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Role of actin cytoskeleton at multiple levels of T cell activation

Laboratory of Adaptive Immunity, Institute of Molecular Genetics, Czech Academy of Sciences, Videnska 1083, Prague, Czech Republic

Topical Section: Cells Signalling and Signal Transduction

Actin cytoskeleton is an essential cellular structure that is involved in many physiological aspects, including T cell antigenic responses. In has been proposed that actin modulates biophysical parameters of the antigen recognition, forms a barrier inhibiting spontaneous signaling in resting T cells, facilitates TCR signal transduction, stabilizes contacts between T cells and antigen presenting cells, and contributes to the establishment of the antigen affinity threshold. In this review, we discuss the role of actin cytoskeleton at these particular levels of T cell activation.
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