1016/j.idairyj.2010.04.003 doi: 10.1016/j.idairyj.2010.04.003
    [11] Mullaicharam AR (2014) A review on medicinal properties of camel milk. World J Pharm Sci 2: 237–242.
    [12] Sharma C, Singh C (2014) Therapeutic value of camel milk—a review. Adv J Pharm Life Sci Res 2: 7–13.
    [13] Wilson RT (1998) Camels: The Tropical Agriculturalist. London, United Kingdom: Macmillan Education Ltd.
    [14] Ngeiywa KJ, Njanja JC (2013) Advocacy for camel research and development in Kenya. J Life Sci 7: 539–546.
    [15] Seifu E (2009) Analysis on the contributions of and constraints to camel production in Shinile and Jijiga zones, eastern Ethiopia. J Agric Environ Int Dev 103: 213–224.
    [16] Yadav AK, Kumar R, Priyadarshini L, et al. (2015) Composition and medicinal properties of camel milk: A Review. Asian J Dairy Food Res 34: 83–91. https://doi.org/10.5958/0976-0563.2015.00018.4 doi: 10.5958/0976-0563.2015.00018.4
    [17] Swelum AA, El-Saadony MT, Abdo M, et al. (2021) Nutritional, antimicrobial and medicinal properties of camel's milk: A review. Saudi J Biolog Sci 28: 3126–3136. https://doi.org/10.1016/j.sjbs.2021.02.057 doi: 10.1016/j.sjbs.2021.02.057
    [18] Bekele T, Zeleke M, Baars RMT (2002) Milk production performance of the one humped camel (Camelus dromedarius) under pastoral management in semi-arid eastern Ethiopia. Liv Prod Sci 76: 37–44. https://doi.org/10.1016/s0301-6226(01)00333-5 doi: 10.1016/s0301-6226(01)00333-5
    [19] Alhadrami GA, Faye B (2016) Animals that produce dairy foods: Camel. Ref Module Food Sci 2016. https://doi.org/10.1016/b978-0-08-100596-5.00620-x doi: 10.1016/b978-0-08-100596-5.00620-x
    [20] Nagy P, Juhasz J (2016) Review of present knowledge on machine milking and intensive milk production in dromedary camels and future challenges. Trop Anim Health Prod 48: 915–926. https://doi.org/10.1007/s11250-016-1036-3 doi: 10.1007/s11250-016-1036-3
    [21] El-Agamy EI (2017) Camel milk. In: Park YW, Haenlein GFW, Wendorf WL, Handbook of Milk of Non-bovine Mammals, 2nd Ed., USA: John Wiley and Sons Ltd., 409–480. https://doi.org/10.1002/9781119110316.ch6
    [22] Ayadi M, Hammadi M, Khorchani T, et al. (2009) Effects of milking interval and cisternal udder evaluation in Tunisian Maghrebi dairy dromedaries (Camelus dromedarius L.). J Dairy Sci 92: 1452–1459. https://doi.org/10.3168/jds.2008-1447 doi: 10.3168/jds.2008-1447
    [23] Nagy P, Thomas S, Marko O, et al. (2013) Milk production, raw milk quality and fertility of dromedary camels (Camelus dromedarius) under intensive management. Acta Vet Hung 61: 71–84. https://doi.org/10.1556/avet.2012.051 doi: 10.1556/avet.2012.051
    [24] Jemmali B, Ferchichi MA, Faye B, et al. (2016) Milk yield and modeling of lactation curves of Tunisian she-camel. Em J Food Agric 28: 208–211. https://doi.org/10.9755/ejfa.2015-07-505 doi: 10.9755/ejfa.2015-07-505
    [25] Alavi F, Salami M, Emam-Djomeh Z, et al. (2017) Nutraceutical properties of camel milk. In: Watson RR, Collier RJ, Preedy VR, Nutrients in Dairy and their Implications for Health and Disease, London, UK: Elsevier, 451–468. https://doi.org/10.1016/B978-0-12-809762-5.00036-X
    [26] Abdalla EB, Ashmawy AEHA, Farouk MH, et al. (2015) Milk production potential in Maghrebi she-camels. Small Rum Res 123: 129–135. https://doi.org/10.1016/j.smallrumres.2014.11.004 doi: 10.1016/j.smallrumres.2014.11.004
    [27] Patel AS, Patel SJ, Patel NR, et al. (2016) Importance of camel milk - An alternative dairy food. J Liv Sci 7: 19–25.
    [28] Vincenzetti S, Cammertoni N, Rapaccetti R, et al. (2022) Nutraceutical and functional properties of camelids' milk. Beverages 8: 12. https://doi.org/10.3390/beverages8010012 doi: 10.3390/beverages8010012
    [29] Smits MG, Huppertz T, Alting AC, et al. (2011) Composition, constituents and properties of dutch camel milk. J Camel Pract Res 18: 1–6.
    [30] Bakry IA, Yang L, Farag MA, et al. (2021) A comprehensive review of the composition, nutritional value, and functional properties of camel milk fat. Foods 10: 2158. https://doi.org/10.3390/foods10092158 doi: 10.3390/foods10092158
    [31] Muthukumaran MS, Mudgil P, Baba WN, et al. (2022) A comprehensive review on health benefits, nutritional composition and processed products of camel milk. Food Rev Int 2022. https://doi.org/10.1080/87559129.2021.2008953 doi: 10.1080/87559129.2021.2008953
    [32] Mehta BM, Jain AM, Patel DH, et al. (2015) Camel milk: Opportunity and challenges. National Seminar on Indian Dairy Industry—Opportunities and Challenges, held in XI Alumni Convention at SMC College of Dairy Science. Gujarat, India: AAU, Anand, 138–142.
    [33] Kumar D, Verma AK, Chatli MK, et al. (2016) Camel milk: Alternative milk for human consumption and its health benefits. Nutr Food Sci 46: 217–227. https://doi.org/10.1108/nfs-07-2015-0085 doi: 10.1108/nfs-07-2015-0085
    [34] El-Hatmi H, Jrad Z, Salhi I, et al. (2015) Comparison of composition and whey protein fractions of human, camel, donkey, goat and cow milk. Mljekarstvo 65: 159–167. https://doi.org/10.15567/mljekarstvo.2015.0302 doi: 10.15567/mljekarstvo.2015.0302
    [35] Kherouatou N, Nasri M, Attia H (2003) A study of the dromedary milk casein micelle and its changes during acidification. Braz J Food Technol 6: 237–244. https://doi.org/10.1051/lait:2000141 doi: 10.1051/lait:2000141
    [36] El-Agamy EI (2006) Camel milk. In: Park YW, Haenlein GFW, Handbook of Milk of Non-bovine Mammals, 1st Ed., Oxford, Blackwell Publishing, 297–344. https://doi.org/10.1002/9780470999738.ch12
    [37] Konuspayeva G, Faye B, Loiseau G (2009) The composition of camel milk: A meta-analysis of the literature data. J Food Comp Anal 22: 95–101. https://doi.org/10.1016/j.jfca.2008.09.008 doi: 10.1016/j.jfca.2008.09.008
    [38] Kanca H (2017) Milk production and composition in ruminants under heat stress. In: Watson RR, Collier RJ, Preedy VR, Nutrients in Dairy and their Implications for Health and Disease, London, UK: Elsevier, 97–109. https://doi.org/10.1016/B978-0-12-809762-5.00008-5
    [39] Medhammar E, Wijesinha-Bettoni R, Stadlmayr B, et al. (2011) Composition of milk from minor dairy animals and buffalo breeds: A biodiversity perspective. J Sci Food Agric 92: 445–474
    [40] Roy D, Ye A, Moughan PJ, et al. (2020) Composition, structure, and digestive dynamics of milk from different species—A Review. Front Nutr 7: 577759. https://doi.org/10.3389/fnut.2020.577759 doi: 10.3389/fnut.2020.577759
    [41] Rafiq S, Huma N, Pasha I, et al. (2016) Chemical composition, nitrogen fractions and amino acids profile of milk from different animal species. Asian Australas J Anim Sci 29: 1022–1028. https://doi.org/10.5713/ajas.15.0452 doi: 10.5713/ajas.15.0452
    [42] Berhe T, Seifu E, Ipsen R, et al. (2017) Processing challenges and opportunities of camel dairy products. Int J Food Sci 2017: 9061757. https://doi.org/10.1155/2017/9061757 doi: 10.1155/2017/9061757
    [43] Villa C, Costa J, Oliveira MBPP, et al. (2018) Bovine milk allergens: A comprehensive review. Comp Rev Food Sci Food Saf 17: 137–164. https://doi.org/10.1111/1541-4337.12318 doi: 10.1111/1541-4337.12318
    [44] Khatoon H, Najam R (2017) Bioactive components in camel milk: Their nutritive value and therapeutic application, In: Watson RR, Collier RJ, Preedy VR, Nutrients in Dairy and their Implications for Health and Disease, London, UK: Elsevier, 377–387. https://doi.org/10.1016/B978-0-12-809762-5.00029-2
    [45] Yagil R, Etzion Z (1980) The effect of drought conditions on the quality of camels' milk. J Dairy Res 47: 159–166. https://doi.org/10.1017/s0022029900021026 doi: 10.1017/s0022029900021026
    [46] Brezovečki A, Čagalj M, Dermit ZF, et al. (2015) Camel milk and milk products. Mljekarstvo 65: 81–90. https://doi.org/10.15567/mljekarstvo.2015.0202 doi: 10.15567/mljekarstvo.2015.0202
    [47] Khaskheli M, Arain M, Chaudhry S, et al. (2005) Physicochemical quality of camel milk. J Agric Social Sci 1: 164–166.
    [48] Dowelmadina IMM, El Zubeir IEM, Salim ADA, et al. (2014) Influence of some factors on composition of dromedary camel milk in Sudan. Global J Anim Sci Res 2: 120–129.
    [49] Makgoeng T, Seifu E, Sekwati-Monang B, et al. (2018) Composition and microbial quality of camel milk produced in Tsabong, south-western Botswana. Liv Res Rural Dev 30: 043. http://www.lrrd.org/lrrd30/3/eyas30043.html.
    [50] Haddadin MSY, Gammoh SI, Robinson RK (2008) Seasonal variations in the chemical composition of camel milk in Jordan. J Dairy Res 75: 8–12. https://doi.org/10.1017/s0022029907002750 doi: 10.1017/s0022029907002750
    [51] Attia H, Kherouatou N, Fakhfakh N, et al. (2000) Dromedary milk fat: biochemical, microscopic and rheological characteristics. J Food Lipids 7: 95–112. https://doi.org/10.1111/j.1745-4522.2000.tb00164.x doi: 10.1111/j.1745-4522.2000.tb00164.x
    [52] Barlowska J, Szwajkowska M, Litwińczuk Z, et al. (2011) Nutritional value and technological suitability of milk from various animal species used for dairy production. Compr Rev Food Sci Food Saf 10: 291–302. https://doi.org/10.1111/j.1541-4337.2011.00163.x doi: 10.1111/j.1541-4337.2011.00163.x
    [53] Farah Z (1996) Camel Milk: Properties and Products. St. Gallen, Switzerland: Swiss Centre for Development Cooperation in Technology and Management.
    [54] Faye B, Konuspayeva G, Narmuratova M, et al. (2008) Comparative fatty acid gross composition of milk in Bactrian camel, and dromedary. J Camelid Sci 1: 48–53.
    [55] Konuspayeva G, Lemarie E, Faye B, et al. (2008) Fatty acid and cholesterol composition of camel's (Camelus bactrianus, Camelus dromedarius and hybrids) milk in Kazakhstan. Dairy Sci Technol 88: 327–340. https://doi.org/10.1051/dst:2008005 doi: 10.1051/dst:2008005
    [56] Claeys WL, Verraes C, Cardoen S, et al. (2014) Consumption of raw or heated milk from different species: An evaluation of the nutritional and potential health benefits: Review. Food Cont 42: 188–201. https://doi.org/10.1016/j.foodcont.2014.01.045 doi: 10.1016/j.foodcont.2014.01.045
    [57] Tultabayeva T, Chomanov U, Tultabayev B, et al. (2015) Study of fatty acids content of lipids in mare's and camel's milk. Int J Chem Environ Biolog Sci 3: 90–93.
    [58] Ereifej KI, Alu'datt MH, AlKhalidy HA, et al. (2011) Comparison and characterisation of fat and protein composition for camel milk from eight Jordanian locations. Food Chem 127: 282–289. https://doi.org/10.1016/j.foodchem.2010.12.112 doi: 10.1016/j.foodchem.2010.12.112
    [59] Dowelmadina IMM, El Zubeir IEM, Arabi OHMH, et al. (2019) Omega-3 fatty acids in milk fat of some Sudanese camels. J Dairy Res Tech 2: 009.
    [60] Faye B, Bengoumi M, Al-Masaud A, et al. (2015) Comparative milk and serum cholesterol content in dairy cow and camel. J King Saud Uni-Sci 27: 168–175. https://doi.org/10.1016/j.jksus.2014.11.003 doi: 10.1016/j.jksus.2014.11.003
    [61] Benmeziane–Derradji F (2021) Evaluation of camel milk: gross composition—a scientific overview. Trop Anim Health Prod 53: 308. https://doi.org/10.1007/s11250-021-02689-0 doi: 10.1007/s11250-021-02689-0
    [62] Kappeler S, Heuberger C, Farah Z, et al. (2004) Expression of the peptidoglycan recognition protein, PGRP, in the lactating mammary gland. J Dairy Sci 87: 2660–2668. https://doi.org/10.3168/jds.s0022-0302(04)73392-5 doi: 10.3168/jds.s0022-0302(04)73392-5
    [63] Ramet JP (2001) The Technology of Making Cheese from Camel Milk (Camelus dromedarius). FAO Animal Production and Health Paper 113. Rome, Italy: Food and Agriculture Organization of the United Nations.
    [64] Hailu Y, Hansen EB, Seifu E, et al. (2016) Functional and technological properties of camel milk proteins: a review. J Dairy Res 83: 422–429. https://doi.org/10.1017/s0022029916000686 doi: 10.1017/s0022029916000686
    [65] Laleye L, Jobe B, Wasesa A (2008) Comparative study on heat stability and functionality of camel and bovine milk whey proteins. J Dairy Sci 91: 4527–4534. https://doi.org/10.3168/jds.2008-1446 doi: 10.3168/jds.2008-1446
    [66] El-Agamy EI, Nawar M, Shamsia SM, et al. (2009) Are camel milk proteins convenient to the nutrition of cow milk allergic children? Small Rum Res 82: 1–6. https://doi.org/10.1016/j.smallrumres.2008.12.016 doi: 10.1016/j.smallrumres.2008.12.016
    [67] Salami M, Moosavi-Movahedi AA, Ehsani MR, et al. (2010) Improvement of the antimicrobial and antioxidant activities of camel and bovine whey proteins by limited proteolysis. J Agric Food Chem 58: 3297–3302. https://doi.org/10.1021/jf9033283 doi: 10.1021/jf9033283
    [68] Merin U, Bernstein S, Bloch-Damti A, et al. (2001) A comparative study of milk serum proteins in camel (Camelus dromedarius) and bovine colostrum. Liv Prod Sci 67: 297–301. https://doi.org/10.1016/s0301-6226(00)00198-6 doi: 10.1016/s0301-6226(00)00198-6
    [69] Shabo Y, Barzel R, Margoulis M, et al. (2005) Camel milk for food allergies in children. Immun Allergy 7: 796–798.
    [70] Nowier AM, Ramadan SI (2020) Association of β-casein gene polymorphism with milk composition traits of Egyptian Maghrebi camels (Camelus dromedarius). Arch Anim Breed 63: 493–500. https://doi.org/10.5194/aab-63-493-2020 doi: 10.5194/aab-63-493-2020
    [71] Letaief N, Bedhiaf-Romdhani S, Ben Salem W, et al. (2022) Tunisian camel casein gene characterization reveals similarities and differences with Sudanese and Nigerian populations. J Dairy Sci 105: 6783–6794. https://doi.org/10.3168/jds.2022-22081 doi: 10.3168/jds.2022-22081
    [72] Amandykova M, Dossybayev K, Mussayeva A, et al. (2022) Comparative analysis of the polymorphism of the casein genes in camels bred in Kazakhstan. Diversity 14: 285. https://doi.org/10.3390/d14040285 doi: 10.3390/d14040285
    [73] Yagil R (1982) Camels and Camel Milk. FAO Animal Production and Health Paper 26. Rome, Italy: Food and Agriculture Organization of the United Nations.
    [74] BreulmannM, Bö er B, Wernery U, et al. (2007) The camel from tradition to modern times. A proposal towards combating desertification via the establishment of camel farms based on fodder production from indigenous plants and halophytes. United Arab Emirates: UNESCO Doha Office.
    [75] Cardoso RRA, Santos RMDB, Cardoso CRA, et al. (2010) Consumption of camel's milk by patients intolerant to lactose. A preliminary study. Rev Alerg Méx 57: 26–32.
    [76] Khalesi M, Salami M, Moslehishad M, et al. (2017) Biomolecular content of camel milk: A traditional superfood towards future healthcare industry. Trends Food Sci Technol 62: 49–58. https://doi.org/10.1016/j.tifs.2017.02.004 doi: 10.1016/j.tifs.2017.02.004
    [77] Mehaia MA, Hablas MA, Abdel-Rahman KM, et al. (1995) Milk composition of Majaheim, Wadah and Hamra camels in Saudi Arabia. Food Chem 52: 115–122. https://doi.org/10.1016/0308-8146(94)p4189-m doi: 10.1016/0308-8146(94)p4189-m
    [78] Sawaya W, Khalil J, AL-Shalhat A, et al. (1984) Chemical composition and nutritional quality of camel milk. J Food Sci 49: 744–747. https://doi.org/10.1111/j.1365-2621.1984.tb13200.x doi: 10.1111/j.1365-2621.1984.tb13200.x
    [79] Konuspayeva G, Faye B, Bengoumi M (2022) Mineral status in camel milk: A critical review. Anim Front 12: 52–60. https://doi.org/10.1093/af/vfac044 doi: 10.1093/af/vfac044
    [80] Al-Attas AS (2009) Determination of essential elements in milk and urine of camel and in Nigella sativa seeds. Arab J Nucl Sci Appl 42: 59–67.
    [81] Abbaspour N, Hurrell R, Kelishadi R (2014) Review on iron and its importance for human health. J Res Med Sci 19: 164.
    [82] Lobo V, Patil A, Phatak A, et al. (2010) Free radicals, antioxidants and functional foods: Impact on human health. Pharmacog Rev 4: 118. https://doi.org/10.4103/0973-7847.70902 doi: 10.4103/0973-7847.70902
    [83] Aqib AI, Kulyar MFA, Ashfaq K, et al. (2019) Ahmed, Camel milk insulin: Pathophysiological and molecular repository. Trends Food Sci Technol 88: 497–504. https://doi.org/10.1016/j.tifs.2019.04.009 doi: 10.1016/j.tifs.2019.04.009
    [84] Karppanen H (1991) Minerals and blood pressure. Annals Med 23: 299–305. https://doi.org/10.3109/07853899109148064 doi: 10.3109/07853899109148064
    [85] Farah Z, Rettenmaier R, Atkins D (1992) Vitamin content of camel milk. Int J Vit Nutr Res 62: 30–33.
    [86] Faye B, Konuspayeva G, Bengoumi M (2019) Vitamins of camel milk: a comprehensive review. J Camelid Sci 12: 17–32.
    [87] Stahl T, Sallmann HP, Duehlmeier R, et al. (2006) Selected vitamins and fatty acid patterns in dromedary milk and colostrum. J Camel Pract Res 13: 53–57.
    [88] Nikkhah A (2011) Science of camel and yak milks: human nutrition and health perspectives. Food Nutr Sci 2: 667–673. https://doi.org/10.4236/fns.2011.26092 doi: 10.4236/fns.2011.26092
    [89] Agrawal RP, Saran S, Sharma P, et al. (2007) Effect of camel milk on residual β-cell function in recent onset type 1 diabetes. Diab Res Clin Pract 77: 494–495. https://doi.org/10.1016/j.diabres.2007.01.012 doi: 10.1016/j.diabres.2007.01.012
    [90] El-Agamy EI, Ruppanner R, Ismail A, et al. (1992) Antibacterial and antiviral activity of camel milk protective proteins. J Dairy Res 59: 169–175. https://doi.org/10.1017/s0022029900030417 doi: 10.1017/s0022029900030417
    [91] Quan S, Tsuda H, Miyamoto T (2008) Angiotensin I-converting enzyme inhibitory peptides in skim milk fermented with Lactobacillus helveticus 130B4 from camel milk in inner Mongolia, China. J Sci Food Agric 88: 2688–2692. https://doi.org/10.1002/jsfa.3394 doi: 10.1002/jsfa.3394
    [92] Magjeed NA (2005) Corrective effect of milk camel on some cancer biomarkers in blood of rats intoxicated with aflatoxin B1. J Saudi Chem Soc 9: 253–263.
    [93] Habib HM, Ibrahim WH, Schneider-Stock R, et al. (2013) Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities. Food Chem 141: 148–152. https://doi.org/10.1016/j.foodchem.2013.03.039 doi: 10.1016/j.foodchem.2013.03.039
    [94] Mihic T, Rainkie D, Wilby KJ, et al. (2016) The Therapeutic effects of camel milk: a systematic review of animal and human trials. J Evid Based Complementary Altern Med 21: NP110–126. https://doi.org/10.1177/2156587216658846
    [95] Khatoon H, Najam R, Mirza T, et al. (2016) Beneficial anti-Parkinson effects of camel milk in Chlorpromazine-induced animal model: Behavioural and histopathological study. Pak J Pharm Sci 29: 1525–1529.
    [96] Khatoon H, Najam R, Mirza T, et al. (2015) Evaluation of anticonvulsant and neuroprotective effects of camel milk in strychnine-induced seizure model. Asian Pac J Trop Dis 5: 817–820. https://doi.org/10.1016/s2222-1808(15)60937-9 doi: 10.1016/s2222-1808(15)60937-9
    [97] Jrad Z, Girardet J-M, Adt I, et al. (2014) Antioxidant activity of camel milk casein before and after in vitro simulated enzymatic digestion. Mljekarstvo 64: 287–294. https://doi.org/10.15567/mljekarstvo.2014.0408 doi: 10.15567/mljekarstvo.2014.0408
    [98] Power O, Jakeman P, FitzGerald R (2013) Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides. Amino Acids 44: 797–820. https://doi.org/10.1007/s00726-012-1393-9 doi: 10.1007/s00726-012-1393-9
    [99] Homayouni-Tabrizi M, Shabestarin H, Asoodeh A, et al. (2016) Identification of two novel antioxidant peptides from camel milk using digestive proteases: impact on expression gene of superoxide dismutase (SOD) in Hepatocellular carcinoma cell line. Int J Pept Res Therap 22: 187–195. https://doi.org/10.1007/s10989-015-9497-1 doi: 10.1007/s10989-015-9497-1
    [100] Korashy HM, Maayah ZH, Abd-Allah AR, et al. (2012) Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism. J Biomed Biotechnol 2012: 593195. https://doi.org/10.1155/2012/593195 doi: 10.1155/2012/593195
    [101] Krishnankutty R, Iskandarani A, Therachiyil L, et al. (2018) Anticancer activity of camel milk via induction of autophagic death in human colorectal and breast cancer cells. Asian Pac J Cancer Prev 19: 3501–3509. https://doi.org/10.31557/apjcp.2018.19.12.3501 doi: 10.31557/apjcp.2018.19.12.3501
    [102] Ali A, Baby B, Vijayan R (2019) From desert to medicine: A review of camel genomics and therapeutic products. Front Genet 10: 1–20. https://doi.org/10.3389/fgene.2019.00017 doi: 10.3389/fgene.2019.00017
    [103] Darwish HA, Abd Raboh NR, Mahdy A (2012) Camel's milk alleviates alcohol-induced liver injury in rats. Food Chem Toxicol 50: 1377–1383. https://doi.org/10.1016/j.fct.2012.01.016 doi: 10.1016/j.fct.2012.01.016
    [104] Ming L, Qi B, Hao S, et al. (2021) Camel milk ameliorates inflammatory mechanisms in an alcohol‑induced liver injury mouse model. Sci Rep-Nature 11: 22811. https://doi.org/10.1038/s41598-021-02357-1 doi: 10.1038/s41598-021-02357-1
    [105] Shabo Y, Yagil R (2005) Etiology of autism and camel milk as therapy. Int J Disabil Hum Dev 4: 67–70. https://doi.org/10.1515/IJDHD.2005.4.2.67 doi: 10.1515/IJDHD.2005.4.2.67
    [106] Williams SC (2013) Small nanobody drugs win big backing from pharma. Nature Med 19: 1355–1356. https://doi.org/10.1038/nm1113-1355 doi: 10.1038/nm1113-1355
    [107] He J, Guo K, Chen Q, et al. (2022) Camel milk modulates the gut microbiota and has anti-inflammatory effects in a mouse model of colitis. J Dairy Sci 105: 3782–3793. https://doi.org/10.3168/jds.2021-21345 doi: 10.3168/jds.2021-21345
    [108] Dharmisthaben P, Basaiawmoit B, Sakure A, et al. (2021) Exploring potentials of antioxidative, anti-inflammatory activities and production of bioactive peptides in lactic fermented camel milk. Food Biosci 44: 101404. https://doi.org/10.1016/j.fbio.2021.101404 doi: 10.1016/j.fbio.2021.101404
    [109] Benkerroum N, Mekkaoui M, Bennani N, et al. (2004), Antimicrobial activity of camel's milk against pathogenic strains of Escherichia coli and Listeria monocytogenes. Int J Dairy Technol 57: 39–43. https://doi.org/10.1111/j.1471-0307.2004.00127.x doi: 10.1111/j.1471-0307.2004.00127.x
    [110] Mal G, Sena D, Jain V, et al. (2006) Therapeutic value of camel milk as a nutritional supplement for multiple drug resistant (MDR) tuberculosis patients. I. J Vet Med 61: 88.
    [111] Conesa C, Sánchez L, Rota C, et al. (2008) Isolation of lactoferrin from milk of different species: Calorimetric and antimicrobial studies. Compar Biochem Physiol-Part B: Biochem Molecul Biol 150: 131–139. https://doi.org/10.1016/j.cbpb.2008.02.005 doi: 10.1016/j.cbpb.2008.02.005
    [112] Konuspayeva G, Faye B, Loiseau G, et al. (2007) Lactoferrin and immunoglobin content in camel milk from Kazakhstan. J Dairy Sci 90: 38–46.
    [113] Kappeler S (1998) Compositional and structural analysis of camel milk proteins with emphasis on protective proteins. PhD Thesis, Swiss Federal Institute of Technology, Zurich, Switzerland.
    [114] Elagamy EI (2000) Effect of heat treatment on camel milk proteins with respect to antimicrobial factors: A comparison with cows' and buffalo milk proteins. Food Chem 68: 227–232. https://doi.org/10.1016/S0308-8146(99)00199-5 doi: 10.1016/S0308-8146(99)00199-5
    [115] Abbas S, Imran R, Nazir A, et al. (2014) Effect of camel milk supplementation on blood parameters and liver function of hepatitis patients. Am J Ethnomed 1: 129–146.
    [116] Halliwell B (2001) Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 18: 685–716. https://doi.org/10.2165/00002512-200118090-00004 doi: 10.2165/00002512-200118090-00004
    [117] El Hatmi H, Jrad J, Khorchani T, et al. (2016) Identification of bioactive peptides derived from caseins, glycosylation-dependent cell adhesion molecule-1 (GlyCAM-1), and peptidoglycan recognition protein-1 (PGRP-1) in fermented camel milk. Int Dairy J 56: 159–168. https://doi.org/10.1016/j.idairyj.2016.01.021 doi: 10.1016/j.idairyj.2016.01.021
    [118] Rahimi M, Ghaffari SM, Salami M, et al. (2016) ACE- inhibitory and radical scavenging activities of bioactive peptides obtained from camel milk casein hydrolysis with proteinase K. Dairy Sci Technol 96: 489–499. https://doi.org/10.1007/s13594-016-0283-4 doi: 10.1007/s13594-016-0283-4
    [119] Salami M, Yousefi R, Ehsani MR, et al. (2009) Enzymatic digestion and antioxidant activity of the native and molten globule states of camel α-lactalbumin: Possible significance for use in infant formula. Int Dairy J 19: 518–523. https://doi.org/10.1016/j.idairyj.2009.02.007 doi: 10.1016/j.idairyj.2009.02.007
    [120] Moslehishad M, Ehsani MR, Salami M, et al. (2013) The comparative assessment of ACE-inhibitory and antioxidant activities of peptide fractions obtained from fermented camel and bovine milk by Lactobacillus rhamnosus PTCC 1637. Int Dairy J 29: 82–87. https://doi.org/10.1016/j.idairyj.2012.10.015 doi: 10.1016/j.idairyj.2012.10.015
    [121] Seppo L, Jauhiainen T, Poussa T, et al. (2003) A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 77: 326–330. https://doi.org/10.1093/ajcn/77.2.326 doi: 10.1093/ajcn/77.2.326
    [122] Redha AA, Valizadenia H, Siddiqui SA, et al. (2022) A state-of-art review on camel milk proteins as an emerging source of bioactive peptides with diverse nutraceutical properties. Food Chem 373: 131–444. https://doi.org/10.1016/j.foodchem.2021.131444 doi: 10.1016/j.foodchem.2021.131444
    [123] Elayan AA, Sulieman AME, Saleh FA (2008) The hypocholesterolemic effect of Gariss and Gariss containing Bifidobacteria in rats fed on a cholesterol-enriched diet. Asian J Biochem 3: 43–47. https://doi.org/10.3923/ajb.2008.43.47 doi: 10.3923/ajb.2008.43.47
    [124] AL-Ayadhi L, Halepoto DM (2017) Camel milk as a potential nutritional therapy in autism. In: Watson RR, Collier RJ, Preedy VR, Nutrients in Dairy and their Implications for Health and Disease, London, UK: Elsevier, 389–405.
    [125] Al-Ayadhi L, Halepoto DM, Al-Dress AM, et al. (2015) Behavioral benefits of camel milk in subjects with autism spectrum disorder. J College Physic Surg Pak 25: 819–823.
    [126] Panwar R, Grover CR, Kumar V, et al. (2021) Camel milk: Natural medicine—boon to dairy industry, 2021. Available from: https://www.dairyfoods.com.
    [127] Yagil R, Zagorski O, van Creveld C, et al. (1994) Science and camel's milk production, In: Saint Marin G, Chameux et Dromedaries, Animeaux Laitiers, Paris, France: Expansion Scientifique Franç ais, 75–89.
    [128] Shori AB (2015) Camel milk as a potential therapy for controlling diabetes and its complications: A review of in vivo studies. J Food Drug Anal 23: 609–618. https://doi.org/10.1016/j.jfda.2015.02.007 doi: 10.1016/j.jfda.2015.02.007
    [129] Kilari BP, Mudgil P, Azimullah S, et al. (2021) Effect of camel milk protein hydrolysates against hyperglycemia, hyperlipidemia, and associated oxidative stress in streptozotocin (STZ)-induced diabetic rats. J Dairy Sci 104: 1304–1317. https://doi.org/10.3168/jds.2020-19412 doi: 10.3168/jds.2020-19412
    [130] Korish AA, Gader AGMA, Alhaider AA (2020) Comparison of the hypoglycemic and antithrombotic (anticoagulant) actions of whole bovine and camel milk in streptozotocin-induced diabetes mellitus in rats. J Dairy Sci 103: 30–41. https://doi.org/10.3168/jds.2019-16606 doi: 10.3168/jds.2019-16606
    [131] He K, Chan C-B, Liu X, et al. (2011) Identification of a molecular activator for insulin receptor with potent anti-diabetic effects. J Biolog Chem 286: 37379–37388. https://doi.org/10.1074/jbc.m111.247387 doi: 10.1074/jbc.m111.247387
    [132] Ayoub MA, Palakkott AR, Ashraf A, et al. (2018) The molecular basis of the anti-diabetic properties of camel milk. Diab Res Clinic Pract 146: 305–312. https://doi.org/10.1016/j.diabres.2018.11.006 doi: 10.1016/j.diabres.2018.11.006
    [133] Ashraf A, Mudgil P, Palakkott A, et al. (2021) Molecular basis of the anti-diabetic properties of camel milk through profiling of its bioactive peptides on dipeptidyl peptidase IV (DPP-IV) and insulin receptor activity. J Dairy Sci 104: 61–77. https://doi.org/10.3168/jds.2020-18627 doi: 10.3168/jds.2020-18627
    [134] Khan FB, Anwar I, Redwan EM, et al. (2022) Camel and bovine milk lactoferrins activate insulin receptor and its related AKT and ERK1/2 pathways. J Dairy Sci 105: 1848–1861. https://doi.org/10.3168/jds.2021-20934 doi: 10.3168/jds.2021-20934
    [135] Anwar I, Khan FB, Maqsood S, et al. (2022) Camel milk targeting insulin receptor—toward understanding the antidiabetic effects of camel milk. Front Nutr 8: 819278. https://doi.org/10.3389/fnut.2021.819278 doi: 10.3389/fnut.2021.819278
    [136] Malik A, Al-Senaidy A, Skrzypczak-Jankun E, et al. (2012) A study of the anti-diabetic agents of camel milk. Int J Mol Med 30: 585–592. https://doi.org/10.3892/ijmm.2012.1051 doi: 10.3892/ijmm.2012.1051
    [137] Agrawal RP, Jain S, Shah S, et al. (2011) Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trial. Eur J Clin Nutr 65: 1048–1052. https://doi.org/10.1038/ejcn.2011.98 doi: 10.1038/ejcn.2011.98
    [138] Ejtahed HS, Naslaji AN, Mirmiran P, et al. (2015) Effect of camel milk on blood sugar and lipid profile of patients with type 2 diabetes: a pilot clinical trial. Int J Endocrinol Metab 13: e21160. https://doi.org/10.5812/ijem.21160
    [139] Mohamad R, Zekry Z, Al-Mehdar H, et al. (2009) Camel milk as an adjuvant therapy for the treatment of type 1 diabetes: verification of a traditional ethnomedical practice. J Med Food 12: 461–465. https://doi.org/10.1089/jmf.2008.0009 doi: 10.1089/jmf.2008.0009
    [140] Agrawal RP, Beniwal R, Kochar DK, et al. (2005) Camel milk as an adjunct to insulin therapy improves long-term glycemic control and reduction in doses of insulin in patients with type-1 diabetes: a 1 year randomized controlled trial. Diabetes Res Clin Pract 68: 176–177. https://doi.org/10.1016/j.diabres.2004.12.007 doi: 10.1016/j.diabres.2004.12.007
    [141] Agrawal RP, Sharma P, Gafoorunissa SJ, et al. (2011) Effect of camel milk on glucose metabolism in adults with normal glucose tolerance and type 2 diabetes in Raica community: a crossover study. Acta Biomed 82: 181–186.
    [142] Agrawal RP, Dogra R, Mohta N, et al. (2009) Beneficial effect of camel milk in diabetic nephropathy. Acta Biomed 80: 131–134.
    [143] Agrawal RP, Budania S, Sharma P, et al. (2007) Zero prevalence of diabetes in camel milk consuming Raica community of northwest Rajasthan, India. Diabetes Res Clin Pract 76: 290–296. https://doi.org/10.1016/j.diabres.2006.09.036 doi: 10.1016/j.diabres.2006.09.036
    [144] Agrawal RP, Singh G, Nayak KC, et al. (2004) Prevalence of diabetes in camel milk consuming Raica rural community of north-west Rajasthan. Int J Diab Dev Count 24: 109–114. https://doi.org/10.1016/j.diabres.2006.09.036 doi: 10.1016/j.diabres.2006.09.036
    [145] Agrawal RP, Swami SC, Beniwal R, et al. (2003) Effect of camel milk on glycemic control lipid profile and diabetes quality of life in type-1 diabetes: a randomised prospective controlled cross over study. Ind J Anim Sci 73: 1105–1110.
    [146] AlKurd R, Hanash N, Khalid N, et al. (2022) Effect of camel milk on glucose homeostasis in patients with diabetes: a systematic review and meta-analysis of randomized controlled trials. Nutrients 14: 1245. https://doi.org/10.3390/nu14061245 doi: 10.3390/nu14061245
    [147] Al-Ayadhi LY, Halepoto DM, AL-Dress AM, et al. (2015) Behavioral benefits of camel milk in subjects with autism spectrum disorder. J Coll Physicians Surg Pak 25: 819–823.
    [148] Kandeel M, El-Deeb W (2022) The application of natural camel milk products to treat autism-spectrum disorders: Risk assessment and meta-analysis of randomized clinical trials. Bioinorg Chem Appl 2022: 6422208. https://doi.org/10.1155/2022/6422208 doi: 10.1155/2022/6422208
    [149] Al-Ayadhi LY, Elamin NE (2013) Camel milk as a potential therapy as an antioxidant in autism spectrum disorder (ASD). Evid Based Complement Alternat Med 2013: 602834.
    [150] Bashir S, Al-Ayadhi LY (2014) Effect of camel milk on thymus and activation-regulated chemokine in autistic children: double-blind study. Pediatr Res 75: 559–563.
    [151] Navarrete-Rodríguez EM, Ríos-Villalobos LA, Alcocer-Arreguín CR, et al. (2018) Cross-over clinical trial for evaluating the safety of camel's milk intake in patients who are allergic to cow's milk protein. Allergol Immunopathol 46: 149–154.
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