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Does Antenatal Administration of Magnesium Sulphate Prevent Cerebral Palsy and Mortality in Preterm Infants? A Study Protocol.

Hvidovre Hospital, Kettegård Alle 30,2650 Hvidovre, Danmark

Special Issues: Magnesium in pregnancy

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Citation: Hanne Trap Wolf, Hanne Kristine Hegaard, Anja Bisgaard Pinborg, Lene Drasbek Huusom. Does Antenatal Administration of Magnesium Sulphate Prevent Cerebral Palsy and Mortality in Preterm Infants? A Study Protocol.. AIMS Public Health , 2015, 3(4): 727-729. doi: 10.3934/publichealth.2015.4.727


  • 1. Himpens E, Van den Broeck C, Oostra A et al. Prevalence, type, distribution, and severity of cerebral palsy in relation to gestational age: a meta-analytic review. Dev Med Child Neurol. May 2008;50(5):334-40.
  • 2. Wolf HT, Hegaard HK, Greisen G et al. Treatment with magnesium sulphate in pre-term birth: a systematic review and meta-analysis of observational studies. J Obstet Gynaecol J Inst Obstet Gynaecol. February 2012;32(2):135-40.
  • 3. Doyle LW, Crowther CA, Middleton P et al. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev. 2009;(1):CD004661.
  • 4. Huusom LD, Secher NJ, Pryds O et al. Antenatal magnesium sulphate may prevent cerebral palsy in preterm infants-but are we convinced? Evaluation of an apparently conclusive meta-analysis with trial sequential analysis. BJOG Int J Obstet Gynaecol. January 2011;118(1):1-5.
  • 5. Schonhaut L, Armijo I, Schönstedt M et al. Validity of the ages and stages questionnaires in term and preterm infants. Pediatrics. May 2013;131(5):e1468-1474.


This article has been cited by

  • 1. Caroline A. Crowther, Philippa F. Middleton, Merryn Voysey, Lisa Askie, Lelia Duley, Peter G. Pryde, Stéphane Marret, Lex W. Doyle, Jenny E Myers, Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: An individual participant data meta-analysis, PLOS Medicine, 2017, 14, 10, e1002398, 10.1371/journal.pmed.1002398
  • 2. Clément Chollat, Loïc Sentilhes, Stéphane Marret, Fetal Neuroprotection by Magnesium Sulfate: From Translational Research to Clinical Application, Frontiers in Neurology, 2018, 9, 10.3389/fneur.2018.00247
  • 3. Lene Drasbek Huusom, Hanne Trap Wolf, Antenatal magnesium sulfate treatment for women at risk of preterm birth is safe and might decrease the risk of cerebral palsy, BMJ Evidence-Based Medicine, 2018, 23, 5, 195, 10.1136/bmjebm-2018-110897

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Copyright Info: 2015, Hanne Trap Wolf, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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