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Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage

  • Human and animal diseases have always been reported to be treated by medicinal herbs owing to their constituents. Excess sodium metavanadate is a potential environmental toxin when consumed and could induce oxidative damage leading to various neurological disorders and Parkinsons-like diseases. This study is designed to investigate the impact of the flavonoid Glycoside Fraction of Ginkgo Biloba Extract (GBE) (at 30 mg/kg body weight) on vanadium-treated rats. Animals were divided randomly into four groups: Control (Ctrl, normal saline), Ginkgo Biloba (GIBI, 30mg/kg BWT), Vanadium (VANA, 10 mg/kg BWT) and Vanadium + Ginkgo biloba (VANA + GIBI). Markers of oxidative stress (Glutathione Peroxidase and Catalase) were assessed and found to be statistically increased with GIBI when compared with CTRL and treatment groups. Results from routine staining revealed that the control and GIBI group had a normal distribution of cells and a pronounced increase in cell count respectively compared to the VANA group. When compared to the VANA group, the NeuN photomicrographs revealed that the levels of GIBI were within the normal range (***p < 0.001; ** p < 001). The treatment with GIBI showed a better response by increasing the neuronal cells in the VANA+GIBI when compared with the VANA group. The NLRP3 Inflammasome photomicrographs denoted that there was a decrease in NLRP3-positive cells in the control and GIBI groups. The treatment group shows fewer cells compared to that of the VANA group. The treatment group shows fewer cells compared to that of the VANA group. The findings of the study confirmed that ginkgo biloba extract via its flavonoid glycoside fraction has favorable impacts in modulating vanadium-induced brain damage with the potential ability to lower antioxidant levels and reduce neuroinflammation.

    Citation: Adeshina O. Adekeye, Adedamola A. Fafure, Morayo M. Omodele, Lawrence D. Adedayo, Victor O. Ekundina, Damilare A. Adekomi, Ephraim Samuel Jen, Thomas K. Adenowo. Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage[J]. AIMS Neuroscience, 2023, 10(2): 178-189. doi: 10.3934/Neuroscience.2023015

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  • Human and animal diseases have always been reported to be treated by medicinal herbs owing to their constituents. Excess sodium metavanadate is a potential environmental toxin when consumed and could induce oxidative damage leading to various neurological disorders and Parkinsons-like diseases. This study is designed to investigate the impact of the flavonoid Glycoside Fraction of Ginkgo Biloba Extract (GBE) (at 30 mg/kg body weight) on vanadium-treated rats. Animals were divided randomly into four groups: Control (Ctrl, normal saline), Ginkgo Biloba (GIBI, 30mg/kg BWT), Vanadium (VANA, 10 mg/kg BWT) and Vanadium + Ginkgo biloba (VANA + GIBI). Markers of oxidative stress (Glutathione Peroxidase and Catalase) were assessed and found to be statistically increased with GIBI when compared with CTRL and treatment groups. Results from routine staining revealed that the control and GIBI group had a normal distribution of cells and a pronounced increase in cell count respectively compared to the VANA group. When compared to the VANA group, the NeuN photomicrographs revealed that the levels of GIBI were within the normal range (***p < 0.001; ** p < 001). The treatment with GIBI showed a better response by increasing the neuronal cells in the VANA+GIBI when compared with the VANA group. The NLRP3 Inflammasome photomicrographs denoted that there was a decrease in NLRP3-positive cells in the control and GIBI groups. The treatment group shows fewer cells compared to that of the VANA group. The treatment group shows fewer cells compared to that of the VANA group. The findings of the study confirmed that ginkgo biloba extract via its flavonoid glycoside fraction has favorable impacts in modulating vanadium-induced brain damage with the potential ability to lower antioxidant levels and reduce neuroinflammation.



    Lifetime models have found widespread application in statistical modeling across various scientific and engineering domains. Lindley distribution, as one of the classical distributions, was first proposed by Lindley [1]. Lindley distribution is highly flexible and has a wide range of applications, such as in the field of medicine, astrophysics, and reliability engineering. However, it has strong limitations in processing complex data, such as skewed and multi-peak data. Based on this, many researchers improved the original Lindley distribution by adding parameters. With the help of the power exponentiated family of distributions, Rajitha and Akhilnath [2] added two parameters to the original Lindley distribution. They called it PEL distribution and notes its higher flexiblility compared to the original model. Fatehi and Chhaya [3] extended the Lindley distribution into the extended odd Weibull-Lindley family. Ashour and Eltehiwy [4] introduced a three-parameter exponentiated power Lindley (EPL) distribution by extending the two-parameter power Lindley distribution. Alizadeh et al. [5] defined a four-parameter exponentiated power Lindley power series distribution on the EPL distribution and found that the newly proposed model provided a better fit than the original Lindley distribution to real datasets.

    In most real-life testing and reliability experiments, it is seldom possible to wait until all test samples fail; in other words, it is difficult for investigators to observe the lifetime of all items under test, so experimental data obtained often contain censored data. The development and replacement of censored samples have been the focus of many researchers [6,7,8]. Type-Ⅰ and type-Ⅱ censored schemes, as classical methods in right examination, can only move the unit point at the end of the experiment, which lacks some flexibility [9]. The progressively type-Ⅱ censored scheme is popular for its flexibility, whose various properties and applications have been extensively studied. Balakrishnan et al. [10] discussed the maximum likelihood estimation and the corresponding interval estimation of extreme value distributions under progressively type-Ⅱ censored samples. Based on progressively type-Ⅱ censored samples, Seo et al. [11] studied the hierarchical Bayesian estimation of the unknown parameters of a lifetime distribution with a bathtub-shaped failure rate function. Alshenawy et al. [12] used the maximum likelihood estimation method and the maximum product spacing method to estimate the parameters of the extended odd Weibull exponential distribution under progressively type-Ⅱ censored samples. Their study further delved into the construction of both asymptotic and bootstrap confidence intervals for the said parameters.

    This paper aims to introduce a variant of the Lindley distribution, referred to as the extension of the generalized Lindley (NGL) distribution. This extension is developed under progressively type-Ⅱ censored samples with the objective of broadening the applicability of the traditional Lindley distribution. The NGL distribution is highly flexible, featuring many variants of the Lindley distribution and exponential function. Another purpose of this paper is to evaluate the estimator performance of the NGL distribution in preparation for the subsequent processing of real datasets.

    The remainder of this paper is organized as follows: In Section 2, we introduce the NGL distribution and its basic properties. The numerical characteristics of the proposed distribution are investigated in Section 3. We study three estimators of this distribution in Section 4, obtain the corresponding point and interval estimates, and perform Monte Carlo simulations in Section 5. In Section 6, we examine the practical application of the proposed distribution using a real dataset. In Section 7, the findings of this paper are summarized, and future research priorities are indicated.

    In this section, we will introduce the NGL distribution, whose probability density function (PDF) and cumulative distribution function (CDF) are

    f(x;λ,θ)=λeλx(1θ+λθx),x>0,λ>0,0<θ<1, (1)
    F(x;λ,θ)=1(1+λθx)eλx,x>0,λ>0,0<θ<1. (2)

    Here, λ and θ are the scale and shape parameters of the NGL(λ,θ), respectively.

    ● If θ=1/(λ+1), then the CDF is the Lindley distribution, i.e.,

    F(x;λ)=1λ+1+λxλ+1eλx,x>0,λ>0. (3)

    ● If θ=β/(λ+β), then the CDF is a two-parameter Lindley distribution [13], i.e.,

    F(x;λ,β)=1(1+βλβ+λx)eλx,x>0,λ>0,β>0. (4)

    ● If θ0+, then the CDF is exponential distribution, i.e.,

    F(x;λ)=1eλx,x>0,λ>0. (5)

    ● If θ=1/(η+1), then the CDF is a two-parameter Lindley distribution [14], i.e.,

    F(x;λ,η)=1(1+λ1+ηx)eλx,x>0,λ>0,η>1. (6)

    The survival function (SF) and hazard rate function (HRF) of the NGL distribution are:

    S(x;λ,θ)=1F(x;λ,θ)=(1+λθx)eλx, (7)
    h(x;λ,θ)=f(x;λ,θ)1F(x;λ,θ)=λλθ1+λθx. (8)

    There are two main models for the NGL distribution: the inverted J-type and the unimodal and left-leaning (see Figure 1). This type of model is very suitable for the study of product life and species abundance distribution. θ, the shape parameter, has a large influence on the probability density distribution: when θ increases, the PDF image changes and shows a constant tendency to shift to the right. λ also has a certain impact on the NGL distribution; with an increase in λ, the peak value of PDF increases, and the image presents a left-leaning trend.

    Figure 1.  PDF curves of the NGL distribution for different shape and scale parameters.

    The HRF curves also have three shapes: increasing, constant, and upside-down bathtub (see Figure 2). With an increase in λ and θ, the slope of (0, 2) will increase continuously along with the decrease of peak value.

    Figure 2.  HRF curves of the NGL distribution for different shape and scale parameters.

    In this section, we discuss some important statistical properties of NGL distribution, such as moments, kurtosis and skewness, quantile functions, order statistical functions, and other statistical properties.

    As one of the most important digital features, the r-th moment plays an important role in both application and theory. It can be represented by the following formula

    μr=0xreλx(1θ+λθx)dx=(1θ)λr1Γ(r+1)+θλr1Γ(r+2). (9)

    The first four moments can be easily calculated:

    μ1=(1+θ)λ2,μ2=(2+4θ)λ3,μ3=(6+18θ)λ4,μ4=(24+96θ)λ5. (10)

    Also, the variance of X is

    Var(X)=(2λ+4θλ12θθ2)λ4. (11)

    The coefficient of kurtosis and skewness are important for describing the tail shape, peak degree, and asymmetry of probability distributions [15]. Let NCS stand for coefficient of skewness and NCK for coefficient of kurtosis. According to Eqs (10) and (11), NCS and NCK can be obtained as:

    NCS=μ33μ1μ2+2(μ1)3[V(X)]3/2=2λ4λ+11θλ+θ2λ39θ6θ2(2λ+4θλ12θθ2)3/2, (12)
    NCK=μ44μ1μ3+6(μ1)2μ23(μ1)4[V(X)]2=24λ3(1+4θ)24λ2(1+3θ)(θ+1)+12λ(1+θ)2(1+2θ)3(1+θ)4(2λ+4θλ12θθ2)2. (13)

    The coefficient of kurtosis and skewness of the NGL distribution show a certain regularity. In the NGL distribution, the coefficient of kurtosis and skewness are usually negatively correlated with θ and positively correlated with λ. This statistical property suggests that the thickness and asymmetry of the NGL distribution tail tend to decrease as θ increases, while an increase in λ increases these characteristics. Table 1 and Figure 3 illustrate different values of the coefficient of kurtosis and skewness.

    Table 1.  The coefficient of kurtosis and skewness of NGL distribution under given parameter values.
    θ λ NCS NCK
    0.1 0.9 2.0001 8.8471
    0.3 1.8457 7.8450
    0.5 1.7213 7.1333
    0.8 1.6875 6.7500
    0.1 1 1.9582 8.6941
    0.3 1.7860 7.6311
    0.5 1.6198 6.7959
    0.8 1.4519 6.1212
    0.1 1.2 2.0342 9.0202
    0.3 1.8506 7.8409
    0.5 1.6577 6.8325
    0.8 1.4134 5.8320
    0.1 1.5 2.2550 10.1405
    0.3 2.0647 8.7803
    0.5 1.8590 7.5600
    0.8 1.5860 6.2452

     | Show Table
    DownLoad: CSV
    Figure 3.  Plots of the coefficient of kurtosis and skewness of the NGL distribution.

    Using Eq (9), the moment-generating function of the NGL distribution can be obtained as

    M(t)=0etxf(x)dx=r=0trr!0xrf(x)dx=r=0trr![(1θ)λr1Γ(r+1)+θλr1Γ(r+2)]. (14)

    The quantile function can be obtained from the inverse function of CDF. That is, x=F1(R). By applying Eq (2), we have

    1(1+λθx)eλx=R (15)

    Let t=(1R)eλx, then x=1λlnt1R. Hence

    lnt1R=1θ(t1)t1R=etθ/e1θtθetθ=R1θe1θtθ=W(R1θe1θ).

    Then

    t=θW(R1θe1θ).

    Here, W is Lambert W function. According to the basic properties of the Lambert W function, the quantile function of the NGL distribution can be obtained as

    x=θW(e1/θ(t1)θ)1λθ. (16)

    Order statistics are an important analytical tool for identifying outliers. The earliest failure time of a product can be expressed by the minimum order statistic (the smallest observed value in the sample), and the longest life of a product can be estimated by the maximum order statistic (the largest observed value in the sample). Let (X1,X2,...,Xn) be a random sample from the NGL distribution, which is sorted from smallest to largest as (X(1),X(2),...,X(n)), where the i-th order statistic is X(i). The PDF of the i-th order statistic X(i) is fX(i)(x)=n!(i1)!(ni)!F(x)i1[1F(x)]nif(x). By inserting Eqs (1) and (2), the PDF of i-th order statistic X(i) of the NGL distribution is

    fX(i)(x)=n!(i1)!(ni)![1(1+λθx)eλx]i1[(1+λθx)eλx]niλeλx(1θ+λθx),x>0,λ>0,0<θ<1. (17)

    The PDF of the minimum order statistics X(1) of the NGL distribution can be obtained as

    fX(1)(x)=nλ(1+λθx)n1enλx(1θ+λθx). (18)

    The PDF of the maximum order statistics X(n) of the NGL distribution can be obtained as

    fX(n)(x)=nλ[1(1+λθx)eλx]n1(1θ+λθx)eλx. (19)

    Maximum product spacing (MPS) estimation is a robust method. It uses an optimization algorithm to find the corresponding parameter values that maximize the product spacing of the parametric functions [16]. Let (X1:m:n,X2:m:n,,Xm:m:n) be the progressively type-Ⅱ censored sample of the NGL distribution, and x1:m:n,x2:m:n,,xm:m:n is the observation of the sample (X1:m:n,X2:m:n,,Xm:m:n). For convenience, in the following discussion, we always set xi=xi:m:n. The product spacing function under the progressively type-Ⅱ censored scheme is [17]:

    G(λ,θ)=m+1i=1[F(xi;λ,θ)F(xi1;λ,θ)]mi=1S(xi;λ,θ)Pi. (20)

    Using Eq (2), the product spacing function of the NGL distribution can be obtained as

    G(λ,θ|x)=m+1i=1[(1+λθxi1)eλxi1(1+λθxi)eλxi]mi=1[(1+λθxi)eλxi]Pi (21)

    and the log-product spacing function is given by

    lnG(λ,θ|x)=m+1i=1ln[(1+λθxi1)eλxi1(1+λθxi)eλxi]+mi=1Pi[ln(1+λθxi)λxi]. (22)
     Let g(λ,θx)=lnG(λ,θx)=H(λ,θx)+M(λ,θx)

    where

    H(λ,θ|x)=m+1i=1ln[(1+λθxi1)eλxi1(1+λθxi)eλxi] (23)
    M(λ,θ|x)=mi=1Pi[ln(1+λθxi)λxi] (24)

    MPS estimators of λ and θ, denoted by ˆλMPS and ˆθMPS, are the solutions of Eqs (25) and (26).

    g(λ,θ|x)λ=H(λ,θ|x)λ+M(λ,θ|x)λ=0, (25)
    g(λ,θ|x)θ=H(λ,θ|x)θ+M(λ,θ|x)θ=0. (26)

    Here,

    H(λ,θ|x)θ=m+1i=1[θxi11+λθxi1eλxi1λxieλxi], (27)
    H(λ,θ|x)λ=m+1i=1{[θxi11+λθxi1xi1ln(1+λθxi1)]eλxi1+[xi+λθx2iθxi]eλxi}, (28)
    M(λ,θ|x)θ=mi=1Piλxi1+λθxi, (29)
    M(λ,θ|x)λ=mi=1Pi(θxi1+λθxixi). (30)

    ˆλMPS and ˆθMPS cannot be obtained directly from the above equations, so we used the Newton Raphson algorithm to obtain the approximate maximum product spacing estimates of these parameters. The steps are as follows:

    (ⅰ) Establish the corresponding log-product spacing function.

    (ⅱ) Compute the gradient vector and Hessian matrix for the log-product spacing function:

    g(λ,θ|x)=(g(λ,θ|x)λ,g(λ,θ|x)θ),H(λ,θ|x)=(2g(λ,θ|x)λ22g(λ,θ|x)λθ2g(λ,θ|x)θλ2g(λ,θ|x)θ2).

    (ⅲ) Select the appropriate initial value (λ(0),θ(0))T.

    (ⅳ) The parameters are updated by Newton iteration formula:

    [λ(k+1)θ(k+1)]=[λ(k)θ(k)](2g(λ(k),θ(k)|x)λ22g(λ(k),θ(k)|x)λθ2g(λ(k),θ(k)|x)θλ2g(λ(k),θ(k)|x)θ2)[g(λ(k),θ(k)|x)λg(λ(k),θ(k)|x)θ]. (31)

    (ⅴ) Repeat (ⅳ) until the change in parameter values between the two iterations is less than a very small threshold: |λ(k+1)λ(k)|<ϵ,|θ(k+1)θ(k)|<ϵ

    (ⅵ) The final estimated parameters can be obtained and are noted by ˆλMPS=λ(k+1),ˆθMPS=θ(k+1).

    Under the progressively type-Ⅱ censored sample, the likelihood function is ([18])

    L(λ,θ|x)=cmi=1f(xi)S(xi;λ,θ)Pi, (32)

    Here, c=n(nP11)(nP1P22)(nm1i=1(Pi+1)). Using Eqs (1) and (7), the likelihood function of the NGL distribution can be represented as

    L(λ,θ|x)=cλmi=1m(1θ+λθxi)(1+λθxi)Piexp(λxi(1+Pi)). (33)

    The log-likelihood function of the NGL distribution is

    l(λ,θ|x)=lnc+mlnλλmi=1xi(1+Pi)+mi=1ln(1θ+λθxi)+mi=1Piln(1+λθxi). (34)

    The ML estimator of λ and θ can be obtained by solving the following equations:

    l(λ,θ|x)λ=mλmi=1xi(1+Pi)+mi=1θxi1θ+λθxi+mi=1Piθxi1+λθxi=0, (35)
    l(λ,θ|x)θ=mi=1λxi11θ+λθxi+mi=1Piλxi1+λθxi=0. (36)

    Newton Raphson algorithm to obtain the corresponding result. Due to the complexity of Eqs (35) and (36), it is difficult to judge the existence and uniqueness of ˆλML and ˆθML by conventional numerical methods. In this paper, a graphical tool, the counter diagram, is employed, as referenced in Alotaibi et al. [19]. Setting the real values (λ,θ)=(0.5,0.75), (m,n)=(50,100), P=(049,50) and generating progressively type-Ⅱ censored samples, the counter diagram of ˆλML and ˆθML, which is obtained from Eq (34), is shown in Figure 4. It shows that the likelihood function obtained has only one obvious peak, that is, there is uniqueness.

    Figure 4.  Counter diagram of ˆλML and ˆθML.

    Figure 4 shows the existence and uniqueness of ML estimates of λ and θ, with (ˆλML,ˆθML)=(0.855,0.625). The ML estimation of S(t) and h(t) can be obtained by substituting ˆλML and ˆθML [20]:

    ˆS(t)=(1+ˆλMLˆθMLt)eˆλMLtandˆh(t)=ˆλMLˆλMLˆθML1+ˆλMLˆθMLt.

    In the above analysis, we have obtained point estimates for λ, θ, S(t), and h(t). Point estimates provide a singular numerical approximation for unknown parameters, yet they fall short of encapsulating the full spectrum of uncertainty associated with these parameters. At this point, we need to transition from point estimation to interval estimation to get a more comprehensive understanding. The ML estimator is asymptotically normal [21]. That is, n(ˆΘΘ)dN(0,I1(Θ)), where Θ=(λ,θ), and I1(Θ) as the inverse of the information matrix for unknown parameters, and it can be obtained as follows:

    I1(ˆΘ)(2l(Θ|x)λ22l(Θ|x)λθ2l(Θ|x)θλ2l(Θ|x)θ2)1|Θ=ˆΘ=(I11I12I21I22)1, (37)

    with the following elements

    2l(Θ|x)λ2=mλ2mi=1θ2xi2(1θ+λθxi)2mi=1Piθ2xi2(1+λθxi)2 (38)
    2l(Θ|x)λθ=mi=1xi(1θ+λθxi)2+mi=1Pixi(1+λθxi)2=2l(Θ|x)θλ (39)
    2l(Θ|x)θ2=mi=1(λxi1)2(1θ+λθxi)2mi=1Piλ2x2i(1+λθxi)2. (40)

    The 100(1α)% asymptotic confidence intervals (ACIs) for λ and θ are (ˆλ±zα/2Var(ˆλ)) and (ˆθ±zα/2Var(ˆθ)), respectively. Here, zα/2 represents the upper α/2 percentage point of N(0,1).

    Similarly, the ACIs of S(t) and h(t) can also be constructed by calculating the corresponding variances, among which one of the most famous methods is Greene's delta method [22]. Under this method, the distribution of ˆS(t) (ˆh(t)) is approximately a normal distribution with mean S(t) (h(t)) and variance σ2S=ΔSI1(λ,θ)ΔTS|(λ=ˆλ,θ=ˆθ)(σ2h=ΔhI1(λ,θ)ΔTh|(λ=ˆλ,θ=ˆθ)) [23], where ΔS=(S(x)λS(x)θ), Δh=(h(x)λh(x)θ), with the following elements

    S(x)λ=(θ1λθx)xeλx,S(x)θ=λxeλx,h(x)λ=1θ(1+λθx)2,h(x)θ=λ(λθx+1)2.

    According to the above conclusions, the 100(1α)% ACIs of S(t) and h(t) for a given t are

    (ˆS(t)±zα/2σ2S),(ˆh(t)±zα/2σ2h).

    Since the asymptotic property of MPS estimator is similar to that of MLE estimator, this paper adopts the above method to obtain the interval estimation of MPS. For more details, see Ghosh and Jammalamadaka [24].

    In this section, the Bayesian estimator is used to estimate the parameters of the NGL distribution, and the corresponding highest posterior density (HPD) intervals are considered. The idea of Bayesian estimation in this paper refers to several papers [25,26,27,28]. Assume that λ and θ are independent and obey gamma distributions. The prior PDFs of λ and θ are:

    π(λ|σ1,ω1)=ωσ11Γ(σ1)λσ11eω1λ,λ>0,σ1>0,ω1>0, (41)
    π(θ|σ2,ω2)=ωσ22Γ(σ2)θσ21eω2θ,θ>0,σ2>0,ω2>0. (42)

    Based on these assumptions, the joint prior density function of λ and θ can be obtained

    π(λ,θ)λσ11θσ21eω1λω2θ,λ,θ>0,ω1,ω2>0. (43)

    According to the likelihood function with the prior knowledge and Bayes' theorem, the posterior density distribution of the unknown parameters λ and θ can be obtained:

    π(λ,θ|x)=L(λ,θ|x)π(λ,θ)00L(λ,θ|x)π(λ,θ)dλdθ. (44)

    Using Eqs (33) and (47), the posterior density distribution can be expressed:

    π(λ,θ|x)=λm+σ11θσ21exp(ω1λω2θλmi=1xi(1+Pi))mi=1(1θ+λθxi)(1+λθxi)Pi00λm+σ11θσ21exp(ω1λω2θλmi=1xi(1+Pi))mi=1(1θ+λθxi)(1+λθxi)Pidλdθ. (45)

    The loss function is a key factor to make decisions in Bayesian estimation. In this paper, the SE and GE loss function are used to measure overestimation and underestimation in the investigation. The SE and GE loss functions, as symmetric loss function and asymmetric loss function, respectively, have different measures of the importance of overestimation and underestimation. The Bayesian estimator represents the posterior mean in the case of the SE loss function, and overestimation and underestimation have equal weight. The SE loss is defined as [29]

    LS(φ(λ,θ),ˆφ(λ,θ))=(φ(λ,θ)ˆφ(λ,θ))2, (46)

    and the corresponding Bayesian estimator is

    ˆφS(λ,θ)=E[φ(λ,θ)|x]=00φ(λ,θ)π(λ,θ|x)dλdθ. (47)

    The GE loss, which has a different tendency to weight overestimation and underestimation, is defined as [30]

    LG(φ(λ,θ),ˆφ(λ,θ))(ˆφ(λ,θ)φ(λ,θ))γγlog(ˆφ(λ,θ)φ(λ,θ))1,γ0, (48)

    here, γ is the parameter of the degree of asymmetry. Under GE loss, the Bayesian estimator is

    ˆφG(λ,θ)=[E({φ(λ,θ)}γ|x)]1/γ={00[φ(λ,θ)]γπ(λ,θ|x)dλdθ}1/γ. (49)

    Obviously, the integral of Eqs (47) and (49) cannot be calculated directly. Therefore, the MCMC approach, which is a very popular method for estimating parameters, is employed to calculate the corresponding HPD intervals and the Bayesian estimates (BE) of λ and θ. The full conditional posterior distribution of λ and θ as a key factor of the MCMC method can be derived by Eq (45)

    π1(λ|θ,x)λm+σ11exp(ω1λλmi=1xi(1+Pi))mi=1(1θ+λθxi)(1+λθxi)Pi, (50)

    and

    π2(θ|λ,x)θσ21exp(ω2θ)mi=1(1θ+λθxi)(1+λθxi)Pi. (51)

    Because of the nonlinearity of the full conditional posterior distribution of λ and θ, the Metropolis-Hastings (M-H) algorithm is applied to obtain the unknown parameters of Bayesian estimation. We assume the normal distribution as the proposed distribution to obtain the Bayesian estimation and HPD intervals of λ, θ, S(t) and h(t). Follow the next steps to generate the MCMC sample:

    (ⅰ) Set k=1.

    (ⅱ) Set the initial values of (λ,θ) to (λ(0),θ(0)).

    (ⅲ) Generate λ and θ from N(λ(k1),σ2λ) and N(θ(k1),σ2θ), respectively. When λ0 or θ(0,1), repeat step (ⅲ), where λ(k1) and θ(k1) represent previous state, σ2λ and σ2θ represent the variance of the previous state.

    (ⅳ) Definite acceptance probability ω(λk1,λ)=min(1,π1(λ|θ(k1),x)π1(λ(k1)|θ(k1),x)) and ω(θk1,θ)=min(1,π2(θ|λ(k),x)π2(θ(k1)|λ(k),x)).

    (ⅴ) Generate u(1) and u(2) from the uniform distribution U(0,1).

    (ⅵ) If u(1)ω(λk1,λ), then λ(k)=λ, otherwise λ(k)=λ(k1).

    (ⅶ) If u(2)ω(θk1,θ), then θ(k)=θ, otherwise θ(k)=θ(k1).

    (ⅷ) Calculate S(k)(t) and h(k)(t) according to the following formulas: S(k)(t)=(1+λ(k)θ(k)t)eλ(k)t and h(k)(t)=λ(k)λ(k)θ(k)1+λ(k)θ(k)t, where t>0.

    (ⅸ) Set k=k+1.

    (ⅹ) Repeat (ⅲ)–(ⅸ) L times to get {λ(k)},{θ(k)},{h(k)(t)} and {S(k)(t)}(k=1,2,,L), and discard the first L samples of {λ(k)},{θ(k)},{h(k)(t)} and {S(k)(t)} to eliminate the influence of initial value selection.

    (xi) Based on SE and GE loss functions, calculate the Bayesian estimation and HPD intervals of λ, θ, S(t) and h(t). Take λ for example:

    ● Compute the Bayesian estimate of λ : ˆλS=1lLi=L+1λ(i) and ˆλG=1l(Li=L+1[λ(i)]γ)1/γ, where l=LL.

    ● Create the HPD interval of λ [31]: Let λ(L+1),λ(L+2),...,λ(L) be the ascending values of λ(L+1),λ(L+2),...,λ(L), the 100(1α)% HPD interval of λ can be approximated to (λ(k),λ(k+[(1α)l])), where k{L+1,L+2,...,L} is selected according to the formula λ(k+[(1α)l])λ(k)=minL+1kL+[αl](λ(k+[(1α)l])λ(k)), where [x] is the downward integer of x, that is, the largest integer less than or equal to x.

    In this section, a Monte Carlo simulation will be performed to demonstrate and compare the performance of the above estimators for the NGL distribution in parameter estimation.

    We simulate 1000 progressively type-Ⅱ censored samples of the NGL(0.5, 0.75) based on the parameter selection of n(Total number of samples), m(Number of valid samples), and P(Censored schemes). Meanwhile, in order to reasonably evaluate the estimates of S(t) and h(t), first obtain their true values at t=0.5, which are 0.9248 and 0.1842, respectively. In addition, n(=50,90) is determined and the valid sample proportion is used to determine that the value of m meets m/n(=60%,80%). Also, the three progressively censored schemes used are shown in Table 2.

    Table 2.  Three kinds of censored schemes.
    Scheme
    1 P= (0(m1),nm)
    2 P= ([(nm)/2],0(m2),nm[(nm)/2])
    3 P= (nm,0(m1))

     | Show Table
    DownLoad: CSV

    Next, the specific steps to generate progressively type-Ⅱ censored samples are given [32]:

    (ⅰ) Generate m observations ςi (for i=1,2,...,m) that follow uniform distribution U(0,1).

    (ⅱ) Give the corresponding value according to the specific censored schemes, set ζi=ς1/(i+mk=mi+1Pk)i (for i=1,2,...,m).

    (ⅲ) Set ξi=1ζmζm1ζmi+1 (for i=1,2,...,m).

    (ⅳ) Generate progressively type-Ⅱ censored samples xi of the NGL (0.5, 0.75), set

    xi=[0.75W(e1/0.75(ξi1)0.75)1]/0.375.

    In Table 2, P = (6, 0, 0, 0, 0, 1) stands for P = (6, 0*4, 1).

    After obtaining progressively type-Ⅱ censored samples, MPS estimates and ML estimates and 95% ACIs of λ, θ, S(t) and h(t) are calculated using Matlab R2016a, as well as Bayesian estimates based on SE and GE (γ(=2)) loss function and HPD interval. The large 12,000 M-H samples are generated by M-H sampler, and then the first 2000 samples are deleted as fluctuation samples. Then we complete the Bayesian estimator by setting up two prior sets called Priora:(σ1,σ2,ω1,ω2)=(8,10,10,5) and Priorb:(σ1,σ2,ω1,ω2)=(4,5,5,2.5). Repeat 1000 times to ensure the accuracy and stability of the estimation results. The evaluation criteria for verifying the reliability of the estimation method are shown in Table 3.

    Table 3.  Evaluation criteria of point estimation and interval estimation.
    Name Formula of errors
    AE (average estimates) ˉˆλ=110001000i=1ˆλi
    RMSE (root mean squared errors) RMSEˉˆλ=110001000i=1(ˆλiλ)2
    MRAB (mean relative absolute biases) MRABˉˆλ=110001000i=11λ|ˆλiλ|
    ACL (average confidence lengths) ACLλ(1α)%=110001000i=1(RˆλiLˆλi)
    CP (coverage percentages) CP(1α)%λ=110001000i=1l(Lˆλi;Rˆλi)(λ)

     | Show Table
    DownLoad: CSV

    Where lA() represents the indicator function, and R() and L() denote the upper and lower bounds, respectively, for each (1α)% ACI/HPD interval.

    RMSE, MRAB, ACL, and CP of λ, θ, S(t) and h(t) estimates of various estimators are shown using heat maps in Figures 58. The corresponding specific numerical results are shown in the appendix [Tables 411]. Here, SE-Pa represents the estimate of Priora by Bayesian estimator based on SE loss, GE-Pb represents the estimate of Priorb by Bayesian estimator based on GE loss (for γ(=2)), and ACL-MPS corresponds to the interval estimate of the MPS.

    Figure 5.  Heat maps of the associated estimates of λ.
    Figure 6.  Heat maps of the associated estimates of θ.
    Figure 7.  Heat maps of the associated estimates of S(t).
    Figure 8.  Heat maps of the associated estimates of h(t).
    Table 4.  Point estimation of λ by estimator under different conditions (AE: first column; RMSE: second column; MRAB: third column).
    (n,m) Scheme MPS ML BE
    SE GE
    Priora Priora
    Priorb Priorb
    -2
    (50, 30) 1 0.4897 0.1395 0.2052 0.5111 0.1412 0.2035 0.5258 0.0906 0.1399 0.5317 0.0888 0.1380
    0.3905 0.1297 0.2240 0.4513 0.0967 0.1557
    2 0.4967 0.1229 0.1846 0.5043 0.1284 0.1899 0.5174 0.0936 0.1453 0.5278 0.0974 0.1509
    0.3826 0.1401 0.2393 0.4481 0.1038 0.1634
    3 0.5404 0.1267 0.1785 0.507 0.1161 0.1729 0.5175 0.1000 0.1534 0.5254 0.1016 0.1582
    0.371 0.1553 0.2665 0.4373 0.1195 0.1916
    (50, 40) 1 0.4954 0.1023 0.1525 0.5095 0.1188 0.1716 0.5176 0.0857 0.1300 0.5261 0.0868 0.1334
    0.4168 0.1205 0.1953 0.4306 0.1102 0.1761
    2 0.5091 0.1025 0.1503 0.5157 0.1131 0.1682 0.508 0.0937 0.1403 0.515 0.0952 0.1451
    0.411 0.1278 0.2056 0.4206 0.1215 0.1903
    3 0.5257 0.1015 0.149 0.5133 0.1068 0.156 0.5074 0.0958 0.1434 0.5178 0.0927 0.1398
    0.3913 0.1401 0.2235 0.4191 0.1301 0.2073
    (90, 54) 1 0.4983 0.111 0.1566 0.5058 0.1219 0.1667 0.5118 0.0717 0.1108 0.5157 0.0728 0.1129
    0.4104 0.1099 0.1881 0.4255 0.0981 0.1634
    2 0.5062 0.0973 0.1435 0.5135 0.107 0.1505 0.5157 0.0769 0.1160 0.5229 0.0716 0.1108
    0.4077 0.1157 0.1934 0.4249 0.1054 0.1700
    3 0.5211 0.0912 0.1324 0.5115 0.0955 0.1362 0.5084 0.0842 0.1261 0.5156 0.0832 0.1269
    0.4096 0.1337 0.2147 0.4003 0.1376 0.2222
    (90, 72) 1 0.5036 0.0817 0.1205 0.5049 0.0865 0.1257 0.511 0.0661 0.0981 0.5185 0.0669 0.099
    0.4386 0.0989 0.1588 0.4112 0.1125 0.1874
    2 0.5069 0.0798 0.118 0.5102 0.0869 0.1252 0.5083 0.0731 0.1067 0.5186 0.0716 0.1046
    0.4306 0.1135 0.183 0.3984 0.1277 0.2115
    3 0.5239 0.0749 0.1106 0.5106 0.0847 0.1182 0.5115 0.0768 0.1113 0.5152 0.0722 0.1041
    0.4228 0.1311 0.2126 0.3852 0.1432 0.2415

     | Show Table
    DownLoad: CSV
    Table 5.  Point estimation of θ by estimator under different conditions (AE: first column; RMSE: second column; MRAB: third column).
    (n,m) Scheme MPS ML BE
    SE GE
    Priora Priora
    Priorb Priorb
    -2
    (50, 30) 1 0.6686 0.5743 0.3249 0.7282 0.3277 0.2828 0.7389 0.1897 0.1652 0.7831 0.108 0.1166
    0.3881 0.3965 0.4825 0.5906 0.2024 0.2125
    2 0.6529 0.5109 0.3051 0.7201 0.5525 0.3064 0.7448 0.1509 0.1402 0.7792 0.1305 0.1306
    0.5263 0.2745 0.2983 0.6020 0.2021 0.1976
    3 0.7168 0.2925 0.2532 0.6427 0.6425 0.3192 0.7142 0.161 0.1319 0.7689 0.1620 0.1503
    0.4916 0.3373 0.3447 0.5740 0.2588 0.2368
    (50, 40) 1 0.6688 0.2753 0.2539 0.7385 0.4545 0.2849 0.7636 0.1484 0.1337 0.7840 0.1244 0.126
    0.4136 0.3722 0.4489 0.5818 0.2229 0.2243
    2 0.7019 0.5158 0.2736 0.7586 0.5247 0.307 0.7419 0.1820 0.1581 0.7640 0.1600 0.1465
    0.4847 0.3278 0.3537 0.5564 0.2576 0.2582
    3 0.7139 0.4281 0.2498 0.7301 0.6584 0.3084 0.7320 0.2008 0.1717 0.7731 0.1638 0.1503
    0.4697 0.3551 0.3737 0.5324 0.3006 0.2906
    (90, 54) 1 0.6973 0.257 0.2188 0.7721 0.2877 0.2455 0.7454 0.1392 0.1282 0.7553 0.126 0.1121
    0.5003 0.3001 0.3329 0.4933 0.2947 0.3423
    2 0.7081 0.3537 0.228 0.7554 0.4585 0.2615 0.7646 0.1363 0.1173 0.7868 0.1052 0.1076
    0.4593 0.3279 0.3876 0.5536 0.2381 0.2622
    3 0.7152 0.2474 0.2033 0.7242 0.6738 0.2884 0.7426 0.1831 0.1551 0.7734 0.1594 0.1448
    0.4140 0.4003 0.4497 0.4875 0.3416 0.3507
    (90, 72) 1 0.7284 0.2088 0.1898 0.7674 0.2309 0.2009 0.7629 0.1267 0.1141 0.7891 0.1242 0.1168
    0.5251 0.2668 0.2999 0.5261 0.2624 0.2993
    2 0.7159 0.4108 0.2002 0.7461 0.2387 0.2108 0.7584 0.1549 0.1343 0.7915 0.1274 0.1191
    0.4086 0.3846 0.4566 0.505 0.2954 0.3278
    3 0.7502 0.5628 0.2173 0.7647 0.5311 0.236 0.7626 0.1778 0.1529 0.7863 0.1524 0.1393
    0.361 0.4457 0.5231 0.4594 0.3608 0.3915

     | Show Table
    DownLoad: CSV
    Table 6.  Point estimation of S(t) by estimator under different conditions (AE: first column; RMSE: second column; MRAB: third column).
    (n,m) Scheme MPS ML BE
    SE GE
    Priora Priora
    Priorb Priorb
    -2
    (50, 30) 1 0.9226 0.1517 0.0392 0.8771 0.0541 0.0327 0.9253 0.0174 0.0147 0.9271 0.017 0.0149
    0.9051 0.0262 0.0228 0.9046 0.0272 0.0236
    2 0.9145 0.0598 0.0336 0.9228 0.0879 0.0364 0.9274 0.0164 0.0144 0.9283 0.0174 0.0151
    0.9088 0.023 0.0197 0.9095 0.0227 0.019
    3 0.9184 0.0589 0.0367 0.9448 0.1018 0.041 0.9269 0.0188 0.0162 0.9272 0.0191 0.0163
    0.9068 0.0262 0.0223 0.9084 0.0252 0.0214
    (50, 40) 1 0.9164 0.0412 0.0303 0.9331 0.0532 0.0343 0.9302 0.0159 0.0140 0.9292 0.0159 0.0141
    0.9087 0.0217 0.0190 0.9097 0.0213 0.0182
    2 0.9197 0.0774 0.0349 0.9204 0.1022 0.0397 0.9288 0.0166 0.0144 0.9284 0.0165 0.0145
    0.9081 0.0232 0.0197 0.9087 0.0218 0.019
    3 0.9165 0.0763 0.0357 0.9257 0.1217 0.0412 0.9278 0.0183 0.0158 0.9294 0.0175 0.0154
    0.9068 0.0253 0.0214 0.9061 0.0255 0.0223
    (90, 54) 1 0.9213 0.042 0.0245 0.9425 0.049 0.0296 0.9226 0.0177 0.0142 0.9234 0.017 0.0135
    0.8886 0.0406 0.0392 0.8889 0.0403 0.0389
    2 0.9223 0.079 0.0276 0.9306 0.0806 0.0335 0.9292 0.0144 0.0127 0.9294 0.0144 0.0127
    0.9038 0.0253 0.023 0.9041 0.0250 0.0229
    3 0.9179 0.049 0.0285 0.9457 0.1544 0.0418 0.9289 0.0041 0.0044 0.9293 0.0180 0.0156
    0.9028 0.0279 0.0248 0.9030 0.0274 0.0246
    (90, 72) 1 0.9244 0.0334 0.0237 0.922 0.0397 0.026 0.9308 0.0175 0.0152 0.9309 0.0155 0.0136
    0.9018 0.0265 0.0252 0.9022 0.0261 0.0248
    2 0.9196 0.0963 0.0285 0.9333 0.0422 0.0283 0.9308 0.0158 0.014 0.9317 0.0150 0.0134
    0.9042 0.0244 0.0229 0.9037 0.0249 0.0231
    3 0.924 0.1124 0.0304 0.938 0.0862 0.0312 0.9307 0.0179 0.0156 0.9315 0.0179 0.0158
    0.9006 0.0289 0.0272 0.9012 0.0286 0.0264

     | Show Table
    DownLoad: CSV
    Table 7.  Point estimation of h(t) by estimator under different conditions (AE: first column; RMSE: second column; MRAB: third column).
    (n,m) Scheme MPS ML BE
    SE GE
    Priora Priora
    Priorb Priorb
    -2
    (50, 30) 1 0.2011 0.0741 0.2683 0.1878 0.0592 0.242 0.1938 0.0404 0.1667 0.1971 0.0428 0.1792
    0.2215 0.0538 0.2311 0.2339 0.0656 0.2881
    2 0.2299 0.4497 0.3735 0.1661 0.4973 0.3925 0.1883 0.0362 0.1541 0.1931 0.0413 0.1682
    0.2133 0.0478 0.2005 0.2211 0.0536 0.2255
    3 0.217 0.5736 0.3982 0.1655 0.4777 0.4144 0.1897 0.0401 0.1710 0.1953 0.0436 0.1843
    0.2170 0.0527 0.2230 0.2219 0.0561 0.2406
    (50, 40) 1 0.2058 0.0627 0.2552 0.1984 0.0647 0.2553 0.1824 0.0338 0.1451 0.1896 0.0350 0.1476
    0.2116 0.0425 0.1810 0.2169 0.0466 0.2001
    2 0.1942 0.2237 0.2046 0.2052 0.2439 0.3358 0.1840 0.0339 0.1451 0.1898 0.0348 0.1485
    0.2123 0.0443 0.1859 0.2175 0.0459 0.2009
    3 0.2131 0.1273 0.3069 0.1894 0.675 0.4708 0.1862 0.0366 0.1564 0.1887 0.0363 0.1543
    0.2151 0.0482 0.2020 0.2231 0.0531 0.2340
    (90, 54) 1 0.197 0.0474 0.1958 0.1794 0.0523 0.2025 0.1967 0.0383 0.1571 0.2018 0.0404 0.1628
    0.2519 0.0781 0.3699 0.2634 0.0884 0.4317
    2 0.1947 0.0904 0.2204 0.1699 0.2216 0.2725 0.1815 0.0296 0.1294 0.1877 0.0305 0.1268
    0.2205 0.0474 0.2114 0.2282 0.0537 0.2460
    3 0.1898 0.7276 0.3584 0.1554 0.2483 0.326 0.1836 0.0341 0.148 0.1873 0.0352 0.1485
    0.221 0.0501 0.2189 0.2265 0.0532 0.2416
    (90, 72) 1 0.1911 0.0475 0.1937 0.1813 0.0516 0.1997 0.1798 0.0280 0.1233 0.1831 0.0290 0.1262
    0.2228 0.0471 0.2169 0.2292 0.0528 0.2486
    2 0.184 0.1361 0.2317 0.1677 0.0541 0.2117 0.1791 0.0290 0.1271 0.1816 0.0276 0.1203
    0.2171 0.0419 0.1889 0.2238 0.0478 0.2201
    3 0.1874 0.1211 0.2138 0.1594 0.2271 0.3026 0.1799 0.0326 0.1391 0.1818 0.0326 0.1396
    0.2235 0.0496 0.2268 0.2279 0.0533 0.2454

     | Show Table
    DownLoad: CSV
    Table 8.  Interval estimation of λ by estimator under different conditions.
    (n,m) Scheme ACI HPD
    MPS ML Priora Priorb
    ACL CP ACL CP ACL CP ACL CP
    (50, 30) 1 0.5959 0.929 0.5407 0.919 0.3655 0.965 0.4281 0.951
    2 0.5383 0.932 0.4926 0.924 0.3515 0.949 0.422 0.932
    3 0.4397 0.923 0.4459 0.951 0.3365 0.910 0.3939 0.853
    (50, 40) 1 0.4299 0.945 0.4102 0.915 0.319 0.956 0.3898 0.918
    2 0.3964 0.926 0.3765 0.903 0.3102 0.929 0.3732 0.864
    3 0.3581 0.928 0.3554 0.912 0.3021 0.905 0.3628 0.834
    (90, 54) 1 0.4106 0.919 0.3758 0.906 0.3131 0.969 0.3428 0.894
    2 0.3530 0.918 0.3558 0.880 0.2922 0.963 0.3662 0.932
    3 0.3037 0.918 0.3012 0.900 0.2713 0.912 0.3400 0.804
    (90, 72) 1 0.2872 0.913 0.2770 0.886 0.2583 0.947 0.3430 0.900
    2 0.2674 0.919 0.2657 0.906 0.2523 0.952 0.3364 0.876
    3 0.2542 0.888 0.2642 0.902 0.2366 0.925 0.3188 0.763

     | Show Table
    DownLoad: CSV
    Table 9.  Interval estimation of θ by estimator under different conditions.
    (n,m) Scheme ACI HPD
    MPS ML Priora Priorb
    ACL CP ACL CP ACL CP ACL CP
    (50, 30) 1 1.3061 0.908 1.0387 0.891 0.5877 0.986 0.8699 0.965
    2 1.1711 0.921 0.9627 0.888 0.5510 0.972 0.8449 0.955
    3 0.8076 0.904 0.9926 0.926 0.5016 0.950 0.7761 0.875
    (50, 40) 1 0.9013 0.921 0.7698 0.873 0.5367 0.980 0.8515 0.939
    2 0.7790 0.902 0.6721 0.881 0.5254 0.960 0.8133 0.898
    3 0.6540 0.895 0.671 0.888 0.5017 0.944 0.7724 0.868
    (90, 54) 1 0.7660 0.842 0.5899 0.800 0.6550 0.978 0.8402 0.887
    2 0.6332 0.836 0.6084 0.805 0.5377 0.981 0.8682 0.951
    3 0.5169 0.867 0.5271 0.826 0.4844 0.931 0.7569 0.830
    (90, 72) 1 0.4541 0.767 0.4141 0.748 0.4985 0.938 0.8488 0.925
    2 0.4432 0.788 0.4027 0.765 0.4908 0.945 0.8223 0.898
    3 0.3628 0.769 0.4004 0.772 0.4378 0.897 0.7363 0.802

     | Show Table
    DownLoad: CSV
    Table 10.  Interval estimation of S(t) by estimator under different conditions.
    (n,m) Scheme ACI HPD
    MPS ML Priora Priorb
    ACL CP ACL CP ACL CP ACL CP
    (50, 30) 1 0.1615 0.899 0.1714 0.924 0.0932 0.995 0.1262 0.997
    2 0.1653 0.895 0.1713 0.926 0.0865 0.991 0.1128 0.993
    3 0.1778 0.935 0.1751 0.911 0.0864 0.971 0.1089 0.958
    (50, 40) 1 0.1483 0.899 0.1572 0.892 0.0805 0.987 0.1059 0.991
    2 0.15 0.902 0.165 0.907 0.08 0.972 0.1014 0.957
    3 0.1517 0.907 0.1626 0.908 0.0813 0.949 0.1019 0.932
    (90, 54) 1 0.1196 0.892 0.1237 0.898 0.0946 0.983 0.1283 0.926
    2 0.1207 0.887 0.1277 0.874 0.0764 0.981 0.1075 0.973
    3 0.1256 0.925 0.1344 0.875 0.0754 0.947 0.0968 0.859
    (90, 72) 1 0.1087 0.897 0.1157 0.894 0.0706 0.958 0.0997 0.946
    2 0.1117 0.913 0.1153 0.9 0.0699 0.957 0.092 0.919
    3 0.1113 0.898 0.1187 0.886 0.069 0.914 0.0905 0.837

     | Show Table
    DownLoad: CSV
    Table 11.  Interval estimation of h(t) by estimator under different conditions.
    (n,m) Scheme ACI HPD
    MPS ML Priora Priorb
    ACL CP ACL CP ACL CP ACL CP
    (50, 30) 1 0.204 0.907 0.2012 0.910 0.1885 0.986 0.2549 0.993
    2 0.4103 0.897 0.2187 0.896 0.1740 0.986 0.2233 0.993
    3 0.2534 0.895 0.2982 0.907 0.1767 0.964 0.216 0.975
    (50, 40) 1 0.2046 0.898 0.1978 0.878 0.1559 0.979 0.2021 0.991
    2 0.2115 0.891 0.2056 0.873 0.1559 0.975 0.1932 0.982
    3 0.3762 0.892 0.2784 0.878 0.1603 0.967 0.1964 0.971
    (90, 54) 1 0.1526 0.887 0.1474 0.887 0.1791 0.981 0.2538 0.948
    2 0.1762 0.877 0.3585 0.873 0.143 0.973 0.2021 0.991
    3 0.1885 0.917 0.1827 0.862 0.1446 0.961 0.1834 0.932
    (90, 72) 1 0.1486 0.889 0.1461 0.873 0.1288 0.965 0.183 0.972
    2 0.1637 0.897 0.1573 0.885 0.1279 0.97 0.167 0.963
    3 0.1599 0.894 0.1826 0.87 0.1293 0.932 0.1692 0.911

     | Show Table
    DownLoad: CSV

    From the heat maps in Figures 58 and Tables 411, the following conclusions can be drawn:

    (1) All estimates of λ, θ, S(t) and h(t) are good estimators because of low RMSE, MRAB, and ACL values and high CP values. Through changing the color of the heat-maps to from down to up, we can find that, in most cases, with the increase of n and m, the estimation performance of all obtained estimators will improve, corresponding to lower RMSE, MRAB, ACL, and CP values.

    (2) Among all estimates, Bayesian estimates based on SE loss and GE loss are more accurate than MPS and ML estimates because of lower RMSE, MRAB, and ACL values and higher CP values.

    (3) Different prior parameters will affect the effectiveness of Bayesian estimation. In Bayesian estimation, the Bayesian estimator based on SE loss and the Bayesian estimator based on GE loss have better estimation performance under the gamma prior function with Priora as parameter than Priorb because the variance of Priora is smaller.

    (4) Different censored schemes may affect the estimated effectiveness to some extent. In most cases, estimates based on scheme-1 work better. In the face of progressively type-Ⅱ censored samples of the NGL distribution, the Bayesian estimation under the gamma prior function with Priora can be used to estimate the corresponding unknown parameters and related functions.

    (5) The Bayesian estimation under the gamma prior function with Priora is overestimated while with Priorb is underestimated.

    (6) The point (or interval) estimation of the MPS estimates and ML estimates of S(t) is significantly weaker than the result obtained by Bayes.

    (7) In summary, with a more complete amount of data from progressively type-Ⅱ censored, Bayesian estimation via M-H algorithm can obtain better estimates when estimating unknown parameters of the NGL distribution.

    This section demonstrates the flexibility of the proposed distribution and the usefulness of the various estimation methods through a practical application. The dataset, which was previously used by Bekker et al. [33] and later applied by Habib et al. [34], is the annual survival time of 46 patients who received chemotherapy and radiation therapy. The specific data is shown in Table 12.

    Table 12.  The annual survival time of 46 patients.
    0.047 0.115 0.121 0.132 0.164 0.197 0.203 0.26 0.282 0.296 0.334 0.395
    0.458 0.466 0.501 0.507 0.529 0.534 0.54 0.57 0.641 0.644 0.696 0.841
    0.863 1.099 1.219 1.271 1.326 1.447 1.485 1.553 1.581 1.589 2.178 2.343
    2.416 2.444 2.825 2.83 3.578 3.658 3.743 3.978 4.003 4.033

     | Show Table
    DownLoad: CSV

    In order to test whether the NGL distribution is suitable for the dataset, ML estimation is first used to estimate λ and θ, and the corresponding values with standard errors (St) are obtained as 0.90788 (0.33141) and 0.20264 (0.41243). Then the Kolmogorov-Smirnov (KS) value and P-value can be obtained as 0.10158 (0.69157). Compared with the truncated Nadarajah-Haghighi Raykeigh distribution, which presents a KS value with a P-value of 0.1080 (0.6307) for this dataset [34], it can be considered that the NGL distribution has a better fitting effect and is suitable for this dataset. As illustrated in Figure 9, the NGL distribution to the fitting effect of the dataset is demonstrated. This includes the fitted CDF, the probability-probability (PP), the scaled total time on test (TTT) transform [35], and the counter of the log-likelihood function. Figure 9 indicates that the NGL distribution is very close to the real data distribution and the existence and uniqueness of the obtained MLE estimates ˆλ and ˆθ.

    Figure 9.  (a) Fitted CDF of NGL, (b) PP, (c) scaled TTT-Transform, (d) counter of log-likelihood function from the annual survival time of 46 patients.

    Let m = 20, and three types of progressively type-Ⅱ censored samples are obtained from this dataset, as shown in Table 13. The point estimates of λ and θ are obtained by the above estimation method (MPS, ML, Bayesian estimation) and are shown in Table 14. At the same time, standard errors (St.es) are used to judge the accuracy of the estimated results. Here, the SE.es of λ and θ obtained by MPS and ML estimation are the square root of the diagonal elements of I1(Θ), respectively.

    Table 13.  Three progressively type-Ⅱ censored samples from the annual survival time.
    Sample Scheme
    S1 (0*19, 26) 0.047 0.115 0.121 0.132 0.164 0.197 0.203 0.26 0.282 0.296
    0.334 0.395 0.458 0.466 0.501 0.507 0.529 0.534 0.54 0.57
    S2 (13, 0*18, 13) 0.047 0.501 0.507 0.529 0.534 0.54 0.57 0.641 0.644 0.696
    0.841 0.863 1.099 1.219 1.271 1.326 1.447 1.485 1.553 4.033
    S3 (26, 0*19) 0.047 1.271 1.326 1.447 1.485 1.553 1.581 1.589 2.178 2.343
    2.416 2.444 2.825 2.83 3.578 3.658 3.743 3.978 4.003 4.033

     | Show Table
    DownLoad: CSV
    Table 14.  Point estimates (St.es) of λ,θ from the annual survival time.
    Si Parameter MPS MLE SE GE
    γ=2
    S1 λ 0.63616(0.11222) 0.74652(0.15355) 0.2378(0.0579) 0.2539(0.0557)
    θ 0.999(0.17427) 0.999(0.4182) 0.7465(0.2911) 0.8367(0.2369)
    S2 λ 0.21672(0.038498) 0.1919(0.033919) 0.0663(0.0120) 0.0670(0.0112)
    θ 0.91092(0.14331) 0.95217(0.15405) 0.7755(0.1317) 0.7933(0.1235)
    S3 λ 0.01693(0.00463) 0.01611(0.00455) 0.0523(0.0216) 0.0935(0.0141)
    θ 0.001(0.42653) 0.001(0.44385) 0.2585(0.3328) 0.8966(0.0917)

     | Show Table
    DownLoad: CSV

    Through the M-H algorithm, 5000 MCMC samples are generated, and the first 1000 samples are omitted. The sample sequence {λ(i)},{θ(i)} formed can approximately obey the posterior distribution, and the variance of the posterior distribution can be estimated by the sample variance, that is:

    Stλ=139994000i=1(λ(i)ˆλ),Stθ=139994000i=1(θ(i)ˆθ).

    It can be seen from Table 14 that under three different censored schemes:

    ● All estimation methods have a better fitting effect when fitting the dataset.

    ● The results estimated by ML and MPS are similar, and the results estimated by Bayes under two different losses are similar.

    ● The MPS and ML estimation fit the scale parameter λ preferentially when fitting, which makes the scale parameter more accurate but tends to lead to overflow of the shape parameter α. Bayesian estimation weighs the two parameters more than the other two estimation methods and is less prone to overflow of the range of estimates.

    ● In general, the results of Bayesian estimates based on GE loss functions are more consistent with the dataset than those of other methods.

    A Lindley distribution with multiple models can be applied to various fields, such as product life research and species presence distribution. This paper focused on the examination of the NGL distribution's inherent properties and significant statistical characteristics. It was determined that the proposed distribution possesses favorable properties and that such properties exhibit relatively straightforward numerical expressions. This finding is instrumental in facilitating subsequent research endeavors. Subsequently, this paper actively explored the application of maximum product spacing estimation, maximum likelihood estimation, and Bayesian estimation to the NGL distribution. The development of a comprehensive simulation plan, incorporating two distinct failure rates, three disparate censored schemes, and four evaluation criteria, was undertaken to investigate the impact of various estimation methods on the proposed distribution point estimation and interval estimation. Finally, it was concluded that the Bayesian estimator under SE loss and GE loss has relatively good estimation effect, and this estimation method can be integrated into the NGL distribution for further exploration in future research. In addition, in order to ensure that the NGL distribution has practical application significance, a real dataset, containing annual survival rates, was used to carry out research. The analysis showed that the proposed distribution has a good fitting effect on the original dataset, and we found that the proposed distribution has a good fit to the censored data of the dataset. The above estimation methods were used to finally conclude that the distribution also has a good fitting effect on the censored data of the real dataset in the Bayesian estimation. In future studies, we will continue to increase the integration of the proposed distribution with real industry scenarios.

    Jiajie Shi: Writing-original draft, Method, Software, Writing-review & editing; Haiping Ren: Methods, Writing-original draft, Writing-review & editing. All authors have read and approved the final version of the manuscript for publication.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    This research was funded by National Natural Science Foundation of China, grant number 71661012.

    The authors declare no conflict of interest.

    clear

    tic

    a0=0.5; b0=0.75; m=30;n=50;num=1000;t=0.5;S0=0.9248;h0=0.1842;ca=0;cb=0;cS=0;ch=0;

    Ra=[zeros(1,m-1),n-m];

    Rb=[floor((n-m)/2),zeros(1,m-2),(n-m-floor((n-m)/2))];

    Rc=[n-m,zeros(1,m-1)];

    a = zeros(num,1);

    b = zeros(num,1);

    ACI1 = zeros(num, 2);

    ACI2 = zeros(num, 2);

    ACI3 = zeros(num, 2);

    ACI4 = zeros(num, 2);

    for i=1:num

    G=rand(1,m);

    for j=1:m

    H(j)=G(j).^(1/(j+sum(Ra(m-j+1:m))));

    end

    for j=1:m

    Z(j)=1-prod(H(m-j+1:m));

    end

    x=(-b0.*lambertw(-1,exp(-1./b0).*(Z-1)./b0)-1)./(a0.*b0);

    [a(i,1),b(i,1),ACI1(i,:),ACI2(i,:),S(i,1),h(i,1),ACI3(i,:),ACI4(i,:)] =MPS(t,Ra,n,x,a0,b0);

    if a0>=ACI1(i,1)&&a0<=ACI1(i,2)

    ca=ca+1;

    end

    if b0>=ACI2(i,1)&&b0<=ACI2(i,2)

    cb=cb+1;

    end

    if S0>=ACI3(i,1)&&S0<=ACI3(i,2)

    cS=cS+1;

    end

    if h0>=ACI4(i,1)&&h0<=ACI4(i,2)

    ch=ch+1;

    end

    end

    aMLi=mean(a)

    mse_a=sqrt(mean((a-a0).^2))

    MRE_a=mean(abs((a-a0)./a0))

    ACL_a=mean(ACI1(:,2)-ACI1(:,1))

    ca=ca/num

    bMLi=mean(b)

    mse_b=sqrt(mean((b-b0).^2))

    MRE_b=mean(abs((b-b0)./b0))

    ACL_b=mean(ACI2(:,2)-ACI2(:,1))

    cb=cb/num

    SMLi=mean(S)

    mse_S=sqrt(mean((S-S0).^2))

    MRE_S=mean(abs((S-S0)./S0))

    ACL_S=mean(ACI3(:,2)-ACI3(:,1))

    cS=cS/num

    hMLi=mean(h)

    mse_h=sqrt(mean((h-h0).^2))

    MRE_h=mean(abs((h-h0)./h0))

    ACL_h=mean(ACI4(:,2)-ACI4(:,1))

    ch=ch/num

    toc

    clear

    tic

    a0=0.5; b0=0.75; m=30;n=50;num=1000;t=0.5;S0=0.9248;h0=0.1842;ca=0;cb=0;cS=0;ch=0;

    Ra=[zeros(1,m-1),n-m];

    Rb=[floor((n-m)/2),zeros(1,m-2),(n-m-floor((n-m)/2))];

    Rc=[n-m,zeros(1,m-1)];

    a = zeros(num,1);

    b = zeros(num,1);

    S=zeros(num,1);

    h=zeros(num,1);

    ACI1 = zeros(num, 2);

    ACI2 = zeros(num, 2);

    ACI3 = zeros(num, 2);

    ACI4 = zeros(num, 2);

    for i=1:num

    G=rand(1,m);

    for j=1:m

    H(j)=G(j).^(1/(j+sum(Ra(m-j+1:m))));

    end

    for j=1:m

    Z(j)=1-prod(H(m-j+1:m));

    end

    x=(-b0.*lambertw(-1,exp(-1./b0).*(Z-1)./b0)-1)./(a0.*b0);

    [a(i,1),b(i,1),ACI1(i,:),ACI2(i,:),S(i,1),h(i,1),ACI3(i,:),ACI4(i,:)] =MLi(t,Ra,n,x,a0,b0);

    if a0>=ACI1(i,1)&&a0<=ACI1(i,2)

    ca=ca+1;

    end

    if b0>=ACI2(i,1)&&b0<=ACI2(i,2)

    cb=cb+1;

    end

    if S0>=ACI3(i,1)&&S0<=ACI3(i,2)

    cS=cS+1;

    end

    if h0>=ACI4(i,1)&&h0<=ACI4(i,2)

    ch=ch+1;

    end

    end

    aMLi=mean(a)

    mse_a=sqrt(mean((a-a0).^2))

    MRE_a=mean(abs((a-a0)./a0))

    ACL_a=mean(ACI1(:,2)-ACI1(:,1))

    ca=ca/num

    bMLi=mean(b)

    mse_b=sqrt(mean((b-b0).^2))

    MRE_b=mean(abs((b-b0)./b0))

    ACL_b=mean(ACI2(:,2)-ACI2(:,1))

    cb=cb/num

    SMLi=mean(S)

    mse_S=sqrt(mean((S-S0).^2))

    MRE_S=mean(abs((S-S0)./S0))

    ACL_S=mean(ACI3(:,2)-ACI3(:,1))

    cS=cS/num

    hMLi=mean(h)

    mse_h=sqrt(mean((h-h0).^2))

    MRE_h=mean(abs((h-h0)./h0))

    ACL_h=mean(ACI4(:,2)-ACI4(:,1))

    ch=ch/num

    toc

    clear

    a0=0.5; b0=0.75; m=30;n=50;num=1000;t=0.5;S0=0.9248;h0=0.1842;c1=0;c2=0;c3=0;c4=0;

    Ra=[zeros(1,m-1),n-m];

    Rb=[floor((n-m)/2),zeros(1,m-2),(n-m-floor((n-m)/2))];

    Rc=[n-m,zeros(1,m-1)];

    a_BMH=zeros(num,1);

    b_BMH=zeros(num,1);

    S_BMH=zeros(num,1);

    h_BMH=zeros(num,1);

    aHPD=zeros(num,1);

    bHPD=zeros(num,1);

    SHPD=zeros(num,1);

    hHPD=zeros(num,1);

    for i=1:num

    G=rand(1,m);

    for j=1:m

    H(j)=G(j).^(1/(j+sum(Rc(m-j+1:m))));

    end

    for j=1:m

    Z(j)=1-prod(H(m-j+1:m));

    end

    x=(-b0.*lambertw(-1,exp(-1./b0).*(Z-1)./b0)-1)./(a0.*b0);

    [a_BMH(i,1),b_BMH(i,1),S_BMH(i,1),h_BMH(i,1),aHPD(i,1),bHPD(i,1),SHPD(i,1),hHPD(i,1),cp1,cp2,cp3,cp4]=BMH(t,Rc,n,x,0.4,0.7);

    c1=c1+cp1;c2=c2+cp2;c3=c3+cp3;c4=c4+cp4;

    end

    aBMH=mean(a_BMH)

    mse_a=sqrt(mean((a_BMH-a0).^2))

    MRE_a=mean(abs((a_BMH-a0)./a0))

    ACL_a=mean(aHPD)

    ca=c1/num

    bBMH=mean(b_BMH)

    mse_b=sqrt(mean((b_BMH-b0).^2))

    MRE_b=mean(abs((b_BMH-b0)./b0))

    ACL_b=mean(bHPD)

    cb=c2/num

    SBMH=mean(S_BMH)

    mse_S=sqrt(mean((S_BMH-S0).^2))

    MRE_S=mean(abs((S_BMH-S0)./S0))

    ACL_S=mean(SHPD)

    cS=c3/num

    hBMH=mean(h_BMH)

    mse_h=sqrt(mean((h_BMH-h0).^2))

    MRE_h=mean(abs((h_BMH-h0)./h0))

    ACL_h=mean(hHPD)

    ch=c4/num

    Counter diagram of the parameters of the NGL distribution

    clear

    syms a b;

    a0=0.5; b0=0.75; m=50;n=100;

    Ra=[zeros(1,m-1),n-m];

    Rb=[floor((n-m)/2),zeros(1,m-2),(n-m-floor((n-m)/2))];

    Rc=[n-m,zeros(1,m-1)];

    G=rand(1,m);

    for j=1:m

    H(j)=G(j).^(1/(j+sum(Ra(m-j+1:m))));

    end

    for j=1:m

    Z(j)=1-prod(H(m-j+1:m));

    end

    P=Ra;

    x=(-b0.*lambertw(-1,exp(-1./b0).*(Z-1)./b0)-1)./(a0.*b0);

    lb=m.*log(a)-a.*sum(x.*(1+P))+sum(log(1-b+a.*b.*x))+sum(P.*log(1+a.*b.*x));

    lc= n.*log(a)-a.*sum(x)+sum(log(1-b+a.*b.*x));

    laa=matlabFunction(lb, 'Vars', {a, b});

    a1 = 0.2:0.01:1;

    b1 = 0.36:0.01:0.75;

    [a1,b1] = meshgrid(a1,b1);

    la=real(laa(b1,a1));

    [M,c]=contour(a1,b1,la,'showText','on');

    xlabel('θ');

    ylabel('λ');

    c.LineWidth=3;

    colorbar.


    Acknowledgments



    We sincerely appreciate the management of Afe Babalola University for graciously providing the enabling environment with adequate cutting edge facilities to carry out this research and for giving permission to collaborate with other universities.

    Conflict of interest



    The authors declare no conflict of interest.

    Author contributions



    AOA conceived the conceptual idea, AOA, AAF, and MMO conducted the experiments and planned the literature search. AAF and VOE analyzed and interpreted the data. AOA, AAF DDA, LDA and TKA drafted the manuscript, read, revised the manuscript. All authors gave the final approval for the manuscript to be published.

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    沈阳化工大学材料科学与工程学院 沈阳 110142

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